TY  - JOUR
AU  - Furdan, Szabina
AU  - Lőrincz, László Magor
TI  - Routing of olfactory inputs to the brainstem raphé nucleus
JF  - CLINICAL NEUROPHYSIOLOGY
J2  - CLIN NEUROPHYSIOL
VL  - 127
PY  - 2016
IS  - 3
PG  - 1
SN  - 1388-2457
DO  - 10.1016/j.clinph.2015.11.417
UR  - https://m2.mtmt.hu/api/publication/3085614
ID  - 3085614
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Lőrincz, László Magor
AU  - Gunner, D
AU  - Bao, Y
AU  - Connelly, WM
AU  - Isaac, JT
AU  - Hughes, SW
AU  - Crunelli, V
TI  - A Distinct Class of Slow ( approximately 0.2-2 Hz) Intrinsically Bursting Layer 5 Pyramidal Neurons Determines UP/DOWN State Dynamics in the Neocortex
JF  - JOURNAL OF NEUROSCIENCE
J2  - J NEUROSCI
VL  - 35
PY  - 2015
IS  - 14
SP  - 5442
EP  - 5458
PG  - 17
SN  - 0270-6474
DO  - 10.1523/JNEUROSCI.3603-14.2015
UR  - https://m2.mtmt.hu/api/publication/2889024
ID  - 2889024
AB  - During sleep and anesthesia, neocortical neurons exhibit rhythmic UP/DOWN membrane potential states. Although UP states are maintained by synaptic activity, the mechanisms that underlie the initiation and robust rhythmicity of UP states are unknown. Using a physiologically validated model of UP/DOWN state generation in mouse neocortical slices whereby the cholinergic tone present in vivo is reinstated, we show that the regular initiation of UP states is driven by an electrophysiologically distinct subset of morphologically identified layer 5 neurons, which exhibit intrinsic rhythmic low-frequency burst firing at approximately 0.2-2 Hz. This low-frequency bursting is resistant to block of glutamatergic and GABAergic transmission but is absent when slices are maintained in a low Ca(2+) medium (an alternative, widely used model of cortical UP/DOWN states), thus explaining the lack of rhythmic UP states and abnormally prolonged DOWN states in this condition. We also characterized the activity of various other pyramidal and nonpyramidal neurons during UP/DOWN states and found that an electrophysiologically distinct subset of layer 5 regular spiking pyramidal neurons fires earlier during the onset of network oscillations compared with all other types of neurons recorded. This study, therefore, identifies an important role for cell-type-specific neuronal activity in driving neocortical UP states.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Vincenzo, Crunelli
AU  - Francois, David
AU  - Lőrincz, László Magor
AU  - Stuart, W Hughes
TI  - The thalamocortical network as a single slow wave-generating unit
JF  - CURRENT OPINION IN NEUROBIOLOGY
J2  - CURR OPIN NEUROBIOL
VL  - 31
PY  - 2015
SP  - 72
EP  - 80
PG  - 9
SN  - 0959-4388
DO  - 10.1016/j.conb.2014.09.001
UR  - https://m2.mtmt.hu/api/publication/2734917
ID  - 2734917
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Borbély, Emőke
AU  - Horváth, János
AU  - Furdan, Szabina
AU  - Bozsó, Zsolt
AU  - Penke, Botond
AU  - Fülöp, Lívia
TI  - Simultaneous changes of spatial memory and spine density after intrahippocampal administration of fibrillar abeta1-42 to the rat brain
JF  - BIOMED RESEARCH INTERNATIONAL
J2  - BIOMED RES INT
VL  - 2014
PY  - 2014
PG  - 9
SN  - 2314-6133
DO  - 10.1155/2014/345305
UR  - https://m2.mtmt.hu/api/publication/2755872
ID  - 2755872
AB  - Several animal models of Alzheimer's disease have been used in laboratory experiments. Intrahippocampal injection of fibrillar amyloid-beta (fAbeta) peptide represents one of the most frequently used models, mimicking Abeta deposits in the brain. In our experiment synthetic fAbeta1-42 peptide was administered to rat hippocampus. The effect of the Abeta peptide on spatial memory and dendritic spine density was studied. The fAbeta1-42-treated rats showed decreased spatial learning ability measured in Morris water maze (MWM). Simultaneously, fAbeta1-42 caused a significant reduction of the dendritic spine density in the rat hippocampus CA1 region. The decrease of learning ability and the loss of spine density were in good correlation. Our results prove that both methods (MWM and dendritic spine density measurement) are suitable for studying Abeta-triggered neurodegeneration processes.
LA  - English
DB  - MTMT
ER  -