TY - JOUR AU - Angyal, Viola Zsuzsanna AU - Bertalan, Ádám AU - Domján, Péter AU - Dinya, Elek TI - ScreenGPT – A mesterséges intelligencia alkalmazásának lehetőségei és korlátai a primer, szekunder és tercier prevencióban JF - ORVOSI HETILAP J2 - ORV HETIL VL - 165 PY - 2024 IS - 16 SP - 629 EP - 635 PG - 7 SN - 0030-6002 DO - 10.1556/650.2024.33029 UR - https://m2.mtmt.hu/api/publication/34817394 ID - 34817394 AB - Bevezetés: A prevenció és a szűrővizsgálatok manapság egyre népszerűbbek. A páciensek – tudatosabbá válásuknak köszönhetően – többet kutatnak az interneten egészségi állapotukkal kapcsolatosan, függetlenül attól, hogy az mennyire megbízható. A ChatGPT megjelenése forradalmasította az információszerzést, így elkezdték azt öndiagnózisra és egészségi állapotuk menedzselésére használni. Annak ellenére, hogy a mesterségesintelligencia-alapú szolgáltatások nem helyettesíthetik az egészségügyi szakemberekkel történő konzultációt, kiegészítő szerepet tölthetnek be a hagyományos szűrési eljárások során, így érdemes megvizsgálni a lehetőségeket és a korlátokat. Célkitűzés: Kutatásunk legfőbb célkitűzése az volt, hogy azonosítsuk azokat a területeket, ahol a ChatGPT képes bekapcsolódni a primer, szekunder és tercier prevenciós folyamatokba. Célunk volt továbbá megalkotni az olyan mesterségesintelligencia-alapú szolgáltatás koncepcióját, amely segítheti a pácienseket a prevenció különböző szintjein. Módszer: A prevenciós területen a ChatGPT által nyújtott lehetőségeket a rendszernek feltett specifikus kérdésekkel térképeztük fel. Ezen tapasztalatok alapján létrehoztunk egy webapplikációt, melynek elkészítéséhez a GPT-4 modell szolgált alapul. A válaszok helyességét strukturált pontos kérdésekkel igyekeztük javítani. A webapplikáció elkészítéséhez Python programozási nyelvet használtunk, az alkalmazást pedig a Streamlit keretrendszer felhőszolgáltatásán keresztül tettük elérhetővé és tesztelhetővé. Eredmények: A tesztek eredményei alapján több olyan prevenciós területet azonosítottunk, ahol a ChatGPT-t hatékonyan lehetne alkalmazni. Az eredmények alapján sikeresen létrehoztuk egy webapplikáció alapjait, amely a ScreenGPT nevet kapta. Következtetés: Megállapítottuk, hogy a ChatGPT a prevenció mindhárom szintjén képes hasznos válaszokat adni pontos kérdésekre. Válaszai jól tükrözik az emberi párbeszédet, ám a ChatGPT nem rendelkezik öntudattal, így fontos, hogy a felhasználók kritikusan értékeljék a válaszait. A ScreenGPT szolgáltatást e tapasztalatok alapján sikerült megalkotnunk, számos további vizsgálatra van azonban szükség, hogy megbizonyosodjunk a megbízhatóságáról. Orv Hetil. 2024; 165(16): 629–635. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Simon, Csilla AU - Tóth, Zoltán TI - Jövőbeli kihívások meglévő rendszerek esetében. A környezeti tényezők változásának relevanciája az energiatermelésben TS - A környezeti tényezők változásának relevanciája az energiatermelésben JF - ELEKTROTECHNIKA J2 - ELEKTROTECHNIKA VL - 117 PY - 2024 IS - 3 SP - 18 EP - 20 PG - 3 SN - 0367-0708 UR - https://m2.mtmt.hu/api/publication/34789151 ID - 34789151 LA - Hungarian DB - MTMT ER - TY - GEN ED - Kyriaki, Anastasiou (INHWE) / Collaborator ED - Matteo, Vezzosi (INHWE) / Collaborator ED - Timo, Sinervo (THL) / Collaborator ED - Elina, Kärkkäinen (THL) / Collaborator ED - Moona, Huhtakangas (THL) / Collaborator ED - Visa, Väisänen (THL) / Collaborator ED - Véronique, Lucas-Gabrielli (IRDES) / Collaborator ED - Julien, Mousques (IRDES-EHESP) / Collaborator ED - Arnaud, Besson (EHESP) / Collaborator ED - Guillaume, Chevillard (IRDES) / Collaborator ED - Galambos, László / Collaborator ED - Ádám, Szilvia / Collaborator ED - Tóth, Zoltán / Collaborator ED - Marosi, Gergely / Collaborator ED - Cserháti, Zoltán / Collaborator ED - Stella, Lanzi (AGENAS) / Collaborator ED - Giovanni, Baglio (AGENAS) / Collaborator ED - Erica, Eugeni (AGENAS) / Collaborator ED - Marcello, Cuomo (AGENAS) / Collaborator ED - Danilo, Catania (AGENAS) / Collaborator ED - Emma, Guagneli (AGENAS) / Collaborator ED - Federica, Vitello (AGENAS) / Collaborator ED - Chiara, De Marchi (AGENAS) / Collaborator ED - Roberta, De Blasiis (AGENAS) / Collaborator ED - Alessia, Carbone (AGENAS) / Collaborator ED - Alessandra, Cese (AGENAS) / Collaborator ED - Giorgia, Duranti (AGENAS) / Collaborator ED - Elisa, Guglielmi (AGENAS) / Collaborator ED - Lisa, Baldini (AGENAS) / Collaborator ED - Aldo, Rosano (Istituto Nazionale per l’Analisi delle Politiche Pubbliche) / Collaborator ED - Roberto, Blaco (independent expert) / Collaborator ED - Alessandra, Burgio (Istituto Nazionale di Statistica) / Collaborator ED - Chiara, Marinacci (Regione Lazio) / Collaborator ED - Mirko, Di Martino (Regione Lazio) / Collaborator ED - Sergiu, Otgon (NPHA) / Collaborator ED - Liliana, Buzdugan (NPHA) / Collaborator ED - Marius-Ionuț, Ungureanu (UBB) / Collaborator ED - Andrei, Rus (UBB) / Collaborator ED - Elena, Bozdog (UBB) / Collaborator ED - Răzvan, Cherecheș (UBB) / Collaborator ED - Cătălin, Baba (UBB) / Collaborator AU - Monica-Georgiana, Brînzac TI - OASES D6.3 - Reports on pilot studies. OASES D6.3 TS - OASES D6.3 PY - 2024 PG - 239 UR - https://m2.mtmt.hu/api/publication/34752691 ID - 34752691 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Gábor AU - Muzsik, Béla AU - Szajkó, Attila AU - Kerber, Pál AU - Dinya, Elek AU - Csákány, Béla AU - Nagy, Zoltán Zsolt AU - Németh, János Tibor TI - Incidence and Mortality of Uveal Melanoma in Hungary: A Nationwide Study JF - CANCERS J2 - CANCERS VL - 16 PY - 2024 IS - 5 PG - 11 SN - 2072-6694 DO - 10.3390/cancers16050931 UR - https://m2.mtmt.hu/api/publication/34687493 ID - 34687493 AB - Uveal melanoma (UM) is the most common primary malignant ocular tumour in adults, although its epidemiology in Central and Eastern Europe is unclear. This study aimed to analyse the incidence and all-cause mortality of UM in Hungary. This nationwide, retrospective, longitudinal study used data from the National Health Insurance Fund and included patients aged ≥18 years who were newly diagnosed with UM (ICD-10 C69.3 or C69.4) between 1 January 2012 and 31 December 2021. Age-standardised incidence and all-cause mortality rates were calculated using European Standard Population data from 2013. We identified 88 and 70 new patients with UM in 2012 and 2021, respectively, showing an almost stable trend. Age-standardised incidence rates varied between 6.40 and 10.96/1,000,000 person-years (PYs) during the analysed period. The highest age-standardised incidence was detected among men (13.38/1,000,000 PYs) in 2015. All-cause mortality decreased from 4.72/1,000,000 PYs to 0.79/1,000,000 PYs between 2012 and 2021. In conclusion, the UM incidence rate in Hungary is comparable to European incidence rates. The incidence did not markedly change, whereas all-cause mortality decreased during the study period, but this decline could not be attributed to improved treatment modalities for primary tumours and metastatic UM. LA - English DB - MTMT ER - TY - JOUR AU - Palaszkó, Dénes AU - Németh, Anna AU - Klopferné Török, Gréta AU - Vecsei, Bálint AU - Vánkos, Boldizsár AU - Dinya, Elek AU - Borbély, Judit AU - Marada, Gyula AU - Hermann, Péter AU - Kispélyi, Ida Barbara TI - Trueness of five different 3D printing systems including budget- and professional-grade printers: An In vitro study JF - HELIYON J2 - HELIYON VL - 10 PY - 2024 IS - 5 PG - 12 SN - 2405-8440 DO - 10.1016/j.heliyon.2024.e26874 UR - https://m2.mtmt.hu/api/publication/34687423 ID - 34687423 N1 - Department of Prosthodontics, Faculty of Dentistry, Semmelweis University, Budapest, Hungary Institute of Digital Health Sciences, Semmelweis University, Budapest, Hungary University of Pécs, Hungary Export Date: 30 April 2024 Correspondence Address: Palaszkó, D.; Department of Prosthodontics, Hungary; email: palaszko.denes@semmelweis.hu AB - Problem Several types of 3D printers with different techniques and prices are available on the market. However, results in the literature are inconsistent, and there is no comprehensive agreement on the accuracy of 3D printers of different price categories for dental applications. Aim This study aimed to investigate the accuracy of five different 3D printing systems, including a comparison of budget- and higher-end 3D printing systems, according to a standardized production and evaluation protocol. Material and methods A maxillary reference model with prepared teeth was created using 16 half-ball markers with a diameter of 1 mm to facilitate measurements. A reference file was fabricated using five different 3D printers. The printed models were scanned and superimposed onto the original standard tesselation language (.stl) file, and digital measurements were performed to assess the 3-dimensional and linear deviations between the reference and test models. Results After examining the entire surface of the models, we found that 3D printers using Fused filament fabrication (FFF) technology −120.2 (20.3) μm create models with high trueness but high distortion. Distortions along the z-axis were found to be the highest with the stereolithography (SLA)-type 3D printer at −153.7 (38.7) μm. For the 4-unit FPD, we found 201.9 (41.8) μm deviation with the digital light processing (DLP) printer. The largest deviation (−265.1 (55.4) μm) between the second molars was observed for the DLP printer. Between the incisor and the second molar, the best results were produced by the FFF printer with −30.5 (76.7) μm. Conclusion Budget-friendly 3D printers are comparable to professional-grade printers in terms of precision. In general, the cost of a printing system is not a reliable indicator of its level of accuracy. LA - English DB - MTMT ER - TY - JOUR AU - Vámos, Orsolya AU - Kulcsár, Norbert AU - Mikecs, Barbara AU - Kelemen, Kata AU - Kaán, Réka AU - Hauzer-Abafalvi, Lilla AU - Dinya, Elek AU - Vág, János AU - Hermann, Péter AU - Kispélyi, Ida Barbara TI - Acute effects of traditional and electronic cigarettes on palatal blood flow in smokers: A cross-over pilot study JF - JOURNAL OF ORAL BIOLOGY AND CRANIOFACIAL RESEARCH J2 - J ORAL BIOL CRANIOFACIAL RES VL - 14 PY - 2024 IS - 2 SP - 152 EP - 157 PG - 6 SN - 2212-4268 DO - 10.1016/j.jobcr.2024.01.012 UR - https://m2.mtmt.hu/api/publication/34558809 ID - 34558809 N1 - Department of Prosthodontics, Faculty of Dentistry, Semmelweis University, Szentkirályi Street 47, Budapest, H-1088, Hungary Department of Restorative Dentistry and Endodontics, Faculty of Dentistry, Semmelweis University, Szentkirályi Street 47, Budapest, H-1088, Hungary Department of Oral Health Sciences, KU Leuven, Oude Markt 13, Leuven, 3000, Belgium Institute of Digital Health Sciences, Faculty of Public Services, Semmelweis University, Üllői Road 26, Budapest, H-1085, Hungary Export Date: 10 March 2024 Correspondence Address: Vámos, O.Szentkirályi Street 47, Hungary; email: vamosorsi13@gmail.com AB - Background Smoking is a significant health hazard and contributes to cardiovascular and pulmonary diseases. It can increase postoperative complications during oral and maxillofacial surgery due to its topical effect on the oral mucosa. New alternatives to traditional tobacco products are gaining popularity, in particular, electronic cigarettes. Objectives This pilot study investigated the acute effects of nicotine-containing and nicotine-free electronic cigarettes on palatal blood flow (PBF), and compared their effects to traditional cigarettes. Materials and methods 14 medically healthy volunteers (8 males, 6 females, age: 34.7 ± 7.0) were recruited for the study. All patients (N = 14) were requested to smoke nicotine-containing (ECN) and nicotine-free electronic cigarettes (EC0) and a mouthpiece (end of a traditional cigarette) as a control sham smoking blind test (BT). EC users did not smoke a traditional cigarette (TC), resulting in 10 people in the TC group. Palatal blood flow was measured by Laser Speckle Contrast Imager before, immediately after, and 15 min after the exposures. Exhaled carbon monoxide (eCO) and carboxyhemoglobin (COHb) were measured before and immediately after smoking with a piCO+ Smokerlyzer machine. Results In all groups, no significant differences were observed in the changes of palatal blood flow between time points. Exhaled carbon monoxide and carboxyhemoglobin were significantly higher in the traditional cigarette (TC) group compared to the nicotine-containing electronic cigarette (ECN) and nicotine-free electronic cigarette (EC0) groups, both before and after the exposure (p < 0.05). Conclusion Acute use of either traditional or electronic cigarettes may have minimal impact on palatal blood flow, but additional studies are required to clarify their impact on the mucosa. LA - English DB - MTMT ER - TY - JOUR AU - Molnár, Gergő Attila AU - Vokó, Zoltán AU - Sütő, Gábor AU - Rokszin, György Aurél AU - Nagy, Dávid AU - Surján, György AU - Surján, Orsolya AU - Nagy, Péter AU - Kenessey, István AU - Wéber, András AU - Pálosi, Mihály AU - Müller, Cecília AU - Kásler, Miklós AU - Wittmann, István AU - Kiss, Zoltán TI - Effectiveness of SARS-CoV-2 primary vaccines and boosters in patients with type 2 diabetes mellitus in Hungary (HUN-VE 4 Study) JF - BMJ OPEN DIABETES RESEARCH & CARE J2 - BMJ OPEN DIAB RES CA VL - 12 PY - 2024 IS - 1 PG - 10 SN - 2052-4897 DO - 10.1136/bmjdrc-2023-003777 UR - https://m2.mtmt.hu/api/publication/34538356 ID - 34538356 N1 - * Megosztott szerzőség AB - Introduction Type 2 diabetes mellitus is a risk factor for severe COVID-19 infection and is associated with increased risk of complications. The present study aimed to investigate effectiveness and persistence of different COVID vaccines in persons with or without diabetes during the Delta wave in Hungary.Research design and methods Data sources were the national COVID-19 registry data from the National Public Health Center and the National Health Insurance Fund on the total Hungarian population. The adjusted incidence rate ratios and corresponding 95% CIs were derived from a mixed-effect negative binomial regression model.Results A population of 672 240 cases with type 2 diabetes and a control group of 2 974 102 non-diabetic persons free from chronic diseases participated. Unvaccinated elderly persons with diabetes had 2.68 (95% CI 2.47 to 2.91) times higher COVID-19-related mortality rate as the ‘healthy’ controls. Primary immunization effectively equalized the risk of COVID-19 mortality between the two groups. Vaccine effectiveness declined over time, but the booster restored the effectiveness against mortality to over 90%. The adjusted vaccine effectiveness of the primary Pfizer-BioNTech against infection in the 14–120 days of postvaccination period was 71.6 (95% CI 66.3 to 76.1)% in patients aged 65–100 years with type 2 diabetes and 64.52 (95% CI 59.2 to 69.2)% in the controls. Overall, the effectiveness tended to be higher in individuals with diabetes than in controls. The booster vaccines could restore vaccine effectiveness to over 80% concerning risk of infection (eg, patients with diabetes aged 65–100 years: 89.1 (88.1–89.9)% with Pfizer-on-Pfizer, controls 65–100 years old: 86.9 (85.8–88.0)% with Pfizer-on-Pfizer, or patients with diabetes aged 65–100 years: 88.3 (87.2–89.2)% with Pfizer-on-Sinopharm, controls 65–100 years old: 87.8 (86.8–88.7)% with Pfizer-on-Sinopharm).Conclusions Our data suggest that people with type 2 diabetes may have even higher health gain when getting vaccinated as compared with non-diabetic persons, eliminating the marked, COVID-19-related excess risk of this population. Boosters could restore protection.Data are available upon reasonable request. LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Loretta Zsuzsa AU - Nyárády, Balázs Bence AU - Pállinger, Éva AU - Lux, Árpád AU - Jermendy, Ádám Levente AU - Csobay-Novák, Csaba AU - Soós, Pál AU - Szelid, Zsolt László AU - Láng, Orsolya AU - Kőhidai, László AU - Dinya, Elek AU - Dósa, Edit AU - Merkely, Béla Péter AU - Bagyura, Zsolt TI - Association of growth and differentiation factor-15 with coronary artery calcium score and ankle-brachial index in a middle-aged and elderly Caucasian population sample free of manifest cardiovascular disease JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 46 PY - 2024 IS - 1 SP - 1343 EP - 1350 PG - 8 SN - 2509-2715 DO - 10.1007/s11357-023-00899-y UR - https://m2.mtmt.hu/api/publication/34090089 ID - 34090089 N1 - Heart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, 1122, Hungary Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest, 1089, Hungary Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, Netherlands Institute of Digital Health Sciences, Semmelweis University, 15 Ferenc Square, Budapest, 1094, Hungary Export Date: 6 October 2023 Correspondence Address: Kiss, L.Z.; Heart and Vascular Center, 68 Városmajor Street, Hungary; email: kisslotti@gmail.com AB - Growth and differentiation factor-15 (GDF-15) is a stress-associated cytokine of the transforming growth factor-β superfamily. The inflammatory and angiogenic effects of GDF-15 in atherosclerosis are controversial, and its correlation with the long asymptomatic phase of the disease is not well understood. Coronary artery calcium score (CACS) and ankle-brachial index (ABI) are sensitive markers of subclinical atherosclerosis. To date, only a few studies have examined the impact of GDF-15 on coronary artery calcification, and the association between GDF-15 and ABI has not been evaluated. Therefore, we aimed to investigate the possible relationship between serum GDF-15 concentrations and CACS and ABI in a Caucasian population sample of middle-aged (35-65 years) and elderly (> 65 years) people. In addition to recording demographic and anthropometric characteristics, atherosclerotic risk factors, and laboratory tests including serum HDL-cholesterol, LDL-cholesterol, hemoglobin A1c (HbA1c), high-sensitivity C-reactive protein, and N-terminal pro-B-type natriuretic peptide (NT-proBNP); GDF-15 level, cardiac computed tomography, and ABI measurements were also performed. A total of 269 asymptomatic individuals (men, n = 125; median age, 61.5 [IQR, 12.7] years) formed the basis of this study. Participants were divided into two groups according to their age (middle-aged, n = 175 and elderly, n = 94). Hypertension and diabetes mellitus were significantly more prevalent and CACS values and HbA1c, NT-proBNP, and GDF-15 levels were significantly higher (all p < 0.001) in the elderly group compared to the middle-aged group. Multivariate ridge regression analysis revealed a significant positive association between GDF-15 and CACS (middle-aged group: β = 0.072, p = 0.333; elderly group: β = 0.148, p = 0.003), and between GDF-15 and ABI (middle-aged group: β = 0.062, p = 0.393; elderly group: β = 0.088, p = 0.041) only in the elderly group. Our results show that GDF-15 is not only a useful biomarker of inflammation but can also predict early signs of asymptomatic atherosclerosis, especially in elderly people with chronic systemic inflammation associated with aging (inflammaging). LA - English DB - MTMT ER - TY - CHAP AU - Drajkó, Szonja Imola AU - Tamus, Zoltán Ádám ED - Vassányi, István ED - Fogarassyné Vathy, Ágnes TI - A koronavírus megbetegedési és halálozási adatainak Fourier-analízise T2 - Orvosi informatika. A XXXVI. Neumann Kollokvium konferencia-kiadványa PB - Neumann János Számítógép-tudományi Társaság CY - Veszprém SN - 9789633962725 PY - 2023 SP - 161 EP - 166 PG - 6 UR - https://m2.mtmt.hu/api/publication/34470803 ID - 34470803 LA - Hungarian DB - MTMT ER - TY - BOOK ED - Mohos, András ED - Táczi, István ED - Tóth, Zoltán TI - XIII. Mechwart András Ifjúsági Találkozó: Konferenciakiadvány PB - Magyar Elektrotechnikai Egyesület, Mechwart András Ifjúsági Társaság CY - Siófok PY - 2023 SP - 181 SN - 9789639299511 DO - 10.54232/MAIT.2023 UR - https://m2.mtmt.hu/api/publication/34431508 ID - 34431508 LA - Hungarian DB - MTMT ER -