@{MTMT:34657079,
	title = {High shear granulation as a promising technique in the direct pelletization process},
	url = {https://m2.mtmt.hu/api/publication/34657079},
	author = {Mahmoud, Azza and Pannonhalminé Csóka, Ildikó and Regdon, Géza (ifj.) and Kristó, Katalin},
	booktitle = {VI. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science},
	unique-id = {34657079},
	year = {2024},
	pages = {40-40},
	orcid-numbers = {Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Regdon, Géza (ifj.)/0000-0002-6921-3069}
}

@CONFERENCE{MTMT:34453415,
	title = {Comprehensive functional analyses of the bzip transciption factors AtfA and AtfB in Aspergillus Nidulans},
	url = {https://m2.mtmt.hu/api/publication/34453415},
	author = {Kocsis, Beatrix and Mi-Kyung, Lee and Jae-Hyuk, Yu and Nagy, Tibor and Daróczi, Lajos and Batta, Gyula Gábor (Ifj.) and Pócsi, István and Leiter, Éva Juliánna},
	booktitle = {16th European Conference on Fungal Genetics: Programme & Abstracts},
	unique-id = {34453415},
	year = {2023},
	pages = {705-706},
	orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X; Batta, Gyula Gábor (Ifj.)/0000-0001-8735-6920}
}

@CONFERENCE{MTMT:34453385,
	title = {Genome-wide study of AtfA/AtfB-mediated menadione stress response during asexual development in Aspergillus nidulans},
	url = {https://m2.mtmt.hu/api/publication/34453385},
	author = {Kocsis, Beatrix and Mi-Kyung, Lee and Antal, Károly and Jae-Hyuk, Yu and Pócsi, István and Leiter, Éva Juliánna and Emri, Tamás},
	booktitle = {The 19th International Aspergillus Meeting: Asperfest},
	unique-id = {34453385},
	year = {2023},
	pages = {31-32}
}

@article{MTMT:34269173,
	title = {Personalized Nasal Protective Devices: Importance and Perspectives},
	url = {https://m2.mtmt.hu/api/publication/34269173},
	author = {Quoc, Thinh To and Bácskay, Ildikó and Siposné Fehér, Pálma and Pallér, Ádám and Papp, Boglárka and Bíró, Krisztina and Ujhelyi, Zoltán},
	doi = {10.3390/life13112116},
	journal-iso = {LIFE-BASEL},
	journal = {LIFE-BASEL},
	volume = {13},
	unique-id = {34269173},
	abstract = {Nowadays, in addition to diseases caused by environmental pollution, the importance of personalized protection against various infectious agents has become of paramount importance. Besides medicine, several technical and technological studies have been carried out to develop suitable devices. One such revolutionary solution is the use of personalized nasal filters, which allow our body to defend itself more effectively against external environmental damage and pathogens. These filters are small devices that are placed in the nose and specifically filter the inhaled environmental contaminants, allergens, and microorganisms according to individual needs. These devices not only play a key role in maintaining our health but also contribute to environmental protection, reducing the inhalation of pollutants and their harmful impact on the natural environment. Another advantage of personalized filters is that they also provide an opportunity to strengthen our individual immune systems. The use of personalized filters allows medicine to provide optimized protection for everyone, focusing on individual genetic and immunological conditions. The momentum behind the development and research of personalized nasal filters has reached astonishing proportions today. Nowadays, many research groups and medical institutions are working to create new materials, nanotechnologies, and bioinformatics solutions in order to create even more effective personalized nasal filters that can also be shaped easily and safely. Considering the needs of the users is at least as important during development as the efficiency of the device. These two properties together determine the success of the product. Industry research focuses not only on improving the efficiency of devices, but also on making them more responsive to user needs, comfort, and portability. Based on all this, it can be concluded that personalized nasal filters can be a promising and innovative solution for protection against environmental pollutants and pathogens. Through a commitment to the research and development of technology, the long-term impact of such devices on our health and the environment can be significant, contributing to improving people’s quality of life and creating a sustainable future. With unique solutions and continuous research, we give hope that in the future, despite the environmental challenges, we can enjoy the protection of our health with even more efficient and sophisticated devices.},
	year = {2023},
	eissn = {2075-1729},
	pages = {2116}
}

@article{MTMT:34201609,
	title = {Carbapenem-resistant Escherichia coli in Black-headed gulls, the Danube, and human clinical samples: A One Health comparison of contemporary isolates},
	url = {https://m2.mtmt.hu/api/publication/34201609},
	author = {Nagy, József Bálint and Koleszár, Balázs and Khayer, Bernadett and Róka, Eszter and Laczkó, Levente and Ungvári, Erika and Kaszab, Eszter and Bali, Krisztina and Bányai, Krisztián and Vargha, Márta and Lovas-Kiss, Ádám and Tóth, Ákos and Kardos, Gábor},
	doi = {10.1016/j.jgar.2023.10.002},
	journal-iso = {J GLOB ANTIMICROB RE},
	journal = {JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE},
	volume = {35},
	unique-id = {34201609},
	issn = {2213-7165},
	year = {2023},
	eissn = {2213-7173},
	pages = {257-261},
	orcid-numbers = {Khayer, Bernadett/0000-0003-3484-9232}
}

@article{MTMT:34081680,
	title = {Antifungal Activity of Glucosinolate-Derived Nitriles and Their Synergistic Activity with Glucosinolate-Derived Isothiocyanates Distinguishes Various Taxa of Brassicaceae Endophytes and Soil Fungi},
	url = {https://m2.mtmt.hu/api/publication/34081680},
	author = {Szűcs, Zsolt and Plaszkó, Tamás and Bódor, Eszter and Csoma, Hajnalka and Ács-Szabó, Lajos and Kiss, Attila and Vasas, Gábor and Gonda, Sándor},
	doi = {10.3390/plants12142741},
	journal-iso = {PLANTS-BASEL},
	journal = {PLANTS-BASEL},
	volume = {12},
	unique-id = {34081680},
	abstract = {The glucosinolates of Brassicaceae plants are converted into bioactive isothiocyanates and other volatiles during a challenge by pathogens and other biotic stressors. However, the role of alternative downstream products with weaker potency (e.g., nitriles) is far from being fully understood. This study tested the possible synergistic antifungal interaction between various glucosinolate-derived nitriles and 2-phenylethyl isothiocyanate (PEITC) on 45 fungal strains, including endophytes from horseradish roots (Brassicaceae) and soil fungi, using an airtight system enabling the accurate study of extremely volatile antifungal agents. The median minimal inhibitory concentrations (MICs) were 1.28, 6.10, 27.00 and 49.72 mM for 1H-indole-3-acetonitrile (IAN), 3-phenylpropanenitrile (PPN), 4-(methylsulfanyl)-butanenitrile (MSBN) and 3-butenenitrile (BN, = allyl cyanide), respectively. Thus, nitriles were considerably weaker antifungal agents compared to PEITC with a median MIC of 0.04 mM. For the same nitriles, the median fractional inhibitory concentration indices (FICIs) of the combinations were 0.562, 0.531, 0.562 and 0.625, respectively. Altogether, 47.7%, 56.8%, 50.0% and 27.3% of tested fungal strains showed a synergistic antifungal activity (FICI ≤ 0.5) for the nitrile–isothiocyanate combinations, respectively. Hypocreales strains showed the least sensitivity towards the GSL decomposition products and their combinations. The mean MIC values for PEITC showed 0.0679 ± 0.0358, 0.0400 ± 0.0214, 0.0319 ± 0.0087 and 0.0178 ± 0.0171 mM for Hypocreales, Eurotiales, Glomerellales and Pleosporales, respectively. In addition, nitriles, especially IAN, also showed significant differences. For the same fungi, the median FICI values fell in the ranges of 0.61–0.67, 0.52–0.61, 0.40–0.50 and 0.48–0.67, respectively, depending on the nitrile. Our results suggest that glucosinolate-derived nitriles may enhance isothiocyanate antifungal activity and that they may play an active role in shaping the plant microbiome and contribute to the filtering of microbes by plants.},
	keywords = {ISOTHIOCYANATE; Antifungal activity; nitrile; ITC; Synergy; Soil fungi; Endophyte fungi},
	year = {2023},
	eissn = {2223-7747},
	orcid-numbers = {Plaszkó, Tamás/0000-0003-4211-3823; Kiss, Attila/0000-0003-3601-5143; Gonda, Sándor/0000-0001-9776-0249}
}

@article{MTMT:34008857,
	title = {Formulation and characterization of pramipexole containing buccal films for using in Parkinson's disease},
	url = {https://m2.mtmt.hu/api/publication/34008857},
	author = {Pamlényi, Krisztián and Regdon, Géza (ifj.) and Jójártné Laczkovich, Orsolya and Nemes, Dániel and Bácskay, Ildikó and Kristó, Katalin},
	doi = {10.1016/j.ejps.2023.106491},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {187},
	unique-id = {34008857},
	issn = {0928-0987},
	year = {2023},
	eissn = {1879-0720},
	orcid-numbers = {Regdon, Géza (ifj.)/0000-0002-6921-3069; Nemes, Dániel/0000-0002-5477-0540}
}

@article{MTMT:33823864,
	title = {Glaukóma : a látás "néma tolvaja"},
	url = {https://m2.mtmt.hu/api/publication/33823864},
	author = {Józsa, Liza},
	journal-iso = {GYÓGYSZERÉSZET},
	journal = {GYÓGYSZERÉSZET},
	volume = {3},
	unique-id = {33823864},
	issn = {0017-6036},
	year = {2023},
	pages = {1-5}
}

@article{MTMT:33788072,
	title = {In Vitro Killing Activities of Anidulafungin and Micafungin with and without Nikkomycin Z against Four Candida auris Clades},
	url = {https://m2.mtmt.hu/api/publication/33788072},
	author = {Adnan, Awid and Borman, Andrew M. and Tóth, Zoltán and Forgács, Lajos and Kovács, Renátó and Balázsi, Dávid and Balázs, Bence and Udvarhelyi, Gergely and Kardos, Gábor and Majoros, László},
	doi = {10.3390/pharmaceutics15051365},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {33788072},
	issn = {1999-4923},
	abstract = {Candida auris is a multidrug-resistant pathogen against which echinocandins are the drug of choice. However, information on how the chitin synthase inhibitor nikkomycin Z influences the killing activities of echinocandins against C. auris is currently lacking. We determined the killing activities of anidulafungin and micafungin (0.25, 1, 8, 16 and 32 mg/L each) with and without nikkomycin Z (8 mg/L) against 15 isolates representing four C. auris clades (South Asian n = 5; East Asian n = 3; South African n = 3; South American n = 4, two of which were of environmental origin). Two and one isolates from the South Asian clade harbored mutations in the hot-spot 1 (S639Y and S639P) and 2 (R1354H) regions of the FKS1 gene, respectively. The anidulafungin, micafungin and nikkomycin Z MIC ranges were 0.015-4, 0.03-4 and 2->16 mg/L, respectively. Anidulafungin and micafungin alone exerted weak fungistatic activity against wild-type isolates and the isolate with a mutation in the hot-spot 2 region of FKS1 but was ineffective against the isolates with a mutation in the hot-spot 1 region. The nikkomycin Z killing curves were always similar to their respective controls. Twenty-two of sixty (36.7%) anidulafungin plus nikkomycin Z and twenty-four of sixty (40%) micafungin plus nikkomycin Z combinations produced at least 100-fold decreases in the CFUs (synergy), with a 41.7% and 20% fungicidal effect, respectively, against wild-type isolates. Antagonism was never observed. Similar results were found with the isolate with a mutation in hot-spot 2 of FKS1, but the combinations were ineffective against the two isolates with prominent mutations in hot-spot 1 of FKS1. The simultaneous inhibition of β-1,3 glucan and chitin synthases in wild-type C. auris isolates produced significantly greater killing rates than either drug alone. Further studies are warranted to verify the clinical efficacy of echinocandin plus nikkomycin Z combinations against echinocandin susceptible C. auris isolates.},
	year = {2023},
	eissn = {1999-4923},
	pages = {1365},
	orcid-numbers = {Borman, Andrew M./0000-0003-0585-5721; Kovács, Renátó/0000-0003-3946-2424}
}

@article{MTMT:33742959,
	title = {Recent Options and Techniques to Assess Improved Bioavailability: In Vitro and Ex Vivo Methods},
	url = {https://m2.mtmt.hu/api/publication/33742959},
	author = {Józsa, Liza and Nemes, Dániel and Pető, Ágota and Kósa, Dóra and Révész, Réka and Bácskay, Ildikó and Haimhoffer, Ádám and Vasvári, Gábor},
	doi = {10.3390/pharmaceutics15041146},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {33742959},
	issn = {1999-4923},
	abstract = {Bioavailability assessment in the development phase of a drug product is vital to reveal the disadvantageous properties of the substance and the possible technological interventions. However, in vivo pharmacokinetic studies provide strong evidence for drug approval applications. Human and animal studies must be designed on the basis of preliminary biorelevant experiments in vitro and ex vivo. In this article, the authors have reviewed the recent methods and techniques from the last decade that are in use for assessing the bioavailability of drug molecules and the effects of technological modifications and drug delivery systems. Four main administration routes were selected: oral, transdermal, ocular, and nasal or inhalation. Three levels of methodologies were screened for each category: in vitro techniques with artificial membranes; cell culture, including monocultures and co-cultures; and finally, experiments where tissue or organ samples were used. Reproducibility, predictability, and level of acceptance by the regulatory organizations are summarized for the readers.},
	year = {2023},
	eissn = {1999-4923},
	pages = {1-25},
	orcid-numbers = {Nemes, Dániel/0000-0002-5477-0540; Révész, Réka/0009-0000-6686-3771}
}