TY - JOUR AU - Szőllősi, György AU - Resch, Vivien Erzsébet AU - Kolcsár, Vanessza Judit TI - Asymmetric transfer hydrogenation of 2,3-diphenylpropenoic acids over heterogeneous palladium catalysts modified by cinchona alkaloids JF - JOURNAL OF CATALYSIS J2 - J CATAL VL - 429 PY - 2024 PG - 12 SN - 0021-9517 DO - 10.1016/j.jcat.2024.115290 UR - https://m2.mtmt.hu/api/publication/34502096 ID - 34502096 LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Péter AU - SHIVA SHANKAR, LAKSHMI AU - Szabados, Márton AU - Roumia, Hala AU - Kukovecz, Ákos AU - Kun, Róbert AU - Szabó, Tamás TI - Aqueous heterocoagulation-driven assembly of graphene oxide and polycation-coated sulfur particles for nanocomposite Li-S battery cathodes JF - JOURNAL OF COLLOID AND INTERFACE SCIENCE J2 - J COLLOID INTERF SCI VL - 655 PY - 2024 SP - 931 EP - 942 PG - 12 SN - 0021-9797 DO - 10.1016/j.jcis.2023.11.026 UR - https://m2.mtmt.hu/api/publication/34405490 ID - 34405490 N1 - Department of Physical Chemistry and Materials Science, University of Szeged, Rerrich Béla tér 1, Szeged, H-6720, Hungary Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, H-1117 Budapest, Magyar tudósok krt. 2., Budapest, Hungary Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary Department of Applied and Environmental Chemistry, University of Szeged, Rerrich Béla tér 1, Szeged, H-6720, Hungary Department of Chemical and Environmental Process Engineering, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, Budapest, H-1111, Hungary Export Date: 30 November 2023 CODEN: JCISA Correspondence Address: Kun, R.; Institute of Materials and Environmental Chemistry, Budapest, Hungary; email: kun.robert@ttk.hu LA - English DB - MTMT ER - TY - JOUR AU - Kozma, Viktória AU - Szőllősi, György TI - Új katalitikus rendszerek alkalmazása aszimmetrikus Michael-addíciókban maleimidekre JF - MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-) J2 - MAGY KÉM FOLY KÉM KÖZL VL - 129 PY - 2023 IS - 3-4 SP - 139 EP - 146 PG - 8 SN - 1418-9933 DO - 10.24100/MKF.2023.03-04.139 UR - https://m2.mtmt.hu/api/publication/34483761 ID - 34483761 N1 - "Kozma Viktória azonos című PhD értekezése és a kapcsolódó tézisfüzet alapján készült." LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kolcsár, Vanessza Judit AU - Szőllősi, György TI - Környezetkímélő katalitikus rendszerek fejlesztése prokirális ketonok aszimmetrikus transzferhidrogénezésére JF - MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-) J2 - MAGY KÉM FOLY KÉM KÖZL VL - 129 PY - 2023 IS - 2 SP - 71 EP - 77 PG - 7 SN - 1418-9933 DO - 10.24100/MKF.2023.02.71 UR - https://m2.mtmt.hu/api/publication/34336155 ID - 34336155 N1 - Kolcsár Vanessza Judit azonos című PhD értekezése és a kapcsolódó tézisfüzet alapján készült. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Senobar Tahaei, Seyyed Ashkan AU - Kulmány, Ágnes Erika AU - Minorics, Renáta AU - Kiss, Anita AU - Szabó, Zoltán AU - Germán, Péter AU - Szebeni, Gábor AU - Gémes, Nikolett AU - Mernyák, Erzsébet AU - Zupkó, István TI - Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 18 PG - 16 SN - 1661-6596 DO - 10.3390/ijms241813749 UR - https://m2.mtmt.hu/api/publication/34131836 ID - 34131836 N1 - Funding Agency and Grant Number: The authors thank Dora Bokor, PharmD, for proofreading the manuscript. Funding text: The authors thank Dora Bokor, PharmD, for proofreading the manuscript. AB - Four diastereomers of 16-azidomethyl substituted 3-O-benzyl estradiol (1–4) and their two estrone analogs (16AABE and 16BABE) were tested for their antiproliferative properties against human gynecological cancer cell lines. The estrones were selected for additional experiments based on their outstanding cell growth-inhibiting activities. Both compounds increased hypodiploid populations of breast cancer cells, and 16AABE elicited cell cycle disturbance as evidenced by flow cytometry. The two analogs substantially increased the rate of tubulin polymerization in vitro. 16AABE and 16BABE inhibited breast cancer cells’ migration and invasive ability, as evidenced by wound healing and Boyden chamber assays. Since both estrone analogs exerted remarkable estrogenic activities, as documented by a luciferase reporter gene assay, they can be considered as promising drug candidates for hormone-independent malignancies. LA - English DB - MTMT ER - TY - JOUR AU - Szabados, Márton AU - Szabados, Tamara AU - Mucsi, Róbert AU - Baán, Kornélia AU - Kiss, János AU - Szamosvölgyi, Ákos AU - Sápi, András AU - Kónya, Zoltán AU - Kukovecz, Ákos AU - Sipos, Pál Miklós TI - Directed thermocatalytic CO2 reduction over NiAl4 layered double hydroxide precursors − activity and selectivity control using different interlayer anions JF - JOURNAL OF CO2 UTILIZATION J2 - J CO2 UTIL VL - 75 PY - 2023 PG - 13 SN - 2212-9820 DO - 10.1016/j.jcou.2023.102567 UR - https://m2.mtmt.hu/api/publication/34105840 ID - 34105840 LA - English DB - MTMT ER - TY - JOUR AU - Zottel, A. AU - Jójárt, Rebeka AU - Ágoston, H. AU - Hafner, E. AU - Lipušček, N. AU - Mernyák, Erzsébet AU - Rižner, T.L. TI - Cytotoxic effect of 13α-estrane derivatives on breast, endometrial and ovarian cancer cell lines JF - JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY J2 - J STEROID BIOCHEM MOL BIOL VL - 232 PY - 2023 PG - 7 SN - 0960-0760 DO - 10.1016/j.jsbmb.2023.106350 UR - https://m2.mtmt.hu/api/publication/34101587 ID - 34101587 N1 - Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, 1000, Slovenia Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary Export Date: 17 August 2023 CODEN: JSBBE Correspondence Address: Mernyák, E.; University of Szeged, Dóm tér 8, Hungary; email: bobe@chem.u-szeged.hu Correspondence Address: Rižner, T.L.; Institute of Biochemistry and Molecular Genetics, Vrazov trg 2, Slovenia; email: Tea.Lanisnik-Rizner@mf.uni-lj.si Funding details: Magyar Tudományos Akadémia, MTA Funding details: Javna Agencija za Raziskovalno Dejavnost RS, ARRS Funding details: National Research, Development and Innovation Office, OTKA SNN 124329, SNN 139323 Funding text 1: This work was supported by projects N1–0066 and N1–0234 from the Slovenian Research Agency to T.L.R. and by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences and the National Research, Development and Innovation Office-NKFIH project OTKA SNN 124329 and SNN 139323 to E.M. AB - Hormone-dependent cancers such as breast, uterine, and ovarian cancers account for more than 35% of all cancers in women. Worldwide, these cancers occur in more than 2.7 million women/year and account for 22% of cancer-related deaths/year. The generally accepted mechanism for the pathophysiology of estrogen-dependent cancers is estrogen receptor-mediated cell proliferation associated with an increased number of mutations. Therefore, drugs that can interfere with either local estrogen formation or estrogen action via estrogen receptors are needed. Estrane derivatives that have low or minimal estrogenic activity can affect both pathways. In this study, we investigated the effect of 36 different estrane derivatives on the proliferation of eight breast, endometrial, and ovarian cancer cell lines and the corresponding three control cell lines. Estrane derivatives 3 and 4_2Cl showed a stronger effect on the endometrial cancer cell lines KLE and Ishikawa, respectively, compared with the control cell line HIEEC, with IC50 values of 32.6 microM and 17.9 microM, respectively. Estrane derivative 4_2Cl was most active in the ovarian cancer cell line COV362 compared to the control cell line HIO80 with an IC50 value of 3.6 microM. In addition, estrane derivative 2_4I showed a strong antiproliferative effect on endometrial and ovarian cancer cell lines, while the effect on the control cell line was slight or absent. The addition of halogen at carbon 2 and/or 4 in estrane derivatives 1 and 2 increased the selectivity for endometrial cancer cells. Overall, these results suggest that single estrane derivatives are efficient cytotoxic agents for endometrial and ovarian cancer cell lines, and thus potential lead compounds for drug development. © 2023 The Authors LA - English DB - MTMT ER - TY - JOUR AU - Lantos, Emese AU - Mótyán, Gergő AU - Nagyné Frank, Éva AU - Eelkema, Rienk AU - van Esch, Jan AU - Horváth, Dezső AU - Tóth, Ágota TI - Dynamics of hydroxide-ion-driven reversible autocatalytic networks JF - RSC ADVANCES J2 - RSC ADV VL - 13 PY - 2023 IS - 29 SP - 20243 EP - 20247 PG - 5 SN - 2046-2069 DO - 10.1039/D3RA04215D UR - https://m2.mtmt.hu/api/publication/34075504 ID - 34075504 AB - An autocatalytic reaction network is designed utilising the interplay of hydroxide concentration dependent reactions and acid–base equilibria of imine hydrolysis. LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Ferenc István AU - Gopisetty, Mohana Krishna AU - Huliák, Ildikó AU - Nagyné Frank, Éva AU - Csontné Kiricsi, Mónika TI - P-01.1-10 Semi-synthetic dihydrotestosterone derivatives modulate inherent multidrug resistance and sensitize colon cancer cells to chemotherapy JF - FEBS OPEN BIO J2 - FEBS OPEN BIO VL - 13 PY - 2023 IS - S2 SP - 66 EP - 66 PG - 198 SN - 2211-5463 DO - 10.1002/2211-5463.13646 UR - https://m2.mtmt.hu/api/publication/34070423 ID - 34070423 LA - English DB - MTMT ER - TY - JOUR AU - Hlogyik, Tamás AU - Laczkó-Rigó, Réka AU - Bakos, Éva AU - Poór, Miklós AU - Kele, Zoltán AU - Laczka, Csilla AU - Mernyák, Erzsébet TI - Synthesis and in vitro photodynamic activity of aza-BODIPY-based photosensitizers JF - ORGANIC & BIOMOLECULAR CHEMISTRY J2 - ORG BIOMOL CHEM VL - 21 PY - 2023 IS - 29 SP - 6018 EP - 6027 PG - 10 SN - 1477-0520 DO - 10.1039/d3ob00699a UR - https://m2.mtmt.hu/api/publication/34067941 ID - 34067941 N1 - * Megosztott szerzőség AB - Aza-BODIPY dyes have recently come to attention owing to their excellent chemical and photophysical properties. In particular, their absorption and emission maxima can efficiently be shifted to the red or even to the NIR spectral region. On this basis, aza-BODIPY derivatives are widely investigated as fluorescent probes or phototherapeutic agents. Here we report the synthesis of a set of novel aza-BODIPY derivatives as potential photosensitizers for use in photodynamic therapy. Triazolyl derivatives were obtained via Cu(I)-catalyzed azide-alkyne cycloaddition as the key step. In vitro photodynamic activities of the newly synthesized compounds were evaluated on the A431 human epidermoid carcinoma cell line. Structural differences influenced the light-induced toxicity of the test compounds markedly. Compared to the initial tetraphenyl aza-BODIPY derivative, the compound bearing two hydrophilic triethylene glycol side chains showed substantial, more than 250-fold, photodynamic activity with no dark toxicity. Our newly synthesized aza-BODIPY derivative, acting in the nanomolar range, might serve as a promising candidate for the design of more active and selective photosensitizers. LA - English DB - MTMT ER -