@article{MTMT:34502096, title = {Asymmetric transfer hydrogenation of 2,3-diphenylpropenoic acids over heterogeneous palladium catalysts modified by cinchona alkaloids}, url = {https://m2.mtmt.hu/api/publication/34502096}, author = {Szőllősi, György and Resch, Vivien Erzsébet and Kolcsár, Vanessza Judit}, doi = {10.1016/j.jcat.2024.115290}, journal-iso = {J CATAL}, journal = {JOURNAL OF CATALYSIS}, volume = {429}, unique-id = {34502096}, issn = {0021-9517}, year = {2024}, eissn = {1090-2694}, orcid-numbers = {Szőllősi, György/0000-0003-4418-9530; Resch, Vivien Erzsébet/0000-0003-0044-5731} } @article{MTMT:34405490, title = {Aqueous heterocoagulation-driven assembly of graphene oxide and polycation-coated sulfur particles for nanocomposite Li-S battery cathodes}, url = {https://m2.mtmt.hu/api/publication/34405490}, author = {Nagy, Péter and SHIVA SHANKAR, LAKSHMI and Szabados, Márton and Roumia, Hala and Kukovecz, Ákos and Kun, Róbert and Szabó, Tamás}, doi = {10.1016/j.jcis.2023.11.026}, journal-iso = {J COLLOID INTERF SCI}, journal = {JOURNAL OF COLLOID AND INTERFACE SCIENCE}, volume = {655}, unique-id = {34405490}, issn = {0021-9797}, year = {2024}, eissn = {1095-7103}, pages = {931-942}, orcid-numbers = {SHIVA SHANKAR, LAKSHMI/0000-0003-0832-4387; Szabados, Márton/0000-0002-7588-335X; Roumia, Hala/0009-0007-3660-6855; Kukovecz, Ákos/0000-0003-0716-9557; Szabó, Tamás/0000-0001-8182-640X} } @article{MTMT:34483761, title = {Új katalitikus rendszerek alkalmazása aszimmetrikus Michael-addíciókban maleimidekre}, url = {https://m2.mtmt.hu/api/publication/34483761}, author = {Kozma, Viktória and Szőllősi, György}, doi = {10.24100/MKF.2023.03-04.139}, journal-iso = {MAGY KÉM FOLY KÉM KÖZL}, journal = {MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-)}, volume = {129}, unique-id = {34483761}, issn = {1418-9933}, year = {2023}, eissn = {1418-8600}, pages = {139-146}, orcid-numbers = {Szőllősi, György/0000-0003-4418-9530} } @article{MTMT:34336155, title = {Környezetkímélő katalitikus rendszerek fejlesztése prokirális ketonok aszimmetrikus transzferhidrogénezésére}, url = {https://m2.mtmt.hu/api/publication/34336155}, author = {Kolcsár, Vanessza Judit and Szőllősi, György}, doi = {10.24100/MKF.2023.02.71}, journal-iso = {MAGY KÉM FOLY KÉM KÖZL}, journal = {MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-)}, volume = {129}, unique-id = {34336155}, issn = {1418-9933}, year = {2023}, eissn = {1418-8600}, pages = {71-77}, orcid-numbers = {Szőllősi, György/0000-0003-4418-9530} } @article{MTMT:34131836, title = {Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs}, url = {https://m2.mtmt.hu/api/publication/34131836}, author = {Senobar Tahaei, Seyyed Ashkan and Kulmány, Ágnes Erika and Minorics, Renáta and Kiss, Anita and Szabó, Zoltán and Germán, Péter and Szebeni, Gábor and Gémes, Nikolett and Mernyák, Erzsébet and Zupkó, István}, doi = {10.3390/ijms241813749}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34131836}, issn = {1661-6596}, abstract = {Four diastereomers of 16-azidomethyl substituted 3-O-benzyl estradiol (1–4) and their two estrone analogs (16AABE and 16BABE) were tested for their antiproliferative properties against human gynecological cancer cell lines. The estrones were selected for additional experiments based on their outstanding cell growth-inhibiting activities. Both compounds increased hypodiploid populations of breast cancer cells, and 16AABE elicited cell cycle disturbance as evidenced by flow cytometry. The two analogs substantially increased the rate of tubulin polymerization in vitro. 16AABE and 16BABE inhibited breast cancer cells’ migration and invasive ability, as evidenced by wound healing and Boyden chamber assays. Since both estrone analogs exerted remarkable estrogenic activities, as documented by a luciferase reporter gene assay, they can be considered as promising drug candidates for hormone-independent malignancies.}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Minorics, Renáta/0000-0001-9685-813X; Kiss, Anita/0000-0003-3352-0996; Szabó, Zoltán/0000-0001-8278-8038; Szebeni, Gábor/0000-0002-6998-5632; Mernyák, Erzsébet/0000-0003-4494-1817; Zupkó, István/0000-0003-3243-5300} } @article{MTMT:34105840, title = {Directed thermocatalytic CO2 reduction over NiAl4 layered double hydroxide precursors − activity and selectivity control using different interlayer anions}, url = {https://m2.mtmt.hu/api/publication/34105840}, author = {Szabados, Márton and Szabados, Tamara and Mucsi, Róbert and Baán, Kornélia and Kiss, János and Szamosvölgyi, Ákos and Sápi, András and Kónya, Zoltán and Kukovecz, Ákos and Sipos, Pál Miklós}, doi = {10.1016/j.jcou.2023.102567}, journal-iso = {J CO2 UTIL}, journal = {JOURNAL OF CO2 UTILIZATION}, volume = {75}, unique-id = {34105840}, issn = {2212-9820}, year = {2023}, eissn = {2212-9839}, orcid-numbers = {Szabados, Márton/0000-0002-7588-335X; Szabados, Tamara/0000-0001-8920-1666; Baán, Kornélia/0000-0001-7511-4422; Sápi, András/0000-0001-6557-0731; Kónya, Zoltán/0000-0002-9406-8596; Kukovecz, Ákos/0000-0003-0716-9557; Sipos, Pál Miklós/0000-0003-1407-0950} } @article{MTMT:34101587, title = {Cytotoxic effect of 13α-estrane derivatives on breast, endometrial and ovarian cancer cell lines}, url = {https://m2.mtmt.hu/api/publication/34101587}, author = {Zottel, A. and Jójárt, Rebeka and Ágoston, H. and Hafner, E. and Lipušček, N. and Mernyák, Erzsébet and Rižner, T.L.}, doi = {10.1016/j.jsbmb.2023.106350}, journal-iso = {J STEROID BIOCHEM MOL BIOL}, journal = {JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY}, volume = {232}, unique-id = {34101587}, issn = {0960-0760}, abstract = {Hormone-dependent cancers such as breast, uterine, and ovarian cancers account for more than 35% of all cancers in women. Worldwide, these cancers occur in more than 2.7 million women/year and account for 22% of cancer-related deaths/year. The generally accepted mechanism for the pathophysiology of estrogen-dependent cancers is estrogen receptor-mediated cell proliferation associated with an increased number of mutations. Therefore, drugs that can interfere with either local estrogen formation or estrogen action via estrogen receptors are needed. Estrane derivatives that have low or minimal estrogenic activity can affect both pathways. In this study, we investigated the effect of 36 different estrane derivatives on the proliferation of eight breast, endometrial, and ovarian cancer cell lines and the corresponding three control cell lines. Estrane derivatives 3 and 4_2Cl showed a stronger effect on the endometrial cancer cell lines KLE and Ishikawa, respectively, compared with the control cell line HIEEC, with IC50 values of 32.6 microM and 17.9 microM, respectively. Estrane derivative 4_2Cl was most active in the ovarian cancer cell line COV362 compared to the control cell line HIO80 with an IC50 value of 3.6 microM. In addition, estrane derivative 2_4I showed a strong antiproliferative effect on endometrial and ovarian cancer cell lines, while the effect on the control cell line was slight or absent. The addition of halogen at carbon 2 and/or 4 in estrane derivatives 1 and 2 increased the selectivity for endometrial cancer cells. Overall, these results suggest that single estrane derivatives are efficient cytotoxic agents for endometrial and ovarian cancer cell lines, and thus potential lead compounds for drug development. © 2023 The Authors}, keywords = {CYTOTOXICITY; breast cancer; ENDOMETRIAL CANCER; Ovarian cancer; Estrane derivatives}, year = {2023}, eissn = {1879-1220}, orcid-numbers = {Mernyák, Erzsébet/0000-0003-4494-1817} } @article{MTMT:34075504, title = {Dynamics of hydroxide-ion-driven reversible autocatalytic networks}, url = {https://m2.mtmt.hu/api/publication/34075504}, author = {Lantos, Emese and Mótyán, Gergő and Nagyné Frank, Éva and Eelkema, Rienk and van Esch, Jan and Horváth, Dezső and Tóth, Ágota}, doi = {10.1039/D3RA04215D}, journal-iso = {RSC ADV}, journal = {RSC ADVANCES}, volume = {13}, unique-id = {34075504}, issn = {2046-2069}, abstract = {An autocatalytic reaction network is designed utilising the interplay of hydroxide concentration dependent reactions and acid–base equilibria of imine hydrolysis.}, year = {2023}, eissn = {2046-2069}, pages = {20243-20247}, orcid-numbers = {Mótyán, Gergő/0000-0002-0741-106X; Nagyné Frank, Éva/0000-0002-1332-0551; Eelkema, Rienk/0000-0002-2626-6371; Horváth, Dezső/0000-0003-3852-6879; Tóth, Ágota/0000-0001-8254-6354} } @article{MTMT:34070423, title = {P-01.1-10 Semi-synthetic dihydrotestosterone derivatives modulate inherent multidrug resistance and sensitize colon cancer cells to chemotherapy}, url = {https://m2.mtmt.hu/api/publication/34070423}, author = {Nagy, Ferenc István and Gopisetty, Mohana Krishna and Huliák, Ildikó and Nagyné Frank, Éva and Csontné Kiricsi, Mónika}, doi = {10.1002/2211-5463.13646}, journal-iso = {FEBS OPEN BIO}, journal = {FEBS OPEN BIO}, volume = {13}, unique-id = {34070423}, issn = {2211-5463}, year = {2023}, eissn = {2211-5463}, pages = {66-66}, orcid-numbers = {Gopisetty, Mohana Krishna/0000-0002-4310-3478; Nagyné Frank, Éva/0000-0002-1332-0551; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @article{MTMT:34067941, title = {Synthesis and in vitro photodynamic activity of aza-BODIPY-based photosensitizers}, url = {https://m2.mtmt.hu/api/publication/34067941}, author = {Hlogyik, Tamás and Laczkó-Rigó, Réka and Bakos, Éva and Poór, Miklós and Kele, Zoltán and Laczka, Csilla and Mernyák, Erzsébet}, doi = {10.1039/d3ob00699a}, journal-iso = {ORG BIOMOL CHEM}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, volume = {21}, unique-id = {34067941}, issn = {1477-0520}, abstract = {Aza-BODIPY dyes have recently come to attention owing to their excellent chemical and photophysical properties. In particular, their absorption and emission maxima can efficiently be shifted to the red or even to the NIR spectral region. On this basis, aza-BODIPY derivatives are widely investigated as fluorescent probes or phototherapeutic agents. Here we report the synthesis of a set of novel aza-BODIPY derivatives as potential photosensitizers for use in photodynamic therapy. Triazolyl derivatives were obtained via Cu(I)-catalyzed azide-alkyne cycloaddition as the key step. In vitro photodynamic activities of the newly synthesized compounds were evaluated on the A431 human epidermoid carcinoma cell line. Structural differences influenced the light-induced toxicity of the test compounds markedly. Compared to the initial tetraphenyl aza-BODIPY derivative, the compound bearing two hydrophilic triethylene glycol side chains showed substantial, more than 250-fold, photodynamic activity with no dark toxicity. Our newly synthesized aza-BODIPY derivative, acting in the nanomolar range, might serve as a promising candidate for the design of more active and selective photosensitizers.}, year = {2023}, eissn = {1477-0539}, pages = {6018-6027}, orcid-numbers = {Mernyák, Erzsébet/0000-0003-4494-1817} }