@article{MTMT:34165287,
	title = {Computer-aided Design and Manufacturing of a Patented, Left Ventricle Assist Device Positioning Tool – 3D Navigated Surgical Treatment of End-Stage Heart Failure},
	url = {https://m2.mtmt.hu/api/publication/34165287},
	author = {Barabás, János Imre and Merkely, Béla Péter and Hartyánszky, István and Palkovics, Dániel},
	doi = {10.12700/APH.20.8.2023.8.2},
	journal-iso = {ACTA POLYTECH HUNG},
	journal = {ACTA POLYTECHNICA HUNGARICA},
	volume = {20},
	unique-id = {34165287},
	issn = {1785-8860},
	year = {2023},
	eissn = {1785-8860},
	pages = {9-25},
	orcid-numbers = {Barabás, János Imre/0000-0002-4404-8730; Merkely, Béla Péter/0000-0001-6514-0723; Hartyánszky, István/0000-0003-1909-6500; Palkovics, Dániel/0000-0001-6398-1836}
}

@article{MTMT:32508661,
	title = {Effect of routine preoperative screening for aortic calcifications using noncontrast computed tomography on stroke rate in cardiac surgery: the randomized controlled CRICKET study},
	url = {https://m2.mtmt.hu/api/publication/32508661},
	author = {Knol, W.G. and Simon, Judit and Den, Harder A.M. and Bekker, M.W.A. and Suyker, W.J.L. and de, Heer L.M. and de, Jong P.A. and Leiner, T. and Merkely, Béla Péter and Pólos, Miklós and Krestin, G.P. and Boersma, E. and Koudstaal, P.J. and Maurovich-Horvat, Pál and Bogers, A.J.J.C. and Budde, R.P.J.},
	doi = {10.1007/s00330-021-08360-4},
	journal-iso = {EUR RADIOL},
	journal = {EUROPEAN RADIOLOGY},
	volume = {32},
	unique-id = {32508661},
	issn = {0938-7994},
	year = {2022},
	eissn = {1432-1084},
	pages = {2611-2619},
	orcid-numbers = {Simon, Judit/0000-0001-8063-3462; Merkely, Béla Péter/0000-0001-6514-0723; Maurovich-Horvat, Pál/0000-0003-0885-736X}
}

@article{MTMT:32856990,
	title = {Long-term survival benefit of male and multimorbid COVID-19 patients with 5-day remdesivir treatment},
	url = {https://m2.mtmt.hu/api/publication/32856990},
	author = {Polivka, Lőrinc and Gajdácsi, József and Fazekas, Levente and Sebők, Szilvia and Bárczi, Enikő and Hidvégi, Edit and Süttő, Zoltán and Dinya, Elek and Maurovich-Horvat, Pál and Szabó, Attila and Merkely, Béla Péter and Müller, Veronika},
	doi = {10.7189/jogh.12.05031},
	journal-iso = {J GLOBAL HEALTH},
	journal = {JOURNAL OF GLOBAL HEALTH},
	volume = {12},
	unique-id = {32856990},
	issn = {2047-2978},
	year = {2022},
	eissn = {2047-2986},
	orcid-numbers = {Polivka, Lőrinc/0009-0004-9576-2776; Bárczi, Enikő/0000-0001-9644-4172; Süttő, Zoltán/0000-0002-6871-0901; Dinya, Elek/0000-0002-2620-8649; Maurovich-Horvat, Pál/0000-0003-0885-736X; Szabó, Attila/0000-0001-7321-9861; Merkely, Béla Péter/0000-0001-6514-0723; Müller, Veronika/0000-0002-1398-3187}
}

@article{MTMT:34486414,
	title = {A tromboembóliás események kockázata és megelőzése COVID-19 betegségben},
	url = {https://m2.mtmt.hu/api/publication/34486414},
	author = {Nagy-Kardos, Cintia and Tihanyi, László and Veress, Gábor and Merkely, Béla Péter and Aradi, Dániel},
	doi = {10.26430/CHUNGARICA.2022.52.5.392},
	journal-iso = {CARDIOL HUNG},
	journal = {CARDIOLOGIA HUNGARICA},
	volume = {52},
	unique-id = {34486414},
	issn = {0133-5596},
	abstract = {COVID-19-betegeknél a betegség súlyosságától függően jelentős arányban fordulhatnak elő artériás és vénás tromboembóliás események, amelyek a fertőzés magas mortalitásáért is felelősek. A tromboembóliás események gyakorisága meghaladja más vírusinfekciók (pl. influenza) kapcsán észlelt arányokat. A SARS-CoV-2 koronavírus és az immunválasz jelentős prokoaguláns szerepét hangsúlyozva a szakirodalom önálló COVID coagulopathiaként említi a kialakult véralvadási zavart, amelynek megelőzése nagy kihívást jelent a napi gyakorlatban. Szerencsére nemzetközi adatok alapján a folyamatosan mutálódó vírus új variánsai az omikron-változattól kezdve szelídebb betegséget és kisebb tromboembóliás kockázatot jelentenek, de kérdéses, hogy ez a kockázat a jövőbeli variánsok mellett miként alakul. Jelen tanulmány célja, hogy összegezze a COVID-coagulopathia jellemzőit és patofiziológiai hátterét, valamint bemutassa azokat a klinikai vizsgálati eredményeket, amelyeket ezen szövődmények kivédése céljából végeztek, kiemelve az antikoaguláns és vérlemezkegátló kezelés lehetséges jelentőségét.},
	year = {2022},
	eissn = {1588-0230},
	pages = {392-399},
	orcid-numbers = {Merkely, Béla Péter/0000-0001-6514-0723}
}

@article{MTMT:30933177,
	title = {Integrating continuous monitoring and evaluation of risk-adjusted outcomes in a cardiac surgical program},
	url = {https://m2.mtmt.hu/api/publication/30933177},
	author = {Ananiadou, Olga and Fazekas, Levente and Vlahou, Athanasia and Ampatzidou, Fotini and Madesis, Athanasios and Karaiskos, Theodoros and Drossos, George},
	doi = {10.1111/jocs.14345},
	journal-iso = {J CARD SURG},
	journal = {JOURNAL OF CARDIAC SURGERY},
	volume = {35},
	unique-id = {30933177},
	issn = {0886-0440},
	abstract = {The variable life-adjusted display (VLAD) method shows the difference between predicted and observed outcomes over time. Our study aims to implement routine in-house monitoring of risk-adjusted 30-day mortality and morbidity following cardiac surgery.The Society of Thoracic Surgeons (STS) risk score was calculated for 249 isolated and combined coronary and aortic or mitral valve cases performed during a 6-month period. The nine predicted STS variables were operative mortality, permanent stroke, renal failure (RF), prolonged ventilation, deep sternal wound (DSW) infection, reoperation for any reason, short and long length of stay (LOS), and major morbidity or operative mortality. EuroSCORE II was also calculated for the study population. VLAD plots were generated for each variable indicating whether performance is better or worse than expected on the basis of predicted risk of failure.The mortality plot was fluctuating close to baseline risk. The prolonged ventilation, RF, reoperation, morbidity/mortality, and LOS plots were consistently positive, indicating favorable results. The stroke chart showed an upward trend for most of the period until two incidents toward last month led to a steep descent. The DSW infections plot though, indicated a worse-than-expected performance. The VLAD charts were shared in multidisciplinary meetings and clinicians were able to confront the performance with the population-specific expectancies and respond to adverse trends with further actions.Graphical tool monitoring of risk-adjusted 30-day mortality and morbidity following cardiac surgery is feasible and allows detection of underperformance and implementation of changes in clinical practice.},
	keywords = {coronary artery disease; Cardiovascular research; valve repair/replacement},
	year = {2020},
	eissn = {1540-8191},
	pages = {151-157}
}

@article{MTMT:3005105,
	title = {Long time enzyme replacement therapy stabilizes obstructive lung disease and alters peripheral immune cell subsets in Fabry patients},
	url = {https://m2.mtmt.hu/api/publication/3005105},
	author = {Odler, Balázs and Cseh, Áron and Constantin, Tamás and Fekete, György and Losonczy, György and Tamási, Lilla and Benke, Kálmán and Szilveszter, Bálint and Müller, Veronika},
	doi = {10.1111/crj.12446},
	journal-iso = {CLIN RESPIR J},
	journal = {CLINICAL RESPIRATORY JOURNAL},
	volume = {11},
	unique-id = {3005105},
	issn = {1752-6981},
	abstract = {Background Fabry disease is an X-linked lysosomal storage disorder, causing accumulation of globotriaosylceramid in different organs. Glycolipids are activators of different immune cell subsets, the resulting inflammation is responsible for organ damage. Pulmonary involvement leads to airway inflammation; however data on severity, as well as the effect of enzyme replacement therapy on lung function parameters and changes in peripheral immune cell subsets on lung involvement are sparse. Methods Seven Fabry patients and 4 carriers underwent detailed clinical examinations screening for pulmonary manifestations. Repetitive measurements were performed on 5 patients on ERT (average follow-up 5 years). Patients with Fabry disease and control volunteers were included into peripheral blood cell measurements. Results Lung involvement was present in all patients. Symptoms suggestive for lung disease were mild, however obstructive ventilatory disorder, dominantly affecting small airways accompanied by hyperinflation was demonstrated in all affected patients. ERT resulted in small improvement of FEV1 in most treated patients. Decreased ratio of myeloid DC, Th17 cells while increase in T helper (Th)1 cells, and no change in Th2 and regulatory T (Treg) cells were detected in Fabry patients. CONCLUSIONS: Fabry disease results mainly in mild symptoms related to lung involvement, characterized by moderate non reversible obstructive ventilatory disorder. Stabilization of airway obstruction during follow-up was observed using ERT in most patients, emphasizing the importance of this treatment in respect of pulmonary manifestations. Changes of immune cell subsets in the peripheral blood might play a role in inflammatory process, including small airways in Fabry patient's lung. This article is protected by copyright. All rights reserved.},
	year = {2017},
	eissn = {1752-699X},
	pages = {942-950},
	orcid-numbers = {Cseh, Áron/0000-0003-1659-3173; Constantin, Tamás/0000-0002-0146-3045; Fekete, György/0000-0002-5312-2541; Losonczy, György/0000-0002-5340-360X; Tamási, Lilla/0000-0003-3477-6125; Benke, Kálmán/0000-0001-7885-2543; Szilveszter, Bálint/0000-0003-1530-4288; Müller, Veronika/0000-0002-1398-3187}
}

@article{MTMT:3211443,
	title = {Prolonging hypothermic ischaemic cardiac and vascular storage by inhibiting the activation of the nuclear enzyme poly(adenosine diphosphate-ribose) polymerase},
	url = {https://m2.mtmt.hu/api/publication/3211443},
	author = {Korkmaz-Icoz, S and Radovits, Tamás and Loganathan, S and Li, S and Ruppert, Mihály and Benke, Kálmán and Brlecic, P and Szabo, C and Karck, M and Szabo, G},
	doi = {10.1093/ejcts/ezw426},
	journal-iso = {EUR J CARDIO-THORAC SURG},
	journal = {EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY},
	volume = {51},
	unique-id = {3211443},
	issn = {1010-7940},
	year = {2017},
	eissn = {1873-734X},
	pages = {829-835},
	orcid-numbers = {Benke, Kálmán/0000-0001-7885-2543}
}

@article{MTMT:3287464,
	title = {Pharmacological preconditioning with gemfibrozil preserves cardiac function after heart transplantation},
	url = {https://m2.mtmt.hu/api/publication/3287464},
	author = {Benke, Kálmán and Mátyás, Csaba and Sayour, Alex Ali and Oláh, Attila and Németh, Balázs Tamás and Ruppert, Mihály and Szabo, G and Kökény, Gábor and Horvath, Eszter Mária and Hartyánszky, István and Szabolcs, Zoltán and Merkely, Béla Péter and Radovits, Tamás},
	doi = {10.1038/s41598-017-14587-3},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {7},
	unique-id = {3287464},
	abstract = {While heart transplantation (HTX) is the definitive therapy of heart failure, donor shortage is emerging. Pharmacological activation of soluble guanylate cyclase (sGC) and increased cGMP-signalling have been reported to have cardioprotective properties. Gemfibrozil has recently been shown to exert sGC activating effects in vitro. We aimed to investigate whether pharmacological preconditioning of donor hearts with gemfibrozil could protect against ischemia/reperfusion injury and preserve myocardial function in a heterotopic rat HTX model. Donor Lewis rats received p.o. gemfibrozil (150 mg/kg body weight) or vehicle for 2 days. The hearts were explanted, stored for 1 h in cold preservation solution, and heterotopically transplanted. 1 h after starting reperfusion, left ventricular (LV) pressure-volume relations and coronary blood flow (CBF) were assessed to evaluate early post-transplant graft function. After 1 h reperfusion, LV contractility, active relaxation and CBF were significantly (p < 0.05) improved in the gemfibrozil pretreated hearts compared to that of controls. Additionally, gemfibrozil treatment reduced nitro-oxidative stress and apoptosis, and improved cGMP-signalling in HTX. Pharmacological preconditioning with gemfibrozil reduces ischemia/reperfusion injury and preserves graft function in a rat HTX model, which could be the consequence of enhanced myocardial cGMP-signalling. Gemfibrozil might represent a useful tool for cardioprotection in the clinical setting of HTX surgery soon.},
	year = {2017},
	eissn = {2045-2322},
	orcid-numbers = {Benke, Kálmán/0000-0001-7885-2543; Mátyás, Csaba/0000-0001-6095-7611; Sayour, Alex Ali/0000-0001-7728-4775; Németh, Balázs Tamás/0000-0001-7202-8107; Kökény, Gábor/0000-0002-0345-6914; Horvath, Eszter Mária/0000-0002-0517-1269; Hartyánszky, István/0000-0003-1909-6500; Merkely, Béla Péter/0000-0001-6514-0723}
}

@article{MTMT:3293218,
	title = {Breakthrough in the Transplantation of Thoracic Organs in Hungary},
	url = {https://m2.mtmt.hu/api/publication/3293218},
	author = {Rényi-Vámos, Ferenc István and Hartyánszky, István and Szabolcs, Zoltán and Lang, György},
	doi = {10.1016/j.transproceed.2017.06.012},
	journal-iso = {TRANSPLANT PROC},
	journal = {TRANSPLANTATION PROCEEDINGS},
	volume = {49},
	unique-id = {3293218},
	issn = {0041-1345},
	abstract = {In 2016 the focus was, by all means, on the transplantation on thoracic organs. More than 50 heart transplantations were performed in this year. With this achievement, the Hungarian Heart Transplantation Program became one of the leading programs in the world. In the Thoracic Surgery Unit of the National Institute of Oncology and the Thoracic Surgery Department of Semmelweis University the first successful lung transplantation was carried out on December 12, 2015 when the Hungarian Lung Transplantation Program was launched.},
	year = {2017},
	eissn = {1873-2623},
	pages = {1515-1516},
	orcid-numbers = {Rényi-Vámos, Ferenc István/0000-0002-0555-2096; Hartyánszky, István/0000-0003-1909-6500; Lang, György/0000-0002-8839-6649}
}

@article{MTMT:2939940,
	title = {TiProtec preserves endothelial function in a rat model},
	url = {https://m2.mtmt.hu/api/publication/2939940},
	author = {Veres, Gábor and Hegedűs, Péter and Barnucz, Enikö and Schmidt, H and Radovits, Tamás and Zoller, R and Karck, M and Szabó, Gábor Balázs},
	doi = {10.1016/j.jss.2015.06.062},
	journal-iso = {J SURG RES},
	journal = {JOURNAL OF SURGICAL RESEARCH},
	volume = {200},
	unique-id = {2939940},
	issn = {0022-4804},
	abstract = {BACKGROUND: Coronary artery bypass surgery provides excellent patency rates; however, the early and/or late graft failure reduces the long-term benefit of myocardial revascularization. We investigated the effectiveness of generally used saline, Custodiol solutions and a new solution (TiProtec) at preserving endothelium after cold ischemia and warm reperfusion injury. MATERIALS AND METHODS: Aortic transplantations were performed in Lewis rats. Aortic arches were stored in saline, Custodiol, and TiProtec solutions for 2 h then were transplanted into the abdominal aorta. Two, 24 hours and 1 week after transplantation, the implanted grafts were harvested. Endothelium-dependent and -independent vasorelaxations were investigated in organ bath. DNA strand breaks were assessed by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling-method, messenger RNA expressions by quantitative real-time polymerase chain reaction, and the expression of CD-31 and alpha smooth muscle actin by immunochemistry. RESULTS: Severely impaired endothelial function and integrity of implanted aortic grafts were shown after 2 h in the saline, Custodiol group (maximal vasorelaxation to acetylcholine: control: 91 +/- 2%, saline: 26 +/- 5%, Custodiol: 24 +/- 5%, CD-31-positive area control: 96 +/- 2%, saline: 35 +/- 13% Custodiol: 54 +/- 5%, P < 0.05, respectively); however, a preserved endothelial function was observed in the TiProtec group when compared with the saline and Custodiol group (maximal vasorelaxation: 46 +/- 7%, CD-31-positive area: 54 +/- 10%, P < 0.05). After 1 wk, endothelial function was partially recovered in all groups; however, it was significantly better in the TiProtec group (maximal vasorelaxation to acetylcholine: saline: 42 +/- 3%, Custodiol: 48 +/- 3%, TiProtec: 56 +/- 3%, CD-31-positive area: saline: 56 +/- 5%, Custodiol: 54 +/- 4%; TiProtec: 83 +/- 6%, P < 0.05, respectively). In addition, messenger RNA levels of Bax, B-cell lymphoma-2, endothelial NOS, vascular endothelial growth factor 2, and caspase-3 were significantly altered in both groups. CONCLUSIONS: TiProtec appears to be superior for the preservation of endothelial- and smooth muscle cells of bypass graft after cold storage and warm reperfusion in our murine model.},
	year = {2016},
	eissn = {1095-8673},
	pages = {346-355}
}