TY - JOUR AU - Barabás, János Imre AU - Merkely, Béla Péter AU - Hartyánszky, István AU - Palkovics, Dániel TI - Computer-aided Design and Manufacturing of a Patented, Left Ventricle Assist Device Positioning Tool – 3D Navigated Surgical Treatment of End-Stage Heart Failure JF - ACTA POLYTECHNICA HUNGARICA J2 - ACTA POLYTECH HUNG VL - 20 PY - 2023 IS - 8 SP - 9 EP - 25 PG - 17 SN - 1785-8860 DO - 10.12700/APH.20.8.2023.8.2 UR - https://m2.mtmt.hu/api/publication/34165287 ID - 34165287 LA - English DB - MTMT ER - TY - JOUR AU - Knol, W.G. AU - Simon, Judit AU - Den, Harder A.M. AU - Bekker, M.W.A. AU - Suyker, W.J.L. AU - de, Heer L.M. AU - de, Jong P.A. AU - Leiner, T. AU - Merkely, Béla Péter AU - Pólos, Miklós AU - Krestin, G.P. AU - Boersma, E. AU - Koudstaal, P.J. AU - Maurovich-Horvat, Pál AU - Bogers, A.J.J.C. AU - Budde, R.P.J. TI - Effect of routine preoperative screening for aortic calcifications using noncontrast computed tomography on stroke rate in cardiac surgery: the randomized controlled CRICKET study JF - EUROPEAN RADIOLOGY J2 - EUR RADIOL VL - 32 PY - 2022 IS - 4 SP - 2611 EP - 2619 PG - 9 SN - 0938-7994 DO - 10.1007/s00330-021-08360-4 UR - https://m2.mtmt.hu/api/publication/32508661 ID - 32508661 LA - English DB - MTMT ER - TY - JOUR AU - Polivka, Lőrinc AU - Gajdácsi, József AU - Fazekas, Levente AU - Sebők, Szilvia AU - Bárczi, Enikő AU - Hidvégi, Edit AU - Süttő, Zoltán AU - Dinya, Elek AU - Maurovich-Horvat, Pál AU - Szabó, Attila AU - Merkely, Béla Péter AU - Müller, Veronika TI - Long-term survival benefit of male and multimorbid COVID-19 patients with 5-day remdesivir treatment JF - JOURNAL OF GLOBAL HEALTH J2 - J GLOBAL HEALTH VL - 12 PY - 2022 PG - 11 SN - 2047-2978 DO - 10.7189/jogh.12.05031 UR - https://m2.mtmt.hu/api/publication/32856990 ID - 32856990 N1 - Contributed equally: Lorinc Polivka, Gajdacsi J and Bela Merkely, Veronika Müller LA - English DB - MTMT ER - TY - JOUR AU - Nagy-Kardos, Cintia AU - Tihanyi, László AU - Veress, Gábor AU - Merkely, Béla Péter AU - Aradi, Dániel TI - A tromboembóliás események kockázata és megelőzése COVID-19 betegségben JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 52 PY - 2022 IS - 5-6 SP - 392 EP - 399 PG - 8 SN - 0133-5596 DO - 10.26430/CHUNGARICA.2022.52.5.392 UR - https://m2.mtmt.hu/api/publication/34486414 ID - 34486414 AB - COVID-19-betegeknél a betegség súlyosságától függően jelentős arányban fordulhatnak elő artériás és vénás tromboembóliás események, amelyek a fertőzés magas mortalitásáért is felelősek. A tromboembóliás események gyakorisága meghaladja más vírusinfekciók (pl. influenza) kapcsán észlelt arányokat. A SARS-CoV-2 koronavírus és az immunválasz jelentős prokoaguláns szerepét hangsúlyozva a szakirodalom önálló COVID coagulopathiaként említi a kialakult véralvadási zavart, amelynek megelőzése nagy kihívást jelent a napi gyakorlatban. Szerencsére nemzetközi adatok alapján a folyamatosan mutálódó vírus új variánsai az omikron-változattól kezdve szelídebb betegséget és kisebb tromboembóliás kockázatot jelentenek, de kérdéses, hogy ez a kockázat a jövőbeli variánsok mellett miként alakul. Jelen tanulmány célja, hogy összegezze a COVID-coagulopathia jellemzőit és patofiziológiai hátterét, valamint bemutassa azokat a klinikai vizsgálati eredményeket, amelyeket ezen szövődmények kivédése céljából végeztek, kiemelve az antikoaguláns és vérlemezkegátló kezelés lehetséges jelentőségét. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ananiadou, Olga AU - Fazekas, Levente AU - Vlahou, Athanasia AU - Ampatzidou, Fotini AU - Madesis, Athanasios AU - Karaiskos, Theodoros AU - Drossos, George TI - Integrating continuous monitoring and evaluation of risk-adjusted outcomes in a cardiac surgical program JF - JOURNAL OF CARDIAC SURGERY J2 - J CARD SURG VL - 35 PY - 2020 IS - 1 SP - 151 EP - 157 PG - 7 SN - 0886-0440 DO - 10.1111/jocs.14345 UR - https://m2.mtmt.hu/api/publication/30933177 ID - 30933177 AB - The variable life-adjusted display (VLAD) method shows the difference between predicted and observed outcomes over time. Our study aims to implement routine in-house monitoring of risk-adjusted 30-day mortality and morbidity following cardiac surgery.The Society of Thoracic Surgeons (STS) risk score was calculated for 249 isolated and combined coronary and aortic or mitral valve cases performed during a 6-month period. The nine predicted STS variables were operative mortality, permanent stroke, renal failure (RF), prolonged ventilation, deep sternal wound (DSW) infection, reoperation for any reason, short and long length of stay (LOS), and major morbidity or operative mortality. EuroSCORE II was also calculated for the study population. VLAD plots were generated for each variable indicating whether performance is better or worse than expected on the basis of predicted risk of failure.The mortality plot was fluctuating close to baseline risk. The prolonged ventilation, RF, reoperation, morbidity/mortality, and LOS plots were consistently positive, indicating favorable results. The stroke chart showed an upward trend for most of the period until two incidents toward last month led to a steep descent. The DSW infections plot though, indicated a worse-than-expected performance. The VLAD charts were shared in multidisciplinary meetings and clinicians were able to confront the performance with the population-specific expectancies and respond to adverse trends with further actions.Graphical tool monitoring of risk-adjusted 30-day mortality and morbidity following cardiac surgery is feasible and allows detection of underperformance and implementation of changes in clinical practice. LA - English DB - MTMT ER - TY - JOUR AU - Odler, Balázs AU - Cseh, Áron AU - Constantin, Tamás AU - Fekete, György AU - Losonczy, György AU - Tamási, Lilla AU - Benke, Kálmán AU - Szilveszter, Bálint AU - Müller, Veronika TI - Long time enzyme replacement therapy stabilizes obstructive lung disease and alters peripheral immune cell subsets in Fabry patients JF - CLINICAL RESPIRATORY JOURNAL J2 - CLIN RESPIR J VL - 11 PY - 2017 IS - 6 SP - 942 EP - 950 PG - 9 SN - 1752-6981 DO - 10.1111/crj.12446 UR - https://m2.mtmt.hu/api/publication/3005105 ID - 3005105 N1 - Department of Pulmonology, Semmelweis University, Budapest, Hungary 1st Department of Pediatrics, Semmelweis University, Budapest, Hungary 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary Semmelweis University, Heart and Vascular Center, Budapest, Hungary Semmelweis University, MTA-SE Lendület Cardiovascular Imaging Research Group, Heart and Vascular Center, Budapest, Hungary Cited By :19 Export Date: 7 November 2024 Correspondence Address: Müller, V.; Department of Pulmonology, Hungary; email: muller.veronika@med.semmelweis-univ.hu Chemicals/CAS: alpha galactosidase, 9025-35-8; Sphingolipids AB - Background Fabry disease is an X-linked lysosomal storage disorder, causing accumulation of globotriaosylceramid in different organs. Glycolipids are activators of different immune cell subsets, the resulting inflammation is responsible for organ damage. Pulmonary involvement leads to airway inflammation; however data on severity, as well as the effect of enzyme replacement therapy on lung function parameters and changes in peripheral immune cell subsets on lung involvement are sparse. Methods Seven Fabry patients and 4 carriers underwent detailed clinical examinations screening for pulmonary manifestations. Repetitive measurements were performed on 5 patients on ERT (average follow-up 5 years). Patients with Fabry disease and control volunteers were included into peripheral blood cell measurements. Results Lung involvement was present in all patients. Symptoms suggestive for lung disease were mild, however obstructive ventilatory disorder, dominantly affecting small airways accompanied by hyperinflation was demonstrated in all affected patients. ERT resulted in small improvement of FEV1 in most treated patients. Decreased ratio of myeloid DC, Th17 cells while increase in T helper (Th)1 cells, and no change in Th2 and regulatory T (Treg) cells were detected in Fabry patients. CONCLUSIONS: Fabry disease results mainly in mild symptoms related to lung involvement, characterized by moderate non reversible obstructive ventilatory disorder. Stabilization of airway obstruction during follow-up was observed using ERT in most patients, emphasizing the importance of this treatment in respect of pulmonary manifestations. Changes of immune cell subsets in the peripheral blood might play a role in inflammatory process, including small airways in Fabry patient's lung. This article is protected by copyright. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Korkmaz-Icoz, S AU - Radovits, Tamás AU - Loganathan, S AU - Li, S AU - Ruppert, Mihály AU - Benke, Kálmán AU - Brlecic, P AU - Szabo, C AU - Karck, M AU - Szabo, G TI - Prolonging hypothermic ischaemic cardiac and vascular storage by inhibiting the activation of the nuclear enzyme poly(adenosine diphosphate-ribose) polymerase JF - EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY J2 - EUR J CARDIO-THORAC SURG VL - 51 PY - 2017 IS - 5 SP - 829 EP - 835 PG - 7 SN - 1010-7940 DO - 10.1093/ejcts/ezw426 UR - https://m2.mtmt.hu/api/publication/3211443 ID - 3211443 N1 - The first two authors (Korkmaz-Icoz S and Radovits T) contributed equally to this study. LA - English DB - MTMT ER - TY - JOUR AU - Benke, Kálmán AU - Mátyás, Csaba AU - Sayour, Alex Ali AU - Oláh, Attila AU - Németh, Balázs Tamás AU - Ruppert, Mihály AU - Szabo, G AU - Kökény, Gábor AU - Horvath, Eszter Mária AU - Hartyánszky, István AU - Szabolcs, Zoltán AU - Merkely, Béla Péter AU - Radovits, Tamás TI - Pharmacological preconditioning with gemfibrozil preserves cardiac function after heart transplantation JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 7 PY - 2017 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-017-14587-3 UR - https://m2.mtmt.hu/api/publication/3287464 ID - 3287464 N1 - Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany Department of Pathophysiology, Semmelweis University, Budapest, Hungary Department of Physiology, Semmelweis University, Budapest, Hungary Cited By :9 Export Date: 8 January 2025 Correspondence Address: Benke, K.; Heart and Vascular Center, Hungary; email: kalman.benke@gmail.com Chemicals/CAS: cyclic GMP, 7665-99-8; endothelial nitric oxide synthase, 503473-02-7; gemfibrozil, 25812-30-0; Cyclic GMP; Gemfibrozil; Nitric Oxide Synthase Type III; RNA, Messenger Funding text 1: Technical assisstance of Tímea Fischinger, Gábor Fritz, Henriett Biró, Dóra Juhász, Edina Urbán, Gabriella Molnár and co-workers of Central Laboratory of the Heart and Vascular Center is gratefully acknowledged. Advices of Judit Skopál, Sevil Korkmaz-Icöz and Shiliang Li are appreciated. This study was supported by the National Research, Development and Innovation Office of Hungary (NKFIH; NVKP-16-1-2016-0017, “National Heart Program”), by the “ÚNKP-16-3 New National Excellence Program of the Ministry of Human Capacities of Hungary” (to K.B.), by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (to T.R.) and by the Human Resource Support Office (National Talent Program; NTP-NFTÖ-16-0081; to C.M.). AB - While heart transplantation (HTX) is the definitive therapy of heart failure, donor shortage is emerging. Pharmacological activation of soluble guanylate cyclase (sGC) and increased cGMP-signalling have been reported to have cardioprotective properties. Gemfibrozil has recently been shown to exert sGC activating effects in vitro. We aimed to investigate whether pharmacological preconditioning of donor hearts with gemfibrozil could protect against ischemia/reperfusion injury and preserve myocardial function in a heterotopic rat HTX model. Donor Lewis rats received p.o. gemfibrozil (150 mg/kg body weight) or vehicle for 2 days. The hearts were explanted, stored for 1 h in cold preservation solution, and heterotopically transplanted. 1 h after starting reperfusion, left ventricular (LV) pressure-volume relations and coronary blood flow (CBF) were assessed to evaluate early post-transplant graft function. After 1 h reperfusion, LV contractility, active relaxation and CBF were significantly (p < 0.05) improved in the gemfibrozil pretreated hearts compared to that of controls. Additionally, gemfibrozil treatment reduced nitro-oxidative stress and apoptosis, and improved cGMP-signalling in HTX. Pharmacological preconditioning with gemfibrozil reduces ischemia/reperfusion injury and preserves graft function in a rat HTX model, which could be the consequence of enhanced myocardial cGMP-signalling. Gemfibrozil might represent a useful tool for cardioprotection in the clinical setting of HTX surgery soon. LA - English DB - MTMT ER - TY - JOUR AU - Rényi-Vámos, Ferenc István AU - Hartyánszky, István AU - Szabolcs, Zoltán AU - Lang, György TI - Breakthrough in the Transplantation of Thoracic Organs in Hungary JF - TRANSPLANTATION PROCEEDINGS J2 - TRANSPLANT PROC VL - 49 PY - 2017 IS - 7 SP - 1515 EP - 1516 PG - 2 SN - 0041-1345 DO - 10.1016/j.transproceed.2017.06.012 UR - https://m2.mtmt.hu/api/publication/3293218 ID - 3293218 AB - In 2016 the focus was, by all means, on the transplantation on thoracic organs. More than 50 heart transplantations were performed in this year. With this achievement, the Hungarian Heart Transplantation Program became one of the leading programs in the world. In the Thoracic Surgery Unit of the National Institute of Oncology and the Thoracic Surgery Department of Semmelweis University the first successful lung transplantation was carried out on December 12, 2015 when the Hungarian Lung Transplantation Program was launched. LA - English DB - MTMT ER - TY - JOUR AU - Veres, Gábor AU - Hegedűs, Péter AU - Barnucz, Enikö AU - Schmidt, H AU - Radovits, Tamás AU - Zoller, R AU - Karck, M AU - Szabó, Gábor Balázs TI - TiProtec preserves endothelial function in a rat model JF - JOURNAL OF SURGICAL RESEARCH J2 - J SURG RES VL - 200 PY - 2016 IS - 1 SP - 346 EP - 355 PG - 10 SN - 0022-4804 DO - 10.1016/j.jss.2015.06.062 UR - https://m2.mtmt.hu/api/publication/2939940 ID - 2939940 AB - BACKGROUND: Coronary artery bypass surgery provides excellent patency rates; however, the early and/or late graft failure reduces the long-term benefit of myocardial revascularization. We investigated the effectiveness of generally used saline, Custodiol solutions and a new solution (TiProtec) at preserving endothelium after cold ischemia and warm reperfusion injury. MATERIALS AND METHODS: Aortic transplantations were performed in Lewis rats. Aortic arches were stored in saline, Custodiol, and TiProtec solutions for 2 h then were transplanted into the abdominal aorta. Two, 24 hours and 1 week after transplantation, the implanted grafts were harvested. Endothelium-dependent and -independent vasorelaxations were investigated in organ bath. DNA strand breaks were assessed by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling-method, messenger RNA expressions by quantitative real-time polymerase chain reaction, and the expression of CD-31 and alpha smooth muscle actin by immunochemistry. RESULTS: Severely impaired endothelial function and integrity of implanted aortic grafts were shown after 2 h in the saline, Custodiol group (maximal vasorelaxation to acetylcholine: control: 91 +/- 2%, saline: 26 +/- 5%, Custodiol: 24 +/- 5%, CD-31-positive area control: 96 +/- 2%, saline: 35 +/- 13% Custodiol: 54 +/- 5%, P < 0.05, respectively); however, a preserved endothelial function was observed in the TiProtec group when compared with the saline and Custodiol group (maximal vasorelaxation: 46 +/- 7%, CD-31-positive area: 54 +/- 10%, P < 0.05). After 1 wk, endothelial function was partially recovered in all groups; however, it was significantly better in the TiProtec group (maximal vasorelaxation to acetylcholine: saline: 42 +/- 3%, Custodiol: 48 +/- 3%, TiProtec: 56 +/- 3%, CD-31-positive area: saline: 56 +/- 5%, Custodiol: 54 +/- 4%; TiProtec: 83 +/- 6%, P < 0.05, respectively). In addition, messenger RNA levels of Bax, B-cell lymphoma-2, endothelial NOS, vascular endothelial growth factor 2, and caspase-3 were significantly altered in both groups. CONCLUSIONS: TiProtec appears to be superior for the preservation of endothelial- and smooth muscle cells of bypass graft after cold storage and warm reperfusion in our murine model. LA - English DB - MTMT ER -