TY - JOUR AU - Árokszállási, Tamás AU - Nagy, Attila Csaba AU - Balogh, Eszter AU - Edit, Boglárka Nagy AU - Máté, Sik AU - Zsófia, Fülesdi AU - Orbán-Kálmándi, Rita Angéla AU - Árokszállási, Anita AU - Juhász, Péter AU - Fekete, Gábor AU - Rácz, Lilla AU - Csépány, Tünde AU - Csiba, László AU - Bagoly, Zsuzsa AU - Oláh, László TI - Elevated Blood Alcohol Concentration at Stroke Onset Predicts Poor Clinical Outcomes and Mortality After Intracerebral Hemorrhage: a Retrospective Cohort Study JF - NEUROLOGY AND THERAPY J2 - NEUROL THERAP VL - 15 PY - 2026 IS - 1 SP - 287 EP - 307 PG - 21 SN - 2193-8253 DO - 10.1007/s40120-025-00866-z UR - https://m2.mtmt.hu/api/publication/36448710 ID - 36448710 LA - English DB - MTMT ER - TY - JOUR AU - Marchi, Rita AU - Katona, Éva AU - Durual, Stephane AU - Demaistre, Emmanuel AU - Savard, Philippe AU - Casini, Alessandro TI - The Hypofibrinolysis State Associated with the Dysfibrinogenemia Dusart is Mainly Related to the Altered Fibrin Clot Structure JF - HAMOSTASEOLOGIE J2 - HAMOSTASEOLOGIE PY - 2026 PG - 9 SN - 0720-9355 DO - 10.1055/a-2739-3030 UR - https://m2.mtmt.hu/api/publication/36900511 ID - 36900511 LA - English DB - MTMT ER - TY - JOUR AU - Kozák, Márk AU - Majoros, Levente AU - Panyiczki, Zoltán AU - Bagoly, Zsuzsa AU - Hodossy-Takács, Rebeka AU - Dobos, Lili Virág AU - Várkonyi, István TI - Severe vitamin K deficiency-associated coagulopathy triggered by Clostridioides difficile infection and antibiotic-associated dysbiosis: A case report and literature review JF - INFECTION J2 - INFECTION PY - 2026 SN - 0300-8126 DO - 10.1007/s15010-026-02735-9 UR - https://m2.mtmt.hu/api/publication/36904483 ID - 36904483 LA - English DB - MTMT ER - TY - JOUR AU - Vásárhelyi, Barna AU - Bereczky, Zsuzsanna AU - Miseta, Attila TI - Néhány gondolat a szérum-kreatininszint, -transzaminázaktivitás és -albuminszint meghatározások módszertanáról JF - ORVOSI HETILAP J2 - ORV HETIL VL - 167 PY - 2026 IS - 6 SP - 211 EP - 216 PG - 6 SN - 0030-6002 DO - 10.1556/650.2026.33490 UR - https://m2.mtmt.hu/api/publication/36932110 ID - 36932110 AB - A modern orvostudomány fejlődése ellenére a klasszikus laboratóriumi paraméterek továbbra is a klinikai döntéshozatal fő pillérei. A közlemény négy, rutinszerűen mért analitra fókuszál: szérum-kreatininszint, májtranszamináz-aktivitások, albuminszint. Ezek 2024-ben a magyarországi laboratóriumi meghatározások több mint 15%-át tették ki. A szérum-kreatininszint mérését a laboratóriumok kétféle módszerrel mérik: Jaffé- vagy enzimatikus módszerrel. Bár mindkettő alkalmas a glomerulusfiltrációs ráta (GFR) becslésére, az eredmények 5–14%-kal eltérhetnek egymástól. A szakmai állásfoglalás szerint mindkét módszer használható, de a leleten jelölni kell az alkalmazott technikát. A transzamináz-aktivitások (GOT/AST, GPT/ALT) meghatározásakor kritikus a piridoxál-foszfát (B6-vitamin) jelenléte a reagensben. Ennek hiányában a mért értékek 15–30%-kal alacsonyabbak lehetnek. Ez téves diagnózishoz vezethet, különösen a májfibrosis becslésére szolgáló FIB4-pontszám számításakor. Ezért piridoxál-foszfátot tartalmazó reagensek alkalmazása javasolt a transzamináz-aktivitások mérésére. Az albumin mérésére a brómkrezolzöld helyett brómkrezolvörös reagens használata javasolt, mivel az előbbi májbetegségben és veseelégtelenségben pontatlan eredményeket ad. A módszerváltásokat a klinikusokkal egyeztetve kell végrehajtani, illetve oda kell figyelni arra is, hogy a vizsgálatok LOINC-kódja (egységes nevezéktanon alapuló kódrendszer) változhat. Orv Hetil. 2026; 167(6): 211–216. | Despite advances in modern medicine, classic laboratory parameters are still crucial pillars of clinical decision-making. The report focuses on four routinely measured analytes: serum creatinine levels, liver transaminase activities and al- bumin levels. In 2024, these accounted for more than 15% of laboratory determinations in Hungary. Laboratories measure serum creatinine levels using two methods: the Jaffé or the enzymatic method. Although both are suitable for estimating the glomerular filtration rate (GFR), the results may differ by 5–14% from each other. According to the professional opinion, both methods can be used, but they should be indicated on the report. The presence of pyridoxal phosphate (vitamin B6) in the reagent is critical for the determination of transaminase activities (GOT/ AST, GPT/ALT). In its absence, the measured values may be 15–30% lower, which may lead to misdiagnosis, espe- cially when calculating the FIB4 score for estimating the severity of liver fibrosis. Therefore, the use of reagents containing pyridoxal phosphate is recommended for measuring transaminase activities. In the case of albumin deter- mination, the use of bromocresol red reagent is recommended instead of bromocresol green, as the former gives inaccurate results in liver disease and renal failure. Method changes should be made in consultation with clinicians, and it should be noted that the LOINC codes (an international standard for parameter identification) for the tests may change. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szegedi, István AU - Éles, Zsolt Barnabás AU - Nagy, Attila Csaba AU - Bagoly, Zsuzsa TI - Venous Blood Cell Ratios as Predictors of Reperfusion Outcomes in Ischemic Stroke: A Systematic Review and Meta-analysis JF - NEUROLOGY AND THERAPY J2 - NEUROL THERAP VL - - PY - 2026 IS - - SP - Online ahead of print. SN - 2193-8253 DO - 10.1007/s40120-025-00881-0 UR - https://m2.mtmt.hu/api/publication/36934363 ID - 36934363 N1 - WoS:hiba:001660529000001 2026-05-18 00:53 kötet nem egyezik, füzet nem egyezik, első oldal nem egyezik LA - English DB - MTMT ER - TY - JOUR AU - Antal-Szalmás, Péter AU - Bencze, Dóra AU - Demeter, Sarolta AU - Pénzes-Daku, Krisztina AU - Szabó, Lilla AU - Tóth, Beáta AU - Földesi, Róza AU - Papp, Mária AU - Nagy, Gábor TI - Autoantibodies in the diagnostics, prognostics and follow-up of primary biliary cholangitis JF - JOURNAL OF TRANSLATIONAL AUTOIMMUNITY J2 - J TRANSL AUTOIMMUN VL - 12 PY - 2026 SN - 2589-9090 DO - 10.1016/j.jtauto.2026.100366 UR - https://m2.mtmt.hu/api/publication/37057169 ID - 37057169 LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Zsigmond Máté AU - Óvári, József AU - Magyar, János AU - Bányász, Tamás AU - Nánási, Péter Pál AU - Horváth, Balázs AU - Balogh, Gábor AU - Szentandrássy, Norbert TI - The Methanesulfonamide Group: Bright and Dark Sides of hERG Potassium Channel Inhibition JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 19 PY - 2026 IS - 6 PG - 19 SN - 1424-8247 DO - 10.3390/ph19060882 UR - https://m2.mtmt.hu/api/publication/37325625 ID - 37325625 AB - Our review focuses on methanesulfonamide-containing compounds, a well-characterized class of high-affinity blockers of the hERG potassium channel, which plays a critical role in cardiac repolarization by mediating the cardiac IKr. These compounds, which include notable class III antiarrhythmic drugs such as dofetilide and d-sotalol, block the hERG channel in its open state by binding within the inner vestibule. This interaction is particularly strong with some residues and the compounds form hydrogen bonds with others. This binding results in high-affinity inhibition with slow dissociation kinetics, frequently leading to drug trapping and prolonged action potential duration (APD). This can predispose patients to arrhythmias, including Torsades de Pointes. Beyond cardiac drugs, there are several non-cardiac methanesulfonamide drugs that also block the hERG channel. This causes pro-arrhythmic side effects despite their primary indications. The clinical significance of these effects, especially in patients with impaired drug elimination, is that accumulation increases the risk of arrhythmia. The objective of forthcoming research endeavors is to mitigate hERG affinity, with the aim of reducing pro-arrhythmic risks while maintaining therapeutic efficacy. This means structural modifications that seek to remove or modify the methanesulfonamide group. Machine learning also emerged as promising tool for exploring drug–protein interactions. It is evident that the methanesulfonamide moiety plays a pivotal role in the structural basis of hERG blockade. However, it should be noted that this moiety does not necessarily represent a universal pharmacophore. This observation underscores the necessity for a nuanced approach in drug development, aimed at achieving a balance between efficacy and safety. LA - English DB - MTMT ER - TY - JOUR AU - Martos, Renáta AU - Harangi, Mariann AU - Szabó, Judit AU - Földvári, Anett AU - Sándor, János AU - Katona, Éva AU - Tar, Ildikó AU - Paragh, György AU - Kiss, Csongor AU - Márton, Ildikó TI - Effects of Combined Periodontal, Endodontic, and Dentoalveolar Surgical Treatments on Laboratory Parameters in Patients with Hyperlipidemia—A Clinical Interventional Study JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 14 PY - 2025 IS - 1 SP - 241 PG - 16 SN - 2077-0383 DO - 10.3390/jcm14010241 UR - https://m2.mtmt.hu/api/publication/35744126 ID - 35744126 AB - Background: Patients with hyperlipidemia are of interest because of the possible interplay between chronic local dental infections and hyperlipidemia. This interventional clinical study aimed to evaluate the oral health status of hyperlipidemic patients receiving lipid-lowering therapy for at least 6 months and the effects of non-surgical and surgical dental treatments on serum C-reactive protein (CRP) levels and lipid markers. Methods: Twenty-eight patients with controlled hyperlipidemia and 18 healthy controls were enrolled in the study. All participants underwent dental examinations (clinical evaluation, X-ray imaging, and microbial analysis of subgingival and supragingival plaque samples) at baseline. Hyperlipidemic patients received periodontal, endodontic, and dentoalveolar surgical treatments. Serum CRP and lipid parameters were assessed at baseline, 1 week, and 3 months, while subgingival and supragingival plaque samples were analyzed at baseline and 3 months after completing dental treatments. Results: At the 3-month follow-up, clinical periodontal characteristics, including the plaque index, gingival index, and periodontal probing depth, improved significantly (p < 0.05). A significant shift in microflora was observed in both subgingival and supragingival plaque samples (p < 0.05), alongside improvements in periodontal values and a significant reduction in serum CRP levels (p < 0.05). Serum cholesterol levels decreased significantly, while moderate improvements in serum triglycerides, low-density lipoprotein, and high-density lipoprotein levels were observed but were not statistically significant (p > 0.05). Conclusions: Treating local dental inflammation is associated with a significant decrease in CRP and cholesterol levels and may serve as beneficial adjunct therapy alongside lipid-lowering therapy in patients with hyperlipidemia. LA - English DB - MTMT ER - TY - JOUR AU - Bravo-Pérez, Carlos AU - Corral, Javier AU - Orlando, Christelle AU - Ignjatovic, Vera AU - Ilonczai, Péter AU - Bereczky, Zsuzsanna TI - How we treat severe inherited antithrombin deficiency: lessons from cases homozygous for the Budapest 3 variant JF - JOURNAL OF THROMBOSIS AND HAEMOSTASIS J2 - J THROMB HAEMOST PY - 2025 SN - 1538-7933 DO - 10.1016/j.jtha.2025.01.015 UR - https://m2.mtmt.hu/api/publication/35754845 ID - 35754845 AB - Antithrombin deficiency represents one of the most severe inherited thrombophilias. Albeit a rare disorder, available knowledge suggests that antithrombin deficiency is underestimated due to limitations of current diagnostic algorithms. The high clinical variability of this patient population may be another cause of underdiagnosis. Heterozygous type I (quantitative) variants are normally associated with a severe thrombophilic phenotype, whilst heterozygous type II (qualitative) variants are heterogeneous, including heparin binding site (HBS) defects, which are mild/moderate and the most prevalent. Antithrombin Budapest 3 (p.Leu131Phe) is the most frequent type II/HBS deficiency in Europe, particularly in Roma population, with a remarkable existence of homozygous subjects.Clinical features, diagnostic procedures, and management of patients with severe antithrombin deficiency, leveraging the study of cases homozygous for the antithrombin Budapest 3 variant.Patients were selected from 699 subjects with antithrombin deficiency, recruited over 25 years in reference centers from Spain, Belgium, and Hungary.Guided by two illustrative cases with homozygous antithrombin Budapest 3, we report the spectrum and clinical management of patients suffering from this disorder. These cases, with very low antithrombin activity (<20%), and juvenile and recurrent venous thromboembolism, recapitulate numerous issues that one might encounter when treating patients with antithrombin deficiency. In addition, special clinical scenarios for which no formal evidence-based guidelines exist might be found more frequently in these patients, including heparin resistance, vena cava anomalies and obstetric complications. Expert proposals on the optimal management of these controversial areas, as well as future perspectives are also formulated. LA - English DB - MTMT ER - TY - JOUR AU - Hajdu, Endre AU - Molnár, Éva AU - Rázsó, Katalin AU - Schlammadinger, Ágota AU - Árokszállási, Anita AU - Lukacs, Csenge Greta AU - Fülesdi, Béla AU - Bereczky, Zsuzsanna AU - Oláh, Zsolt TI - A Modified Viscoelastic Point-of-Care Method for Rapid Quantitative Detection of Enoxaparin: A Single-Centre Observational Study. JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 14 PY - 2025 IS - 4 SN - 2077-0383 DO - 10.3390/jcm14041328 UR - https://m2.mtmt.hu/api/publication/35958975 ID - 35958975 AB - Background: Laboratory monitoring of the effect of low-molecular-weight heparins (LMWHs) is generally not necessary. However, prompt evaluation of heparin inhibitory effects (i.e., anti-Xa activity) is important in cases of life-threatening bleeding, need for urgent surgery or acute thromboembolism under LMWH treatment. We aimed to establish a simple and reliable point-of-care method for the detection of enoxaparin. Methods: Eighty patients under enoxaparin therapy and ten healthy volunteers without any anticoagulant treatment were enrolled. Simultaneous measurements of anti-Xa activity using the chromogenic method and clotting times in the absence and presence of polybrene using viscoelastometric assays containing Russell's viper venom (RVV-test) were performed on the ClotPro device. Results: Among the measured and derived RVV-test parameters, the ratio of the RVV clotting times (RVV CT) detected in the absence and presence of polybrene showed the best statistically significant correlation with anti-Xa activity (r = 0.774, p < 0.001). Based on ROC analysis, we designated RVV CT ratios of 1.02, 1.23 and 1.6 as the best cut-off values for separating anti-Xa ranges below and above 0.3 and 0.6 IU/mL, respectively. If the RVV CT ratio is below or above 1.23, the anti-Xa activity is suggested to be below 0.6 IU/mL or above 0.3 IU/mL with high certainty, respectively. Further differentiation is possible if the RVV CT ratio is measured below 1.02 or above 1.6. In these cases, the measured anti-Xa values are below 0.3 IU/mL or above 0.6 IU/mL, respectively, with high probability and good predictive values. Conclusions: Our method can provide semiquantitative information on the effect of enoxaparin and the expected anti-Xa activity within 10 min in real clinical situations. LA - English DB - MTMT ER -