@article{MTMT:34790124, title = {International guidelines for intratumoral and intranodal injection of NBTXR3 nanoparticles in head and neck cancers.}, url = {https://m2.mtmt.hu/api/publication/34790124}, author = {Liem, Xavier and de Baère, Thierry and Vivar, Omar I and Seiwert, Tanguy Y and Shen, Colette and Pápai, Zsuzsanna and Moreno, Victor and Takácsi-Nagy, Zoltán and Helferich, Frigyes and Thariat, Juliette and Gooi, Zhen and Yom, Sue S and Bossi, Paolo and Ferris, Robert L and Hackman, Trevor G and Le Tourneau, Christophe and Rodriguez, Joseph and Hoffmann, Caroline}, doi = {10.1002/hed.27739}, journal-iso = {HEAD NECK-J SCI SPEC}, journal = {HEAD AND NECK : JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK}, volume = {Apr 10.}, unique-id = {34790124}, issn = {1043-3074}, abstract = {An international multidisciplinary panel of experts aimed to provide consensus guidelines describing the optimal intratumoral and intranodal injection of NBTXR3 hafnium oxide nanoparticles in head and neck squamous cell carcinoma (HNSCC) of the oral cavity, oropharynx, and cervical lymph nodes and to review data concerning safety, feasibility, and procedural aspects of administration.The Delphi method was used to determine consensus. A 4-member steering committee and a 10-member monitoring committee wrote and revised the guidelines, divided into eight sections. An independent 3-member reading committee reviewed the recommendations.After two rounds of voting, strong consensus was obtained on all recommendations. Intratumoral and intranodal injection was deemed feasible. NBTXR3 volume calculation, choice of patients, preparation and injection procedure, potential side effects, post injection, and post treatment follow-up were described in detail.Best practices for the injection of NBTXR3 were defined, thus enabling international standardization of intratumoral nanoparticle injection.}, keywords = {nanoparticle; RADIOTHERAPY; Neck; head; NBTXR3}, year = {2024}, eissn = {1097-0347}, orcid-numbers = {Takácsi-Nagy, Zoltán/0000-0002-3261-0271} } @article{MTMT:34761802, title = {A Belügyminisztérium egészségügyi szakmai irányelve a daganatos nőbetegek termékenységének megőrzéséről}, url = {https://m2.mtmt.hu/api/publication/34761802}, author = {Sipos, Miklós and Polgár, Csaba and Vesztergom, Dóra and Novák, Zoltán and Székely, Borbála and Masszi, András and Pintér, Tamás and Rubovszky, Gábor and Nánássy, László and Varga, Szilvia}, journal-iso = {EGÉSZSÉGÜGYI KÖZLÖNY}, journal = {EGÉSZSÉGÜGYI KÖZLÖNY}, volume = {74}, unique-id = {34761802}, issn = {2063-1146}, year = {2024}, pages = {869-891}, orcid-numbers = {Polgár, Csaba/0000-0001-7245-0762; Novák, Zoltán/0000-0002-2060-6654; Masszi, András/0000-0003-4303-764X; Rubovszky, Gábor/0000-0003-1723-5589} } @article{MTMT:34744616, title = {Positive correlation between persistence of medical nutrition therapy and overall survival in patients with head and neck cancer}, url = {https://m2.mtmt.hu/api/publication/34744616}, author = {Molnár, Andrea and Pálfi, Erzsébet and Belák, Barbara and Blasszauer, Célia and Reibl, Dániel and Lövey, József}, doi = {10.3389/pore.2024.1611664}, journal-iso = {PATHOL ONCOL RES}, journal = {PATHOLOGY AND ONCOLOGY RESEARCH}, volume = {30}, unique-id = {34744616}, issn = {1219-4956}, abstract = {Background: Several factors can affect overall survival of head and neck cancer (HNC) patients, including characteristics of the cancer disease and response to treatments. However, patients’ nutritional status and the effectiveness of medical nutrition therapy (MNT) can also impact overall survival. The primary goal of our research was to collect real-life data on the use of MNT in HNC patients and to specifically investigate the correlation between survival and the duration of uninterrupted (persistent) nutrition.}, year = {2024}, eissn = {1532-2807}, orcid-numbers = {Pálfi, Erzsébet/0000-0001-5006-027X; Belák, Barbara/0000-0001-8884-6307; Lövey, József/0000-0001-6467-191X} } @article{MTMT:34729969, title = {Very accelerated partial breast irradiation in 1 or 2 days. Late toxicity and early oncological outcome of the GEC-ESTRO VAPBI cohort.}, url = {https://m2.mtmt.hu/api/publication/34729969}, author = {Hannoun-Levi, Jean-Michel and Gimeno Morales, Marta and Gal, Jocelyn and Anchuelo, Javier and Guinot, Jose-Luis and Gastanaga, Miren and Mészáros, Norbert and Polgár, Csaba and Strnad, Vratislav and Schiappa, Renaud and Gutierrez, Cristina}, doi = {10.1016/j.radonc.2024.110217}, journal-iso = {RADIOTHER ONCOL}, journal = {RADIOTHERAPY AND ONCOLOGY}, volume = {194}, unique-id = {34729969}, issn = {0167-8140}, abstract = {To analyze late toxicity after very accelerated partial breast irradiation (VAPBI) for low-risk breast cancer.Methods: In this retrospective, observational, international multicenter study (HDH F20220713143949), patients with low-risk breast cancer underwent lumpectomy + vAPBI (high-dose rate multicatheter interstitial brachytherapy-MIBT). VAPBI was performed with 4(4x6.2Gy/2d), 3(3x7.45Gy/2d) or 1 fraction (1x16Gy or 1x18Gy/1d). Primary endpoint was late toxicity. Secondary endpoints were cumulative incidence of breast cancer local relapse (LR) and distant metastatic relapse (DMR) and specific (SS) and overall (OS) survivals. Prognostic factors for late toxicity were analyzed.From 01/2012 to 06/2022, 516 pts with early breast cancer were enrolled. Median follow-up was 44 months [95%CI 39-46]. Median age was 71 years [40-100]. Median tumor size was 12mm [1-35]. VAPBI delivered 1, 3 and 4 fractions for 205pts (39.7%), 167pts (32.4%) and 144pts (28%) respectively. 221 late toxicity events were observed in 168pts (32.6%) (Fibrosis, dyschromia, pain and telangiectasia). Grade 2 and 3 late toxicities were observed in 7.2 and 0.6% respectively (no G4) with no difference between 1 and ≥2 treatment days. CTV>50cc (p=0.007) and V150>40% (p=0.027) were prognostic factors for G≥2 late toxicity. Four-year cumulative incidence rates of LR and DMR were 2% [95%CI 0-3] and 1% [95%CI 0-2] respectively.VAPBI based on 1 or ≥2 days of MIBT represents an attractive de-escalation of irradiation approach for low-risk breast cancer. Late toxicity profile appears acceptable while early oncological outcome shows encouraging local control. Longer follow-up is warranted in order to confirm these preliminary results.}, keywords = {TOXICITY; Brachytherapy; breast cancer; fractionation; APBI; De-escalation}, year = {2024}, eissn = {1879-0887}, orcid-numbers = {Mészáros, Norbert/0000-0002-1570-7565; Polgár, Csaba/0000-0001-7245-0762} } @misc{MTMT:34669216, title = {Combined biological effects of CBCT and therapeutic X-ray dose on chromosomal aberrations of lymphocytes}, url = {https://m2.mtmt.hu/api/publication/34669216}, author = {Gáldi, Ádám and Farkas, Gyöngyi and Gazdag-Hegyesi, Szilvia and Koszta, Enikő and Ágoston, Péter Zoltán and Pesznyák, Csilla and Major, Tibor and Takácsi-Nagy, Zoltán and Polgár, Csaba and Jurányi, Zsolt}, unique-id = {34669216}, year = {2024}, orcid-numbers = {Gáldi, Ádám/0000-0001-8910-1788; Gazdag-Hegyesi, Szilvia/0000-0003-2283-464X; Koszta, Enikő/0000-0001-7221-8023; Ágoston, Péter Zoltán/0000-0003-0264-630X; Pesznyák, Csilla/0000-0001-5815-0974; Major, Tibor/0000-0002-4672-6910; Takácsi-Nagy, Zoltán/0000-0002-3261-0271; Polgár, Csaba/0000-0001-7245-0762; Jurányi, Zsolt/0000-0001-9101-5096} } @article{MTMT:34544359, title = {Alterations of Sexual and Erectile Functions after Brachytherapy for Prostate Cancer Based on Patient-Reported Questionnaires}, url = {https://m2.mtmt.hu/api/publication/34544359}, author = {Gesztesi, László and Kocsis, Zsuzsa and Jorgo, Kliton and Fröhlich, Georgina and Polgár, Csaba and Ágoston, Péter Zoltán}, doi = {10.1155/2024/5729185}, journal-iso = {PROSTATE CANC}, journal = {PROSTATE CANCER}, volume = {2024}, unique-id = {34544359}, issn = {2090-3111}, abstract = {The aim of the study was to compare the side effects of high-dose-rate brachytherapy (HDRBT) and low-dose-rate brachytherapy (LDRBT), with a particular focus on the effects on sexual functions and sexual well-being (PROMOBRA study, NCT02258087). Localized low-risk and low-intermediate-risk prostate cancer patients were treated with mono LDR (N = 123, 145 Gy dose) or mono HDR brachytherapy (N = 117, 19/21 Gy). Prior to the treatment and during follow-up (at 3, 6, 9, 12, 18, and 24 months after treatment, and then annually after two years), patients completed patient-reported outcome measurement (PROM) questionnaires EORTC QLQ-PR-25, International Index of Erectile Function (IIEF), and IIEF-5 (SHIM). We compared the patients in different group breakdowns (HDR vs. LDR, hormone naïve and hormone-receiving HDR vs. LDR, hormone naïve and hormone-receiving patients in general, and 19 Gy HDR vs. 21 Gy HDR). In the hormone-naive LDR group, erectile function, orgasm function, sexual desire, satisfaction with intercourse, and overall satisfaction functions significantly decreased compared to baseline throughout the whole follow-up period. However, there were significant decreases in function at a maximum of three time points after HDR therapy without hormone therapy. In hormone-receiving patients, the orgasm function was significantly better in the HDR group at multiple time points compared to the baseline, and sexual desire improved at four time points. According to our results, both LDRBT and HDRBT can be safely administered to patients with localized prostate cancer. In hormone-naive patients, the HDR group showed only recovering decreases in sexual functions, while the LDR group showed a lasting decline in multiple areas. Thus, HDR appears to be more advantageous to hormone-naive patients.}, year = {2024}, eissn = {2090-312X}, orcid-numbers = {Kocsis, Zsuzsa/0000-0002-4336-3325; Jorgo, Kliton/0000-0002-0325-6795; Fröhlich, Georgina/0000-0001-6428-6536; Polgár, Csaba/0000-0001-7245-0762; Ágoston, Péter Zoltán/0000-0003-0264-630X} } @CONFERENCE{MTMT:34574656, title = {Sugárérzékenység mérés cervix tumoros betegekben, a RILA módszer finomhangolása}, url = {https://m2.mtmt.hu/api/publication/34574656}, author = {Sándor, Gyöngyvér Orsolya and Kocsis, Zsuzsa and Farkas, Gyöngyi and Vízkeleti, Júlia and Erdélyi, Borbála and Mészáros, Norbert and Lakosi, Ferenc and Végváry, Zoltán and Varga, Szilvia and Nguyen, Anhhong and Székely, Gábor and Takácsi-Nagy, Zoltán and Polgár, Csaba and Jurányi, Zsolt}, booktitle = {MST XVI. KONGRESSZUSA}, unique-id = {34574656}, year = {2023}, pages = {online}, orcid-numbers = {Sándor, Gyöngyvér Orsolya/0000-0002-0838-2838; Kocsis, Zsuzsa/0000-0002-4336-3325; Vízkeleti, Júlia/0000-0002-1566-1165; Mészáros, Norbert/0000-0002-1570-7565; Takácsi-Nagy, Zoltán/0000-0002-3261-0271; Polgár, Csaba/0000-0001-7245-0762; Jurányi, Zsolt/0000-0001-9101-5096} } @misc{MTMT:34554744, title = {RILA módszer laborgyakorlatba való bevezetése}, url = {https://m2.mtmt.hu/api/publication/34554744}, author = {Fodor, Martin and Kocsis, Zsuzsa and Sándor, Gyöngyvér Orsolya and Farkas, Gyöngyi and Vízkeleti, Júlia and Erdélyi, Borbála and Mészáros, Norbert and Lakosi, Ferenc and Végváry, Zoltán and Varga, Szilvia and Nguyen, Anhhong and Székely, Gábor and Takácsi-Nagy, Zoltán and Polgár, Csaba and Jurányi, Zsolt}, unique-id = {34554744}, year = {2023}, orcid-numbers = {Kocsis, Zsuzsa/0000-0002-4336-3325; Sándor, Gyöngyvér Orsolya/0000-0002-0838-2838; Vízkeleti, Júlia/0000-0002-1566-1165; Mészáros, Norbert/0000-0002-1570-7565; Takácsi-Nagy, Zoltán/0000-0002-3261-0271; Polgár, Csaba/0000-0001-7245-0762; Jurányi, Zsolt/0000-0001-9101-5096} } @misc{MTMT:34554714, title = {TNBC immun profil műtét/kemo/radioterápia után}, url = {https://m2.mtmt.hu/api/publication/34554714}, author = {Kocsis, Zsuzsa and Sándor, Gyöngyvér Orsolya and Rubovszky, Gábor and Székely, Borbála and Sávolt, Ákos and Smanykó, Viktor and Farkas, Gyöngyi and Székely, Gábor and Polgár, Csaba and Takácsi-Nagy, Zoltán and Jurányi, Zsolt}, unique-id = {34554714}, year = {2023}, orcid-numbers = {Kocsis, Zsuzsa/0000-0002-4336-3325; Sándor, Gyöngyvér Orsolya/0000-0002-0838-2838; Rubovszky, Gábor/0000-0003-1723-5589; Sávolt, Ákos/0009-0001-4108-0516; Polgár, Csaba/0000-0001-7245-0762; Takácsi-Nagy, Zoltán/0000-0002-3261-0271; Jurányi, Zsolt/0000-0001-9101-5096} } @misc{MTMT:34554678, title = {Előzetes eredmények prediktív immunológiai markerek kiválasztásához TNBC betegek esetében}, url = {https://m2.mtmt.hu/api/publication/34554678}, author = {Kocsis, Zsuzsa and Sándor, Gyöngyvér Orsolya and Farkas, Gyöngyi and Székely, Gábor and Rubovszky, Gábor and Székely, Borbála and Sávolt, Ákos and Smanykó, Viktor and Takácsi-Nagy, Zoltán and Polgár, Csaba and Jurányi, Zsolt}, unique-id = {34554678}, year = {2023}, orcid-numbers = {Kocsis, Zsuzsa/0000-0002-4336-3325; Sándor, Gyöngyvér Orsolya/0000-0002-0838-2838; Rubovszky, Gábor/0000-0003-1723-5589; Sávolt, Ákos/0009-0001-4108-0516; Takácsi-Nagy, Zoltán/0000-0002-3261-0271; Polgár, Csaba/0000-0001-7245-0762; Jurányi, Zsolt/0000-0001-9101-5096} }