TY - JOUR AU - Szirmai, Danuta AU - Zabihi, A. AU - Kói, Tamás AU - Hegyi, Péter AU - Wenning, A.S. AU - Engh, Marie Anne AU - Molnár, Zsolt AU - Csukly, Gábor AU - Horváth, András Attila TI - EEG connectivity and network analyses predict outcome in patients with disorders of consciousness – A systematic review and meta-analysis JF - HELIYON J2 - HELIYON VL - 10 PY - 2024 IS - 10 PG - 12 SN - 2405-8440 DO - 10.1016/j.heliyon.2024.e31277 UR - https://m2.mtmt.hu/api/publication/34877513 ID - 34877513 N1 - Export Date: 31 May 2024 Correspondence Address: Szirmai, D.Amerikai út 57, Hungary; email: szirmaidanuta@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Shamsodini, Júlia AU - Molnár, Dávid TI - A Computed Tomography Study on the Prevalence of Lusorian Artery Among Hungarian Adults JF - CUREUS J2 - CUREUS VL - 16 PY - 2024 IS - 4 PG - 12 SN - 2168-8184 DO - 10.7759/cureus.58622 UR - https://m2.mtmt.hu/api/publication/34873452 ID - 34873452 AB - Introduction The aberrant right subclavian artery (ARSA), also called as lusorian artery (LA) is a developmental anomaly that exists in conjunction with a right non-recurrent laryngeal nerve (NRLN) in almost all cases. The average prevalence of such a vascular variation is estimated as 1%, although, studies have reported very different population means. Up to date, there is no available data on the frequency of this pattern in the Hungarian population. It can be treated as an indirect marker of a NRLN. Any preoperative information on the course of the inferior laryngeal nerves can help surgeons reduce the risk of an iatrogenic injury during thyroidectomies, especially in an environment where access to intraoperative neuromonitoring is limited. Objectives The primary aims were to determine the prevalence of an ARSA, predict the existence of an NRLN in the Hungarian population, and provide demographic analysis. Methods A retrospective, computed tomography-based study was carried out. Demographic description and statistical analysis were provided where applicable. Detected anomalous vasculatures were visualized with 3D segmentation, and images were interpreted. Results The imaging database review identified three patients with ARSA out of 686 eligible recordings, resulting in a frequency of 0.437% in the study population. All three patients were female and had a retroesophageal LA. Two of them had a Kommerell's diverticulum. One patient had common carotid arteries with a single origin. Conclusions The frequency of an ARSA and a concomitant NRLN among Hungarians fits into the results of recent metaanalyses. Preoperative assessment of this anomaly may reduce vocal cord complication rates of thyroidectomies. LA - English DB - MTMT ER - TY - JOUR AU - Oláh, Imre AU - Felföldi, B. AU - Benyeda, Z. AU - Magyar, Attila AU - Nagy, Nándor AU - Soós, Ádám AU - Szőcs, Emőke TI - Life cycle of chicken bursal secretory dendritic cell (BSDC) JF - POULTRY SCIENCE J2 - POULTRY SCI VL - 103 PY - 2024 IS - 6 PG - 10 SN - 0032-5791 DO - 10.1016/j.psj.2024.103640 UR - https://m2.mtmt.hu/api/publication/34836845 ID - 34836845 LA - English DB - MTMT ER - TY - JOUR AU - Puska, Gina AU - Szendi, Vivien AU - Dobolyi, Árpád TI - Lateral septum as a possible regulatory center of maternal behaviors JF - NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS J2 - NEUROSCI BIOBEHAV R VL - 161 PY - 2024 PG - 11 SN - 0149-7634 DO - 10.1016/j.neubiorev.2024.105683 UR - https://m2.mtmt.hu/api/publication/34828140 ID - 34828140 N1 - Export Date: 10 May 2024 CODEN: NBRED Correspondence Address: Dobolyi, A.; Department of Physiology and Neurobiology, Hungary; email: dobolyi.arpad@ttk.elte.hu LA - English DB - MTMT ER - TY - JOUR AU - Chaves, Tiago AU - Török, Bibiána AU - Fazekas, Csilla Lea AU - Correia, Pedro AU - Bodóné Sipos, Eszter AU - Várkonyi, Dorottya AU - Tóth, Zsuzsanna AU - Dóra, Fanni AU - Dobolyi, Árpád AU - Zelena, Dóra TI - The Dopaminergic Cells in the Median Raphe Region Regulate Social Behavior in Male Mice JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 8 PG - 22 SN - 1661-6596 DO - 10.3390/ijms25084315 UR - https://m2.mtmt.hu/api/publication/34825010 ID - 34825010 N1 - Funding Agency and Grant Number: National Brain Research Program (NAP 3.0) of the Hungarian Academy of Sciences Funding text: No Statement Available AB - According to previous studies, the median raphe region (MRR) is known to contribute significantly to social behavior. Besides serotonin, there have also been reports of a small population of dopaminergic neurons in this region. Dopamine is linked to reward and locomotion, but very little is known about its role in the MRR. To address that, we first confirmed the presence of dopaminergic cells in the MRR of mice (immunohistochemistry, RT-PCR), and then also in humans (RT-PCR) using healthy donor samples to prove translational relevance. Next, we used chemogenetic technology in mice containing the Cre enzyme under the promoter of the dopamine transporter. With the help of an adeno-associated virus, designer receptors exclusively activated by designer drugs (DREADDs) were expressed in the dopaminergic cells of the MRR to manipulate their activity. Four weeks later, we performed an extensive behavioral characterization 30 min after the injection of the artificial ligand (Clozapine-N-Oxide). Stimulation of the dopaminergic cells in the MRR decreased social interest without influencing aggression and with an increase in social discrimination. Additionally, inhibition of the same cells increased the friendly social behavior during social interaction test. No behavioral changes were detected in anxiety, memory or locomotion. All in all, dopaminergic cells were present in both the mouse and human samples from the MRR, and the manipulation of the dopaminergic neurons in the MRR elicited a specific social response. LA - English DB - MTMT ER - TY - JOUR AU - Shahbazi, Arvin Irani AU - Mueller, Andreas A. AU - Mezey, Szilvia AU - Gschwindt, Sebastian Andreas AU - Kiss, Tamás AU - Baksa, Gábor AU - Kisnisci, Reha S. TI - Is the collateral circulation pattern in the hard palate affected by cleft deformity? JF - CLINICAL ORAL INVESTIGATIONS J2 - CLIN ORAL INVEST VL - 28 PY - 2024 IS - 5 PG - 8 SN - 1432-6981 DO - 10.1007/s00784-024-05627-0 UR - https://m2.mtmt.hu/api/publication/34824532 ID - 34824532 AB - Objectives: To evaluate the influence of collateral vascularization on surgical cleft palate closure and deformities. Materials and methods: Corrosion casting was performed using red-colored acrylic resin in twelve fresh adult cadavers with a normal hard palate. Additionally, white-colored barium sulfate was injected into a fetus with a unilateral complete cleft palate, and layer-by-layer tissue dissection was performed. Both substances were injected into the external carotid arteries. Corrosion casting involved dissolving the soft and hard tissues of the orofacial area utilizing an enzymatic solution. Results: In normal palates, bilateral intraosseous infraorbital arteries formed a network in the premaxilla with the intraosseous nasopalatine- and greater palatine arteries (GPAs). The perforating GPAs anastomosed with the sphenopalatine artery sub-branches. Bilateral extraosseous GPA anastomoses penetrated the median palatine suture. Complex vascularization in the retrotuberal area was detected. In the cleft zone, anastomoses were omitted, whereas in the non-cleft zone, enlarged GPAs were distributed along the cleft edges and followed the anatomical course anteriorly to initiate the network with facial artery sub-branches. Conclusions: The anatomical subunits of the palate exhibited distinct anastomosis patterns. Despite omitted anastomoses with collateral circulation in the cleft zone, arteries maintained their anatomical pattern as seen in the normal specimen in the non-cleft zone. Clinical relevance: Based on the findings in normal- and cleft palates, surgeons may expect developed anastomosis patterns in the non-cleft zone. Due to the lack of microcirculation in the cleft zone, the existent anastomoses should be maintained as much as possible by the surgical technique. This applies anteriorly in the incisive canal territory, alveolar ridges, and posteriorly in the retrotuberal area. LA - English DB - MTMT ER - TY - JOUR AU - Mészáros, Cintia AU - Kurucz, Péter AU - Baksa, Gábor AU - Alpár, Alán AU - Ganslandt, Oliver AU - Brandner, Sebastian AU - Bárány, László TI - Topographical anatomy of the subthalamic region with special interest in the human medial forebrain bundle JF - JOURNAL OF NEUROSURGERY J2 - J NEUROSURG VL - 2024 PY - 2024 PG - 11 SN - 0022-3085 DO - 10.3171/2024.1.JNS232066 UR - https://m2.mtmt.hu/api/publication/34818909 ID - 34818909 LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Klaudia AU - Dékány, Bulcsú AU - Énzsöly, Anna AU - Hajdú, Rozina Ida AU - Laurik-Feuerstein, Lenke Kornélia AU - Szabó, Arnold AU - Radovits, Tamás AU - Mátyás, Csaba AU - Oláh, Attila AU - Kovács, Krisztián András AU - Szél, Ágoston AU - Somfai, Gábor Márk AU - Lukáts, Ákos TI - Possible retinotoxicity of long-term vardenafil treatment JF - EXPERIMENTAL EYE RESEARCH J2 - EXP EYE RES VL - 243 PY - 2024 PG - 15 SN - 0014-4835 DO - 10.1016/j.exer.2024.109890 UR - https://m2.mtmt.hu/api/publication/34814042 ID - 34814042 N1 - Institute of Education and Psychology at Szombathely, Faculty of Education and Psychology, ELTE Eötvös Loránd University, Szombathely, Hungary Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary Department of Ophthalmology, Semmelweis University, Budapest, Hungary Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany Heart and Vascular Center, Semmelweis University, Budapest, Hungary Institute of Translational Medicine, Translational Retina Research Group, Semmelweis University, Budapest, Hungary Spross Research Institute, Zurich, Switzerland Department of Ophthalmology, Stadtspital Zurich, Zurich, Switzerland Export Date: 3 May 2024 CODEN: EXERA Correspondence Address: Lukáts, Á.; Institute of Translational Medicine, Hungary; email: lukatsakos@gmail.com Chemicals/CAS: cyclic GMP, 7665-99-8; rhodopsin, 60383-01-9, 9009-81-8; vardenafil, 224785-90-4, 224785-91-5, 224789-15-5 Funding text 1: Project no. RRF-2.3.1-21-2022-00003 has been implemented with the support provided by the European Union. Funding text 2: TKP2021-EGA-23 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. LA - English DB - MTMT ER - TY - JOUR AU - Csukly, Gábor AU - Tombor, László AU - Hidasi, Zoltán AU - Csibri, Eva AU - Fullajtár, Máté AU - Huszár, Zsolt AU - Koszovácz, Vanda AU - Lányi, Orsolya AU - Vass, Edit AU - Koleszár, Boróka AU - Kóbor, István AU - Farkas, Katalin AU - Rosenfeld, Viktória AU - Berente, Dalida Borbála AU - Bolla, Gergő Levente AU - Kiss, Mate AU - Kamondi, Anita AU - Horváth, András Attila TI - Low Functional network integrity in cognitively unimpaired and MCI subjects with depressive symptoms. results from a multi-center fMRI study. TS - results from a multi-center fMRI study. JF - TRANSLATIONAL PSYCHIATRY J2 - TRANSL PSYCHIAT VL - 14 PY - 2024 IS - 1 PG - 11 SN - 2158-3188 DO - 10.1038/s41398-024-02891-2 UR - https://m2.mtmt.hu/api/publication/34774958 ID - 34774958 AB - Evidence suggests that depressive symptomatology is a consequence of network dysfunction rather than lesion pathology. We studied whole-brain functional connectivity using a Minimum Spanning Tree as a graph-theoretical approach. Furthermore, we examined functional connectivity in the Default Mode Network, the Frontolimbic Network (FLN), the Salience Network, and the Cognitive Control Network. All 183 elderly subjects underwent a comprehensive neuropsychological evaluation and a 3 Tesla brain MRI scan. To assess the potential presence of depressive symptoms, the 13-item version of the Beck Depression Inventory (BDI) or the Geriatric Depression Scale (GDS) was utilized. Participants were assigned into three groups based on their cognitive status: amnestic mild cognitive impairment (MCI), non-amnestic MCI, and healthy controls. Regarding affective symptoms, subjects were categorized into depressed and non-depressed groups. An increased mean eccentricity and network diameter were found in patients with depressive symptoms relative to non-depressed ones, and both measures showed correlations with depressive symptom severity. In patients with depressive symptoms, a functional hypoconnectivity was detected between the Anterior Cingulate Cortex (ACC) and the right amygdala in the FLN, which impairment correlated with depressive symptom severity. While no structural difference was found in subjects with depressive symptoms, the volume of the hippocampus and the thickness of the precuneus and the entorhinal cortex were decreased in subjects with MCI, especially in amnestic MCI. The increase in eccentricity and diameter indicates a more path-like functional network configuration that may lead to an impaired functional integration in depression, a possible cause of depressive symptomatology in the elderly. LA - English DB - MTMT ER - TY - JOUR AU - Benevento, M. AU - Alpár, Alán AU - Gundacker, A. AU - Afjehi, L. AU - Balueva, K. AU - Hevesi, Z. AU - Hanics, János AU - Rehman, S. AU - Pollak, D.D. AU - Lubec, G. AU - Wulff, P. AU - Prevot, V. AU - Horvath, T.L. AU - Harkany, T. TI - A brainstem–hypothalamus neuronal circuit reduces feeding upon heat exposure JF - NATURE J2 - NATURE VL - 628 PY - 2024 SP - 826 EP - 834 PG - 9 SN - 0028-0836 DO - 10.1038/s41586-024-07232-3 UR - https://m2.mtmt.hu/api/publication/34771191 ID - 34771191 LA - English DB - MTMT ER -