TY - CHAP AU - Kereszty, Éva Margit ED - Sótonyi, Péter TI - A személyi sérülésekből eredő kártérítési igények elbírálásnak jogi alapjai T2 - A felelősségbiztosítás orvosszakértői irányelvei PB - Magyar Biztosítók Szövetsége (MABISZ) CY - Budapest ET - 0 PY - 1995 SP - 8 EP - 26 PG - 19 UR - https://m2.mtmt.hu/api/publication/1886997 ID - 1886997 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Abraham, E AU - Karacsonyi, L AU - Dinya, Elek TI - [Could tuberculosis again be an endemic disease in Hungary? (Model study 1968-1993)].. Népbetegség lehet-e ismét a tuberculosis Magyarországon? (Modellvizsgálat 1968-1993). TS - Népbetegség lehet-e ismét a tuberculosis Magyarországon? (Modellvizsgálat 1968-1993). JF - ORVOSI HETILAP J2 - ORV HETIL VL - 136 PY - 1995 IS - 25 SP - 1329 EP - 1332 PG - 4 SN - 0030-6002 UR - https://m2.mtmt.hu/api/publication/1617926 ID - 1617926 N1 - TT: Nepbetegseg lehet-e ismet a tuberculosis Magyarorszagon? (Modellvizsgalat : 1968-1993). AB - The aim of this examination started in an industrial district of Budapest with 100,000 inhabitants in 1968, was the determination of risk groups of pulmonary tuberculosis and the organisation of X-ray screening. The initial decrease in the incidence of pulmonary tuberculosis stopped (between 1981 and 1993) and, a minimal increase could be even demonstrated in the last years. The cause of the increase is explained by sociological factors (the influx of refugees, growth in the number of homeless people and of chronic alcoholics). The authors propose the modernization of the preventive and exploratory medical work: the use of computers in the lung-screening center and the institutionalisation of screening aimed at risk groups of pulmonary tuberculosis. In the population over forty years of age 92% of 408 new pulmonary tuberculosis patients, emerged from risk groups between 1981 and 1993, and only 8% from people who did not belong to the risk groups. The effectiveness of screening in the risk groups was 3 to 4 times higher than that of indiscriminate screening. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Németh, András AU - Szakrnary, K AU - Kramer, Judit AU - Dinya, Elek AU - Pados, G AU - Füst, György AU - Huettinger, M TI - Apolipoprotein E and complement C3 polymorphism and their role in the response to gemfibrozil and low fat low cholesterol therapy JF - EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY J2 - EUR J CLIN CHEM CLIN VL - 33 PY - 1995 IS - 11 SP - 799 EP - 804 PG - 6 SN - 0939-4974 DO - 10.1515/cclm.1995.33.11.799 UR - https://m2.mtmt.hu/api/publication/1447277 ID - 1447277 AB - Three different allelic variants of apolipoprotein E determine, in concert with other gene products, the levels of plasma lipoproteins. Recently, cleavage products of the complement C3 molecule have also been implicated in determining plasma triacylglycerol concentrations. This study presents data of an ongoing study to dissect the role of the apolipoprotein E gene locus in the response to low fat/low cholesterol diet combined with gemfibrozil treatment. In addition, for the first time, the significance of C3 allelic variants to such hypolipidaemic therapy response was analysed. To this end data from 81 obese hyperlipoproteinaemic patients (Fredrickson type II/A and B and type TV and V) confirmed the usefulness of the combined gemfibrozil/diet treatment and unveiled apolipoprotein E allele group specific therapy responses. The mean changes of lipid properties due to combined treatment was 15% for total cholesterol, 48% for triacylglycerols and 28% for atherogenic index. Division into hyperlipidaemia types according to Fredrickson and subgrouping into E2, E3 and E4 groups (apolipoprotein E2/2 and 2/3, apolipoprotein E3/3 and apolipoprotein E4/2 and 4/3 phenotype groups respectively) exposed pronounced differences from these mean changes, suggesting substantial influence of apolipoprotein E variants on this therapy. We observed triacylglycerol reductions of from 17% in type IIA-apolipoprotein E3 group patients up to 78% in the type IV and V-apolipoprotein E2 group. Thus it might be concluded the apolipoprotein E genotyping aides therapy success prediction. Although, low sample numbers in some subgroups obscures significance in this pilot study, significant therapy success emerges for the E3 and E4 group in type IV and V hyperlipidaemia and type IIB-apolipoprotein E3 homozygous patients can be predicted to respond better than apolipoprotein E2 carriers. Finally, we present evidence that positive changes of lipid properties are also determined by the 'fast' complement C3 allel (C3-F). Patients with complement factor C3-FS pattern respond better to treatment than patients with C3-SS configuration. In summary these data endorse the genotyping of apolipoprotein E alleles to predict maximal success of 'fibrate' treatment. In addition they argue strongly for further assessment of the involvement of complement C3 allelic variations in lipid homeostasis. LA - English DB - MTMT ER - TY - CHAP AU - Kereszty, Éva Margit AU - Törő, Klára Andrea ED - Sótonyi, Péter TI - Sexual offences T2 - Lecture notes of forensic medicine PB - Semmelweis Orvostudományi Egyetem, Képzéskutató, Oktatástechnológiai és Dokumentációs Központ CY - Budapest ET - 0 PY - 1994 SP - 73 EP - 79 PG - 7 UR - https://m2.mtmt.hu/api/publication/2021449 ID - 2021449 LA - English DB - MTMT ER - TY - CHAP AU - Kereszty, Éva Margit AU - Törő, Klára Andrea ED - Sótonyi, Péter TI - Forensic Points of reproduction T2 - Lecture notes of forensic medicine PB - Semmelweis Orvostudományi Egyetem, Képzéskutató, Oktatástechnológiai és Dokumentációs Központ CY - Budapest ET - 0 PY - 1994 SP - 58 EP - 61 PG - 4 UR - https://m2.mtmt.hu/api/publication/2021447 ID - 2021447 LA - English DB - MTMT ER - TY - CHAP AU - Kereszty, Éva Margit ED - Sótonyi, Péter TI - Medico legal aspects of mental disease. Chapter X1V TS - Chapter X1V T2 - Lecture notes of forensic medicine PB - Semmelweis Orvostudományi Egyetem, Képzéskutató, Oktatástechnológiai és Dokumentációs Központ CY - Budapest ET - 0 PY - 1994 SP - 105 EP - 110 PG - 6 UR - https://m2.mtmt.hu/api/publication/1898903 ID - 1898903 LA - English DB - MTMT ER - TY - CHAP AU - Kereszty, Éva Margit ED - Sótonyi, Péter TI - Law and legal points of medicine. (Chapter 1) TS - (Chapter 1) T2 - Lecture notes of forensic medicine PB - Semmelweis Orvostudományi Egyetem, Képzéskutató, Oktatástechnológiai és Dokumentációs Központ CY - Budapest ET - 0 PY - 1994 SP - 8 EP - 12 PG - 5 UR - https://m2.mtmt.hu/api/publication/1898899 ID - 1898899 LA - English DB - MTMT ER - TY - JOUR AU - Németh, András AU - Dinya, Elek AU - Audikovszky, M AU - Pados, G AU - Mannfred, H TI - A Gevilon-terápia hatása az apolipoprotein E polimorfizmus függvényében JF - ORVOSI HETILAP J2 - ORV HETIL VL - 135 PY - 1994 IS - 14 SP - 735 EP - 741 PG - 7 SN - 0030-6002 UR - https://m2.mtmt.hu/api/publication/1617927 ID - 1617927 N1 - Export Date: 27 January 2024 AB - Our clinical trial was set out to estimate the apoE allele frequency by way of polymerase chain reaction and restriction enzyme isoform genotyping amongst 81 obese, hyperlipoproteinemic patients (treated with gemfibrozil + diet). The relative frequencies of the E2, E3, E4 alleles were 0.28, 0.61, 0.11 respectively (according to the Hardy-Weinberg equilibrium). Phenotypes with increased triglycerides levels were dominant in both sexes: IV + V > II/B > II/A (44.4%, 39.5%, 16.0%). Therapy significantly decreased the atherogen lipid values with differing efficacy among each genotype group: E3 > E4 > E2. Our findings demonstrate that in the II/A group there was no great change using the gemfibrozil + diet combination: whereas in IV + V group this combination was effective in each apoE isoform. In the case of II/B it is highly important to determine the apoE genotypes, because the therapy is only efficacious in the E33 group taking all lipid parameters into consideration. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kramer, Judit AU - Rajczy, K AU - Hegyi, L AU - Fulop, T AU - Mohácsi, Attila AU - Mezei, Z AU - Keltai, Mátyás AU - Blaskó, György AU - Ferenczy, E AU - Anh-Tuan, N AU - Füst, György TI - C4B(ASTERISK)Q0 ALLOTYPE AS RISK FACTOR FOR MYOCARDIAL-INFARCTION JF - BRITISH MEDICAL JOURNAL (BMJ) J2 - BRIT MED J VL - 309 PY - 1994 IS - 6950 SP - 313 EP - 314 PG - 2 SN - 0959-535X UR - https://m2.mtmt.hu/api/publication/1447282 ID - 1447282 LA - English DB - MTMT ER - TY - JOUR AU - Abraham, E AU - Karacsonyi, L AU - Dinya, Elek TI - Dohányzás és halálozás: longitudinális epidemiológiai vizsgálat (1975-1991) JF - ORVOSI HETILAP J2 - ORV HETIL VL - 134 PY - 1993 IS - 21 SP - 1137 EP - 1141 PG - 5 SN - 0030-6002 UR - https://m2.mtmt.hu/api/publication/1617930 ID - 1617930 AB - The authors have started a basic screening examination in one of the industrial districts of Budapest in 1975. The district has nearly 100,000 inhabitants. The aim of the examination was to determine the risk factors of lung cancer. 30,566 persons have participated. The health of all patients has been followed up between 1975-1991. During this period 3,573 patients have moved out of the district. On 26,993 patients they have examined the death ratio, the prospective life-span, in the various age groups divided into subgroups according to their smoking habits. They have studied the formation of death rate in the four risk groups determined by them on the basis of the simultaneous examination of more lung cancer risk-factors (risk-free, moderate, high and superhigh risk groups). During these 16 years the death rate both among the heavy smokers and among patients in the high and superhigh risk groups has been two, three, even almost five times higher than that in the non-smoking and in the risk-free group of the relatively younger age groups of the population (born between 1921-1930 and 1931-1938). The knowledge of these connections makes economic calculations possible in respect of life and health insurance. LA - Hungarian DB - MTMT ER -