@article{MTMT:3065667,
	title = {Different desensitization patterns for sensory and vascular TRPV1 populations in the rat: Expression, localization and functional consequences},
	url = {https://m2.mtmt.hu/api/publication/3065667},
	author = {Czikora, Ágnes and Rutkai, Ibolya and Pásztorné, Tóth Enikő and Szalai, Andrea and Pórszász, Róbert and Boczán, Judit and Édes, István and Papp, Zoltán and Tóth, Attila},
	doi = {10.1371/journal.pone.0078184},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {8},
	unique-id = {3065667},
	issn = {1932-6203},
	year = {2013},
	eissn = {1932-6203}
}

@article{MTMT:2504650,
	title = {A veseműtétek során alkalmazott érleszorítás hatása a veseartéria funkcionális aktivitására – az érkárosodás farmakológiai prevenciója},
	url = {https://m2.mtmt.hu/api/publication/2504650},
	author = {Pető, Katalin and Szentmiklósi, József András and Schmidt, E and Kovács, J and Furka, István and Mikó, Irén},
	journal-iso = {MAGYAR UROLÓGIA},
	journal = {MAGYAR UROLÓGIA},
	volume = {15},
	unique-id = {2504650},
	issn = {0864-8921},
	year = {2013},
	pages = {175-180}
}

@article{MTMT:2442826,
	title = {Investigation of the metabolic effects of chronic clozapine treatment on CCK-1 receptor deficient Otsuka Long Evans Tokushima Fatty (OLETF) rats.},
	url = {https://m2.mtmt.hu/api/publication/2442826},
	author = {Hegedűs, Csaba and Kovacs, D and Drimba, László Péter and Sari, R and Varga, Angelika and Nemeth, J and Szilvássy, Zoltán and Peitl, Barna},
	doi = {10.1016/j.ejphar.2013.08.034},
	journal-iso = {EUR J PHARMACOL},
	journal = {EUROPEAN JOURNAL OF PHARMACOLOGY},
	volume = {718},
	unique-id = {2442826},
	issn = {0014-2999},
	abstract = {Clozapine increases meal size and meal duration, effects similar to the pharmacological blockade or congenital deficiency of CCK-1 receptor. We aimed to investigate the role of CCK-1 receptor in clozapine-induced weight gain and insulin sensitivity in CCK-1 receptor deficient, male Otsuka Long Evans Tokushima Fatty rats (OLETF). Long Evans Tokushima Otsuka (LETO) rats served as healthy control. Animals were orally treated with either clozapine (10mg/kg) or its vehicle over 25 days. Daily metabolic parameters were measured by metabolic cages. The insulin sensitivity was determined by hyperinsulinaemic euglycaemic glucose clamping (HEGC). Adiposity was determined by measuring the perirenal, intraabdominal and epididymal white adipose tissue fat pads. Hypothalamic mRNA expression of CCK-1 and CCK-2 receptor was measured by real-time PCR, plasma insulin by radioimmunoassay. Clozapine failed to increase weight gain or daily food intake, but it increased adiposity, 1st meal size and duration and decreased insulin sensitivity both in OLETF or LETO rats. The glucose infusion rate during the steady state of the HEGC was unaltered, but the metabolic clearance rate of insulin was reduced by the clozapine treatment. Hypothalamic mRNA of CCK-1 and CCK-2 receptor was elevated in LETO rats, but the mRNA of CCK-2 receptor was reduced by clozapine in OLETF rats. Our results suggest that the CCK-1 receptor has no direct role in the clozapine-induced adiposity and insulin resistance. We also demonstrated that atypical antipsychotic treatment can induce insulin resistance in the absence of manifest obesity in male rats.},
	year = {2013},
	eissn = {1879-0712},
	pages = {188-196}
}

@article{MTMT:2442825,
	title = {Identification of PPARgamma ligands with One-dimensional Drug Profile Matching.},
	url = {https://m2.mtmt.hu/api/publication/2442825},
	author = {Kovacs, D and Simon, Zoltán and Hari, P and Málnási Csizmadia, András and Hegedűs, Csaba and Drimba, László Péter and Nemeth, J and Sari, R and Szilvássy, Zoltán and Peitl, Barna},
	doi = {10.2147/DDDT.S47173},
	journal-iso = {DRUG DES DEV THER},
	journal = {DRUG DESIGN DEVELOPMENT AND THERAPY},
	volume = {7},
	unique-id = {2442825},
	issn = {1177-8881},
	abstract = {INTRODUCTION: Computational molecular database screening helps to decrease the time and resources needed for drug development. Reintroduction of generic drugs by second medical use patents also contributes to cheaper and faster drug development processes. We screened, in silico, the Food and Drug Administration-approved generic drug database by means of the One-dimensional Drug Profile Matching (oDPM) method in order to find potential peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. The PPARgamma action of the selected generics was also investigated by in vitro and in vivo experiments. MATERIALS AND METHODS: The in silico oDPM method was used to determine the binding potency of 1,255 generics to 149 proteins collected. In vitro PPARgamma activation was determined by measuring fatty acid-binding protein 4/adipocyte protein gene expression in a Mono Mac 6 cell line. The in vivo insulin sensitizing effect of the selected compound (nitazoxanide; 50-200 mg/kg/day over 8 days; n = 8) was established in type 2 diabetic rats by hyperinsulinemic euglycemic glucose clamping. RESULTS: After examining the closest neighbors of each of the reference set's members and counting their most abundant neighbors, ten generic drugs were selected with oDPM. Among them, four enhanced fatty acid-binding protein/adipocyte protein gene expression in the Mono Mac 6 cell line, but only bromfenac and nitazoxanide showed dose-dependent actions. Induction by nitazoxanide was higher than by bromfenac. Nitazoxanide lowered fasting blood glucose levels and improved insulin sensitivity in type 2 diabetic rats. CONCLUSION: We demonstrated that the oDPM method can predict previously unknown therapeutic effects of generic drugs. Nitazoxanide can be the prototype chemical structure of the new generation of insulin sensitizers.},
	keywords = {peroxisome proliferator activated receptor gamma; Type two diabetes; PPARγ; One-dimensional drug profle matching; Insulin sensitizers; In silico lead selection; Computer-aided prediction of receptor-ligand interaction},
	year = {2013},
	pages = {917-928},
	orcid-numbers = {Málnási Csizmadia, András/0000-0002-2430-8398}
}

@article{MTMT:2392796,
	title = {In Vivo Preclinical Evaluation of a Promising Antiarrhythmic Agent, EGIS‐7229},
	url = {https://m2.mtmt.hu/api/publication/2392796},
	author = {Drimba, László Péter and Nemeth, J. and Sári, R. and Di, Y. and Kovács, A. and Szénási, Gábor and Szilvássy, Zoltán and Peitl, Barna},
	doi = {10.1002/ddr.21058},
	journal-iso = {DRUG DEVELOP RES},
	journal = {DRUG DEVELOPMENT RESEARCH},
	volume = {74},
	unique-id = {2392796},
	issn = {0272-4391},
	abstract = {The basic hemodynamic, electrophysiological, and pharmacological effects of EGIS-7229 (E-7229) were evaluated and compared with those of a pure “Class III“ antiarrhythmic drug (GLG-V-13) in conscious rabbits. Both compounds decreased heart rate dose-dependently. Mean arterial blood pressure was not influenced by E-7229; however, GLG-V-13 produced a significant elevation on this parameter. Left ventricular end-diastolic pressure was gradually increased by E-7229, while GLG-V-13 induced more considerable elevation on that at intermediate doses. QT and QTcb were lengthened by both compounds; however, higher doses of E-7229 resulted in shortening of the prolonged QT and QTcb. Ventricular effective refractory period (VERP) was significantly prolonged by either drug studied. Threshold doses to produce QT50%, QTmax, VERP50%, and VERPmax were significantly higher for E-7229 compared with GLG-V-13. Significantly higher doses were required for E-7229 to induce arrhythmias. The safety ratio was comparable for both of the compounds. E-7229 can exert multiple actions on cardiac ion channels with minimal influence on hemodynamic parameters and reduced proarrhytmic profile in our preclinical model.},
	year = {2013},
	eissn = {1098-2299},
	pages = {173-185},
	orcid-numbers = {Szénási, Gábor/0000-0002-7350-6091}
}

@article{MTMT:2389065,
	title = {The potential of materials analysis by electron rutherford backscattering as illustrated by a case study of mouse bones and related compounds},
	url = {https://m2.mtmt.hu/api/publication/2389065},
	author = {Vos, M and Tőkési, Károly and Benkő, Ilona},
	doi = {10.1017/S143192761300041X},
	journal-iso = {MICROSC MICROANAL},
	journal = {MICROSCOPY AND MICROANALYSIS},
	volume = {19},
	unique-id = {2389065},
	issn = {1431-9276},
	abstract = {Electron Rutherford backscattering (ERBS) is a new technique that could be developed into a tool for materials analysis. Here we try to establish a methodology for the use of ERBS for materials analysis of more complex samples using bone minerals as a test case. For this purpose, we also studied several reference samples containing Ca: calcium carbonate (CaCO3) and hydroxyapatite and mouse bone powder. A very good understanding of the spectra of CaCO3 and hydroxyapatite was obtained. Quantitative interpretation of the bone spectrum is more challenging. A good fit of these spectra is only obtained with the same peak widths as used for the hydroxyapatite sample, if one allows for the presence of impurity atoms with a mass close to that of Na and Mg. Our conclusion is that a meaningful interpretation of spectra of more complex samples in terms of composition is indeed possible, but only if widths of the peaks contributing to the spectra are known. Knowledge of the peak widths can either be developed by the study of reference samples (as was done here) or potentially be derived from theory. Copyright © Microscopy Society of America 2013 Â.},
	keywords = {hydroxyapatite; osteoporosis; Elemental analysis; bone mineral; calcium carbonate; Elastic electron scattering; electron Rutherford backscattering},
	year = {2013},
	eissn = {1435-8115},
	pages = {576-586},
	orcid-numbers = {Tőkési, Károly/0000-0001-8772-8472}
}

@article{MTMT:2387075,
	title = {The role of acute hyperinsulinemia in the development of cardiac arrhythmias.},
	url = {https://m2.mtmt.hu/api/publication/2387075},
	author = {Drimba, László Péter and Dobronte, R and Hegedűs, Csaba and Sari, R and Di, Y and Nemeth, J and Szilvássy, Zoltán and Peitl, Barna},
	doi = {10.1007/s00210-013-0845-4},
	journal-iso = {N-S ARCH PHARMACOL},
	journal = {NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY},
	volume = {386},
	unique-id = {2387075},
	issn = {0028-1298},
	abstract = {Patients with perturbed metabolic control are more prone to develop cardiac rhythm disturbances. The main purpose of the present preclinical study was to investigate the possible role of euglycemic hyperinsulinemia in development of cardiac arrhythmias. Euglycemic hyperinsulinemia was induced in conscious rabbits equipped with a right ventricular pacemaker electrode catheter by hyperinsulinemic euglycemic glucose clamp (HEGC) applying two different rates of insulin infusion (5 and 10 mIU/kg/min) and variable rate of glucose infusion to maintain euglycemia (5.5 +/- 0.5 mmol/l). The effect of hyperinsulinemia on cardiac electrophysiological parameters was continuously monitored by means of 12-lead surface ECG recording. Arrhythmia incidence was determined by means of programmed electrical stimulation (PES). The possible role of adrenergic activation was investigated by determination of plasma catecholamine levels and intravenous administration of a beta adrenergic blocking agent, metoprolol. All of the measurements were performed during the steady-state period of HEGC and subsequent to metoprolol administration. Both 5 and 10 mIU/kg/min insulin infusion prolonged significantly QTend, QTc, and Tpeak-Tend intervals. The incidence of ventricular arrhythmias generated by PES was increased significantly by euglycemic hyperinsulinemia and exhibited linear relationship to plasma levels of insulin. No alteration on plasma catecholamine levels could be observed; however, metoprolol treatment restored the prolonged QTend, QTc, and Tpeak-Tend intervals and significantly reduced the hyperinsulinemia-induced increase of arrhythmia incidence. Euglycemic hyperinsulinemia can exert proarrhythmic effect presumably due to the enhancement of transmural dispersion of repolarization. Metoprolol treatment may be of benefit in hyperinsulinemia associated with increased incidence of cardiac arrhythmias.},
	year = {2013},
	eissn = {1432-1912},
	pages = {435-444}
}

@article{MTMT:2360355,
	title = {The guinea pig atrial A1 adenosine receptor reserve for the direct negative inotropic effect of adenosine},
	url = {https://m2.mtmt.hu/api/publication/2360355},
	author = {Kiss, Zsuzsanna Mária and Pák, Krisztián and Zsuga, Judit and Juhász, Béla and Varga, Balázs and Szentmiklósi, József András and Haines, David and Tósaki, Árpád and Gesztelyi, Rudolf},
	doi = {10.4149/gpb_2013041},
	journal-iso = {GEN PHYSIOL BIOPHYS},
	journal = {GENERAL PHYSIOLOGY AND BIOPHYSICS},
	volume = {32},
	unique-id = {2360355},
	issn = {0231-5882},
	year = {2013},
	eissn = {1338-4325},
	pages = {325-335},
	orcid-numbers = {Zsuga, Judit/0000-0002-5350-8188; Gesztelyi, Rudolf/0000-0001-7911-055X}
}

@article{MTMT:2286566,
	title = {Synergetic Insulin Sensitizing Effect of Rimonabant and BGP-15 in Zucker-Obes Rats},
	url = {https://m2.mtmt.hu/api/publication/2286566},
	author = {Literáti-Nagy, Zsuzsanna and Tory, K and Literáti-Nagy, Botond and Bajza, A and Vígh, László Jr. and Vigh, László and Mandl, József and Szilvássy, Zoltán},
	doi = {10.1007/s12253-013-9620-6},
	journal-iso = {PATHOL ONCOL RES},
	journal = {PATHOLOGY AND ONCOLOGY RESEARCH},
	volume = {19},
	unique-id = {2286566},
	issn = {1219-4956},
	abstract = {Abdominal obesity is referred for as a common pathogenic root of 
		multiple risk factors, which include insulin resistance, 
		dyslipidemia, hypertension, and a pro-atherogenic and pro-
		inflammatory state. Irrespective of its psychiatric side 
		effects, rimonabant through blocking cannabinoid-1 receptor 
		(CB1R) induces an increase in whole body insulin sensitivity. 
		The aim of this work was to study the effect of selected doses 
		of another insulin sensitizer compound BGP-15, and rimonabant on 
		insulin resistance in Zucker obese rats with a promise of 
		inducing insulin sensitization together at lower doses than 
		would have been expected by rimonabant alone. We found that BGP-
		15 potentiates the insulin sensitizing effect of rimonabant. The 
		combination at doses, which do not induce insulin sensitization 
		by themselves, improved insulin signaling. Furthermore our 
		results suggest that capsaicin-induced signal may play a role in 
		insulin sensitizing effect of both molecules. Our data might 
		indicate that a lower dose of rimonabant in the treatment of 
		insulin resistance and type 2 diabetes is sufficient to 
		administer, thus a lower incidence of the unfavorable 
		psychiatric side effects of rimonabant are to be expected.},
	year = {2013},
	eissn = {1532-2807},
	pages = {571-575},
	orcid-numbers = {Literáti-Nagy, Botond/0000-0002-1319-6474; Mandl, József/0000-0001-9172-7202}
}

@article{MTMT:2096112,
	title = {Hydroximic Acid Derivatives: Pleiotropic Hsp Co-Inducers Restoring Homeostasis and Robustness},
	url = {https://m2.mtmt.hu/api/publication/2096112},
	author = {Crul, Tim and Crul-Tóth, Noémi and Piotto, S and Literáti-Nagy, Péter and Tory, K and Haldimann, P and Kalmar, B and Greensmith, L and Török, Zsolt and Balogh, Gábor and Gombos, Imre and Campana, F and Concilio, S and Gallyas, Ferenc and Nagy, G and Berente, Zoltán and Güngör, Burcin and Péter, Mária and Glatz, Attila and Hunya, Ákos and Literáti-Nagy, Zsuzsanna and Vígh, László Jr. and Hoogstra-Berends, F and Heeres, A and Kuipers, I and Loen, L and Seerden, JP and Zhang, D and Meijering, RA and Henning, RH and Brundel, BJ and Kampinga, HH and Korányi, László and Szilvássy, Zoltán and Mandl, József and Sümegi, Balázs and Febbraio, MA and Horváth, Ibolya and Hooper, PL and Vigh, László},
	doi = {10.2174/1381612811306030309},
	journal-iso = {CURR PHARM DESIGN},
	journal = {CURRENT PHARMACEUTICAL DESIGN},
	volume = {19},
	unique-id = {2096112},
	issn = {1381-6128},
	abstract = {According to the "membrane sensor" hypothesis, the membranes physical properties and microdomain organization play an initiating role in the heat shock response. Clinical conditions such as cancer, diabetes and neurodegenerative diseases are all coupled with specific changes in the physical state and lipid composition of cellular membranes and characterized by altered heat shock protein levels in cells suggesting that these "membrane defects" can cause suboptimal hsp-gene expression. Such observations provide a new rationale for the introduction of novel, heat shock protein modulating drug candidates. Intercalating compounds can be used to alter membrane properties and by doing so normalize dysregulated expression of heat shock proteins, resulting in a beneficial therapeutic effect for reversing the pathological impact of disease. The membrane (and lipid) interacting hydroximic acid (HA) derivatives discussed in this review physiologically restore the heat shock protein stress response, creating a new class of "membrane-lipid therapy" pharmaceuticals. The diseases that HA derivatives potentially target are diverse and include, among others, insulin resistance and diabetes, neuropathy, atrial fibrillation, and amyotrophic lateral sclerosis. At a molecular level HA derivatives are broad spectrum, multi-target compounds as they fluidize yet stabilize membranes and remodel their lipid rafts while otherwise acting as PARP inhibitors. The HA derivatives have the potential to ameliorate disparate conditions, whether of acute or chronic nature. Many of these diseases presently are either untreatable or inadequately treated with currently available pharmaceuticals. Ultimately, the HA derivatives promise to play a major role in future pharmacotherapy.},
	year = {2013},
	eissn = {1873-4286},
	pages = {309-346},
	orcid-numbers = {Crul, Tim/0000-0002-6053-7016; Gallyas, Ferenc/0000-0002-1906-4333; Hunya, Ákos/0000-0002-4547-9284; Mandl, József/0000-0001-9172-7202}
}