@article{MTMT:2015022, title = {Electrospray Ionization Mass Spectrometric Analysis of Highly Reactive Glycosyl Halides}, url = {https://m2.mtmt.hu/api/publication/2015022}, author = {Bokros, Attila and Bánfi, Annamária and Kupihár, Zoltán and Kele, Zoltán and Tóthné Illyés, Tünde Zita and Szolomájer, János and Kovács, Lajos}, doi = {10.3390/molecules17078351}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {17}, unique-id = {2015022}, issn = {1420-3049}, abstract = {Highly reactive glycosyl chlorides and bromides have been analysed by a routine mass spectrometric method using electrospray ionization and lithium salt adduct-forming agents in anhydrous acetonitrile solution, providing salient lithiated molecular ions [M+Li]+, [2M+Li]+ etc. The role of other adduct-forming salts has also been evaluated. The lithium salt method is useful for accurate mass determination of these highly sensitive compounds.}, year = {2012}, eissn = {1420-3049}, pages = {8351-8358}, orcid-numbers = {Kovács, Lajos/0000-0002-0331-3980} } @article{MTMT:1629372, title = {Synthesis of beta-(1->6)-linked N-acetyl-D-glucosamine oligosaccharide substrates and their hydrolysis by Dispersin B}, url = {https://m2.mtmt.hu/api/publication/1629372}, author = {Fekete, Anikó and Borbás, Anikó and Gyémánt, Gyöngyi and Kandra, Lili and Fazekas, Erika and Ramasubbu, N and Antus, Sándor}, doi = {10.1016/j.carres.2011.03.029}, journal-iso = {CARBOHYD RES}, journal = {CARBOHYDRATE RESEARCH}, volume = {346}, unique-id = {1629372}, issn = {0008-6215}, abstract = {Dispersin B (DspB) from Aggregatibacter actinomycetemcomitans is a p-hexosaminidase exhibiting biofilm detachment activity. A series of beta-(1 -> 6)-linked N-acetyl-D-glucosamine thiophenyl glycosides with degree of polymerisation (DP) of 2, 3, 4 and 5 were synthesized, and substrate specificity of DspB was studied on the obtained oligosaccharides. For oligomer synthesis a 1+2, 2+2, 1+4 coupling strategy was applied, using bromo-sugars as glycosyl donors. The formation of 1,2-trans interglycosidic bond has been ensured by 2-phtalimido protecting group: chloroacetyl group was installed to mask temporarily the 6-hydroxyl and acetate esters were applied as permanent protecting groups. Enzymatic studies revealed that DP of the GlcNAc oligomers strongly affected the hydrolysis rate, and the hydrolytic activity of DspB on the tetramer and pentamer have been found to be approximately 10-fold higher than that of the dimer. This fact indicates that four units are required for a strong binding at the active centre of DspB. The role of aromatic amino acids W237, Y187 and Y278 in substrate specificity and catalysis was also examined using mutant enzymes. (C) 2011 Elsevier Ltd. All rights reserved.}, year = {2011}, eissn = {1873-426X}, pages = {1445-1453}, orcid-numbers = {Borbás, Anikó/0000-0001-8462-4547; Gyémánt, Gyöngyi/0000-0003-2374-3408} } @article{MTMT:1629360, title = {Quantum chemical studies on the partial hydrogenolysis of methyl 2,3-O-diphenylmethylene-alpha-L-rhamnopyranoside}, url = {https://m2.mtmt.hu/api/publication/1629360}, author = {Mándi, Attila and Komáromi, István and Borbás, Anikó and Szikra, Dezső and Nagy, István Péter and Lipták, András and Antus, Sándor}, doi = {10.1016/j.tetlet.2011.01.021}, journal-iso = {TETRAHEDRON LETT}, journal = {TETRAHEDRON LETTERS}, volume = {52}, unique-id = {1629360}, issn = {0040-4039}, year = {2011}, eissn = {1873-3581}, pages = {1256-1259}, orcid-numbers = {Borbás, Anikó/0000-0001-8462-4547} } @article{MTMT:1779925, title = {Heterociklusos glükózszármazékok, mint lehetséges antidiabetikumok}, url = {https://m2.mtmt.hu/api/publication/1779925}, author = {Bokor, Éva}, journal-iso = {MAGY KEM LAP}, journal = {MAGYAR KÉMIKUSOK LAPJA}, volume = {65}, unique-id = {1779925}, issn = {0025-0163}, year = {2010}, eissn = {1588-1199}, pages = {77-78} } @article{MTMT:1464734, title = {Elaboration of composite electrodes based on raney nickel- and Pd/C for electrosynthesis applications}, url = {https://m2.mtmt.hu/api/publication/1464734}, author = {Szikra, Dezső and Dublinszki, K and Cserháti, Csaba and Nagy, István Péter}, journal-iso = {J NEW MAT ELECTR SYS}, journal = {JOURNAL OF NEW MATERIALS FOR ELECTROCHEMICAL SYSTEMS}, volume = {13}, unique-id = {1464734}, issn = {1480-2422}, abstract = {Conductive composites of acrylamide and triethylene glycol dimethacrylate were prepared via frontal polymerization with various Raney nickel- and Pd/C content. These materials are proven to be applicable as electrodes in organic electrosynthesis. The incorporation of electrocatalytic metals results in a significant change in the chemoselectivity of the electroreduction of acetophenone, which indicates a change in the mechanism from electronation-protonation to electrocatalytic hydrogenation. © J. New Mat. Electrochem. Systems.}, keywords = {POLYMERIZATION; POLYMERS; Electrodes; KETONES; AMIDES; Acetophenones; Electrolytic reduction; Organic electrosynthesis; Conductive composites; Chemo-selectivity; Frontal polymerization; Electroreduction; Composite electrode; Acetophenone; Acrylic monomers; Glycols; Triethylene glycol dimethacrylate; Raney nickel; Electrocatalytic hydrogenation; Electrocatalytic; Electro reduction; Acrylamides}, year = {2010}, eissn = {2292-1168}, pages = {133-140} } @article{MTMT:1779815, title = {Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case}, url = {https://m2.mtmt.hu/api/publication/1779815}, author = {Chrysina, E D and Bokor, Éva and Alexacou, K-M and Charavgi, M-D and Oikonomakos, G N and Zographos, S E and Leonidas, D D and Oikonomakos, N G and Somsák, László}, doi = {10.1016/j.tetasy.2009.03.021}, journal-iso = {TETRAHEDRON ASYMMETR}, journal = {TETRAHEDRON-ASYMMETRY}, volume = {20}, unique-id = {1779815}, issn = {0957-4166}, year = {2009}, eissn = {1362-511X}, pages = {733-740}, orcid-numbers = {Somsák, László/0000-0002-9103-9845} } @article{MTMT:1779732, title = {Assessment of synthetic methods for the preparation of N'-b-D-glucopyranosyl-N-substituted ureas, thioureas and related compounds}, url = {https://m2.mtmt.hu/api/publication/1779732}, author = {Somsák, László and Felföldi, N and Kónya, B and Hüse, Cs and Telepó, K and Bokor, Éva and Czifrák, Katalin}, doi = {10.1016/j.carres.2008.01.045}, journal-iso = {CARBOHYD RES}, journal = {CARBOHYDRATE RESEARCH}, volume = {343}, unique-id = {1779732}, issn = {0008-6215}, year = {2008}, eissn = {1873-426X}, pages = {2083-2093}, orcid-numbers = {Somsák, László/0000-0002-9103-9845} } @article{MTMT:1464742, title = {In vitro FT-IR study of the effects of hydrogen peroxide on superficial tooth enamel}, url = {https://m2.mtmt.hu/api/publication/1464742}, author = {Bistey, Tamás and Nagy, István Péter and Simó, A and Hegedűs, Csaba}, doi = {10.1016/j.jdent.2006.10.004}, journal-iso = {J DENTISTRY}, journal = {JOURNAL OF DENTISTRY}, volume = {35}, unique-id = {1464742}, issn = {0300-5712}, abstract = {Objectives: The aim of the present study was to determine the alteration in human enamel after hydrogen peroxide treatment using FT-IR spectroscopy. It is hypothesized that infrared spectroscopy is capable of showing alterations in human enamel after peroxide treatment and the alteration in enamel is proportional to peroxide concentration. Methods: The effects of 10, 20 and 30% hydrogen peroxide solutions on human enamel were tested. Thirty non-carious human teeth, extracted for periodontal reasons, were used in this study. They were divided into 3 groups of 10, according to the peroxide concentration, sectioned, and the specimens were embedded in resin for infrared spectroscopic analysis. The total treatment time was 120 min. Spectra of the specimens were taken before treatment and 30, 60 and 120 min after it. Another spectrum was taken in a week. Results: Infrared spectroscopic analysis showed two distinct bands (biological PO4 ν1 and ν2) that were capable of describing the alterations in enamel structure. On comparing the infrared spectra of non-treated and treated specimens, structural changes were detected in the superficial enamel. The alteration in enamel was proportional to treatment time and hydrogen peroxide concentration. Higher concentration and longer treatment time resulted in more severe alterations. The numerical analysis of the spectra revealed that on using concentrated hydrogen peroxide solutions the alterations of the IR spectra were more pronounced. The spectra taken in 1 week after treatment did not show spontaneous reversibility in enamel structure. Conclusion: At-home and in-office peroxide-containing bleaching agents are capable of causing alteration in enamel at low and high concentrations as well. According to the results of this study it is recommended to perform tooth whitening using low concentration of hydrogen and/or carbamide peroxide, and shorten treatment time to reduce the possible destruction but reach the required change in color. © 2006 Elsevier Ltd. All rights reserved.}, keywords = {Humans; ARTICLE; human; Chemistry; Dose-Response Relationship, Drug; dose response; drug effect; hydroxyapatite; Surface Properties; Spectrophotometry, Infrared; hydrogen peroxide; infrared spectroscopy; Dental Enamel; enamel; surface property; infrared spectrophotometry; Dental Enamel Permeability; tooth permeability; oxidizing agent; Oxidants; Hydroxyapatites; Tooth whitening; Human enamel}, year = {2007}, eissn = {1879-176X}, pages = {325-330} } @article{MTMT:1391828, title = {Interaction between Mo(VI) and siderophore models in aqueous solution}, url = {https://m2.mtmt.hu/api/publication/1391828}, author = {Farkas, Etelka and Megyeri, K and Somsák, László and Kovács, Lajos}, doi = {10.1016/S0162-0134(98)00011-7}, journal-iso = {J INORG BIOCHEM}, journal = {JOURNAL OF INORGANIC BIOCHEMISTRY}, volume = {70}, unique-id = {1391828}, issn = {0162-0134}, abstract = {A series of dihydroxamic acids (HORNOC-(CH2)(n)-CONROH, where if R = H - then n = 2, 5-7 and if R = CH3- then n = 4, 5) and two new dihydroxamate-based siderophore models, hexanedioic acid bis (3-hydroxycarbamoyl-methyl)amide (DhaI) and hexanedioic acid bis(3-hydroxycarbamoyl-propyl)amide (DhaII) have been characterized in terms of chelating properties toward molybdenum(VI). For comparison, the molybdenum(VI)-acetohydroxamic acid (Aha) and molybdenum(VI)-aminohydroxamic acid systems have also been studied. Potentiometric and spectrophotometric studies at ionic strength of 0.2 mol/dm(3) (KCl) and at 25 degrees C have been performed and the equilibrium constants have been determined. It has been found, that of the dihydroxamic acids, only the DhaI and DhaII form water soluble complexes with molybdenum(VI). Polynuclear complexes most probably precipitate with the other dihydroxamic acids. Complexes are formed up to ca. the neutral pH in all systems. Above this pH MoO42- and the free ligands exist. Although, very stable complexes are formed especially with DhaII, none of the studied ligands form a single bis(hydroxamato)dioxomolybdenum(VI) species. Mo no(hydroxamato) trioxomolybdenum(VI) species are also formed, containing the uncoordinated moiety of the DhaI or DhaII in its protonated form. Out of aminohydroxamic acids, the beta-alaninehydroxamic acid (beta-Alaha) shows "Aha-like" coordination properties as the glutamic acid-gamma-hydroxamic acid (Glu-gamma-ha) does. The small differences with this latter ligand are possibly due to weak coordination of the carboxylate which makes the mono(hydroxamato)trioxomolybdenum(VI) species more stable and the uncoordinated carboxylates in bis(hydroxamato) dioxomolybdenum(VI) can protonate below pH 3. The tridentate coordination mode of aspartic acid-P-hydroxamic acid (Asp-P-ha) via the hydroxamate and carboxylate oxygens results in the formation of a dinuclear complex, [Mo2O5(LH)(2)](2-) in addition to [MoO3(LH)](-) (the protons are on the amino groups) in the pi-I-range 2.5-7.0. (C) 1998 Elsevier Science Inc. All rights reserved.}, keywords = {Equilibrium studies; stability constants; COMPLEX-FORMATION; aminohydroxamic acid; Hydroxamic acid; HYDROXAMIC ACIDS; molybdenum (VI) complexes}, year = {1998}, eissn = {1873-3344}, pages = {41-47}, orcid-numbers = {Somsák, László/0000-0002-9103-9845; Kovács, Lajos/0000-0002-0331-3980} } @article{MTMT:1163352, title = {Thiazole c-nucleosides .3. Synthesis of pyranose analogs of tiazofurin}, url = {https://m2.mtmt.hu/api/publication/1163352}, author = {Kovács, Lajos and Herczegh, Pál and Batta, Gyula and I, Farkas}, doi = {10.1016/S0040-4020(01)80985-6}, journal-iso = {TETRAHEDRON}, journal = {TETRAHEDRON}, volume = {47}, unique-id = {1163352}, issn = {0040-4020}, abstract = {A large-scale synthesis of 3,4,5-tri-0-acetyl-2,6-anhydro-L-mannono-and-D-gulonothioamides (5, 6) has been achieved from the corresponding nitriles. The Hantzsch reaction of (5) or (6) with ethyl bromopyruvate afforded the expected thiazoles (7.8) only in a low yield along with furan derivatives (9-11), the formation of which is rationalized by an acid-catalysed rearrangement-elimination process. The some Hantzsch reaction in the presence of barium carbonate yielded hydroxythiazolines (16,17). Attempted dehydration of (16) or (17) with trifluoroacetic anhydride or trifluoroacetic anhydride/pyridine resulted in the formation of pent-1′-enopyranosylthiazoles (18-20). Deprotected thioamides (24,25) furnished with ethyl bromopyruvate thiazoles (27,28). The obtained thiazole esters (7,8, 18-20. 27,28) were transformed into new tiazofurin analogues (12, 13, 21- 23). New tiazofurin analogues (1-5) have been synthesized starting from the corresponding thioamides.}, year = {1991}, eissn = {1464-5416}, pages = {5539-5548}, orcid-numbers = {Kovács, Lajos/0000-0002-0331-3980; Batta, Gyula/0000-0002-0442-1828} }