@article{MTMT:33088384, title = {Association of genetic variants of Glutamate Metabotropic Receptor 5 gene and state-anhedonia}, url = {https://m2.mtmt.hu/api/publication/33088384}, author = {Török, Dóra and Gonda, Xénia and Gál, Zsófia and Eszlári, Nóra and Bagdy, György and Juhász, Gabriella and Petschner, Péter}, doi = {10.1192/j.eurpsy.2022.398}, journal-iso = {EUR PSYCHIAT}, journal = {EUROPEAN PSYCHIATRY}, volume = {65}, unique-id = {33088384}, issn = {0924-9338}, year = {2022}, eissn = {1778-3585}, pages = {S148-S148}, orcid-numbers = {Török, Dóra/0000-0001-9213-4345; Gonda, Xénia/0000-0001-9015-4203; Gál, Zsófia/0000-0002-9441-1497; Eszlári, Nóra/0000-0003-4913-028X; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267; Petschner, Péter/0000-0002-3198-858X} } @{MTMT:33061562, title = {Precision Medicine in Psychiatric Disorders}, url = {https://m2.mtmt.hu/api/publication/33061562}, author = {Gonda, Xénia and Gecse, Kinga and Gál, Zsófia and Juhász, Gabriella}, booktitle = {Precision Medicine in Clinical Practice}, doi = {10.1007/978-981-19-5082-7_6}, unique-id = {33061562}, year = {2022}, pages = {93-112}, orcid-numbers = {Gonda, Xénia/0000-0001-9015-4203; Gecse, Kinga/0000-0002-3512-2572; Gál, Zsófia/0000-0002-9441-1497; Juhász, Gabriella/0000-0002-5975-4267} } @article{MTMT:31526985, title = {Sex differences in maturation and aging of human personality on the basis of a recently developed complex hierarchical model of temperament and character}, url = {https://m2.mtmt.hu/api/publication/31526985}, author = {Fountoulakis, K.N. and Gonda, Xénia}, doi = {10.1080/13651501.2020.1804941}, journal-iso = {INT J PSYCHIAT CLIN}, journal = {INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE}, volume = {26}, unique-id = {31526985}, issn = {1365-1501}, year = {2022}, eissn = {1471-1788}, pages = {58-71}, orcid-numbers = {Gonda, Xénia/0000-0001-9015-4203} } @article{MTMT:32064502, title = {Genetic underpinnings of affective temperaments: a pilot GWAS investigation identifies a new genome-wide significant SNP for anxious temperament in ADGRB3 gene}, url = {https://m2.mtmt.hu/api/publication/32064502}, author = {Gonda, Xénia and Eszlári, Nóra and Török, Dóra and Gál, Zsófia and Bokor, János and Millinghoffer, Andras and Baksa, Dániel and Petschner, Péter and Antal, Péter and Breen, Gerome and Juhász, Gabriella and Bagdy, György}, doi = {10.1038/s41398-021-01436-1}, journal-iso = {TRANSL PSYCHIAT}, journal = {TRANSLATIONAL PSYCHIATRY}, volume = {11}, unique-id = {32064502}, issn = {2158-3188}, abstract = {Y Although recently a large-sample GWASs identified significant loci in the background of depression, the heterogeneity of the depressive phenotype and the lack of accurate phenotyping hinders applicability of findings. We carried out a pilot GWAS with in-depth phenotyping of affective temperaments, considered as subclinical manifestations and high-risk states for affective disorders, in a general population sample of European origin. Affective temperaments were measured by TEMPS-A. SNP-level association was assessed by linear regression models, assuming an additive genetic effect, using PLINK1.9. Gender, age, the first ten principal components (PCs) and the other four temperaments were included in the regression models as covariates. SNP-level relevances (p-values) were aggregated to gene level using the PEGASUS method(1). In SNP-based tests, a Bonferroni-corrected significance threshold of p <= 5.0 x 10(-8) and a suggestive significance threshold of p <= 1.0 x 10(-5), whereas in gene-based tests a Bonferroni-corrected significance of 2.0 x 10(-6) and a suggestive significance of p <= 4.0 x 10(-4) was established. To explore known functional effects of the most significant SNPs, FUMA v1.3.5 was used. We identified 1 significant and 21 suggestively significant SNPs in ADGRB3, expressed in the brain, for anxious temperament. Several other brain-relevant SNPs and genes emerged at suggestive significance for the other temperaments. Functional analyses reflecting effect on gene expression and participation in chromatin interactions also pointed to several genes expressed in the brain with potentially relevant phenotypes regulated by our top SNPs. Our findings need to be tested in larger GWA studies and candidate gene analyses in well-phenotyped samples in relation to affective disorders and related phenotypes.}, year = {2021}, eissn = {2158-3188}, orcid-numbers = {Gonda, Xénia/0000-0001-9015-4203; Eszlári, Nóra/0000-0003-4913-028X; Török, Dóra/0000-0001-9213-4345; Gál, Zsófia/0000-0002-9441-1497; Bokor, János/0000-0002-8422-6271; Baksa, Dániel/0000-0002-7826-9179; Petschner, Péter/0000-0002-3198-858X; Breen, Gerome/0000-0003-2053-1792; Juhász, Gabriella/0000-0002-5975-4267; Bagdy, György/0000-0001-8141-3410} } @article{MTMT:31383651, title = {What's Love Got to do with it. Role of oxytocin in trauma, attachment and resilience}, url = {https://m2.mtmt.hu/api/publication/31383651}, author = {Sharma, Samata R and Gonda, Xénia and Döme, Péter and Tarazi, Frank I}, doi = {10.1016/j.pharmthera.2020.107602}, journal-iso = {PHARMACOL THERAPEUT}, journal = {PHARMACOLOGY & THERAPEUTICS}, volume = {214}, unique-id = {31383651}, issn = {0163-7258}, abstract = {Oxytocin (OT) is a neurohypophysial hormone and neuropeptide produced by the hypothalamus and released by the pituitary gland. It has multiple physiological roles including stimulation of parturition and lactation, and promotion of pro-adaptive social behaviors necessary for mammalian survival. OT interacts with one receptor subtype: the OT receptor (OTR), which, upon stimulation, triggers different intracellular signal transduction cascades to mediate its physiological actions. Preclinical studies show that OT regulates social behaviors such as pair bonding, recognition and social interaction. It also coordinates the activation of the hypothalamic-pituitary-adrenal (HPA) axis and the release of corticotrophin-releasing hormone. Further evidence suggests that OT plays an important role in regulating caloric intake and metabolism, and in maintaining electrolyte and cardiovascular homeostasis. OT is also involved in attenuating the neurophysiological and neurochemical effects of trauma on the brain and body by facilitating both physical attachment such as wound healing, and psychological/social attachment, thereby increasing resilience to subsequent traumatic events. Clinical trials have reported that intranasal administration of OT provides therapeutic benefits for patients diagnosed with traumatic stress-related diseases such as major depressive disorders and post-traumatic stress disorder. OT's therapeutic benefits may result from context-dependent interactions with key neural pathways (social, cognitive, and reward), neurotransmitters (dopamine, norepinephrine, serotonin, and endogenous opioids), and biomarkers (adrenocorticotropic hormone, cortisol, and dehydroepiandrosterone sulfate), that lead to a decrease in stress associated behaviors, and facilitate post-traumatic growth, ultimately leading to increased resilience, through improved social cohesion and attachment. OT induced-augmentation of physical and cognitive resilience may play a significant role in both the prevention of, and improved clinical outcomes for, traumatic stress-related disorders following either acute or enduring traumatic experiences.}, keywords = {OXYTOCIN; TRAUMA; MAJOR DEPRESSIVE DISORDER; RESILIENCE; early life stress; adverse childhood experiences; Post-Traumatic Stress Disorder; post-traumatic growth}, year = {2020}, eissn = {1879-016X}, orcid-numbers = {Gonda, Xénia/0000-0001-9015-4203; Döme, Péter/0000-0003-3847-0553} } @misc{MTMT:31368877, title = {GABA-A and CB1 receptor variants mediate different types of stress in the development of depression and anxiety - O0122}, url = {https://m2.mtmt.hu/api/publication/31368877}, author = {Gonda, Xénia and Eszlári, Nóra and Sütöri, Sára and Gál, Zsófia and Török, Dóra and Petschner, Péter and Juhász, Gabriella and Bagdy, György}, unique-id = {31368877}, year = {2020}, orcid-numbers = {Gonda, Xénia/0000-0001-9015-4203; Eszlári, Nóra/0000-0003-4913-028X; Gál, Zsófia/0000-0002-9441-1497; Török, Dóra/0000-0001-9213-4345; Petschner, Péter/0000-0002-3198-858X; Juhász, Gabriella/0000-0002-5975-4267; Bagdy, György/0000-0001-8141-3410} } @article{MTMT:31368870, title = {Depressive polarity at illness onset is associated with lifetime suicide attempts in euthymic bipolar outpatients - O0009}, url = {https://m2.mtmt.hu/api/publication/31368870}, author = {Serafini, Gianluca and Aguglia, Andrea and Santi, Francesca and Canepa, Giovanna and Gonda, Xénia and Rihmer, Zoltán and Pompili, Maurizio and Amore, Mario}, journal-iso = {EUR PSYCHIAT}, journal = {EUROPEAN PSYCHIATRY}, volume = {63}, unique-id = {31368870}, issn = {0924-9338}, year = {2020}, eissn = {1778-3585}, pages = {S4-S5}, orcid-numbers = {Gonda, Xénia/0000-0001-9015-4203; Rihmer, Zoltán/0000-0002-5104-0569} } @article{MTMT:31270854, title = {P43 The Association of Irritable Affective Temperament with 24-Hour Brachial and Central Blood Pressure and Hemodynamic Parameters in Untreated Hypertensive Men}, url = {https://m2.mtmt.hu/api/publication/31270854}, author = {Kőrösi, Beáta Zita and Batta, Dóra and Vecsey-Nagy, Milán and Gonda, Xénia and Rihmer, Zoltán and Nemcsik-Bencze, Zsófia and László, Andrea and Nemcsik, János}, doi = {10.2991/artres.k.191224.074}, journal-iso = {ARTERY RES}, journal = {ARTERY RESEARCH}, volume = {25}, unique-id = {31270854}, issn = {1872-9312}, year = {2020}, eissn = {1876-4401}, pages = {S83}, orcid-numbers = {Kőrösi, Beáta Zita/0000-0003-4995-6401; Batta, Dóra/0000-0001-7207-8665; Vecsey-Nagy, Milán/0000-0001-9306-289X; Gonda, Xénia/0000-0001-9015-4203; Rihmer, Zoltán/0000-0002-5104-0569; László, Andrea/0000-0002-8619-9684; Nemcsik, János/0000-0002-3573-0287} } @article{MTMT:31270815, title = {P92 The Association of Agreeableness and Conscientiousness with 24-Hour Brachial Blood Pressure and Hemodynamic Parameters in Untreated Hypertensive Patients}, url = {https://m2.mtmt.hu/api/publication/31270815}, author = {Vecsey-Nagy, Milán and Kőrösi, Beáta Zita and Batta, Dóra and Gonda, Xénia and Rihmer, Zoltán and Nemcsik-Bencze, Zsófia and László, Andrea and Nemcsik, János}, doi = {10.2991/artres.k.191224.121}, journal-iso = {ARTERY RES}, journal = {ARTERY RESEARCH}, volume = {25}, unique-id = {31270815}, issn = {1872-9312}, year = {2020}, eissn = {1876-4401}, pages = {S134}, orcid-numbers = {Vecsey-Nagy, Milán/0000-0001-9306-289X; Kőrösi, Beáta Zita/0000-0003-4995-6401; Batta, Dóra/0000-0001-7207-8665; Gonda, Xénia/0000-0001-9015-4203; Rihmer, Zoltán/0000-0002-5104-0569; László, Andrea/0000-0002-8619-9684; Nemcsik, János/0000-0002-3573-0287} } @article{MTMT:31266667, title = {A DEPRESSZIÓ, SZORONGÁS ÉS AZ AFFEKTÍV TEMPERAMENTUM-TÍPUSOK HATÁSA A 2-ES TÍPUSÚ CUKORBETEGEK SZÉNHIDRÁTHÁZTARTÁSÁRA}, url = {https://m2.mtmt.hu/api/publication/31266667}, author = {Hargittay, Csenge and Eőry, Ajándék and Gonda, Xénia and Márkus, Bernadett and Szélvári, Ágnes and Vörös, Krisztián and Rihmer, Zoltán and Kalabay, László and Torzsa, Péter}, journal-iso = {MED UNIV}, journal = {MEDICUS UNIVERSALIS}, volume = {53}, unique-id = {31266667}, issn = {0133-1973}, year = {2020}, pages = {41}, orcid-numbers = {Hargittay, Csenge/0000-0001-6994-8316; Eőry, Ajándék/0000-0002-4434-1339; Gonda, Xénia/0000-0001-9015-4203; Márkus, Bernadett/0000-0002-3880-5168; Szélvári, Ágnes/0000-0001-8970-196X; Vörös, Krisztián/0000-0002-4095-3012; Rihmer, Zoltán/0000-0002-5104-0569; Kalabay, László/0000-0002-8329-3755; Torzsa, Péter/0000-0002-8148-4961} }