@article{MTMT:35136564, title = {Isotopic study of honey documents widespread plant uptake of old carbon in North America}, url = {https://m2.mtmt.hu/api/publication/35136564}, author = {Varga, Tamás and Sajtos, Zsófi and Baranyai, Edina and Lisztes-Szabó, Zsuzsa and Ragyák, Ágota and Molnár, Mihály and Jull, Timothy AJ and Szabó, Szilárd and Kosdi, Krisztina Hajduné and Futó, István and Kaste, James M.}, doi = {10.1016/j.scitotenv.2024.174691}, journal-iso = {SCI TOTAL ENVIRON}, journal = {SCIENCE OF THE TOTAL ENVIRONMENT}, volume = {947}, unique-id = {35136564}, issn = {0048-9697}, year = {2024}, eissn = {1879-1026}, orcid-numbers = {Lisztes-Szabó, Zsuzsa/0000-0002-6322-8542; Szabó, Szilárd/0000-0002-2670-7384} } @article{MTMT:34934550, title = {Nanostructured Gelatin Aerogel for Selective Recovery of Aqueous Pd(II) Based on Coordination to the Peptide Backbone}, url = {https://m2.mtmt.hu/api/publication/34934550}, author = {Pércsi, Dániel and Forgács, Attila and Fodor, Tamás and Fábián, István and Kalmár, József and Herman, Petra}, doi = {10.1021/acsanm.4c02188}, journal-iso = {ACS APPL NANO MATER}, journal = {ACS APPLIED NANO MATERIALS}, volume = {7}, unique-id = {34934550}, year = {2024}, eissn = {2574-0970}, pages = {14629-14640}, orcid-numbers = {Kalmár, József/0000-0002-2422-6106} } @article{MTMT:34846781, title = {Competing Domino Knoevenagel-Cyclization Sequences with N -Arylcinnamylamines}, url = {https://m2.mtmt.hu/api/publication/34846781}, author = {Kajtár, Mihály and Király, Sándor Balázs and Bényei, Attila Csaba and Kiss, Attila and Kónya-Ábrahám, Anita and Zhang, Ning and Horváth, Lilla and Bősze, Szilvia and Li, Dehai and Kotschy, András and Paczal, Attila and Kurtán, Tibor}, doi = {10.1021/acs.joc.4c00299}, journal-iso = {J ORG CHEM}, journal = {JOURNAL OF ORGANIC CHEMISTRY}, volume = {89}, unique-id = {34846781}, issn = {0022-3263}, abstract = {Domino Knoevenagel-cyclization reactions of Narylcinnamylamines were carried out with active methylene reagents, which took place with five competing cyclization mechanisms: intramolecular hetero Diels-Alder reaction, stepwise polar [2 + 2] cycloaddition, styryl or aza-Diels-Alder reactions followed by rearomatization, and [1,5]-hydride shift-6-endo cyclization. In the stepwise aza-Diels-Alder reaction, the Nvinylpyridinium moiety acted as an azadiene, producing a condensed heterocycle with tetrahydroquinolizinium and tetrahydroquiniline subunits. Antiproliferative activity with low micromolar IC50 values was identified for some of the novel scaffolds.}, year = {2024}, eissn = {1520-6904}, pages = {6937-6950}, orcid-numbers = {Kiss, Attila/0000-0003-3601-5143; Bősze, Szilvia/0000-0001-9555-699X; Li, Dehai/0000-0002-7191-2002; Kotschy, András/0000-0002-7675-3864} } @article{MTMT:34831627, title = {[52Mn]Mn-BPPA-Trastuzumab: A Promising HER2-Specific PET Radiotracer}, url = {https://m2.mtmt.hu/api/publication/34831627}, author = {Toàn, Ngô Minh and Vágner, Adrienn and Nagy, Gábor and Ország, Gábor and Nagy, Tamás and Csikos, Csaba and Váradi, Balázs and Sajtos, Gergő Zoltán and Kapus, István and Szoboszlai, Zoltán and Szikra, Dezső and Trencsényi, György and Tircsó, Gyula and Garai, Ildikó}, doi = {10.1021/acs.jmedchem.4c00344}, journal-iso = {J MED CHEM}, journal = {JOURNAL OF MEDICINAL CHEMISTRY}, volume = {67}, unique-id = {34831627}, issn = {0022-2623}, abstract = {This study aimed to develop a novel radiotracer using trastuzumab and the long-lived [52Mn]Mn isotope for HER2-targeted therapy selection and monitoring. A new Mn(II) chelator, BPPA, synthesized from a rigid bispyclen platform possessing a picolinate pendant arm, formed a stable and inert Mn(II) complex with favorable relaxation properties. BPPA was converted into a bifunctional chelator (BFC), conjugated to trastuzumab, and labeled with [52Mn]Mn isotope. In comparison to DOTA-GA-trastuzumab, the BPPA-trastuzumab conjugate exhibits a labeling efficiency with [52Mn]Mn approximately 2 orders of magnitude higher. In female CB17 SCID mice bearing 4T1 (HER2−) and MDA-MB-HER2+ (HER2+) xenografts, [52Mn]Mn-BPPA-trastuzumab demonstrated superior uptake in HER2+ cells on day 3, with a 3–4 fold difference observed on day 7. Overall, the hexadentate BPPA chelator proves to be exceptional in binding Mn(II). Upon coupling with trastuzumab as a BFC ligand, it becomes an excellent imaging probe for HER2-positive tumors. [52Mn]Mn-BPPA-trastuzumab enables an extended imaging time window and earlier detection of HER2-positive tumors with superior tumor-to-background contrast.}, year = {2024}, eissn = {1520-4804}, pages = {8261-8270}, orcid-numbers = {Trencsényi, György/0000-0001-6456-6212; Tircsó, Gyula/0000-0002-7896-7890} } @article{MTMT:34802521, title = {Organic Solvent-Based Li–Air Batteries with Cotton and Charcoal Cathode}, url = {https://m2.mtmt.hu/api/publication/34802521}, author = {Nagy, Lajos and Üneri, Haymana Serra and Kordován, Marcell Árpád and Nagy, Tibor and Kuki, Ákos and Nyul, Dávid and Pál, Petra and Erdélyi, Zoltán and Zsuga, Miklós and Kéki, Sándor}, doi = {10.1149/1945-7111/ad3857}, journal-iso = {J ELECTROCHEM SOC}, journal = {JOURNAL OF THE ELECTROCHEMICAL SOCIETY}, volume = {171}, unique-id = {34802521}, issn = {0013-4651}, abstract = {We report on the construction and investigation of Li–air batteries consisting of a charcoal cathode and cotton texture soaked with different organic solvents containing a lithium triflate (LiOTf) electrolyte. Charcoal was found to be an appropriate cathode for Li–air batteries. Furthermore, cycling tests showed stable operation at over 800 cycles when dimethyl sulfoxide (DMSO) and diethylene glycol dimethyl ether (DEGME) were used as solvents, whereas low electrochemical stability was observed when propylene carbonate was used. The charging, discharging, and long-term discharging steps were mathematically modeled. Electrochemical impedance spectroscopy showed Gerischer impedance, suggesting intensive oxygen transport at the surface of the charcoal cathode. Diffusion, charge transfer, and solid electrolyte interphase processes were identified using distribution of relaxation time analysis. In the polypropylene (PP) membrane soaked with LiOTf in DEGME, three different states of Li ions were identified by 7 Li-triple-quantum time proportional phase increment nuclear magnetic resonance measurements. On the basis of the latter results, a mechanism was suggested for Li-ion transport inside the PP membrane. The activity of the charcoal cathode was confirmed by Raman and cyclic voltammetry measurements.}, year = {2024}, eissn = {1945-7111}, orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X} } @article{MTMT:34797366, title = {Improving the Stability and Kinetic Inertness of Mn(II) Complexes by Increasing the Bridge Length in Bicyclic CDTA‐like Ligands}, url = {https://m2.mtmt.hu/api/publication/34797366}, author = {Martinelli, Jonathan and Romano, Elisabetta and Laczovics, Attila and Horváth, Dávid and Grattoni, Elena and Baranyai, Zsolt and Tei, Lorenzo}, doi = {10.1002/chem.202400570}, journal-iso = {CHEM-EUR J}, journal = {CHEMISTRY-A EUROPEAN JOURNAL}, volume = {30}, unique-id = {34797366}, issn = {0947-6539}, abstract = {Kinetic inertness of Mn(II)‐based MRI contrast agents can be improved by increasing the rigidity of the polydentate ligand that tightly coordinate the metal ion. Taking inspiration from the remarkable increase in kinetic inertness of [Mn(CDTA)]2‐ compared to [Mn(EDTA)]2‐ due to the cyclohexyl backbone rigidity, we devised that bicyclic ligands would further improve the kinetic inertness of the Mn(II) complexes. The length of the alkyl bridge on the cyclohexane ring was varied from methylene (BCH‐DTA), ethylene (BCO‐DTA) to propylene (BCN‐DTA) to evaluate the influence of the different trans‐diaminotetraacetate ligands on relaxometric, thermodynamic and kinetic properties of the Mn(II)‐complexes. 1H and 17O NMR relaxometric studies showed a slight increase in relaxivity and a faster water exchange rate in these Mn(II)‐complexes with respect to [Mn(CDTA)]2‐. Solution studies revealed that the conditional stability (pMn) and dissociation half‐life (t1/2) at pH 7.4 follow the order [Mn(BCH‐DTA)]2‐ < [Mn(BCO‐DTA)]2‐ < [Mn(BCN‐DTA)]2‐ by highlighting the effect of the bridge length on the overall stability of the Mn(II)‐complexes. Remarkably, [Mn(BCN‐DTA)]2‐ shows an improved pMn value and a 7‐times higher kinetic inertness than [Mn(CDTA)]2‐. NMR studies on the Zn(II) analogues confirm the rigidity of the bicyclic complexes with an isomerization process at >313K for the smaller bridged complex [Zn(BCH‐DTA)]2‐}, year = {2024}, eissn = {1521-3765}, orcid-numbers = {Baranyai, Zsolt/0000-0001-6844-7974} } @article{MTMT:34763386, title = {Hydration and wetting mechanism of borosilicate – Polyvinyl alcohol (PVA) hybrid aerogels of potential bioactivity}, url = {https://m2.mtmt.hu/api/publication/34763386}, author = {Ecsédi, Bertold and Forgács, Attila and Balogh, Zoltán and Fábián, István and Kalmár, József}, doi = {10.1016/j.molliq.2024.124605}, journal-iso = {J MOL LIQ}, journal = {JOURNAL OF MOLECULAR LIQUIDS}, volume = {401}, unique-id = {34763386}, issn = {0167-7322}, year = {2024}, eissn = {1873-3166}, orcid-numbers = {Kalmár, József/0000-0002-2422-6106} } @article{MTMT:34744438, title = {The triumvirate of effective and rapid synthesis, analysis, and artificial intelligence to explore the structure-property relationship of copolymers}, url = {https://m2.mtmt.hu/api/publication/34744438}, author = {Nagy, Tibor and Róth, Gergő and Kuki, Ákos and Pardi-Tóth, Veronika Csilla and Nyul, Dávid and Kyzy, Zuura Kaldybek and Palacios, Isaac Alexander Iglesias and Benedek, Máté and Nagy, Lajos and Zsuga, Miklós and Kéki, Sándor}, doi = {10.1016/j.giant.2024.100248}, journal-iso = {GIANT}, journal = {GIANT}, volume = {17}, unique-id = {34744438}, issn = {2666-5425}, abstract = {Understanding the structure-property relationship is of paramount importance for tailoring copolymers for specific applications. Poly(N-acryloylmorpholine)-block-poly(N-isopropylacrylamide) (PNAM-b-PNIPAM) diblock copolymers were synthesized by reversible addition?fragmentation chain transfer (RAFT) polymerization with varying Mn and composition, providing the basis for deducing structure-property relationships. The chemical structure of the copolymers was analyzed by mass spectrometry (MS). A novel and efficient mass spectrum processing methodology was developed for the detailed analysis of polymers/copolymers that greatly expands the upper mass limit of the time-of-flight (TOF) analyzers in the linear mode up to 20,000 Da. Our method "makes visible" the mass peaks of the individual copolymer species and their isotopologues providing effective and fast automatized analysis. The self-assembly property of the thermoresponsive PNAM-b-PNIPAM diblocks in aqueous solutions was investigated by dynamic light scattering (DLS) experiments, and quantified by determining the incipient temperature of the phase transition. For rapid evaluation, an artificial neural network (ANN) was created to explore the hidden relationships between the structural information obtained by our novel mass analysis method and the properties as well as to predict the self-assembly behavior of the copolymers.}, keywords = {COPOLYMERS; Artificial intelligence; MALDI-TOF MS; Structure-property relation}, year = {2024}, eissn = {2666-5425}, orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X} } @article{MTMT:34655160, title = {Wetting of alginate aerogels, from mesoporous solids to hydrogels: a small-angle scattering analysis}, url = {https://m2.mtmt.hu/api/publication/34655160}, author = {Balogh, Zoltán and Kalmár, József and Gommes, Cedric J.}, doi = {10.1107/S1600576724001705}, journal-iso = {J APPL CRYSTALLOGR}, journal = {JOURNAL OF APPLIED CRYSTALLOGRAPHY}, volume = {57}, unique-id = {34655160}, issn = {0021-8898}, keywords = {Small-angle scattering; Aerogels; SCATTERING DATA-ANALYSIS; Boolean models}, year = {2024}, eissn = {1600-5767}, pages = {369-379}, orcid-numbers = {Kalmár, József/0000-0002-2422-6106} } @article{MTMT:34629003, title = {Alginate aerogels by spray gelation for enhanced pulmonary delivery and solubilization of beclomethasone dipropionate}, url = {https://m2.mtmt.hu/api/publication/34629003}, author = {Duong, Thoa and Vivero-Lopez, Maria and Ardao, Inés and Alvarez-Lorenzo, Carmen and Forgács, Attila and Kalmár, József and García-González, Carlos A.}, doi = {10.1016/j.cej.2024.149849}, journal-iso = {CHEM ENG J}, journal = {CHEMICAL ENGINEERING JOURNAL}, volume = {485}, unique-id = {34629003}, issn = {1385-8947}, year = {2024}, eissn = {1873-3212}, orcid-numbers = {Kalmár, József/0000-0002-2422-6106} }