TY - JOUR AU - Szűcs, Gabriella AU - Szekanecz, Zoltán AU - Szamosi, Szilvia TI - Can we define difficult-to-treat systemic sclerosis? JF - EXPERT REVIEW OF CLINICAL IMMUNOLOGY J2 - EXPERT REV CLIN IMMUNOL PY - 2024 SP - 1 EP - 17 PG - 17 SN - 1744-666X DO - 10.1080/1744666X.2024.2352450 UR - https://m2.mtmt.hu/api/publication/34855342 ID - 34855342 LA - English DB - MTMT ER - TY - JOUR AU - Szekanecz, Zoltán AU - Szamosi, Szilvia AU - Benkő, Szilvia AU - Szűcs, Gabriella TI - Monogénesen öröklődő és szerzett autoinflammatoricus betegségek JF - ORVOSI HETILAP J2 - ORV HETIL VL - 165 PY - 2024 IS - 18 SP - 683 EP - 697 PG - 15 SN - 0030-6002 DO - 10.1556/650.2024.33038 UR - https://m2.mtmt.hu/api/publication/34845388 ID - 34845388 AB - Az autoinflammatio a természetes (innate) immunitás zavara, mely veleszületett, monogénes vagy szerzett lehet. A monogénes autoinflammatoricus kórképek közé tartoznak az inflammasomopathiák, az actinopathiák, az endoplazmatikus reticulum stresszt okozó mutációk, az NFκB-hez társult betegségek, az interferonopathiák, az endogén antagonisták génjeinek mutációi és a DADA2. A szerzett autoinflammatoricus betegségek közé számos gyulladásos reumatológiai kórképet, bél-, bőr- és csontbetegséget, valamint egyéb kórképeket (például VEXAS, IgG4-gyel társult betegség, recurrens pericarditis, 2-es típusú diabetes, interstitialis tüdőbetegség) sorolhatunk. Ebben az összefoglalóban áttekintjük az autoinflammatio koncepcióját és főbb mechanizmusait, a legfontosabb monogénes és szerzett autoinflammatoricus kórképeket, az immundeficientiák autoinflammatióban játszott szerepét, valamint a szóba jövő terápiás lehetőségeket. Autoinflammation is a disorder of natural (innate) immunity, which can be monogenic, or acquired. Monogenic autoinflammatory diseases include inflammasomopathies, actinopathies, endoplasmic reticulum stress mutations, NFκB-associated diseases, interferonopathies, mutations in endogenous antagonist genes, and DADA2. Acquired autoinflammatory diseases include numerous inflammatory rheumatological diseases, intestinal, skin and bone diseases, as well as other conditions (e.g., VEXAS, IgG4-related disease, recurrent pericarditis, type 2 diabetes, interstitial lung disease). In this summary, we review the concept and main mechanisms of autoinflammation, the most important monogenic and acquired autoinflammatory conditions, the role of inborn errors of immunity in autoinflammation, as well as the possible therapeutic options. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szekanecz, Zoltán AU - Szamosi, Szilvia AU - Benkő, Szilvia AU - Szűcs, Gabriella TI - Autoinflammatio és autoinflammatorikus kórképek JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE PY - 2024 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/34836389 ID - 34836389 LA - English DB - MTMT ER - TY - JOUR AU - Szekanecz, Zoltán AU - Kacsándi, Dorottya AU - Soós, Boglárka TI - A rheumatoid arthritis etiopatogenezise - újdonságok JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 16 PY - 2024 IS - 1 SP - 4 EP - 14 PG - 11 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/34831051 ID - 34831051 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szekanecz, Zoltán TI - A JAK-gátlók alkalmazásának jövőbeli lehetőségei krónikus gyulladásos kórképekben JF - ORVOSTOVÁBBKÉPZŐ SZEMLE J2 - ORVOSTOVÁBBKÉPZŐ SZLE PY - 2024 SN - 1218-2583 UR - https://m2.mtmt.hu/api/publication/34829474 ID - 34829474 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Geetha, Duvuru AU - Dua, Anisha AU - Yue, Huibin AU - Springer, Jason AU - Salvarani, Carlo AU - Jayne, David AU - Merkel, Peter AU - Szűcs, Gabriella TI - Efficacy and safety of avacopan in patients with ANCA-associated vasculitis receiving rituximab in a randomised trial JF - ANNALS OF THE RHEUMATIC DISEASES J2 - ANN RHEUM DIS VL - 83 PY - 2024 IS - 2 SP - 223 EP - 232 PG - 10 SN - 0003-4967 DO - 10.1136/ard-2023-224816 UR - https://m2.mtmt.hu/api/publication/34820283 ID - 34820283 LA - English DB - MTMT ER - TY - JOUR AU - Gulyás, Anita AU - Pinczés, László Imre AU - Mátyus, János AU - Végh, Edit AU - Bedekovics, Judit AU - Tóth, Judit AU - Barna, Sándor Kristóf AU - Hunya, Zsolt AU - Szabó, Imre Lőrinc AU - Gazdag, Annamária AU - Illés, Árpád AU - Magyari, Ferenc TI - Case report: Targeted treatment strategies for Erdheim-Chester disease JF - FRONTIERS IN ONCOLOGY J2 - FRONT ONCOL VL - 14 PY - 2024 SN - 2234-943X DO - 10.3389/fonc.2024.1305518 UR - https://m2.mtmt.hu/api/publication/34794833 ID - 34794833 LA - English DB - MTMT ER - TY - JOUR AU - Major, Tamás AU - Nagy, Gábor AU - Szabó, Judit AU - Mózes, Huba AU - Szűcs, Gabriella AU - Szekanecz, Zoltán AU - Szamosi, Szilvia TI - Granulomatosis with polyangiitis or its mimic? A case report JF - JOURNAL OF INTERNATIONAL MEDICAL RESEARCH J2 - J INT MED RES VL - 52 PY - 2024 IS - 4 SP - 1 EP - 8 PG - 8 SN - 0300-0605 DO - 10.1177/03000605241237876 UR - https://m2.mtmt.hu/api/publication/34788385 ID - 34788385 AB - Differentiation between granulomatosis with polyangiitis (GPA) limited to the upper airways and cocaine-induced midline destructive lesion (CIMDL) may be particularly difficult because of their common histopathologic features and antineutrophil cytoplasmic antibody (ANCA) profiles. We herein present a case involving a young woman with an initial diagnosis of GPA based on upper and lower airway manifestations and constitutional symptoms, histopathologic evidence of granulomas, a positive cytoplasmic ANCA indirect immunofluorescent test result, and proteinase 3 positivity by enzyme-linked immunosorbent assay (ELISA). CIMDL was confirmed based on the appearance of a hard palate perforation, positivity for methylecgonine on urine toxicology, a positive perinuclear ANCA indirect immunofluorescent test result, and subsequent human neutrophil elastase (HNE) ANCA positivity by ELISA. Finally, based on the coexistence of CIMDL, constitutional symptoms, and lower airway manifestations, the diagnosis was modified to cocaine-induced GPA mimic. Urine toxicology for cocaine and HNE ELISA are indicated in young patients with GPA who develop limited airway disease to check for the presence of CIMDL and cocaine-/levamisole-induced ANCA-associated vasculitis. Continued abstinence from cocaine is the first-choice therapy for both CIMDL and cocaine-induced GPA mimic. LA - English DB - MTMT ER - TY - JOUR AU - Simon, Diána AU - Kacsándi, Dorottya AU - Karancsiné Pusztai, Anita AU - Soós, Boglárka AU - Végh, Edit AU - Kerekes, György AU - Czókolyová, Monika AU - Szamosi, Szilvia AU - Szűcs, Gabriella AU - Prohászka, Zoltán AU - Németh, Péter AU - Berki, Tímea AU - Szekanecz, Zoltán TI - Natural Autoantibodies in Biologic-Treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients: Associations with Vascular Pathophysiology JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 6 PG - 14 SN - 1661-6596 DO - 10.3390/ijms25063429 UR - https://m2.mtmt.hu/api/publication/34745209 ID - 34745209 N1 - * Megosztott szerzőség AB - Cardiovascular (CV) morbidity and mortality have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Natural autoantibodies (nAAb) are involved in innate immunity, as well as autoimmunity, inflammation, and atherosclerosis. There have not been any studies assessing the effects of biologics on nAAbs in RA and AS, also in relation to vascular pathophysiology. Fifty-three anti-TNF-treated RA and AS patients were included in a 12-month follow-up study. Anti-citrate synthase (CS) and anti-topoisomerase I fragment 4 (TOPO-F4) IgM and IgG levels were determined by ELISA. Ultrasonography was performed to assess brachial artery flow-mediated vasodilation (FMD), common carotid intima-media thickness (ccIMT), and arterial pulse-wave velocity (PWV). Other variables were also evaluated at baseline and 6 and 12 months after treatment initiation. Anti-TNF therapy improved FMD in RA and PWV in AS and stabilized ccIMT. TNF inhibition increased anti-CS IgM and IgG, and possibly also anti-TOPO-F4 IgG levels. Various correlation analyses revealed that nAAbs might be independently involved in autoimmunity as well as changes in inflammation and vascular pathology over time in biologic-treated patients (p < 0.05). We also found associations between anti-TOPO-F4 IgG and anti-Hsp60 IgG (p < 0.05). Baseline nAAb levels or nAAb level changes might determine changes in CRP, disease activity, FMD, PWV, and ccIMT over time (p < 0.05). The interplay between arthritis and inflammatory atherosclerosis, as well as the effects of anti-TNF biologics on these pathologies, might independently involve nAAbs. LA - English DB - MTMT ER - TY - JOUR AU - Charles‐Schoeman, Christina AU - Fleischmann, Roy AU - Mysler, Eduardo AU - Greenwald, Maria AU - Ytterberg, Steven R. AU - Koch, Gary G. AU - Bhatt, Deepak L. AU - Wang, Cunshan AU - Mikuls, Ted R. AU - Chen, All‐shine AU - Connell, Carol A. AU - Woolcott, John C. AU - Menon, Sujatha AU - Chen, Yan AU - Lee, Kristen AU - Szekanecz, Zoltán TI - Risk of Venous Thromboembolism with Tofacitinib Versus Tumor Necrosis Factor Inhibitors in Cardiovascular Risk‐enriched Rheumatoid Arthritis Patients JF - ARTHRITIS & RHEUMATOLOGY J2 - ARTHRITIS RHEUMATOL PY - 2024 SN - 2326-5191 DO - 10.1002/art.42846 UR - https://m2.mtmt.hu/api/publication/34742893 ID - 34742893 LA - English DB - MTMT ER -