TY - JOUR AU - Erdei, Csilla AU - Heizer, Ágnes AU - Mensch, Károly AU - Szarka, Krisztina AU - Kiss, Emese AU - Márton, Krisztina TI - Oral Mucosal Human Papillomavirus and Epstein-Bar Virus Rates in Patients with Dry Mouth and/or Sjögren's Syndrome in a Hungarian Cohort. JF - ORAL HEALTH & PREVENTIVE DENTISTRY J2 - ORAL HLTH PREV DENT VL - 22 PY - 2024 IS - 1 SP - 443 EP - 452 PG - 10 SN - 1602-1622 DO - 10.3290/j.ohpd.b5718350 UR - https://m2.mtmt.hu/api/publication/35277519 ID - 35277519 AB - To find an association between oral mucosal human papilloma- and/or Epstein-Barr (HPV, EBV) virus infection in patients with dry mouth and/or Sjögren's syndrome (SS) compared to healthy controls and to find connections with salivary gland histopathological alterations.Ninety-two participants were divided into four groups: 1. healthy controls (n = 32); 2. xerostomia (n = 28); 3. hyposalivation (n = 22); and 4. SS groups (n = 10). To detect virus infection brush biopsy was outlined in all groups. Detections of virus-specific sequences were achieved with polymerase chain reaction (PCR). Lip biopsy and histopathological assessment was performed in groups 2, 3 and 4.HPV positivity of oral mucosal cells was shown in group 1: 1 (3.12%); group 2: 3 (10.7%); group 3: 2 (8.26%); and in group 4: 0 of the samples. EBV was present in group 1: 14 (43.7%); group 2: 17 (60.7%); group 3: 6 (27.3%); and in group 4: 5 (50%) of the cases. There was no statistically significant difference between the attributes. Intact salivary gland in 28.2%, chronic sialadenitis in 28.2%, stromal fibrosis in 6.5%, lipomatous atrophy in 8.6%, fibrous atrophy in 6.5% and positive focus score (SS) in 26.1% were found in the subjects. Neither HPV nor EBV infection caused statistically significantly more histological abnormalities.Orofacial mucosal HPV and/or EBV DNA rates did not differ statistically significantly in patients with xerostomia or hyposalivation or SS compared to healthy controls, therefore, it cannot prove the provocative role of these viruses in dry mouth and/or SS. Neither dry mouth nor SS were accompanied by statistically significantly more salivary gland alterations in HPV- and/or EBV-positive subjects; these alterations are frequent in the virus-negative cases too. LA - English DB - MTMT ER - TY - CHAP AU - Gömör, Béla ED - Szekanecz, Zoltán ED - Nagy, György TI - A hazai reumatológia története T2 - Reumatológia PB - Medicina Könyvkiadó CY - Budapest SN - 9789632266589 PY - 2019 SP - 3 EP - 10 PG - 8 UR - https://m2.mtmt.hu/api/publication/33055711 ID - 33055711 N1 - Ellenőrizve a teljes szöveg alapján GT LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kiss, Emese TI - Autoimmun megbetegedések és kezelésük lehetőségei JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 68 PY - 2015 IS - 2 SP - 121 EP - 126 PG - 6 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/3092507 ID - 3092507 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gömör, Béla AU - Dávid, Dezső AU - Lányi, Éva AU - Kelemen, Judit AU - Ratkó, István TI - Reumatológiai kórképekben alkalmazott, alacsony (3x50 mg/nap) és emelt (3x150 mg/nap) dózisú Mydeton terápiával kapcsolatos megfigyeléseink. A hatékonyság és a biztonságosság összehasonlító értékelése TS - A hatékonyság és a biztonságosság összehasonlító értékelése JF - PRAXIS: A MINŐSÉGI GYÓGYÍTÁS ELMÉLETE ÉS GYAKORLATA J2 - PRAXIS (BUDAPEST) VL - 10 PY - 2001 IS - 3 SP - 65 EP - 69 PG - 5 SN - 1216-3228 UR - https://m2.mtmt.hu/api/publication/30819085 ID - 30819085 N1 - Ellenőrizve teljes szöveg alapján GT LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gömör, Béla AU - Juhász, Bernadett TI - A seronegativ spondarthritisek hazai szakirodalma az utóbbi húsz évben JF - MAGYAR REUMATOLÓGIA J2 - MAGYAR REUMATOL VL - 42 PY - 2001 IS - 2 SP - 85 EP - 88 PG - 4 SN - 0139-4495 UR - https://m2.mtmt.hu/api/publication/30819078 ID - 30819078 N1 - Ellenőrizve teljes szöveg alapján GT LA - Hungarian DB - MTMT ER - TY - JOUR AU - Géher, Pál AU - Gömör, Béla TI - Repeated cyclosporine therapy of peripheral arthritis associated with ankylosing spondylitis. JF - MEDICAL SCIENCE MONITOR J2 - MED SCI MONIT VL - 7 PY - 2001 IS - 1 SP - 105 EP - 107 PG - 3 SN - 1234-1010 UR - https://m2.mtmt.hu/api/publication/2286415 ID - 2286415 AB - BACKGROUND: A case history of a patient with ankylosing spondylitis and peripheral arthritis unresponsive to the conventional drug therapy, but successfully controlled by the use of cyclosporin. MATERIAL AND METHODS: In a 68 years old female patient with a 36 years history of typical ankylosing spondylitis a peripheral polyarthritis (hands, feet, wrists, and knees) developed. The patient did not suffer any other disease known to cause secondary spondylitis (psoriasis, inflammatory, bowel, disease). After the unsuccessful use of non-steroidal antiinflammatory drugs a combination therapy with cyclosporin (4 mg/kg/day) and azapropazone (300 mg t.i.d.) was introduced. RESULTS: Clinical improvement was achieved after 6 months of combined therapy, the polyarthritis completely resolved after one year. Therefore cyclosporin was discontinued. After one year the polyarthritis reappeared therefore the cyclosporin therapy was reinstituted with success. CONCLUSION: Cyclosporin has proved consistently effective in our case to control the peripheral arthritis associated with ankylosing spondylitis. LA - English DB - MTMT ER -