TY - JOUR AU - Parvind, Singh AU - Gáspár, Krisztián AU - Szegedi, Andrea AU - Sajtos, Laszlo AU - Baráth, Sándor AU - Hevessy Zsuzsanna, Dóra TI - Investigating Vα7.2+/CD161− T Cell and MAIT Cell Profiles Using Flow Cytometry in Healthy Subjects and Subjects with Atopic Dermatitis JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 6 SP - 3486 SN - 1661-6596 DO - 10.3390/ijms25063486 UR - https://m2.mtmt.hu/api/publication/34759290 ID - 34759290 AB - This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2+/CD161− T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for bridging innate and adaptive immunity, were analyzed alongside Vα7.2+/CD161− T cells in peripheral blood samples from 14 atopic dermatitis patients and 10 healthy controls. Flow cytometry and machine learning algorithms were employed for a comprehensive analysis. The results indicate a significant decrease in MAIT cells and CD69 subsets in atopic dermatitis, coupled with elevated CD38 and polyfunctional MAIT cells producing TNFα and Granzyme B (TNFα+/GzB+). Vα7.2+/CD161− T cells in atopic dermatitis exhibited a decrease in CD8 and IFNγ-producing subsets but an increase in CD38 activated and IL-22-producing subsets. These results highlight the distinctive features of MAIT cells and Vα7.2+/CD161− T cells and their different roles in the pathogenesis of atopic dermatitis and provide insights into their potential roles in immune-mediated skin diseases. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Attila Ádám AU - Enyedi, Enikő Edit AU - Altorjay, István AU - Hajnal, Péter AU - Pintér, Tamás Bence AU - Mányiné Siket, Ivetta AU - Váradi, Csongor AU - Bányai, Emese AU - Tóth, Attila AU - Papp, Zoltán AU - Fagyas, Miklós TI - Get reliable laboratory findings – how to recognize the deceptive effects of angiotensin-converting enzyme inhibitor therapy in the laboratory diagnostics of sarcoidosis? JF - CLINICAL CHEMISTRY AND LABORATORY MEDICINE J2 - CLIN CHEM LAB MED PY - 2024 SN - 1434-6621 DO - 10.1515/cclm-2023-1288 UR - https://m2.mtmt.hu/api/publication/34496858 ID - 34496858 AB - Objectives Serum angiotensin-converting enzyme (ACE) is the only biomarker routinely used in the laboratory diagnostics of sarcoidosis, and ACE inhibitor (ACEi) drugs are among the most prescribed drugs worldwide. Taking ACEi can mislead medical teams by lowering ACE activity, delaying diagnosis and giving a false impression of disease activity of sarcoidosis. We aimed to develop a simple method to detect the presence of ACEi drugs in samples, to investigate the ACEi medication-caused interference and consequences in a retrospective study. Methods ACE activity and the level of ACE inhibition were determined for 1823 patients with suspected sarcoidosis. These values were compared with the therapeutic information at the first and follow-up visits. Results A total of 302 patients had biochemical evidence of an ACEi drug effect during diagnostic ACE activity testing. In their case, ACE activity was significantly lower (median(IQR): 4.41 U/L(2.93–6.72)) than in patients not taking ACEi (11.32 U/L(8.79–13.92), p<0.01). In 62 sarcoidosis patients, the ACEi reduced ACE activity to the reference range or below. Only in 40 % of the cases was the medication list recorded in the outpatient chart and only in 3 cases was low ACE activity associated with ACEi use. 67 % of the repeated ACE activity measurements were also performed during ACEi therapy. Conclusions Our study revealed that the use of ACEi is common in patients with suspected sarcoidosis. The ACE activity lowering effect of ACEi drugs may escape the attention of medical teams which can lead to diagnostic errors and unnecessary tests. Nevertheless, these pitfalls can be avoided by using a method suggested by our team. LA - English DB - MTMT ER - TY - JOUR AU - Harriet, Ghansah AU - Orbán-Kálmándi, Rita Angéla AU - Bekéné Debreceni, Ildikó AU - Katona, Éva AU - Rejtő, László AU - Váróczy, László AU - Lóczi, Linda AU - de Laat, Bas AU - Huskens, Dana AU - Kappelmayer, János AU - Bagoly, Zsuzsa TI - Low factor XIII levels and altered fibrinolysis in patients with multiple myeloma JF - THROMBOSIS RESEARCH J2 - THROMB RES VL - 234 PY - 2024 SP - 12 EP - 20 PG - 9 SN - 0049-3848 DO - 10.1016/j.thromres.2023.12.004 UR - https://m2.mtmt.hu/api/publication/34441776 ID - 34441776 LA - English DB - MTMT ER - TY - JOUR AU - Snijders, Romee AU - Janik, Maciej K. AU - Mund, Meike AU - Gerussi, Alessio AU - Bolis, Francesca AU - Cristoferi, Laura AU - Invernizzi, Pietro AU - Kováts, Patrícia AU - Papp, Mária AU - Gronbaek, Lisbet AU - Gronbaek, Henning AU - Tjwa, E. T. T. L. AU - Aamann, Luise AU - Ytting, Henriette AU - Ronca, Vincenzo AU - Olsen, Katheryn AU - Oo, Ye Htun AU - Van, der Meer Adriaan AU - Madaleno, Joao AU - Canhao, Bernardo AU - Engel, Bastian AU - Campos-Murguia, Alejandro AU - Taubert, Richard AU - Koc, Ozgur AU - Kramer, Matthijs AU - Willemse, Jose AU - Loewe, Bernd AU - Lohse, Ansgar W. AU - Drenth, Joost P. H. AU - Schramm, Christoph AU - Milkiewicz, Piotr AU - Gevers, Tom TI - The impact of a complete biochemical response on health-related quality of life in patients with autoimmune hepatitis: a multicentre prospective cross-sectional study JF - JOURNAL OF HEPATOLOGY J2 - J HEPATOL VL - 78 PY - 2023 IS - S1 SP - S982 EP - S982 SN - 0168-8278 UR - https://m2.mtmt.hu/api/publication/34769050 ID - 34769050 LA - English DB - MTMT ER - TY - JOUR AU - Schregel, Ida AU - Papp, Mária AU - Sipeki, Nóra AU - Kováts, Patrícia AU - Taubert, Richard AU - Engel, Bastian AU - Campos-Murguia, Alejandro AU - Dalekos, George AU - Gatselis, Nikolaos AU - Zachou, Kalliopi AU - Milkiewicz, Piotr AU - Janik, Maciej K. AU - Raszeja-Wyszomirska, Joanna AU - Ytting, Henriette AU - Braun, Felix AU - Casar, Christian AU - Lohse, Ansgar W. AU - Schramm, Christoph TI - Results of the prospective multicentre European R-LIVER registry reveal the unmet clinical needs of autoimmune hepatitis JF - JOURNAL OF HEPATOLOGY J2 - J HEPATOL VL - 78 PY - 2023 IS - S1 SP - S45 EP - S46 SN - 0168-8278 UR - https://m2.mtmt.hu/api/publication/34768346 ID - 34768346 LA - English DB - MTMT ER - TY - JOUR AU - Kest, Michael AU - Ágoston, András AU - Szabó, Gábor Tamás AU - Kiss, Attila AU - Üveges, Áron AU - Czuriga, Dániel AU - Komócsi, András AU - Hizoh, István AU - Kőszegi, Zsolt TI - Angiography-based coronary microvascular assessment with and without intracoronary pressure measurements: a systematic review JF - CLINICAL RESEARCH IN CARDIOLOGY J2 - CLIN RES CARDIOL VL - In press PY - 2023 SP - In press SN - 1861-0684 DO - 10.1007/s00392-023-02338-6 UR - https://m2.mtmt.hu/api/publication/34395283 ID - 34395283 LA - English DB - MTMT ER - TY - JOUR AU - Al-Smadi, Mohammad AU - Fazekas, László Ádám AU - Aslan, Siran AU - Bernát, Brigitta Renáta AU - Beqain, Anas AU - Al-Khafaji, Mustafa Qais Muhsin AU - Priksz, Dániel AU - Orlik, Brigitta AU - Németh, Norbert TI - A Microsurgical Arteriovenous Malformation Model on Saphenous Vessels in the Rat JF - BIOMEDICINES J2 - BIOMEDICINES VL - 11 PY - 2023 IS - 11 SP - 2970 SN - 2227-9059 DO - 10.3390/biomedicines11112970 UR - https://m2.mtmt.hu/api/publication/34394226 ID - 34394226 AB - Arteriovenous malformation (AVM) is an anomaly of blood vessel formation. Numerous models have been established to understand the nature of AVM. These models have limitations in terms of the diameter of the vessels used and the impact on the circulatory system. Our goal was to establish an AVM model that does not cause prompt and significant hemodynamic and cardiac alterations but is feasible for follow-up of the AVM’s progression. Sixteen female rats were randomly divided into sham-operated and AVM groups. In the AVM group, the saphenous vein and artery were interconnected using microsurgical techniques. The animals were followed up for 12 weeks. Anastomosis patency and the structural and hemodynamic changes of the heart were monitored. The hearts and vessels were histologically analyzed. During the follow-up period, shunts remained unobstructed. Systolic, diastolic, mean arterial pressure, and heart rate values slightly and non-significantly decreased in the AVM group. Echocardiogram results indicated minor systolic function impact, with slight and insignificant changes in aortic pressure and blood velocity, and minimal left ventricular wall enlargement. The small-caliber saphenous AVM model does not cause acute hemodynamic changes. Moderate but progressive alterations and venous dilatation confirmed AVM-like features. The model seems to be suitable for studying further the progression, enlargement, or destabilization of AVM. LA - English DB - MTMT ER - TY - JOUR AU - Sipeki, Nóra AU - Kováts, Patrícia AU - Deutschmann, Claudia AU - Schierack, Peter AU - Roggenbuck, Dirk AU - Papp, Mária TI - Location-based prediction model for Crohn’s disease regarding a novel serological marker, anti-chitinase 3-like 1 autoantibodies JF - WORLD JOURNAL OF GASTROENTEROLOGY J2 - WORLD J LGASTROENTEROL VL - 29 PY - 2023 IS - 42 SP - 5728 EP - 5750 PG - 23 SN - 1007-9327 DO - 10.3748/wjg.v29.i42.5728 UR - https://m2.mtmt.hu/api/publication/34323619 ID - 34323619 AB - Esophageal cancer (EC) has a high incidence and mortality rate and is emerging as one of the most common health problems globally. Owing to the lack of sensitive detection methods, uncontrollable rapid metastasis, and pervasive treatment resistance, EC is often diagnosed in advanced stages and is susceptible to local recurrence. Exosomes are important components of intercellular communication and the exosome-mediated crosstalk between the cancer and surrounding cells within the tumor microenvironment plays a crucial role in the metastasis, progression, and therapeutic resistance of EC. Considering the critical role of exosomes in tumor pathogenesis, this review focused on elucidating the impact of exosomes on EC metastasis and therapeutic resistance. Here, we summarized the relevant signaling pathways involved in these processes. In addition, we discussed the potential clinical applications of exosomes for the early diagnosis, prognosis, and treatment of EC. LA - English DB - MTMT ER - TY - JOUR AU - Pócsi, Marianna AU - Fejes, Zsolt AU - Bene, Zsolt AU - Nagy, Attila Csaba AU - Balogh, István AU - Amaral, Margarida D. AU - Macek, Milan AU - Nagy, Béla TI - Human epididymis protein 4 (HE4) plasma concentration inversely correlates with the improvement of cystic fibrosis lung disease in p.Phe508del-CFTR homozygous cases treated with the CFTR modulator lumacaftor/ivacaftor combination JF - JOURNAL OF CYSTIC FIBROSIS J2 - J CYST FIBROS VL - 22 PY - 2023 IS - 6 SP - 1085 EP - 1092 PG - 8 SN - 1569-1993 DO - 10.1016/j.jcf.2023.04.001 UR - https://m2.mtmt.hu/api/publication/34089998 ID - 34089998 LA - English DB - MTMT ER - TY - JOUR AU - Szuromi, Lilla AU - Hajas, Orsolya AU - Nagy-Baló, Edina AU - Forgács, Ildikó Noémi AU - László, T. Nagy AU - Fagyas, Miklós AU - Tóth, Attila AU - Nagy, Béla AU - Kappelmayer, János AU - Csanádi, Zoltán TI - Long-Term Changes in the Biomarkers of Left Atrial Fibrosis after Pulmonary Vein Isolation for Paroxysmal and Persistent Atrial Fibrillation JF - REVIEWS IN CARDIOVASCULAR MEDICINE J2 - REV CARDIOVASC MED VL - 24 PY - 2023 IS - 6 PG - 11 SN - 1530-6550 DO - 10.31083/j.rcm2406171 UR - https://m2.mtmt.hu/api/publication/34011238 ID - 34011238 N1 - Division of Cardiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary Export Date: 11 September 2023 CODEN: RCMEC Correspondence Address: Csanádi, Z.; Division of Cardiology, Hungary; email: kardiologia@med.unideb.hu LA - English DB - MTMT ER -