@article{MTMT:34569163, title = {A generic approach based on long-lifetime fluorophores for the assessment of protein binding to polymer nanoparticles by fluorescence anisotropy}, url = {https://m2.mtmt.hu/api/publication/34569163}, author = {Ahmed, Marwa and Hessz, Dóra and Gyarmati, Benjámin Sándor and Pancsics, Mirko and Kovács, Norbert and Gyurcsányi, Ervin Róbert and Kubinyi, Miklós and Horváth, Viola}, doi = {10.1039/d3nr02460a}, journal-iso = {NANOSCALE}, journal = {NANOSCALE}, volume = {16}, unique-id = {34569163}, issn = {2040-3364}, abstract = {Quantitation of protein-nanoparticle interactions is essential for the investigation of the protein corona around NPs in vivo and when using synthetic polymer nanoparticles as affinity reagents for selective protein recognition in vitro. Here, a method based on steady-state fluorescence anisotropy measurement is presented as a novel, separation-free tool for the assessment of protein-nanoparticle interactions. For this purpose, a long-lifetime luminescent Ru-complex is used for protein labelling, which exhibits low anisotropy when conjugated to the protein but displays high anisotropy when the proteins are bound to the much larger polymer nanoparticles. As a proof of concept, the interaction of lysozyme with poly(N-isopropylacrylamide-co-N-tert-butylacrylamide-co-acrylic acid) nanoparticles is studied, and fluorescence anisotropy measurements are used to establish the binding kinetics, binding isotherm and a competitive binding assay. Using long-lifetime fluorophores as protein labels, protein-nanoparticle interactions can be monitored through anisotropy change. Besides gaining thermodynamic and kinetic information on the binding process, competitive protein assays can be set up.}, keywords = {SILICA; AFFINITY; POLARIZATION; ADSORPTION; GOLD NANOPARTICLES; lysozyme; Materials Science, Multidisciplinary; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; EVALUATE; CORONA FORMATION}, year = {2024}, eissn = {2040-3372}, pages = {3659-3667}, orcid-numbers = {Hessz, Dóra/0000-0003-3033-2762; Kovács, Norbert/0000-0003-0753-0146; Gyurcsányi, Ervin Róbert/0000-0002-9929-7865; Horváth, Viola/0000-0003-1014-7930} } @article{MTMT:34133474, title = {d-Idose-Based Monoaza-15-Crown-5 Lariat Ethers: Synthesis of an Elusive d-Hexose and Application of Derived Macrocycles in Enantioselective Syntheses}, url = {https://m2.mtmt.hu/api/publication/34133474}, author = {Orbán, István and Ujj, Dóra Viktória and Mátravölgyi, Béla and Holczbauer, Tamás and Rapi, Zsolt}, doi = {10.3390/sym15091714}, journal-iso = {SYMMETRY-BASEL}, journal = {SYMMETRY (BASEL)}, volume = {15}, unique-id = {34133474}, abstract = {Carbohydrate-based macrocycles can be enantioselective catalysts in certain reactions. Previously, it was proven that the carbohydrate moiety could affect the catalytic activity of the monoaza-15-crown-5 type macrocycles derived from sugars. According to our experiments so far, the most effective enantioselective catalysts were the d-glucose- and the d-galactose-based crown ethers. To obtain more information about the effect of the carbohydrate unit, a rare monosaccharide, d-idose was incorporated into the monoaza-15-crown-5 structure. The key intermediates were methyl 4,6-O-benzylidene-α-d-idopyranoside and methyl 4,6-O-benzylidene-β-d-idopyranoside, which were synthesized from d-galactose. The efficiency of the idopyranoside-based crown compounds synthesized was investigated in asymmetric phase transfer reactions. In liquid-liquid biphasic reactions the highest enantioselectivity was 81% ee, while in solid-liquid phase systems the highest asymmetric induction was 67% ee. It was observed that the enantiodiscrimination was strongly dependent on the configuration of the anomeric center, on the side arm of the nitrogen, and on the structure of the substrate.}, year = {2023}, eissn = {2073-8994}, orcid-numbers = {Ujj, Dóra Viktória/0000-0003-0724-9346; Mátravölgyi, Béla/0000-0001-8782-7972; Rapi, Zsolt/0000-0002-6035-5482} } @article{MTMT:34096300, title = {A Study of the Bisphosphonic Derivatives from the Pudovik Reaction of Dialkyl α-Oxophosphonates and >P(O)H Reagents: X-ray Structure and Bioactivity}, url = {https://m2.mtmt.hu/api/publication/34096300}, author = {Szalai, Zsuzsanna and Tóth, Boldizsár and Szabó, Rita (Oláhné) and Bősze, Szilvia and Karaghiosoff, Konstantin and Czugler, Mátyás and Drahos, László and Keglevich, György}, doi = {10.3390/molecules28166037}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {28}, unique-id = {34096300}, issn = {1420-3049}, abstract = {New hydroxy-methylenebisphosphonic derivatives were prepared with different P-functions. The outcome of the reaction of α-oxophosphonates (YC(O)P(O)(OR)2) and dialkyl phosphites or diarylphosphine oxides depended on the Y substituent of the oxo-compound, the nature of the P-reagent and the amount of the diethylamine catalyst. Starting from dimethyl α-oxoethylphosphonate, in the presence of 5% of diethylamine, the corresponding Pudovik adduct was the single product. While using 40% of the catalyst, the rearranged species with the >P(O)–O–CH–P(O)< skeleton was the exclusive component. A similar reaction of α-oxobenzylphosphonate followed the rearrangement protocol. X-ray crystallography revealed not only the spatial structures of the three products, but also an intricate pattern evolving from the interplay of slight chemical differences, solvent inclusion and disorder as well as H-bridge patterns, which invite further investigation. In vitro activity of the compounds was assessed on different tumor cell cultures using end-point-type cell tetrazolium-based measurements. These structure–activity studies revealed a cytostatic effect for four rearranged derivatives containing aromatic units. One of them had a pronounced effect on MDA-MB 231 and Ebc-1 cells, showing IC50 = 37.8 and 25.9 µM, respectively.}, year = {2023}, eissn = {1420-3049}, orcid-numbers = {Bősze, Szilvia/0000-0001-9555-699X; Karaghiosoff, Konstantin/0000-0002-8855-730X; Drahos, László/0000-0001-9589-6652} } @article{MTMT:33861620, title = {The Possible Connection of Ferroptosis and the JNK Pathway}, url = {https://m2.mtmt.hu/api/publication/33861620}, author = {Varga, Dóra and Hajdinák, Péter and Makk-Merczel, Kinga and Szarka, András}, doi = {10.1016/j.freeradbiomed.2023.03.127}, journal-iso = {FREE RADICAL BIO MED}, journal = {FREE RADICAL BIOLOGY AND MEDICINE}, volume = {201}, unique-id = {33861620}, issn = {0891-5849}, year = {2023}, eissn = {1873-4596}, pages = {30}, orcid-numbers = {Hajdinák, Péter/0000-0002-7705-2074} } @article{MTMT:33861592, title = {ROS based synergetic anticancer effect of pharmacologic ascorbate and chloroquine derivatives}, url = {https://m2.mtmt.hu/api/publication/33861592}, author = {Makk-Merczel, Kinga Szilvia and Szarka, András and Varga, Dóra and Hajdinák, Péter}, doi = {10.1016/j.freeradbiomed.2023.03.131}, journal-iso = {FREE RADICAL BIO MED}, journal = {FREE RADICAL BIOLOGY AND MEDICINE}, volume = {201}, unique-id = {33861592}, issn = {0891-5849}, year = {2023}, eissn = {1873-4596}, pages = {31-32}, orcid-numbers = {Szarka, András/0000-0001-6594-254X; Hajdinák, Péter/0000-0002-7705-2074} } @inproceedings{MTMT:34603561, title = {Cink-oxid és titán-dioxid nanorészecskék hatása a Pseudomonas aeruginosa baktérium életjelenségeire}, url = {https://m2.mtmt.hu/api/publication/34603561}, author = {Németh, Imre and Szikszai, Sára and Molnár, Mónika}, booktitle = {TIZENKILENC ÉVE AZ EURÓPAI MAGYARORSZÁG TUDOMÁNYOS MEGÚJULÁSA ÉS A FIATAL KUTATÓK SZOLGÁLATÁBAN : A PEME XXIII. PhD – Konferenciájának előadásai (Budapest, 2022. április 28.)}, unique-id = {34603561}, year = {2022}, pages = {104-113}, orcid-numbers = {Németh, Imre/0000-0003-2412-1184; Molnár, Mónika/0000-0001-5296-7924} } @{MTMT:33758572, title = {The Behavior of Not Only Structurally Similar Molecules in the Resolution Processes}, url = {https://m2.mtmt.hu/api/publication/33758572}, author = {Pálovics, Emese Csilla and Bánhegyi, Dorottya Fruzsina}, booktitle = {Reference Module in Chemistry, Molecular Sciences and Chemical Engineering}, doi = {10.1016/B978-0-32-390644-9.00009-3}, unique-id = {33758572}, year = {2022}, orcid-numbers = {Bánhegyi, Dorottya Fruzsina/0000-0003-2438-8567} } @misc{MTMT:33627140, title = {Improving the conditions of human utilization of oat and rye in terms of processing technology and nutritional value}, url = {https://m2.mtmt.hu/api/publication/33627140}, author = {Jaksics, Edina and Farkas, Alexandra and Németh, Renáta and Schall, Eszter and Szentmiklóssy, Marietta and Zsuzsanna, Kormosné Bugyi and Muskovics, Gabriella and Tömösközi, Sándor}, unique-id = {33627140}, year = {2022}, orcid-numbers = {Jaksics, Edina/0000-0001-6128-2302; Farkas, Alexandra/0000-0003-4118-1760; Németh, Renáta/0000-0003-3064-5056; Schall, Eszter/0000-0003-1660-8195; Szentmiklóssy, Marietta/0000-0002-1306-3444} } @misc{MTMT:33627085, title = {Rozsfajták és új malomipari frakcióik összetételi és technológiai tulajdonságainak jellemzése}, url = {https://m2.mtmt.hu/api/publication/33627085}, author = {Jaksics, Edina and Horváth, Réka and Drozdik, Álmos Attila and Csányi, Brigitta Viktória and Farkas, Alexandra and Németh, Renáta and Tömösközi, Sándor}, unique-id = {33627085}, year = {2022}, orcid-numbers = {Jaksics, Edina/0000-0001-6128-2302; Farkas, Alexandra/0000-0003-4118-1760; Németh, Renáta/0000-0003-3064-5056} } @misc{MTMT:33627077, title = {A búza és egyéb gabonák funkcionális tulajdonságainak jellemzése, valamint a reológiai tulajdonságok és a beltartalmi összetétel között kapcsolat feltérképezése}, url = {https://m2.mtmt.hu/api/publication/33627077}, author = {Jaksics, Edina and Tömösközi, Sándor}, unique-id = {33627077}, year = {2022}, orcid-numbers = {Jaksics, Edina/0000-0001-6128-2302} }