@article{MTMT:34794768,
	title = {Subarachnoid Hemorrhage Depletes Calcitonin Gene-Related Peptide Levels of Trigeminal Neurons in Rat Dura Mater},
	url = {https://m2.mtmt.hu/api/publication/34794768},
	author = {Masood, Thann Oon Saleh Saeed Saleh and Lakatos, Szandra and Karcsúné Kis, Gyöngyi and Ignácz, Melissza and Domoki, Ferenc and Rosta, Judit},
	doi = {10.3390/cells13080653},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {13},
	unique-id = {34794768},
	abstract = {Subarachnoid hemorrhage (SAH) remains a major cause of cerebrovascular morbidity, eliciting severe headaches and vasospasms that have been shown to inversely correlate with vasodilator calcitonin gene-related peptide (CGRP) levels. Although dura mater trigeminal afferents are an important source of intracranial CGRP, little is known about the effects of SAH on these neurons in preclinical models. The present study evaluated changes in CGRP levels and expression in trigeminal primary afferents innervating the dura mater 72 h after experimentally induced SAH in adult rats. SAH, eliciting marked damage revealed by neurological examination, significantly reduced the density of CGRP-immunoreactive nerve fibers both in the dura mater and the trigeminal caudal nucleus in the medulla but did not affect the total dural nerve fiber density. SAH attenuated ex vivo dural CGRP release by ~40% and in the trigeminal ganglion, reduced both CGRP mRNA levels and the number of highly CGRP-immunoreactive cell bodies. In summary, we provide novel complementary evidence that SAH negatively affects the integrity of the CGRP-expressing rat trigeminal neurons. Reduced CGRP levels suggest likely impaired meningeal neurovascular functions contributing to SAH complications. Further studies are to be performed to reveal the importance of impaired CGRP synthesis and its consequences in central sensory processing.},
	year = {2024},
	eissn = {2073-4409},
	orcid-numbers = {Ignácz, Melissza/0009-0004-9154-0885; Domoki, Ferenc/0000-0002-5581-2167}
}

@article{MTMT:34742326,
	title = {Mechanisms and Target Parameters in Relation to Polycystic Ovary Syndrome and Physical Exercise: Focus on the Master Triad of Hormonal Changes, Oxidative Stress, and Inflammation},
	url = {https://m2.mtmt.hu/api/publication/34742326},
	author = {Lőrincz, Csanád Endre and Börzsei, Denise and Nagyné Hoffmann, Alexandra and Varga, Csaba and Szabó, Renáta},
	doi = {10.3390/biomedicines12030560},
	journal-iso = {BIOMEDICINES},
	journal = {BIOMEDICINES},
	volume = {12},
	unique-id = {34742326},
	abstract = {Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females of reproductive age with heterogeneous prevalence. It is well known that female reproductive competence depends on the dynamic regulation of the hypothalamic–pituitary–gonadal (HPG) axis; therefore, disruption of this highly regulated system leads to fertility problems. Among disruptors, both oxidative stress and inflammation contribute to an increased LH-FSH ratio and a consequent hyperandrogenism. Shifts in this bidirectional interplay between the neuroendocrine system and oxidative/inflammatory homeostasis result in the accumulation of reactive oxygen/nitrogen species and inflammatory markers as well as alterations in antioxidant defense mechanisms. Evidence shows that lifestyle changes, including regular physical exercise, are recognized as the most effective first-line management to reduce the severity of PCOS symptoms. The aim of our narrative review is to provide insights into the mechanisms and target factors of PCOS-related hormonal changes, oxidative/antioxidant homeostasis, and inflammation, and to discuss the effects of exercise, which takes into account various factors, in relation to PCOS. A better understanding of the PCOS-associated hormonal changes, oxidative and inflammatory circuits, as well as exercise-induced mechanisms of action on those targets may improve the quality of life of women with PCOS.},
	year = {2024},
	eissn = {2227-9059},
	pages = {560},
	orcid-numbers = {Varga, Csaba/0000-0002-2678-665X}
}

@CONFERENCE{MTMT:34694071,
	title = {Oxytocin Receptor Expression In Primary Sensory Neurons: Unveiling How Oxytocin And Its Receptor Contribute To The Sensory Processing And The Modulation Of Pain},
	url = {https://m2.mtmt.hu/api/publication/34694071},
	author = {Péter, Bátor Kemenesi-Gedei and Karcsúné Kis, Gyöngyi},
	booktitle = {International Neuroscience Conference, Pécs 2024},
	unique-id = {34694071},
	year = {2024},
	pages = {S6.05}
}

@article{MTMT:34572141,
	title = {Digital game-based inquiry learning to improve eighth graders’ inquiry skills in biology},
	url = {https://m2.mtmt.hu/api/publication/34572141},
	author = {Bónus, Lilla and Nagy Lászlóné Antal, Erzsébet and Korom, Erzsébet},
	doi = {10.1007/s10956-024-10096-x},
	journal-iso = {J SCI EDUC TECHNOL},
	journal = {JOURNAL OF SCIENCE EDUCATION AND TECHNOLOGY},
	unique-id = {34572141},
	issn = {1059-0145},
	year = {2024},
	eissn = {1573-1839},
	orcid-numbers = {Bónus, Lilla/0000-0003-3812-1644; Korom, Erzsébet/0000-0001-9534-8146}
}

@article{MTMT:34538600,
	title = {P072 LDN-071, a novel first-in-class amino acid-based PAI-1 inhibitor, significantly reduces the severity of experimental colitis in mice},
	url = {https://m2.mtmt.hu/api/publication/34538600},
	author = {Jójárt, Boldizsár and Csákány-Papp, Noémi and Laub, H and Vasas, Béla and Barta, B and Szabó, Viktória and Bagyánszki, Mária and Mándity, I and Heltovics, G and Pallagi, Petra and Maléth, József},
	doi = {10.1093/ecco-jcc/jjad212.0202},
	journal-iso = {J CROHNS COLITIS},
	journal = {JOURNAL OF CROHNS & COLITIS},
	volume = {18},
	unique-id = {34538600},
	issn = {1873-9946},
	year = {2024},
	eissn = {1876-4479},
	pages = {i342-i342},
	orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Csákány-Papp, Noémi/0000-0002-3614-2698; Szabó, Viktória/0000-0001-6547-9102; Bagyánszki, Mária/0000-0003-3533-9461; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090}
}

@article{MTMT:34443978,
	title = {Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons},
	url = {https://m2.mtmt.hu/api/publication/34443978},
	author = {El Heni, Heni and Kemenesi-Gedei, Péter Bátor and Pálvölgyi, Laura and Szeredi, Ivett Dorina and Karcsúné Kis, Gyöngyi},
	doi = {10.3390/ijms25010007},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34443978},
	issn = {1661-6596},
	abstract = {Considerable evidence suggests that oxytocin, as a regulatory nonapeptide, participates in modulatory mechanisms of nociception. Nonetheless, the role of this hypothalamic hormone and its receptor in the sensory pathway has yet to be fully explored. The present study performed immunohistochemistry, enzyme-linked immunosorbent assay, and RT-qPCR analysis to assess changes in the expression of the neuronal oxytocin receptor in female rats following tight ligation of the sciatic nerve after 1, 3, and 7 days of survival. Oxytocin receptor immunoreactivity was present in both dorsal root ganglia and lumbar spinal cord segments, but not accumulated at the site of the ligation of the peripheral nerve branch. We found a time-dependent change in the expression of oxytocin receptor mRNA in L5 dorsal root ganglion neurons, as well as an increase in the level of the receptor protein in the lumbar segment of the spinal cord. A peak in the expression was observed on day 3, which downturned slightly by day 7 after the nerve ligation. These results show that OTR expression is up-regulated in response to peripheral nerve lesions. We assume that the importance of OTR is to modify spinal presynaptic inputs of the sensory neurons upon injury-induced activation, thus to be targets of the descending oxytocinergic neurons from supraspinal levels. The findings of this study support the concept that oxytocin plays a role in somatosensory transmission.},
	year = {2024},
	eissn = {1422-0067}
}

@misc{MTMT:34672053,
	title = {The inhibition of Orai1 calcium channel reduces the progression of chronic pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/34672053},
	author = {Szabó, Viktória and Csákány-Papp, Noémi and Görög, Marietta and Madácsy, Tamara and Varga, Árpád and Kiss, Aletta Kata and Tél, Bálint and Jójárt, Boldizsár and Crul, Tim and Dudás, Krisztina Márta and Bagyánszki, Mária and Bódi, Nikolett and Ayaydin, Ferhan and Shyam, Jee and Tiszlavicz, László and Stauderman, Kenneth and Hebbar, Sudarshan and Pallagi, Petra and Maléth, József},
	unique-id = {34672053},
	year = {2023},
	pages = {1},
	orcid-numbers = {Szabó, Viktória/0000-0001-6547-9102; Csákány-Papp, Noémi/0000-0002-3614-2698; Görög, Marietta/0000-0003-3615-3140; Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Kiss, Aletta Kata/0000-0001-6404-1555; Tél, Bálint/0000-0003-2066-6494; Jójárt, Boldizsár/0000-0002-2764-3925; Crul, Tim/0000-0002-6053-7016; Dudás, Krisztina Márta/0000-0003-2383-7412; Bagyánszki, Mária/0000-0003-3533-9461; Bódi, Nikolett/0000-0002-9774-1387; Tiszlavicz, László/0000-0003-1134-6587; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090}
}

@article{MTMT:34593826,
	title = {LDN-071, a novel first-in-class peptide-based plasminogen activator inhibitor 1, significantly reduces the severity of experimental colitis in mic},
	url = {https://m2.mtmt.hu/api/publication/34593826},
	author = {Jójárt, Boldizsár and Csákány-Papp, Noémi and H., Laub and Vasas, Béla and Barta, Bence Pál and Szabó, Viktória and Bagyánszki, Mária and I., Mándity and G., Heltovics and Pallagi, Petra and Maléth, József},
	journal-iso = {UEG JOURNAL},
	journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL},
	volume = {11},
	unique-id = {34593826},
	issn = {2050-6406},
	year = {2023},
	eissn = {2050-6414},
	pages = {209-2010},
	orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Csákány-Papp, Noémi/0000-0002-3614-2698; Barta, Bence Pál/0000-0002-5309-8633; Szabó, Viktória/0000-0001-6547-9102; Bagyánszki, Mária/0000-0003-3533-9461; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090}
}

@article{MTMT:34486293,
	title = {Single-cell immunophenotyping revealed the association of CD4+ central and CD4+ effector memory T cells linking exacerbating chronic obstructive pulmonary disease and NSCLC.},
	url = {https://m2.mtmt.hu/api/publication/34486293},
	author = {Gémes, Nikolett and Balog, József Ágoston and Neuperger, Patricia and Schlegl, Erzsébet and Barta, Imre and Fillinger, János and Antus, Balázs and Zvara, Ágnes and Hegedűs, Zoltán and Czimmerer, Zsolt and Manczinger, Máté and Balogh, Gergő Mihály and Tóvári, József and Puskás, László and Szebeni, Gábor},
	doi = {10.3389/fimmu.2023.1297577},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {14},
	unique-id = {34486293},
	issn = {1664-3224},
	abstract = {Tobacco smoking generates airway inflammation in chronic obstructive pulmonary disease (COPD), and its involvement in the development of lung cancer is still among the leading causes of early death. Therefore, we aimed to have a better understanding of the disbalance in immunoregulation in chronic inflammatory conditions in smoker subjects with stable COPD (stCOPD), exacerbating COPD (exCOPD), or non-small cell lung cancer (NSCLC).Smoker controls without chronic illness were recruited as controls. Through extensive mapping of single cells, surface receptor quantification was achieved by single-cell mass cytometry (CyTOF) with 29 antibodies. The CyTOF characterized 14 main immune subsets such as CD4+, CD8+, CD4+/CD8+, CD4-/CD8-, and γ/δ T cells and other subsets such as CD4+ or CD8+ NKT cells, NK cells, B cells, plasmablasts, monocytes, CD11cdim, mDCs, and pDCs. The CD4+ central memory (CM) T cells (CD4+/CD45RA-/CD45RO+/CD197+) and CD4+ effector memory (EM) T cells (CD4+/CD45RA-/CD45RO+/CD197-) were FACS-sorted for RNA-Seq analysis. Plasma samples were assayed by Luminex MAGPIX® for the quantitative measurement of 17 soluble immuno-oncology mediators (BTLA, CD28, CD80, CD27, CD40, CD86, CTLA-4, GITR, GITRL, HVEM, ICOS, LAG-3, PD-1, PD-L1, PD-L2, TIM-3, TLR-2) in the four studied groups.Our focus was on T-cell-dependent differences in COPD and NSCLC, where peripheral CD4+ central memory and CD4+ effector memory cells showed a significant reduction in exCOPD and CD4+ CM showed elevation in NSCLC. The transcriptome analysis delineated a perfect correlation of differentially expressed genes between exacerbating COPD and NSCLC-derived peripheral CD4+ CM or CD4+ EM cells. The measurement of 17 immuno-oncology soluble mediators revealed a disease-associated phenotype in the peripheral blood of stCOPD, exCOPD, and NSCLC patients.The applied single-cell mass cytometry, the whole transcriptome profiling of peripheral CD4+ memory cells, and the quantification of 17 plasma mediators provided complex data that may contribute to the understanding of the disbalance in immune homeostasis generated or sustained by tobacco smoking in COPD and NSCLC.},
	keywords = {Tobacco smoking; non-small cell lung cancer; single-cell mass cytometry; CD4 central memory T cells; CD4 effector memory T cells; exacerbating COPD; stable COPD},
	year = {2023},
	eissn = {1664-3224},
	orcid-numbers = {Manczinger, Máté/0000-0003-0831-9617; Tóvári, József/0000-0002-5543-3204; Szebeni, Gábor/0000-0002-6998-5632}
}

@article{MTMT:34289826,
	title = {Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex},
	url = {https://m2.mtmt.hu/api/publication/34289826},
	author = {Lee, B.R. and Dalley, R. and Miller, J.A. and Chartrand, T. and Close, J. and Mann, R. and Mukora, A. and Ng, L. and Alfiler, L. and Baker, K. and Bertagnolli, D. and Brouner, K. and Casper, T. and Csajbók, Éva and Donadio, N. and Driessens, S.L.W. and Egdorf, T. and Enstrom, R. and Galakhova, A.A. and Gary, A. and Gelfand, E. and Goldy, J. and Hadley, K. and Heistek, T.S. and Hill, D. and Hou, W.-H. and Johansen, N. and Jorstad, N. and Kim, L. and Kocsis, Ágnes Katalin and Kruse, L. and Kunst, M. and León, G. and Long, B. and Mallory, M. and Maxwell, M. and McGraw, M. and McMillen, D. and Melief, E.J. and Molnár, Gábor and Mortrud, M.T. and Newman, D. and Nyhus, J. and Opitz-Araya, X. and Ozsvár, A. and Pham, T. and Pom, A. and Potekhina, L. and Rajanbabu, R. and Ruiz, A. and Sunkin, S.M. and Szöts, Ildikó and Taskin, N. and Thyagarajan, B. and Tieu, M. and Trinh, J. and Vargas, S. and Vumbaco, D. and Waleboer, F. and Walling-Bell, S. and Weed, N. and Williams, G. and Wilson, J. and Yao, S. and Zhou, T. and Bakken, T. and Cobbs, C. and Dee, N. and Ellenbogen, R.G. and Esposito, L. and Ferreira, M. and Gouwens, N.W. and Grannan, B. and Gwinn, R.P. and Hauptman, J.S. and Hodge, R. and Jarsky, T. and Keene, C.D. and Ko, A.L. and Korshoej, A.R. and Levi, B.P. and Meier, K. and Ojemann, J.G. and Patel, A. and Ruzevick, J. and Silbergeld, D.L. and Smith, K. and Sørensen, J.C. and Waters, J. and Zeng, H. and Berg, J. and Capogna, M. and Goriounova, N.A. and Kalmbach, B. and de, Kock C.P.J. and Mansvelder, H.D. and Sorensen, S.A. and Tamás, Gábor and Lein, E.S. and Ting, J.T.},
	doi = {10.1126/science.adf6484},
	journal-iso = {SCIENCE},
	journal = {SCIENCE},
	volume = {382},
	unique-id = {34289826},
	issn = {0036-8075},
	year = {2023},
	eissn = {1095-9203},
	orcid-numbers = {Barzó, Pál/0000-0001-8717-748X; Tamás, Gábor/0000-0002-7905-6001}
}