@article{MTMT:33603762,
	title = {Methane Admixture Protects Liver Mitochondria and Improves Graft Function after Static Cold Storage and Reperfusion},
	url = {https://m2.mtmt.hu/api/publication/33603762},
	author = {Horváth, Tamara and Sándor, Lilla and Baráth, Bálint and Donka, Tibor and Baráth, Bence and Mohácsi, Árpád and Jász, Dávid Kurszán and Hartmann, Petra and Boros, Mihály},
	doi = {10.3390/antiox12020271},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {12},
	unique-id = {33603762},
	abstract = {Mitochondria are targets of cold ischemia-reperfusion (IR), the major cause of cell damage during static cold preservation of liver allografts. The bioactivity of methane (CH4) has recently been recognized in various hypoxic and IR conditions as having influence on many aspects of mitochondrial biology. We therefore hypothesized that cold storage of liver grafts in CH4-enriched preservation solution can provide an increased defence against organ dysfunction in a preclinical rat model of liver transplantation. Livers were preserved for 24 h in cold histidine–tryptophan–ketoglutarate (HTK) or CH4-enriched HTK solution (HTK-CH4) (n = 24 each); then, viability parameters were monitored for 60 min during normothermic isolated reperfusion and perfusate and liver tissue were collected. The oxidative phosphorylation capacity and extramitochondrial Ca2+ movement were measured by high resolution respirometry. Oxygen and glucose consumption increased significantly while hepatocellular damage was decreased in the HTK-CH4 grafts compared to the HTK group. Mitochondrial oxidative phosphorylation capacity was more preserved (128.8 ± 31.5 pmol/s/mL vs 201.3 ± 54.8 pmol/s/mL) and a significantly higher Ca2+ flux was detected in HTK-CH4 storage (2.9 ± 0.1 mV/s) compared to HTK (2.3 ± 0.09 mV/s). These results demonstrate the direct effect of CH4 on hepatic mitochondrial function and extramitochondrial Ca2+ fluxes, which may have contributed to improved graft functions and a preserved histomorphology after cold IR.},
	keywords = {Mitochondria; Reperfusion; METHANE; liver transplantation; static cold storage},
	year = {2023},
	eissn = {2076-3921},
	orcid-numbers = {Horváth, Tamara/0000-0003-4437-9924; Baráth, Bálint/0000-0001-8837-2375; Donka, Tibor/0000-0003-3793-9647; Baráth, Bence/0000-0001-5713-8471; Jász, Dávid Kurszán/0000-0003-3700-5668; Hartmann, Petra/0000-0002-4746-9792; Boros, Mihály/0000-0003-1410-1999}
}

@CONFERENCE{MTMT:33298194,
	title = {Nyitott fotoakusztikus kamra alkalmazása vízgőzfluxus mérésére},
	url = {https://m2.mtmt.hu/api/publication/33298194},
	author = {Bozóki, Zoltán and Horváth, László and Huszár, Helga and Nagy, Zoltán and Pintér, Krisztina and Torma, Péter and Weidinger, Tamás},
	booktitle = {ÉLETTERÜNK A LÉGKÖR.},
	unique-id = {33298194},
	year = {2022},
	pages = {5},
	orcid-numbers = {Nagy, Zoltán/0000-0003-2839-522X; Torma, Péter/0000-0001-9282-6931; Weidinger, Tamás/0000-0001-7500-6579}
}

@article{MTMT:33134651,
	title = {Formation of gold/silver composite nanoparticles by pulsed laser ablation of gold–silver layered films in liquid},
	url = {https://m2.mtmt.hu/api/publication/33134651},
	author = {Homik, Zsolt and Heszlerné Kopniczky, Judit and Smausz Kolumbán, Tamás and Berkesi, Dániel Simon and Hopp, Béla},
	doi = {10.1007/s00339-022-05938-7},
	journal-iso = {APPL PHYS A-MATER},
	journal = {APPLIED PHYSICS A - MATERIALS SCIENCE AND PROCESSING},
	volume = {128},
	unique-id = {33134651},
	issn = {0947-8396},
	abstract = {Nanoparticles of high purity can be produced from a variety of materials by pulsed laser ablation of solids in liquid. Composite nanoparticles are of great importance in various applications such as catalysis or biomedicine and the process of their formation is still a subject of intense research. In this work, gold/silver composite nanoparticles were synthesized in aqueous media by ns pulsed laser ablation of gold–silver multilayer targets with different absolute layer thicknesses and layer thickness ratios. The generated nanoparticles showed a log-normal distribution of sizes, with average diameter in the 20–40 nm range and standard deviation of 9–30 nm. By comparing the UV–VIS absorbance spectra of the nanoparticle colloids with two theoretical calculations (based on the Mie and the BEM model), it was found that there is a direct correlation between the average Au and Ag content of the nanoparticles and the composition of the films on the substrate. Assuming thermal ablation, our model calculations showed that there is a maximum thickness of the top layer up to which both layers can be ablated simultaneously and alloy nanoparticles can be produced.},
	year = {2022},
	eissn = {1432-0630},
	orcid-numbers = {Smausz Kolumbán, Tamás/0000-0002-5184-6124; Hopp, Béla/0000-0002-4272-7721}
}

@article{MTMT:32856164,
	title = {Hűtőközeg-szivárgási pontok meghatározására alkalmas fotoakusztikus műszer fejlesztése},
	url = {https://m2.mtmt.hu/api/publication/32856164},
	author = {Huszár, Helga and Végh, Panna},
	journal-iso = {ÉPÜLETGÉPÉSZ},
	journal = {ÉPÜLETGÉPÉSZ: A MAGYAR ÉPŰLETGÉPÉSZEK SZÖVETSÉGÉNEK SZAKLAPJA},
	volume = {11},
	unique-id = {32856164},
	issn = {2063-5400},
	year = {2022},
	pages = {44-46}
}

@misc{MTMT:32856301,
	title = {Dependence of the photoacoustic sensitivity parameter on the heat capacity ratio of the measured gas and on the acoustic properties of the measuring system},
	url = {https://m2.mtmt.hu/api/publication/32856301},
	author = {Végh, Panna and Gábor, Gulyás and Huszár, Helga and Szabó, Gábor and Bozóki, Zoltán},
	unique-id = {32856301},
	year = {2021},
	pages = {313},
	orcid-numbers = {Szabó, Gábor/0000-0001-6756-4677}
}

@article{MTMT:32012606,
	title = {Reduction in hypoxia-reoxygenation-induced myocardial mitochondrial damage with exogenous methane},
	url = {https://m2.mtmt.hu/api/publication/32012606},
	author = {Jász, Dávid Kurszán and Szilágyi, Ágnes and Tuboly, Eszter and Baráth, Bálint and Márton, Anett Roxána and Varga, Petra and Varga, Gabriella and Érces, Dániel and Mohácsi, Árpád and Szabó, Anna and Bozó, Renáta and Gömöri, Kamilla and Görbe, Anikó and Boros, Mihály and Hartmann, Petra},
	doi = {10.1111/jcmm.16498},
	journal-iso = {J CELL MOL MED},
	journal = {JOURNAL OF CELLULAR AND MOLECULAR MEDICINE},
	volume = {25},
	unique-id = {32012606},
	issn = {1582-1838},
	abstract = {Albeit previous experiments suggest potential anti-inflammatory effect of exogenous methane (CH4) in various organs, the mechanism of its bioactivity is not entirely understood. We aimed to investigate the potential mitochondrial effects and the underlying mechanisms of CH4 in rat cardiomyocytes and mitochondria under simulated ischaemia/reperfusion (sI/R) conditions. Three-day-old cultured cardiomyocytes were treated with 2.2% CH4-artificial air mixture during 2-hour-long reoxygenation following 4-hour-long anoxia (sI/R and sI/R + CH4, n = 6-6), with normoxic groups serving as controls (SH and SH + CH4; n = 6-6). Mitochondrial functions were investigated with high-resolution respirometry, and mitochondrial membrane injury was detected by cytochrome c release and apoptotic characteristics by using TUNEL staining. CH4 admixture had no effect on complex II (CII)-linked respiration under normoxia but significantly decreased the complex I (CI)-linked oxygen consumption. Nevertheless, addition of CH4 in the sI/R + CH4 group significantly reduced the respiratory activity of CII in contrast to CI and the CH4 treatment diminished mitochondrial H2O2 production. Substrate-induced changes to membrane potential were partially preserved by CH4, and additionally, cytochrome c release and apoptosis of cardiomyocytes were reduced in the CH4-treated group. In conclusion, the addition of CH4 decreases mitochondrial ROS generation via blockade of electron transport at CI and reduces anoxia-reoxygenation-induced mitochondrial dysfunction and cardiomyocyte injury in vitro.},
	year = {2021},
	eissn = {1582-4934},
	pages = {5113-5123},
	orcid-numbers = {Jász, Dávid Kurszán/0000-0003-3700-5668; Baráth, Bálint/0000-0001-8837-2375; Varga, Gabriella/0000-0003-1888-8629; Érces, Dániel/0000-0002-4283-2441; Bozó, Renáta/0000-0003-4242-2474; Görbe, Anikó/0000-0003-4908-1094; Boros, Mihály/0000-0003-1410-1999; Hartmann, Petra/0000-0002-4746-9792}
}

@article{MTMT:31662130,
	title = {Methane supplementation improves graft function in experimental heart transplantation},
	url = {https://m2.mtmt.hu/api/publication/31662130},
	author = {Benke, Kálmán and Jász, Dávid Kurszán and Szilágyi, Ágnes and Baráth, Bálint and Tuboly, Eszter and Márton, Anett Roxána and Varga, Petra and Mohácsi, Árpád and Szabó, Anna and Széll, Zsófia and Ruppert, Mihály and Radovits, Tamás and Szabó, Gábor and Merkely, Béla Péter and Hartmann, Petra and Boros, Mihály},
	doi = {10.1016/j.healun.2020.11.003},
	journal-iso = {J HEART LUNG TRANSPL},
	journal = {JOURNAL OF HEART AND LUNG TRANSPLANTATION},
	volume = {40},
	unique-id = {31662130},
	issn = {1053-2498},
	abstract = {BACKGROUND: Maintenance of cell viability during cold storage is a key issue in organ transplantation. Methane (CH4) bioactivity has recently been recognized in ischemia/reperfusion conditions; we therefore hypothesized that cold storage in CH4-enriched preservation solution can provide an increased defense against organ dysfunction during experimental heart transplantation (HTX).
		
		METHODS: The hearts of donor Lewis rats were stored for 60 minutes in cold histidine-tryptophan-ketoglutarate (Custodiol [CS]) or CH4-saturated CS solution (CS-CH4) (n = 12 each). Standard heterotopic HTX was performed, and 60 minutes later, the left ventricular (LV) pressure-volume relationships LV systolic pressure (LVSP), systolic pressure increment (dP/dtmax), diastolic pressure decrement, and coronary blood flow (CBF) were measured. Tissue samples were taken to detect proinflammatory parameters, structural damage (by light microscopy), endoplasmic reticulum (ER) stress, and apoptosis markers (CCAAT/enhancer binding protein [C/EBP] homologous protein, GRP78, glycogen synthase kinase-3 beta, very low-density lipoprotein receptor, caspase 3 and 9, B-cell lymphoma 2, and bcl-2-like protein 4), whereas mitochondrial functional changes were analyzed by high-resolution respirometry.
		
		RESULTS: LVSP and dP/dtmax increased significantly at the largest pre-load volumes in CS-CH4 grafts as compared with the CS group (114.5 +/- 16.6 mm Hg vs 82.8 +/- 4.6 mm Hg and 3,133 +/- 430 mm Hg/s vs 1,739 +/- 169 mm Hg/s, respectively); the diastolic function and CBF (2.4 +/- 0.4 ml/min/g vs 1.3 +/- 0.3 ml/min/g) also improved. Mitochondrial oxidative phosphorylation capacity was more preserved (58.5 +/- 9.4 pmol/s/ml vs 27.7 +/- 6.6 pmol/s/ml), and cytochrome c release was reduced in CS-CH4 storage. Signs of HTX-caused myocardial damage, level of ER stress, and the transcription of proapoptotic proteins were significantly lower in CS-CH4 grafts.
		
		CONCLUSION: The addition of CH4 during 1 hour of cold storage improved early in vitro graft function and reduced mitochondrial dysfunction and activation of inflammation. Evidence shows that CH4 reduced ER stress-linked proapoptotic signaling. (C) 2020 International Society for Heart and Lung Transplantation. All rights reserved.},
	year = {2021},
	eissn = {1557-3117},
	pages = {183-192},
	orcid-numbers = {Benke, Kálmán/0000-0001-7885-2543; Jász, Dávid Kurszán/0000-0003-3700-5668; Baráth, Bálint/0000-0001-8837-2375; Merkely, Béla Péter/0000-0001-6514-0723; Hartmann, Petra/0000-0002-4746-9792; Boros, Mihály/0000-0003-1410-1999}
}

@article{MTMT:31637828,
	title = {Methane Exhalation Can Monitor the Microcirculatory Changes of the Intestinal Mucosa in a Large Animal Model of Hemorrhage and Fluid Resuscitation},
	url = {https://m2.mtmt.hu/api/publication/31637828},
	author = {Bársony, Anett and Noémi, Vida and Ámos, Gajda and Rutai, Attila and Mohácsi, Árpád and Szabó, Anna and Boros, Mihály and Varga, Gabriella and Érces, Dániel},
	doi = {10.3389/fmed.2020.567260},
	journal-iso = {FRONT MED},
	journal = {FRONTIERS IN MEDICINE},
	volume = {7},
	unique-id = {31637828},
	year = {2020},
	eissn = {2296-858X},
	orcid-numbers = {Rutai, Attila/0000-0002-8878-1790; Boros, Mihály/0000-0003-1410-1999; Varga, Gabriella/0000-0003-1888-8629; Érces, Dániel/0000-0002-4283-2441}
}

@article{MTMT:31395807,
	title = {Alternative methanogenesis - Methanogenic potential of organosulfur administration},
	url = {https://m2.mtmt.hu/api/publication/31395807},
	author = {Varga, Petra and Vida, Noémi and Hartmann, Petra and Szabó, Anna and Mohácsi, Árpád and Szabó, Gábor and Boros, Mihály and Tuboly, Eszter},
	doi = {10.1371/journal.pone.0236578},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {15},
	unique-id = {31395807},
	issn = {1932-6203},
	year = {2020},
	eissn = {1932-6203},
	orcid-numbers = {Hartmann, Petra/0000-0002-4746-9792; Szabó, Gábor/0000-0001-6756-4677; Boros, Mihály/0000-0003-1410-1999}
}

@article{MTMT:31388984,
	title = {Adsorption of Azobenzene on Hexagonal Boron Nitride Nanomesh Supported by Rh(111)},
	url = {https://m2.mtmt.hu/api/publication/31388984},
	author = {Szitás, Ádám and Gubó, Richard and Pásztor, Tibor and Farkas, Arnold Péter and Ajtai, Tibor and Óvári, László and Palotás, Krisztián and Berkó, András and Kónya, Zoltán},
	doi = {10.1021/acs.jpcc.0c01725},
	journal-iso = {J PHYS CHEM C},
	journal = {JOURNAL OF PHYSICAL CHEMISTRY C},
	volume = {124},
	unique-id = {31388984},
	issn = {1932-7447},
	year = {2020},
	eissn = {1932-7455},
	pages = {14182-14194},
	orcid-numbers = {Szitás, Ádám/0000-0002-3550-0481; Gubó, Richard/0000-0001-6612-7264; Farkas, Arnold Péter/0000-0002-9392-7221; Óvári, László/0000-0001-8991-2708; Palotás, Krisztián/0000-0002-1914-2901; Berkó, András/0000-0002-6934-3808; Kónya, Zoltán/0000-0002-9406-8596}
}