@article{MTMT:34820283, title = {Efficacy and safety of avacopan in patients with ANCA-associated vasculitis receiving rituximab in a randomised trial}, url = {https://m2.mtmt.hu/api/publication/34820283}, author = {Geetha, Duvuru and Dua, Anisha and Yue, Huibin and Springer, Jason and Salvarani, Carlo and Jayne, David and Merkel, Peter and Szűcs, Gabriella}, doi = {10.1136/ard-2023-224816}, journal-iso = {ANN RHEUM DIS}, journal = {ANNALS OF THE RHEUMATIC DISEASES}, volume = {83}, unique-id = {34820283}, issn = {0003-4967}, year = {2024}, eissn = {1468-2060}, pages = {223-232}, orcid-numbers = {Geetha, Duvuru/0000-0001-8353-5542; Dua, Anisha/0000-0002-3508-9290; Springer, Jason/0000-0002-3903-6049; Salvarani, Carlo/0000-0001-5426-5133; Jayne, David/0000-0002-1712-0637; Merkel, Peter/0000-0001-9284-7345} } @article{MTMT:34817301, title = {Hyperlipoproteinaemiák és kezelési lehetőségeik}, url = {https://m2.mtmt.hu/api/publication/34817301}, author = {Paragh, György and Harangi, Mariann}, journal-iso = {ORVOSTOVÁBBKÉPZŐ SZLE}, journal = {ORVOSTOVÁBBKÉPZŐ SZEMLE}, volume = {31}, unique-id = {34817301}, issn = {1218-2583}, year = {2024}, pages = {61-68} } @article{MTMT:34817266, title = {Milyen volt a hyperlipidaemia kezelése és a kezelőorvosok attitűdje 2022-ben?}, url = {https://m2.mtmt.hu/api/publication/34817266}, author = {Paragh, György and Harangi, Mariann and Bársony, Gábor and Mazzag, Bálint and Együd, Ferenc}, journal-iso = {METABOLIZMUS}, journal = {METABOLIZMUS}, volume = {22}, unique-id = {34817266}, issn = {1589-7311}, year = {2024}, pages = {26-32} } @article{MTMT:34817183, title = {Milyen kezelési lehetőségeink vannak a magas lipoprotein(a) csökkentésére?}, url = {https://m2.mtmt.hu/api/publication/34817183}, author = {Paragh, György and Zilahi, Péter and Szentimrei, Réka and Lőrincz, Hajnalka and Kolozsvári, László and Harangi, Mariann}, journal-iso = {METABOLIZMUS}, journal = {METABOLIZMUS}, volume = {22}, unique-id = {34817183}, issn = {1589-7311}, year = {2024}, pages = {16-22} } @article{MTMT:34797501, title = {Monogénesen öröklődő és szerzett autoinflammatoricus betegségek}, url = {https://m2.mtmt.hu/api/publication/34797501}, author = {Szekanecz, Zoltán and Szamosi, Szilvia and Benkő, Szilvia and Szűcs, Gabriella}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {165}, unique-id = {34797501}, issn = {0030-6002}, year = {2024}, eissn = {1788-6120}, pages = {683-697} } @article{MTMT:34794833, title = {Case report: Targeted treatment strategies for Erdheim-Chester disease}, url = {https://m2.mtmt.hu/api/publication/34794833}, author = {Gulyás, Anita and Pinczés, László Imre and Mátyus, János and Végh, Edit and Bedekovics, Judit and Tóth, Judit and Barna, Sándor Kristóf and Hunya, Zsolt and Szabó, Imre Lőrinc and Gazdag, Annamária and Illés, Árpád and Magyari, Ferenc}, doi = {10.3389/fonc.2024.1305518}, journal-iso = {FRONT ONCOL}, journal = {FRONTIERS IN ONCOLOGY}, volume = {14}, unique-id = {34794833}, issn = {2234-943X}, year = {2024}, eissn = {2234-943X}, orcid-numbers = {Pinczés, László Imre/0000-0003-0453-1709} } @article{MTMT:34788385, title = {Granulomatosis with polyangiitis or its mimic? A case report}, url = {https://m2.mtmt.hu/api/publication/34788385}, author = {Major, Tamás and Nagy, Gábor and Szabó, Judit and Mózes, Huba and Szűcs, Gabriella and Szekanecz, Zoltán and Szamosi, Szilvia}, doi = {10.1177/03000605241237876}, journal-iso = {J INT MED RES}, journal = {JOURNAL OF INTERNATIONAL MEDICAL RESEARCH}, volume = {52}, unique-id = {34788385}, issn = {0300-0605}, abstract = {Differentiation between granulomatosis with polyangiitis (GPA) limited to the upper airways and cocaine-induced midline destructive lesion (CIMDL) may be particularly difficult because of their common histopathologic features and antineutrophil cytoplasmic antibody (ANCA) profiles. We herein present a case involving a young woman with an initial diagnosis of GPA based on upper and lower airway manifestations and constitutional symptoms, histopathologic evidence of granulomas, a positive cytoplasmic ANCA indirect immunofluorescent test result, and proteinase 3 positivity by enzyme-linked immunosorbent assay (ELISA). CIMDL was confirmed based on the appearance of a hard palate perforation, positivity for methylecgonine on urine toxicology, a positive perinuclear ANCA indirect immunofluorescent test result, and subsequent human neutrophil elastase (HNE) ANCA positivity by ELISA. Finally, based on the coexistence of CIMDL, constitutional symptoms, and lower airway manifestations, the diagnosis was modified to cocaine-induced GPA mimic. Urine toxicology for cocaine and HNE ELISA are indicated in young patients with GPA who develop limited airway disease to check for the presence of CIMDL and cocaine-/levamisole-induced ANCA-associated vasculitis. Continued abstinence from cocaine is the first-choice therapy for both CIMDL and cocaine-induced GPA mimic.}, year = {2024}, eissn = {1473-2300}, pages = {1-8}, orcid-numbers = {Nagy, Gábor/0000-0002-2943-2750; Szabó, Judit/0009-0004-0782-9505} } @article{MTMT:34775662, title = {Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies: a longitudinal study}, url = {https://m2.mtmt.hu/api/publication/34775662}, author = {Lodin, Karin and Espinosa-Ortega, Fabricio and Dastmalchi, Maryam and Vencovsky, Jiri and Andersson, Helena and Chinoy, Hector and Lilleker, James B. and Shinjo, Samuel Katsuyuki and Maurer, Britta and Griger, Zoltán and Ceribelli, Angela and Torres-Ruiz, Jiram and Mercado, Mónica Vázquez-Del and Leonard, Dag and Alexanderson, Helene and Lundberg, Ingrid}, doi = {10.1016/j.semarthrit.2024.152379}, journal-iso = {SEMIN ARTHRITIS RHEU}, journal = {SEMINARS IN ARTHRITIS AND RHEUMATISM}, volume = {65}, unique-id = {34775662}, issn = {0049-0172}, abstract = {Aim : To explore if patient global assessment (PGA) is associated with inflammation over time and if associations are explained by other measures of disease activity and function in patients with idiopathic inflammatory myopathies (IIM). Methods : PGA and systemic inflammatory markers prospectively collected over five years were retrieved from the International MyoNet registry for 1200 patients with IIM. Associations between PGA, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and creatine kinase (CK) were analysed using mixed models. Mediation analysis was used to test if the association between PGA and inflammatory markers during the first year of observation could be explained by measures of disease activity and function. Results : PGA improved, and inflammatory markers decreased during the first year of observation. In the mixed models, high levels of inflammatory markers were associated with worse PGA in both men and women across time points during five years of observation. In men, but not in women, the association between elevated ESR, CRP and poorer PGA was explained by measures of function and disease activity. With a few exceptions, the association between improved PGA and reduced inflammatory markers was partially mediated by improvements in all measures of function and disease activity. Conclusion : Increased levels of systemic inflammation are associated with poorer PGA in patients with IIM. In addition to known benefits of lowered inflammation, these findings emphasize the need to reduce systemic inflammation to improve subjective health in patients with IIM. Furthermore, the results demonstrate the importance of incorporating PGA as an outcome measure in clinical practice and clinical trials.}, keywords = {Inflammation; MYOSITIS; IDIOPATHIC INFLAMMATORY MYOPATHIES; Patient reported outcome measures}, year = {2024}, eissn = {1532-866X}, pages = {1-10} } @article{MTMT:34745209, title = {Natural Autoantibodies in Biologic-Treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients: Associations with Vascular Pathophysiology}, url = {https://m2.mtmt.hu/api/publication/34745209}, author = {Simon, Diána and Kacsándi, Dorottya and Karancsiné Pusztai, Anita and Soós, Boglárka and Végh, Edit and Kerekes, György and Czókolyová, Monika and Szamosi, Szilvia and Szűcs, Gabriella and Prohászka, Zoltán and Németh, Péter and Berki, Tímea and Szekanecz, Zoltán}, doi = {10.3390/ijms25063429}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {34745209}, issn = {1661-6596}, abstract = {Cardiovascular (CV) morbidity and mortality have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Natural autoantibodies (nAAb) are involved in innate immunity, as well as autoimmunity, inflammation, and atherosclerosis. There have not been any studies assessing the effects of biologics on nAAbs in RA and AS, also in relation to vascular pathophysiology. Fifty-three anti-TNF-treated RA and AS patients were included in a 12-month follow-up study. Anti-citrate synthase (CS) and anti-topoisomerase I fragment 4 (TOPO-F4) IgM and IgG levels were determined by ELISA. Ultrasonography was performed to assess brachial artery flow-mediated vasodilation (FMD), common carotid intima-media thickness (ccIMT), and arterial pulse-wave velocity (PWV). Other variables were also evaluated at baseline and 6 and 12 months after treatment initiation. Anti-TNF therapy improved FMD in RA and PWV in AS and stabilized ccIMT. TNF inhibition increased anti-CS IgM and IgG, and possibly also anti-TOPO-F4 IgG levels. Various correlation analyses revealed that nAAbs might be independently involved in autoimmunity as well as changes in inflammation and vascular pathology over time in biologic-treated patients (p < 0.05). We also found associations between anti-TOPO-F4 IgG and anti-Hsp60 IgG (p < 0.05). Baseline nAAb levels or nAAb level changes might determine changes in CRP, disease activity, FMD, PWV, and ccIMT over time (p < 0.05). The interplay between arthritis and inflammatory atherosclerosis, as well as the effects of anti-TNF biologics on these pathologies, might independently involve nAAbs.}, year = {2024}, eissn = {1422-0067}, orcid-numbers = {Prohászka, Zoltán/0000-0003-1761-7982; Berki, Tímea/0000-0002-0134-8127} } @article{MTMT:34742893, title = {Risk of Venous Thromboembolism with Tofacitinib Versus Tumor Necrosis Factor Inhibitors in Cardiovascular Risk‐enriched Rheumatoid Arthritis Patients}, url = {https://m2.mtmt.hu/api/publication/34742893}, author = {Charles‐Schoeman, Christina and Fleischmann, Roy and Mysler, Eduardo and Greenwald, Maria and Ytterberg, Steven R. and Koch, Gary G. and Bhatt, Deepak L. and Wang, Cunshan and Mikuls, Ted R. and Chen, All‐shine and Connell, Carol A. and Woolcott, John C. and Menon, Sujatha and Chen, Yan and Lee, Kristen and Szekanecz, Zoltán}, doi = {10.1002/art.42846}, journal-iso = {ARTHRITIS RHEUMATOL}, journal = {ARTHRITIS & RHEUMATOLOGY}, unique-id = {34742893}, issn = {2326-5191}, year = {2024}, eissn = {2326-5205}, orcid-numbers = {Fleischmann, Roy/0000-0002-6630-1477; Mikuls, Ted R./0000-0002-0897-2272} }