@article{MTMT:3380328, title = {Exercise in the Prevention and Management of Oxidative Stress-Linked Diseases}, url = {https://m2.mtmt.hu/api/publication/3380328}, author = {Venditti, P and Zhang, Y and Radák, Zsolt and Magalhaes, J}, doi = {10.1155/2018/7643721}, journal-iso = {OXID MED CELL LONGEV}, journal = {OXIDATIVE MEDICINE AND CELLULAR LONGEVITY}, unique-id = {3380328}, issn = {1942-0900}, year = {2018}, eissn = {1942-0994}, orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:3207798, title = {Adaptation mechanisms of the knee extensors contractile properties in response to short-term stretch-shortening exercise training}, url = {https://m2.mtmt.hu/api/publication/3207798}, author = {Négyesi, János and Váczi, Márk and Magyar, Olivér Mátyás and Pantovic, Milan and Tihanyi, József and Rácz, Levente}, doi = {10.3233/IES-160646}, journal-iso = {ISOKINET EXERC SCI}, journal = {ISOKINETICS AND EXERCISE SCIENCE}, volume = {25}, unique-id = {3207798}, issn = {0959-3020}, year = {2017}, eissn = {1878-5913}, pages = {65-72}, orcid-numbers = {Négyesi, János/0000-0001-5055-3242} } @article{MTMT:3031729, title = {Physical exercise, reactive oxygen species and neuroprotection}, url = {https://m2.mtmt.hu/api/publication/3031729}, author = {Radák, Zsolt and Suzuki, K and Higuchi, M and Balogh, László and Boldogh, I and Koltai, Erika}, doi = {10.1016/j.freeradbiomed.2016.01.024}, journal-iso = {FREE RADICAL BIO MED}, journal = {FREE RADICAL BIOLOGY AND MEDICINE}, volume = {98}, unique-id = {3031729}, issn = {0891-5849}, abstract = {Regular exercise has systemic beneficial effects, including the promotion of brain function. The adaptive response to regular exercise involves the up-regulation of the enzymatic antioxidant system and modulation of oxidative damage. Reactive oxygen species (ROS) are important regulators of cell signaling. Exercise, via intensity-dependent modulation of metabolism and/or directly activated ROS generating enzymes, regulates the cellular redox state of the brain. ROS are also involved in the self-renewal and differentiation of neuronal stem cells and the exercise-mediated neurogenesis could be partly associated with ROS production. Exercise has strong effects on the immune system and readily alters the production of cytokines. Certain cytokines, especially IL-6, IL-1, TNF-alpha, IL-18 and IFN gamma, are actively involved in the modulation of synaptic plasticity and neurogenesis. Cytokines can also contribute to ROS production. ROS-mediated alteration of lipids, protein, and DNA could directly affect brain function, while exercise modulates the accumulation of oxidative damage. Oxidative alteration of macromolecules can activate signaling processes, membrane remodeling, and gene transcription. The well known neuroprotective effects of exercise are partly due to redox-associated adaptation.}, year = {2016}, eissn = {1873-4596}, pages = {187-196}, orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804; Koltai, Erika/0000-0002-1370-2955} } @article{MTMT:3031728, title = {Exercise-induced oxidative stress: past, present and future}, url = {https://m2.mtmt.hu/api/publication/3031728}, author = {Powers, SK and Radák, Zsolt and Ji, LL}, doi = {10.1113/JP270646}, journal-iso = {J PHYSIOL-LONDON}, journal = {JOURNAL OF PHYSIOLOGY-LONDON}, volume = {594}, unique-id = {3031728}, issn = {0022-3751}, abstract = {The existence of free radicals in living cells was first reported in 1954 and this important finding helped launch the field of free radical biology. However, the discovery that muscular exercise is associated with increased biomarkers of oxidative stress did not occur until 1978. Following the initial report that exercise promotes oxidative stress in humans, many studies have confirmed that prolonged or short-duration high intensity exercise results in increased radical production in active skeletal muscles resulting in the formation of oxidized lipids and proteins in the working muscles. Since these early descriptive studies, the investigation of radicals and redox biology related to exercise and skeletal muscle has grown as a discipline and the importance of this research in the biomedical sciences is widely recognized. This review will briefly summarize the history of research in exercise-induced oxidative stress and will discuss the major paradigm shifts that the field has undergone and continues to experience. We conclude with a discussion of future directions in the hope of stimulating additional research in this important field.}, year = {2016}, eissn = {1469-7793}, pages = {5081-5092}, orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804} } @{MTMT:25972590, title = {Posttranslational modification of proteins}, url = {https://m2.mtmt.hu/api/publication/25972590}, author = {Radák, Zsolt}, booktitle = {Physical Activity, Exercise, Sedentary Behavior and Health}, doi = {10.1007/978-4-431-55333-5_14}, unique-id = {25972590}, year = {2015}, pages = {165-169}, orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:3090079, title = {Interaction between high vs. low calorie intake and physical exercise on cognition in rats}, url = {https://m2.mtmt.hu/api/publication/3090079}, author = {Felszeghy, Klára and Pósa, Anikó and Varga, Csaba and Nyakas, Csaba}, journal-iso = {OBESIT HUNG}, journal = {OBESITOLOGIA HUNGARICA}, volume = {14}, unique-id = {3090079}, issn = {1586-7935}, year = {2015}, pages = {42-43}, orcid-numbers = {Felszeghy, Klára/0000-0002-3539-1457; Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X; Nyakas, Csaba/0000-0003-3756-0186} } @inproceedings{MTMT:3060597, title = {A hazai és nemzetközi labdarúgó játékosok sporttáplálkozása napjainkban}, url = {https://m2.mtmt.hu/api/publication/3060597}, author = {Dobák, Z and Kovács, P and Nyakas, Csaba}, booktitle = {Színes sporttudomány}, unique-id = {3060597}, year = {2015}, pages = {156-160}, orcid-numbers = {Nyakas, Csaba/0000-0003-3756-0186} } @article{MTMT:2990840, title = {Effects of nitric oxide synthase inhibition on fiber-type composition, mitochondrial biogenesis, and SIRT1 expression in rat skeletal muscle}, url = {https://m2.mtmt.hu/api/publication/2990840}, author = {Suwa, M and Nakano, H and Radák, Zsolt and Kumagai, S}, journal-iso = {J SPORT SCI MED}, journal = {JOURNAL OF SPORTS SCIENCE AND MEDICINE}, volume = {14}, unique-id = {2990840}, issn = {1303-2968}, abstract = {It was hypothesized that nitric oxide synthases (NOS) regulated SIRT1 expression and lead to a corresponding changes of contractile and metabolic properties in skeletal muscle. The purpose of the present study was to investigate the influence of long-term inhibition of nitric oxide synthases (NOS) on the fiber-type composition, metabolic regulators such as and silent information regulator of transcription 1 (SIRT1) and peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha), and components of mitochondrial biogenesis in the soleus and plantaris muscles of rats. Rats were assigned to two groups: control and NOS inhibitor (N (omega)-nitro-L-arginine methyl ester hydrochloride (L-NAME), ingested for 8 weeks in drinking water)-treated groups. The percentage of Type I fibers in the L-NAME group was significantly lower than that in the control group, and the percentage of Type IIA fibers was concomitantly higher in soleus muscle. In plantaris muscle, muscle fiber composition was not altered by L-NAME treatment. L-NAME treatment decreased the cytochrome C protein expression and activity of mitochondrial oxidative enzymes in the plantaris muscle but not in soleus muscle. NOS inhibition reduced the SIRT1 protein expression level in both the soleus and plantaris muscles, whereas it did not affect the PGC-1alpha protein expression. L-NAME treatment also reduced the glucose transporter 4 protein expression in both muscles. These results suggest that NOS plays a role in maintaining SIRT1 protein expression, muscle fiber composition and components of mitochondrial biogenesis in skeletal muscle. Key pointsNOS inhibition by L-NAME treatment decreased the SIRT1 protein expression in skeletal muscle.NOS inhibition induced the Type I to Type IIA fiber type transformation in soleus muscle.NOS inhibition reduced the components of mitochondrial biogenesis and glucose metabolism in skeletal muscle.}, year = {2015}, eissn = {1303-2968}, pages = {548-555}, orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804} } @article{MTMT:2919751, title = {Egy passzív testedzési forma, a pulzáló elektromágneses terápia (EMF) hatásai idős patkányokban}, url = {https://m2.mtmt.hu/api/publication/2919751}, author = {Téglás, Tímea and Bretz, Károly and Nyakas, Csaba}, journal-iso = {M SPORTTUD SZLE}, journal = {MAGYAR SPORTTUDOMÁNYI SZEMLE}, volume = {16}, unique-id = {2919751}, issn = {1586-5428}, year = {2015}, pages = {68}, orcid-numbers = {Nyakas, Csaba/0000-0003-3756-0186} } @article{MTMT:2908128, title = {Magas illetve csökkentett kalória-tartalmú táplálék és az önkéntes fizikai tréning kölcsönhatása a kognitív teljesítményre patkányban}, url = {https://m2.mtmt.hu/api/publication/2908128}, author = {Felszeghy, Klára and Pósa, Anikó and Varga, Csaba and Nyakas, Csaba}, journal-iso = {M SPORTTUD SZLE}, journal = {MAGYAR SPORTTUDOMÁNYI SZEMLE}, volume = {16}, unique-id = {2908128}, issn = {1586-5428}, year = {2015}, pages = {30}, orcid-numbers = {Felszeghy, Klára/0000-0002-3539-1457; Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X; Nyakas, Csaba/0000-0003-3756-0186} }