TY - CHAP AU - Mahmoud, Azza AU - Pannonhalminé Csóka, Ildikó AU - Regdon, Géza (ifj.) AU - Kristó, Katalin ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - High shear granulation as a promising technique in the direct pelletization process T2 - VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2024 SP - 40 EP - 40 PG - 65 UR - https://m2.mtmt.hu/api/publication/34657079 ID - 34657079 LA - English DB - MTMT ER - TY - CONF AU - Kocsis, Beatrix AU - Mi-Kyung, Lee AU - Jae-Hyuk, Yu AU - Nagy, Tibor AU - Daróczi, Lajos AU - Batta, Gyula Gábor (Ifj.) AU - Pócsi, István AU - Leiter, Éva Juliánna TI - Comprehensive functional analyses of the bzip transciption factors AtfA and AtfB in Aspergillus Nidulans T2 - 16th European Conference on Fungal Genetics: Programme & Abstracts PB - Universität Innsbruck C1 - Innsbruck PY - 2023 SP - 705 EP - 706 PG - 2 UR - https://m2.mtmt.hu/api/publication/34453415 ID - 34453415 LA - English DB - MTMT ER - TY - CONF AU - Kocsis, Beatrix AU - Mi-Kyung, Lee AU - Antal, Károly AU - Jae-Hyuk, Yu AU - Pócsi, István AU - Leiter, Éva Juliánna AU - Emri, Tamás TI - Genome-wide study of AtfA/AtfB-mediated menadione stress response during asexual development in Aspergillus nidulans T2 - The 19th International Aspergillus Meeting: Asperfest PY - 2023 SP - 31 EP - 32 PG - 2 UR - https://m2.mtmt.hu/api/publication/34453385 ID - 34453385 LA - English DB - MTMT ER - TY - JOUR AU - Quoc, Thinh To AU - Bácskay, Ildikó AU - Siposné Fehér, Pálma AU - Pallér, Ádám AU - Papp, Boglárka AU - Bíró, Krisztina AU - Ujhelyi, Zoltán TI - Personalized Nasal Protective Devices: Importance and Perspectives JF - LIFE-BASEL J2 - LIFE-BASEL VL - 13 PY - 2023 IS - 11 SP - 2116 SN - 2075-1729 DO - 10.3390/life13112116 UR - https://m2.mtmt.hu/api/publication/34269173 ID - 34269173 AB - Nowadays, in addition to diseases caused by environmental pollution, the importance of personalized protection against various infectious agents has become of paramount importance. Besides medicine, several technical and technological studies have been carried out to develop suitable devices. One such revolutionary solution is the use of personalized nasal filters, which allow our body to defend itself more effectively against external environmental damage and pathogens. These filters are small devices that are placed in the nose and specifically filter the inhaled environmental contaminants, allergens, and microorganisms according to individual needs. These devices not only play a key role in maintaining our health but also contribute to environmental protection, reducing the inhalation of pollutants and their harmful impact on the natural environment. Another advantage of personalized filters is that they also provide an opportunity to strengthen our individual immune systems. The use of personalized filters allows medicine to provide optimized protection for everyone, focusing on individual genetic and immunological conditions. The momentum behind the development and research of personalized nasal filters has reached astonishing proportions today. Nowadays, many research groups and medical institutions are working to create new materials, nanotechnologies, and bioinformatics solutions in order to create even more effective personalized nasal filters that can also be shaped easily and safely. Considering the needs of the users is at least as important during development as the efficiency of the device. These two properties together determine the success of the product. Industry research focuses not only on improving the efficiency of devices, but also on making them more responsive to user needs, comfort, and portability. Based on all this, it can be concluded that personalized nasal filters can be a promising and innovative solution for protection against environmental pollutants and pathogens. Through a commitment to the research and development of technology, the long-term impact of such devices on our health and the environment can be significant, contributing to improving people’s quality of life and creating a sustainable future. With unique solutions and continuous research, we give hope that in the future, despite the environmental challenges, we can enjoy the protection of our health with even more efficient and sophisticated devices. LA - English DB - MTMT ER - TY - JOUR AU - Nagy, József Bálint AU - Koleszár, Balázs AU - Khayer, Bernadett AU - Róka, Eszter AU - Laczkó, Levente AU - Ungvári, Erika AU - Kaszab, Eszter AU - Bali, Krisztina AU - Bányai, Krisztián AU - Vargha, Márta AU - Lovas-Kiss, Ádám AU - Tóth, Ákos AU - Kardos, Gábor TI - Carbapenem-resistant Escherichia coli in Black-headed gulls, the Danube, and human clinical samples: A One Health comparison of contemporary isolates JF - JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE J2 - J GLOB ANTIMICROB RE VL - 35 PY - 2023 SP - 257 EP - 261 PG - 5 SN - 2213-7165 DO - 10.1016/j.jgar.2023.10.002 UR - https://m2.mtmt.hu/api/publication/34201609 ID - 34201609 LA - English DB - MTMT ER - TY - JOUR AU - Szűcs, Zsolt AU - Plaszkó, Tamás AU - Bódor, Eszter AU - Csoma, Hajnalka AU - Ács-Szabó, Lajos AU - Kiss, Attila AU - Vasas, Gábor AU - Gonda, Sándor TI - Antifungal Activity of Glucosinolate-Derived Nitriles and Their Synergistic Activity with Glucosinolate-Derived Isothiocyanates Distinguishes Various Taxa of Brassicaceae Endophytes and Soil Fungi JF - PLANTS-BASEL J2 - PLANTS-BASEL VL - 12 PY - 2023 IS - 14 PG - 13 SN - 2223-7747 DO - 10.3390/plants12142741 UR - https://m2.mtmt.hu/api/publication/34081680 ID - 34081680 AB - The glucosinolates of Brassicaceae plants are converted into bioactive isothiocyanates and other volatiles during a challenge by pathogens and other biotic stressors. However, the role of alternative downstream products with weaker potency (e.g., nitriles) is far from being fully understood. This study tested the possible synergistic antifungal interaction between various glucosinolate-derived nitriles and 2-phenylethyl isothiocyanate (PEITC) on 45 fungal strains, including endophytes from horseradish roots (Brassicaceae) and soil fungi, using an airtight system enabling the accurate study of extremely volatile antifungal agents. The median minimal inhibitory concentrations (MICs) were 1.28, 6.10, 27.00 and 49.72 mM for 1H-indole-3-acetonitrile (IAN), 3-phenylpropanenitrile (PPN), 4-(methylsulfanyl)-butanenitrile (MSBN) and 3-butenenitrile (BN, = allyl cyanide), respectively. Thus, nitriles were considerably weaker antifungal agents compared to PEITC with a median MIC of 0.04 mM. For the same nitriles, the median fractional inhibitory concentration indices (FICIs) of the combinations were 0.562, 0.531, 0.562 and 0.625, respectively. Altogether, 47.7%, 56.8%, 50.0% and 27.3% of tested fungal strains showed a synergistic antifungal activity (FICI ≤ 0.5) for the nitrile–isothiocyanate combinations, respectively. Hypocreales strains showed the least sensitivity towards the GSL decomposition products and their combinations. The mean MIC values for PEITC showed 0.0679 ± 0.0358, 0.0400 ± 0.0214, 0.0319 ± 0.0087 and 0.0178 ± 0.0171 mM for Hypocreales, Eurotiales, Glomerellales and Pleosporales, respectively. In addition, nitriles, especially IAN, also showed significant differences. For the same fungi, the median FICI values fell in the ranges of 0.61–0.67, 0.52–0.61, 0.40–0.50 and 0.48–0.67, respectively, depending on the nitrile. Our results suggest that glucosinolate-derived nitriles may enhance isothiocyanate antifungal activity and that they may play an active role in shaping the plant microbiome and contribute to the filtering of microbes by plants. LA - English DB - MTMT ER - TY - JOUR AU - Pamlényi, Krisztián AU - Regdon, Géza (ifj.) AU - Jójártné Laczkovich, Orsolya AU - Nemes, Dániel AU - Bácskay, Ildikó AU - Kristó, Katalin TI - Formulation and characterization of pramipexole containing buccal films for using in Parkinson's disease JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 187 PY - 2023 PG - 12 SN - 0928-0987 DO - 10.1016/j.ejps.2023.106491 UR - https://m2.mtmt.hu/api/publication/34008857 ID - 34008857 N1 - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720, Szeged, Hungary Department of Pharmaceutical Technology, University of Debrecen, Nagyerdei krt. 98., H-4032, Debrecen, Hungary Export Date: 1 August 2023 CODEN: EPSCE Correspondence Address: Regdon, G.; Institute of Pharmaceutical Technology and Regulatory Affairs, Eötvös u. 6., H-6720, Hungary; email: geza.regdon@pharm.u-szeged.hu Chemicals/CAS: pramipexole, 104632-26-0, 104632-25-9, 191217-81-9; Drug Carriers; Pramipexole Funding details: 5991 Funding details: Richter Gedeon Talentum Alapítvány, 100822 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, ÚNKP-21-3 Funding details: Innovációs és Technológiai Minisztérium Funding text 1: The publication was funded by The University of Szeged Open Access Fund (FundRef, Grant No. 5991). This research work was supported by Richter Gedeon Talentum Foundation to help me participate in the PhD program (Grant No. 100822 ). This work was also supported by the New National Excellence Program of the Ministry for Innovation and Technology from the Source of the National Research, Development and Innovation Fund (Grant No. ÚNKP-21-3 ). LA - English DB - MTMT ER - TY - JOUR AU - Józsa, Liza TI - Glaukóma : a látás "néma tolvaja" JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 3 PY - 2023 IS - 67 SP - 1 EP - 5 PG - 5 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/33823864 ID - 33823864 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Adnan, Awid AU - Borman, Andrew M. AU - Tóth, Zoltán AU - Forgács, Lajos AU - Kovács, Renátó AU - Balázsi, Dávid AU - Balázs, Bence AU - Udvarhelyi, Gergely AU - Kardos, Gábor AU - Majoros, László TI - In Vitro Killing Activities of Anidulafungin and Micafungin with and without Nikkomycin Z against Four Candida auris Clades JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 5 SP - 1365 SN - 1999-4923 DO - 10.3390/pharmaceutics15051365 UR - https://m2.mtmt.hu/api/publication/33788072 ID - 33788072 AB - Candida auris is a multidrug-resistant pathogen against which echinocandins are the drug of choice. However, information on how the chitin synthase inhibitor nikkomycin Z influences the killing activities of echinocandins against C. auris is currently lacking. We determined the killing activities of anidulafungin and micafungin (0.25, 1, 8, 16 and 32 mg/L each) with and without nikkomycin Z (8 mg/L) against 15 isolates representing four C. auris clades (South Asian n = 5; East Asian n = 3; South African n = 3; South American n = 4, two of which were of environmental origin). Two and one isolates from the South Asian clade harbored mutations in the hot-spot 1 (S639Y and S639P) and 2 (R1354H) regions of the FKS1 gene, respectively. The anidulafungin, micafungin and nikkomycin Z MIC ranges were 0.015-4, 0.03-4 and 2->16 mg/L, respectively. Anidulafungin and micafungin alone exerted weak fungistatic activity against wild-type isolates and the isolate with a mutation in the hot-spot 2 region of FKS1 but was ineffective against the isolates with a mutation in the hot-spot 1 region. The nikkomycin Z killing curves were always similar to their respective controls. Twenty-two of sixty (36.7%) anidulafungin plus nikkomycin Z and twenty-four of sixty (40%) micafungin plus nikkomycin Z combinations produced at least 100-fold decreases in the CFUs (synergy), with a 41.7% and 20% fungicidal effect, respectively, against wild-type isolates. Antagonism was never observed. Similar results were found with the isolate with a mutation in hot-spot 2 of FKS1, but the combinations were ineffective against the two isolates with prominent mutations in hot-spot 1 of FKS1. The simultaneous inhibition of β-1,3 glucan and chitin synthases in wild-type C. auris isolates produced significantly greater killing rates than either drug alone. Further studies are warranted to verify the clinical efficacy of echinocandin plus nikkomycin Z combinations against echinocandin susceptible C. auris isolates. LA - English DB - MTMT ER - TY - JOUR AU - Józsa, Liza AU - Nemes, Dániel AU - Pető, Ágota AU - Kósa, Dóra AU - Révész, Réka AU - Bácskay, Ildikó AU - Haimhoffer, Ádám AU - Vasvári, Gábor TI - Recent Options and Techniques to Assess Improved Bioavailability: In Vitro and Ex Vivo Methods JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 4 SP - 1 EP - 25 PG - 25 SN - 1999-4923 DO - 10.3390/pharmaceutics15041146 UR - https://m2.mtmt.hu/api/publication/33742959 ID - 33742959 AB - Bioavailability assessment in the development phase of a drug product is vital to reveal the disadvantageous properties of the substance and the possible technological interventions. However, in vivo pharmacokinetic studies provide strong evidence for drug approval applications. Human and animal studies must be designed on the basis of preliminary biorelevant experiments in vitro and ex vivo. In this article, the authors have reviewed the recent methods and techniques from the last decade that are in use for assessing the bioavailability of drug molecules and the effects of technological modifications and drug delivery systems. Four main administration routes were selected: oral, transdermal, ocular, and nasal or inhalation. Three levels of methodologies were screened for each category: in vitro techniques with artificial membranes; cell culture, including monocultures and co-cultures; and finally, experiments where tissue or organ samples were used. Reproducibility, predictability, and level of acceptance by the regulatory organizations are summarized for the readers. LA - English DB - MTMT ER -