TY - JOUR AU - Fehér, Zsuzsanna AU - Németh, Réka AU - Kiss, Johanna AU - Balterer, Bence AU - Verebélyi, Klára AU - Iván, Béla AU - Kupai, József TI - A silica-supported organocatalyst for polycarbonate methanolysis under mild and economic conditions JF - CHEMICAL ENGINEERING JOURNAL J2 - CHEM ENG J VL - 485 PY - 2024 PG - 12 SN - 1385-8947 DO - 10.1016/j.cej.2024.149832 UR - https://m2.mtmt.hu/api/publication/34679053 ID - 34679053 N1 - Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., Budapest, H-1111, Hungary NMR Research Laboratory, Centre for Structural Science, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok krt. 2., Budapest, H-1117, Hungary Polymer Chemistry and Physics Research Group, Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok krt. 2., Budapest, H-1117, Hungary Export Date: 18 March 2024 CODEN: CMEJA Correspondence Address: Kupai, J.; Department of Organic Chemistry and Technology, Műegyetem rkp. 3., Hungary; email: kupai.jozsef@vbk.bme.hu Funding details: ÚNKP-22-2-II-BME-161 Funding details: European Commission, EC Funding details: Richter Gedeon Talentum Alapítvány Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, 1-21-2022-00015, RRF-2.3 Funding details: National Research, Development and Innovation Office, FK138037 Funding text 1: The authors are grateful to Balázs Orbán for recording the SEM images of the modified silica gels. This research was funded by the National Research, Development, and Innovation Office (grant number FK138037) and the Richter Gedeon Excellence PhD Scholarship of the Richter Gedeon Talentum Foundation, Gedeon Richter Plc. (Z.F.). Further support was provided by the ÚNKP-22-2-II-BME-161 New National Excellence Program of the Ministry for Culture and Innovation sourced from the National Research, Development and Innovation Fund . Project no. RRF-2.3. 1-21-2022-00015 has been implemented with the support provided by the European Union . LA - English DB - MTMT ER - TY - JOUR AU - Csomos, Attila AU - Kovács, Ervin AU - Madarász, Miklós AU - Fedor, Flóra Zsófia AU - Fülöp, Anna AU - Katona, Gergely AU - Rózsa J., Balázs AU - Mucsi, Zoltán TI - Two-Photon Fluorescent Chemosensors Based on the GFP-Chromophore for the Detection of Zn2+ in Biological Samples – From Design to Application JF - SENSORS AND ACTUATORS B-CHEMICAL J2 - SENSOR ACTUAT B CHEM VL - 398 PY - 2024 PG - 14 SN - 0925-4005 DO - 10.1016/j.snb.2023.134753 UR - https://m2.mtmt.hu/api/publication/34191513 ID - 34191513 N1 - Department of Chemistry, Femtonics Ltd, Tűzoltó utca 59, Budapest, H-1094, Hungary Hevesy György PhD School of Chemistry, Eötvös Loránd University, Pázmány Péter sétány 1/A, Budapest, H-1117, Hungary Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok körútja 2, Budapest, H-1117, Hungary BrainVisionCenter, Liliom utca 43, Budapest, H-1094, Hungary Two-Photon Measurement Technology Research Group, The Faculty of Information Technology, Pázmány Péter Catholic University, Práter utca 50/a, Budapest, H-1083, Hungary Laboratory of 3D Functional Network and Dendritic Imaging, HUN-REN Institute of Experimental Medicine, Budapest, H-1083, Hungary Faculty of Materials and Chemical Sciences, University of Miskolc, Miskolc, H-3515, Hungary Cited By :1 Export Date: 12 February 2024 CODEN: SABCE Correspondence Address: Kovács, E.; Institute of Materials and Environmental Chemistry, Magyar Tudósok körútja 2, Hungary; email: kovacs.ervin@ttk.hu Funding details: Magyar Tudományos Akadémia, MTA Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, BO/799/21/7, ÚNKP-22-ME3 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, KDP-2021 Funding text 1: This work was supported by the KDP-2021 program of the Ministry of Innovation and Technology from the Source of the National Research, Development and Innovation Fund (NKFIH). Zoltán Mucsi is grateful for Bolyai János Research Scholarship (BO/799/21/7, ÚNKP-22-ME3) provided by Hungarian Academy of Sciences and the National Research, Development and Innovation Fund. Funding text 2: The research was supported by the 2018–1.3.1-VKE-2018–00032, TKP2021-EGA-42, -NVA-14, 2020–1.1.5-GYORSÍTÓSÁV-2021–00004 and KFI-18–2018-00097 grants. Project no. 2020–2.1.1.-ED-2022–00208 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund., This work was supported by the KDP-2021 program of the Ministry of Innovation and Technology from the Source of the National Research, Development and Innovation Fund (NKFIH). Zoltán Mucsi is grateful for Bolyai János Research Scholarship (BO/799/21/7, ÚNKP-22-ME3) provided by Hungarian Academy of Sciences and the National Research, Development and Innovation Fund. We are grateful for the possibility to use ELKH Cloud [74] which helped us achieve the results published in this paper. We are grateful to the Nikon Center of Excellence (Nikon-KOKI Imaging Center of the Institute of Experimental Medicine, Budapest) for providing us the Stochastic Optica Reconstruction Microscopy (STORM) system and to Dr. Pál Vági for kindly providing microscopy support. The authors also acknowledge Dr. Áron Szepesi, Anett Matuscsák and Dr. Tamás Visnovitz for their assistance in microscopy. We are deeply grateful to Dr. Michael C. Owen and Dr. Levente Cseri for their helpful discussions. Dr. Tamás Gáti, Dr. Dóra Bogdán, Dr. Gábor Turczel, Dr. Csaba Váradi, Arnold Steckel and Dr. Gitta Schlosser are acknowledged for their generous help in NMR and MS analysis. BR and GK are founders of Femtonics and members of its scientific advisory board. The other authors declare that no conflict of interest exists. Preparation of acute brain slices: all procedures were in accordance with the Hungarian Act of Animal Care and Experimentation (2013, (II.14), section 40/2013). Funding text 3: The research was supported by the 2018–1.3.1-VKE-2018–00032 , TKP2021-EGA-42 , -NVA-14 , 2020–1.1.5-GYORSÍTÓSÁV-2021–00004 and KFI-18–2018-00097 grants. Project no. 2020–2.1.1.-ED-2022–00208 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund . LA - English DB - MTMT ER - TY - JOUR AU - Szepesi Kovács, Dénes AU - Kontra, Bence AU - Chiovini, Balázs AU - Müller, Dalma AU - Tóth, Estilla Zsófia AU - Ábrányi-Balogh, Péter AU - Wittner, Lucia AU - Várady, György AU - Turczel, Gábor AU - Farkas, Ödön AU - Owen, Michael Christopher AU - Katona, Gergely AU - Győrffy, Balázs AU - Keserű, György Miklós AU - Mucsi, Zoltán AU - Rózsa J., Balázs AU - Kovács, Ervin TI - Effective Synthesis, Development and Application of a Highly Fluorescent Cyanine Dye for Antibody Conjugation and Microscopy Imaging JF - ORGANIC & BIOMOLECULAR CHEMISTRY J2 - ORG BIOMOL CHEM VL - 21 PY - 2023 IS - 44 SP - 8829 EP - 8836 PG - 8 SN - 1477-0520 DO - 10.1039/D3OB01471A UR - https://m2.mtmt.hu/api/publication/34205650 ID - 34205650 AB - An asymmetric cyanine-type fluorescent dye was designed and synthesized via a versatile, multi-step process, aiming to conjugate with an Her2+ receptor specific antibody by an azide-alkyne click reaction. The aromaticity and the excitation and relaxation energetics of the fluorophore were characterized by computational methods. The synthesized dye exhibited excellent fluorescence properties for confocal microscopy, offering efficient applicability in in vitro imaging due to its merits such as a high molar absorption coefficient (36 816 M-1 cm-1), excellent brightness, optimal wavelength (627 nm), larger Stokes shift (26 nm) and appropriate photostability compared to cyanines. The conjugated cyanine-trastuzumab was constructed via an effective, metal-free, strain-promoted azide-alkyne click reaction leading to a regulated number of dyes being conjugated. This novel cyanine-labelled antibody was successfully applied for in vitro confocal imaging and flow cytometry of Her2+ tumor cells. An azido cyanine dye was synthesized and characterized by computational and experimental techniques and applied in tumor cell imaging. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Ervin AU - Szepesi Kovács, Dénes AU - Mucsi, Zoltán TI - Láthatóvá tenni a ráksejteket. Új festék a mikroszkópos tumordiagnosztikábanLáthatóvá tenni a ráksejteket/ Új festék a mikroszkópos tumordiagnosztikában JF - TERMÉSZET VILÁGA J2 - TERMÉSZET VILÁGA VL - 154 PY - 2023 IS - 6 SP - 259 EP - 263 PG - 5 SN - 0040-3717 UR - https://m2.mtmt.hu/api/publication/34016504 ID - 34016504 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szepesi Kovács, Dénes AU - Chiovini, Balázs AU - Müller, Dalma AU - Tóth, Estilla Zsófia AU - Fülöp, Anna AU - Ábrányi-Balogh, Péter AU - Wittner, Lucia AU - Várady, György AU - Farkas, Ödön AU - Turczel, Gábor AU - Katona, Gergely AU - Győrffy, Balázs AU - Keserű, György Miklós AU - Mucsi, Zoltán AU - Rózsa J., Balázs AU - Kovács, Ervin TI - Synthesis and Application of Two-Photon Active Fluorescent Rhodol Dyes for Antibody Conjugation and In Vitro Cell Imaging JF - ACS OMEGA J2 - ACS OMEGA VL - 8 PY - 2023 IS - 25 SP - 22836 EP - 22843 PG - 8 SN - 2470-1343 DO - 10.1021/acsomega.3c01796 UR - https://m2.mtmt.hu/api/publication/34015800 ID - 34015800 LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Ervin AU - Mucsi, Zoltán TI - Csizmadia Imre Gyulára emlékezve JF - MAGYAR KÉMIKUSOK LAPJA J2 - MAGY KEM LAP VL - 78 PY - 2023 IS - 1 SP - 30 EP - 31 PG - 2 SN - 0025-0163 UR - https://m2.mtmt.hu/api/publication/33700517 ID - 33700517 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kovács, Ervin AU - Mucsi, Zoltán TI - A szerves kémia digitalizációjának úttörője – Megemlékezés Csizmadia Imre Gyula professzorról JF - TERMÉSZET VILÁGA J2 - TERMÉSZET VILÁGA VL - 154 PY - 2023 IS - 3 SP - 102 EP - 107 PG - 6 SN - 0040-3717 UR - https://m2.mtmt.hu/api/publication/33700427 ID - 33700427 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Verebélyi, Klára AU - Szabó, Ákos AU - Réti, Zsombor AU - Szarka, Györgyi Éva AU - Villányi, Ákos AU - Iván, Béla TI - Highly Efficient Cationic Polymerization of β-Pinene, a Bio-Based, Renewable Olefin, with TiCl4 Catalyst from Cryogenic to Energy-Saving Room Temperature Conditions JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 6 PG - 17 SN - 1661-6596 DO - 10.3390/ijms24065170 UR - https://m2.mtmt.hu/api/publication/33687683 ID - 33687683 N1 - Export Date: 3 May 2023 Correspondence Address: Verebélyi, K.; Polymer Chemistry and Physics Research Group, Magyar Tudósok Krt 2, Hungary; email: verebelyi.klara@ttk.hu Correspondence Address: Iván, B.; Polymer Chemistry and Physics Research Group, Magyar Tudósok Krt 2, Hungary; email: ivan.bela@ttk.hu AB - Polymers based on renewable monomers are projected to have a significant role in the sustainable economy, even in the near future. Undoubtedly, the cationically polymerizable β-pinene, available in considerable quantities, is one of the most promising bio-based monomers for such purposes. In the course of our systematic investigations related to the catalytic activity of TiCl4 on the cationic polymerization of this natural olefin, it was found that the 2-chloro-2,4,4-trimethylpentane (TMPCl)/TiCl4/N,N,N′,N′-tetramethylethylenediamine (TMEDA) initiating system induced efficient polymerization in dichloromethane (DCM)/hexane (Hx) mixture at both −78 °C and room temperature. At −78 °C, 100% monomer conversion was observed within 40 min, resulting in poly(β-pinene) with relatively high Mn (5500 g/mol). The molecular weight distributions (MWD) were uniformly shifted towards higher molecular weights (MW) in these polymerizations as long as monomer was present in the reaction mixture. However, chain–chain coupling took place after reaching 100% conversion, i.e., under monomer-starved conditions, resulting in considerable molecular weight increase and MWD broadening at −78 °C. At room temperature, the polymerization rate was lower, but chain coupling did not occur. The addition of a second feed of monomer in the polymerization system led to increasing conversion and polymers with higher MWs at both temperatures. 1H NMR spectra of the formed polymers indicated high in-chain double-bond contents. To overcome the polarity decrease by raising the temperature, polymerizations were also carried out in pure DCM at room temperature and at −20 °C. In both cases, rapid polymerization occurred with nearly quantitative yields, leading to poly(β-pinene)s with Mns in the range of 2000 g/mol. Strikingly, polymerization by TiCl4 alone, i.e., without any additive, also occurred with near complete conversion at room temperature within a few minutes, attributed to initiation by adventitious protic impurities. These results convincingly prove that highly efficient carbocationic polymerization of the renewable β-pinene can be accomplished with TiCl4 as catalyst under both cryogenic conditions, applied widely for carbocationic polymerizations, and the environmentally benign, energy-saving room temperature, i.e., without any additive and cooling or heating. These findings enable TiCl4-catalyzed eco-friendly manufacturing of poly(β-pinene)s, which can be utilized in various applications, and in addition, subsequent derivatizations could result in a range of high-added-value products. LA - English DB - MTMT ER - TY - JOUR AU - Ovc-Okene , Derek AU - Angamuthu, Gnanavel AU - Szabó, Ákos AU - Szarka, Györgyi Éva AU - Iván, Béla AU - Kun, Róbert TI - Investigation of poly(3,6-dioxa-1,8-octane-dithiol)-based organosulfur polymer as the positive electrode material in rechargeable Li-S battery JF - JOURNAL OF ELECTROANALYTICAL CHEMISTRY J2 - J ELECTROANAL CHEM VL - 929 PY - 2023 PG - 8 SN - 1572-6657 DO - 10.1016/j.jelechem.2022.117113 UR - https://m2.mtmt.hu/api/publication/33674915 ID - 33674915 LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Ervin AU - Balterer, Bence AU - Nguyen, Duc AU - Szarka, Györgyi Éva AU - Owen, Michael Christopher AU - Domján, Attila AU - Iván, Béla TI - Ring-Opening Metathesis Polymerization and Related Olefin Metathesis Reactions in Benzotrifluoride as an Environmentally Advantageous Medium JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 1 PG - 12 SN - 1661-6596 DO - 10.3390/ijms24010671 UR - https://m2.mtmt.hu/api/publication/33532503 ID - 33532503 AB - A tremendous number of solvents, either as liquids or vapors, contaminate the environment on a daily basis worldwide. Olefin metathesis, which has been widely used as high-yielding protocols for ring-opening metathesis polymerization (ROMP), ring-closing metathesis (RCM), and isomerization reactions, is typically performed in toxic and volatile solvents such as dichloromethane. In this study, the results of our systematic experiments with the Grubbs G1, G2, and Hoveyda-Grubbs HG2 catalysts proved that benzotrifluoride (BTF) can replace dichloromethane (DCM) in these reactions, providing high yields and similar or even higher reaction rates in certain cases. The ROMP of norbornene resulted not only in high yields but also in polynorbornenes with a high molecular weight at low catalyst loadings. Ring-closing metathesis (RCM) experiments proved that, with the exception of the G1 catalyst, RCM occurs with similar high efficiencies in BTF as in DCM. It was found that isomerization of (Z)-but-2-ene-1,4-diyl diacetate with the G2 and HG2 catalysts proceeds at significantly higher initial rates in BTF than in DCM, leading to rapid isomerization with high yields in a short time. Overall, BTF is a suitable solvent for olefin metathesis, such as polymer syntheses by ROMP and the ring-closing and isomerization reactions. LA - English DB - MTMT ER -