TY - JOUR AU - Espinosa-Ortega, Fabricio AU - Lodin, Karin AU - Dastmalchi, Maryam AU - Vencovsky, Jiri AU - Diederichsen, Louise P. AU - Shinjo, Samuel Katsuyuki AU - Danieli, Maria Giovanna AU - Selva-O'Callaghan, Albert AU - de Visser, Marianne AU - Griger, Zoltán AU - Ceribelli, Angela AU - Gómez-Martin, Diana AU - Andersson, Helena AU - Mercado, Mónica Vázquez-Del AU - Chinoy, Hector AU - Lilleker, James B. AU - New, Paul AU - Krogh, Niels S. AU - Lundberg, Ingrid E. AU - Alexanderson, Helene AU - MYONET, Registry Study Group TI - Autoantibodies and damage in patients with idiopathic inflammatory myopathies : a longitudinal multicenter study from the MYONET international network JF - SEMINARS IN ARTHRITIS AND RHEUMATISM J2 - SEMIN ARTHRITIS RHEU VL - 68 PY - 2024 SP - 1 EP - 10 PG - 10 SN - 0049-0172 DO - 10.1016/j.semarthrit.2024.152529 UR - https://m2.mtmt.hu/api/publication/35309407 ID - 35309407 LA - English DB - MTMT ER - TY - JOUR AU - Harangi, Mariann AU - Homoródi, Nóra TI - A lizoszomális savas lipázdeficientia jelentősége, felismerése és hatékony kezelése JF - LEGE ARTIS MEDICINAE J2 - LEGE ART MED VL - 34 PY - 2024 IS - 7-8 SP - 337 EP - 345 PG - 9 SN - 0866-4811 DO - 10.33616/lam.34.0337 UR - https://m2.mtmt.hu/api/publication/35308622 ID - 35308622 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Juhász Péterné Esze, Regina AU - Barna, Sándor Kristóf AU - Fülöp, Péter AU - Kempler, Péter AU - Mikó, Márton AU - Páll, Dénes AU - Paragh, György AU - Somodi, Sándor AU - Emri, Miklós AU - Képes, Zita AU - Garai, Ildikó AU - Káplár, Miklós TI - C-peptide : an essential ally in microvascular complications of type 2 diabetes mellitus and obesity. an essential ally in microvascular complications of type 2 diabetes mellitus and obesity TS - an essential ally in microvascular complications of type 2 diabetes mellitus and obesity JF - DIABETOLOGY AND METABOLIC SYNDROME J2 - DIABETOL METAB SYNDR VL - 16 PY - 2024 IS - 1 PG - 11 SN - 1758-5996 DO - 10.1186/s13098-024-01454-1 UR - https://m2.mtmt.hu/api/publication/35195769 ID - 35195769 AB - In order to investigate microvascular complications in metabolic diseases, we aimed to investigate cerebral and peripheral microcirculation in relation to peripheral neuropathy and laboratory biomarkers in type 2 diabetes mellitus (T2DM) and obesity.Based on the degree of neuropathy (NP), study participants (40 T2DM and 30 obese individuals) were classified into no-NP, mild-NP and severe-NP subgroups. After the injection of Technetium-99 m hexamethylpropylene amine oxime, both T2DM and obese participants underwent single-photon emission computed tomography/computed tomography ([99mTc]Tc-HMPAO SPECT/CT) and SPECT-only examinations to assess lower limb and brain perfusion; respectively. Peripheral nerve function was evaluated with a neurometer and glycaemic markers were measured from plasma in both groups.Compared to the obese individuals, lower extremity perfusion was significantly reduced in the diabetic subjects (p < 0.005), while it showed a positive correlation with C-peptide levels and negative association with HbA1c values. A U-shape pattern of peripheral microcirculation was observed between the NP groups, indicating a surprisingly better perfusion in the severe-NP group than in the mild one, with the highest levels in obese patients. Since changes in the C-peptide levels exhibited a similar U-shaped trend across the NP subgroups, we suggest a positive correlation between C-peptide levels and the extent of peripheral perfusion. Although, C-peptide values and cerebral microcirculation correlated positively (rho = 0.27), brain perfusion did not show any differences neither between the diabetic and the obese patients, nor between the NP subgroups (at p < 0.05).Establishing the link between neuropathy and peripheral microcirculation, C-peptide seems to be a promising biomarker for the prediction of microvascular alterations in metabolic diseases. Of note, the dominance of metabolic factors over microvascular damage in the development of obesity-related neuropathy should be emphasized as well. LA - English DB - MTMT ER - TY - JOUR AU - Béldi, Tibor AU - Nagy-Vincze, Melinda AU - Griger, Zoltán TI - A tumorasszociált myositisek sajátosságai : szűrési és kezelési szempontok JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 16 PY - 2024 IS - 2 SP - 39 EP - 45 PG - 7 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/35160079 ID - 35160079 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szekanecz, Zoltán AU - Szamosi, Szilvia AU - Benkő, Szilvia AU - Szűcs, Gabriella TI - Autoinflammáció és autoinflammatorikus kórképek JF - MOZGÁSSZERVI TOVÁBBKÉPZŐ SZEMLE : INTERDISZCIPLINÁRIS SZAKMAI LAP J2 - MOZGÁSSZERVI TOVÁBBKÉPZŐ SZEMLE VL - 7 PY - 2024 IS - 3 SP - 90 EP - 103 PG - 14 SN - 2630-8924 UR - https://m2.mtmt.hu/api/publication/35152035 ID - 35152035 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Fodor, Mariann AU - Lukács, Miklós Ágoston AU - Szekanecz, Zoltán AU - Nagy, Zoltán Zsolt TI - A klorokin és hidroxiklorokin okozta toxikus maculopathia : a diagnosztika és a terápiás irányelvek áttekintése a hazai és a nemzetközi gyakorlatban JF - ORVOSI HETILAP J2 - ORV HETIL VL - 165 PY - 2024 IS - 30 SP - 1147 EP - 1153 PG - 7 SN - 0030-6002 DO - 10.1556/650.2024.33094 UR - https://m2.mtmt.hu/api/publication/35151912 ID - 35151912 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Hernyák, Marcell AU - Tóth, László AU - Sztanek, Ferenc TI - A fájdalmas diabéteszes neuropátia patogenetikai alapon nyugvó és tüneti kezelésének modern szemlélete JF - DIABETOLOGIA HUNGARICA J2 - DIABETOLOGIA HUNGARICA VL - 32 PY - 2024 IS - 2 SP - 109 EP - 116 PG - 8 SN - 1217-372X UR - https://m2.mtmt.hu/api/publication/35149711 ID - 35149711 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Sztanek, Ferenc TI - A GLP-1-Receptor-Agonisták És Az SGLT2-Gátlók Kombinált Alkalmazásának Előnyei 2-Es Típusú Cukorbetegségben JF - HÁZIORVOS TOVÁBBKÉPZŐ SZEMLE J2 - HÁZIORVOS TOVÁBBKÉPZŐ SZEMLE VL - 29 PY - 2024 IS - 6 SP - 268 EP - 276 PG - 9 SN - 1219-8641 UR - https://m2.mtmt.hu/api/publication/35149674 ID - 35149674 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Borbásné Sebestyén, Veronika AU - Ratku, Balázs AU - Ujvárosy, Dóra AU - Lőrincz, Hajnalka AU - Tari , Dóra AU - Végh, Lilla AU - Majai, Gyöngyike AU - Somodi, Sándor AU - Páll, Dénes AU - Szűcs, Gabriella AU - Harangi, Mariann AU - Szabó, Zoltán TI - Progranulin, sICAM-1, and sVCAM-1 May Predict an Increased Risk for Ventricular Arrhythmias in Patients with Systemic Sclerosis JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 13 SP - 7380 SN - 1661-6596 DO - 10.3390/ijms25137380 UR - https://m2.mtmt.hu/api/publication/35146359 ID - 35146359 AB - In systemic sclerosis (SSc), fibrosis of the myocardium along with ongoing autoimmune inflammation can alter the electric function of the cardiac myocytes, which may increase the risk for ventricular arrhythmias and sudden cardiac death. We analyzed the electrocardiographic (ECG) variables describing ventricular repolarization such as QT interval, QT dispersion (QTd), T wave peak-to-end interval (Tpe), and arrhythmogeneity index (AIX) of 26 patients with SSc and 36 healthy controls. Furthermore, echocardiographic and laboratory parameters were examined, with a focus on inflammatory proteins like C-reactive ptotein (CRP), soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), and progranulin (PGRN). The CRP, sICAM-1, and sVCAM-1 levels were positively correlated with the length of the QT interval. Although the serum PGRN levels were not increased in the SSc group compared to the controls, in SSc patients, the PGRN levels were positively correlated with the QT interval and the AIX. According to our results, we conclude that there may be a potential association between autoimmune inflammation and the risk for ventricular arrhythmias in patients with SSc. We emphasize that the measurement of laboratory parameters of inflammatory activity including CRP, PGRN, sVCAM-1, and sICAM-1 could be helpful in the prediction of sudden cardiac death in patients with SSc. LA - English DB - MTMT ER - TY - JOUR AU - Szőke, Csenge AU - Zsíros, Noémi AU - Lőrincz, Hajnalka AU - Paragh, György AU - Harangi, Mariann TI - CLINICAL FEATURES OF FAMILIAL HYPERCHOLESTEROLEMIA PATIENTS IN HUNGARY'S NORTHERN GREAT PLAIN REGION - SIGNIFICANCE OF THE FAMILIAL HYPERCHOLESTEROLEMIA REGISTRY JF - LEGE ARTIS MEDICINAE J2 - LEGE ART MED VL - 34 PY - 2024 IS - 5-6 SP - 269 EP - 277 PG - 9 SN - 0866-4811 DO - 10.33616/lam.34.0269 UR - https://m2.mtmt.hu/api/publication/35137745 ID - 35137745 LA - Hungarian DB - MTMT ER -