@article{MTMT:34486045, title = {Follicular Fluid Proteomic Analysis of Women Undergoing Assisted Reproduction Suggests That Apolipoprotein A1 Is a Potential Fertility Marker}, url = {https://m2.mtmt.hu/api/publication/34486045}, author = {Kurdi, Csilla and Schmidt, János and Horváth-Szalai, Zoltán and Mauchart, Péter and Gödöny, Krisztina and Várnagy, Ákos and Kovács, L. Gábor and Kőszegi, Tamás}, doi = {10.3390/ijms25010486}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {34486045}, issn = {1661-6596}, abstract = {Infertility affects millions worldwide, posing a significant global health challenge. The proteomic analysis of follicular fluid provides a comprehensive view of the complex molecular landscape within ovarian follicles, offering valuable information on the factors influencing oocyte development and on the overall reproductive health. The follicular fluid is derived from the plasma and contains various proteins that can have different roles in oocyte health and infertility, and this fluid is a critical microenvironment for the developing oocytes as well. Using the high-performance liquid chromatography-mass spectrometry method, we investigated the protein composition of the follicular fluid, and after classification, we carried out relative quantification of the identified proteins in the pregnant (P) and non-pregnant (NP) groups. Based on the protein–protein interaction analysis, albumin and apolipoprotein A1 (ApoA1) were found to be hub proteins, and the quantitative comparison of the P and NP groups resulted in a significantly lower concentration of ApoA1 and high-density lipoprotein cholesterol in the P group. As both molecules are involved in the cholesterol transport, we also investigated their role in the development of oocytes and in the prediction of fertility.}, keywords = {PREDICTIVE VALUE; Mass spectrometry; follicular fluid; proteomics; apolipoprotein A1; HDL CHOLESTEROL; assisted reproductive treatment}, year = {2024}, eissn = {1422-0067}, orcid-numbers = {Kovács, L. Gábor/0000-0001-5298-5401} } @CONFERENCE{MTMT:34788081, title = {Baseline survey of pastoralist pregnant mothers who attended integrated maternal mobile outreach in Moyale Sub-County, Kenya}, url = {https://m2.mtmt.hu/api/publication/34788081}, author = {Galgalo, Dahabo and Prémusz, Viktória and Várnagy, Ákos and Ibrahim, Kontoma and Annamaria, Pakai and József, Bódis and Kálmán, András Kovács}, booktitle = {MedPECS - Medical Conference for PhD Students and Experts of Clinical Science}, unique-id = {34788081}, year = {2023}, pages = {12}, orcid-numbers = {Galgalo, Dahabo/0000-0002-9508-7182; Prémusz, Viktória/0000-0002-4059-104X} } @article{MTMT:34215499, title = {Trophoblast immune cell dialogue via extracellular vesicles and non-coding RNA}, url = {https://m2.mtmt.hu/api/publication/34215499}, author = {Gorgey, Eva and Tanics, Timea Judith Csabai and Bognar, Zoltan and Miko, Eva and Szekeres, Júlia}, doi = {10.1016/j.jri.2022.103519}, journal-iso = {J REPROD IMMUNOL}, journal = {JOURNAL OF REPRODUCTIVE IMMUNOLOGY}, volume = {158}, unique-id = {34215499}, issn = {0165-0378}, keywords = {immunology}, year = {2023}, eissn = {1872-7603} } @article{MTMT:34214976, title = {The effect of Calcitriol on the development and implantation capacity of embryos from hyper-stimulated mice}, url = {https://m2.mtmt.hu/api/publication/34214976}, author = {Bognar, Zoltan and Csabai-Tanics, Timea J. and Gorgey, Eva and Miko, Eva and Szekeres, Júlia}, doi = {10.1016/j.jri.2023.104060}, journal-iso = {J REPROD IMMUNOL}, journal = {JOURNAL OF REPRODUCTIVE IMMUNOLOGY}, volume = {159}, unique-id = {34214976}, issn = {0165-0378}, keywords = {immunology}, year = {2023}, eissn = {1872-7603}, pages = {27-27} } @article{MTMT:34212243, title = {The effect of Calcitriol on oocyte and embryo development mice}, url = {https://m2.mtmt.hu/api/publication/34212243}, author = {Bognar, Zoltan and Csabai-Tanics, Timea Judith and Gorgey, Eva and Szekeres, Júlia}, doi = {10.1016/j.jri.2022.103612}, journal-iso = {J REPROD IMMUNOL}, journal = {JOURNAL OF REPRODUCTIVE IMMUNOLOGY}, volume = {158}, unique-id = {34212243}, issn = {0165-0378}, keywords = {immunology}, year = {2023}, eissn = {1872-7603} } @article{MTMT:34212242, title = {[8h30-50] Foetal-maternal interactions in pregnancy}, url = {https://m2.mtmt.hu/api/publication/34212242}, author = {Szekeres, Júlia and Tanics, Timea Judith Csabai and Gorgey, Eva and Bognar, Zoltan and Mikó, Éva}, doi = {10.1016/j.jri.2022.103517}, journal-iso = {J REPROD IMMUNOL}, journal = {JOURNAL OF REPRODUCTIVE IMMUNOLOGY}, volume = {158}, unique-id = {34212242}, issn = {0165-0378}, keywords = {immunology}, year = {2023}, eissn = {1872-7603} } @article{MTMT:34212237, title = {[9h20-9h30] Immune checkpoint ligands expressed by embryo-derived extracellular vesicles}, url = {https://m2.mtmt.hu/api/publication/34212237}, author = {Gorgey, Eva and Tanics, Timea Judith Csabai and Bognar, Zoltan and Mikó, Éva and Szekeres, Júlia}, doi = {10.1016/j.jri.2022.103520}, journal-iso = {J REPROD IMMUNOL}, journal = {JOURNAL OF REPRODUCTIVE IMMUNOLOGY}, volume = {158}, unique-id = {34212237}, issn = {0165-0378}, keywords = {immunology}, year = {2023}, eissn = {1872-7603} } @article{MTMT:34141302, title = {Association of Outdoor Physical Activity and Sports with Life Satisfaction among Women of Reproductive Age According to a European Representative Sample—A Longitudinal Analysis}, url = {https://m2.mtmt.hu/api/publication/34141302}, author = {Prémusz, Viktória and Makai, Alexandra and Ács, Pongrác and Derkács, Evelin Andrea and Laczkó, Tamás}, doi = {10.3390/ejihpe13090135}, journal-iso = {EUR J INVEST HEALTH PSYCHOL EDUC}, journal = {EUROPEAN JOURNAL OF INVESTIGATION IN HEALTH PSYCHOLOGY AND EDUCATION}, volume = {13}, unique-id = {34141302}, issn = {2174-8144}, year = {2023}, eissn = {2254-9625}, pages = {1859-1879}, orcid-numbers = {Prémusz, Viktória/0000-0002-4059-104X; Makai, Alexandra/0000-0002-1907-120X; Ács, Pongrác/0000-0002-4999-7345} } @article{MTMT:34124223, title = {Long-Term Effects of ART on the Health of the Offspring}, url = {https://m2.mtmt.hu/api/publication/34124223}, author = {Ahmadi, Hamid and Aghebati-Maleki, Leili and Rashidiani, Shima and Csabai-Tanics, Tímea Judith and Nnaemeka, Obodo B. and Szekeres, Júlia}, doi = {10.3390/ijms241713564}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34124223}, issn = {1661-6596}, abstract = {Assisted reproductive technologies (ART) significantly increase the chance of successful pregnancy and live birth in infertile couples. The different procedures for ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and gamete intrafallopian tube transfer (GIFT), are widely used to overcome infertility-related problems. In spite of its inarguable usefulness, concerns about the health consequences of ART-conceived babies have been raised. There are reports about the association of ART with birth defects and health complications, e.g., malignancies, high blood pressure, generalized vascular functional disorders, asthma and metabolic disorders in later life. It has been suggested that hormonal treatment of the mother, and the artificial environment during the manipulation of gametes and embryos may cause genomic and epigenetic alterations and subsequent complications in the health status of ART-conceived babies. In the current study, we aimed to review the possible long-term consequences of different ART procedures on the subsequent health status of ART-conceived offspring, considering the confounding factors that might account for/contribute to the long-term consequences.}, keywords = {STRESS; art; epigenetics; Long-term effects}, year = {2023}, eissn = {1422-0067} } @article{MTMT:34106696, title = {Oxido-Reduction Potential as a Method to Determine Oxidative Stress in Semen Samples}, url = {https://m2.mtmt.hu/api/publication/34106696}, author = {Balló, András and Czétány, Péter and Székvári, Kinga and Márk, László and Henn-Mike, Nóra and Török, Attila and Szántó, Árpád László and Máté, Gábor}, doi = {10.3390/ijms241511981}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34106696}, issn = {1661-6596}, abstract = {There are different estimates for the incidence of infertility. Its occurrence may vary from area to area, but on average, it affects 15% of couples and 10-12% of men worldwide. Many aspects of infertility can be linked to reactive oxygen species (ROS) and the process of oxidative stress (OS). The association between poor semen quality and OS is well known. Unfortunately, there is no accepted protocol for the diagnosis and treatment of OS in andrology. Oxido-reduction potential (ORP) measurement is a new method for determining the ratio between oxidant and antioxidant molecules. Currently, ORP measurement is one of the fastest and most user-friendly methods of andrological OS determination and our goals were to confirm published correlations between ORP values and sperm parameters, examine how sperm concentration influences these results, and investigate whether intracellular ROS formations are also manifested in the ORP values or not after artificial ROS induction. Intracellular ROS formations were induced by menadione (superoxide anion inducer), hydrogen peroxide, and tert-butyl hydroperoxide (lipid peroxidation inducer) treatments; sperm parameters like motility and viability were determined with an SCA Scope system, and ORP changes were recorded by the Mioxsys system. Significant correlations were noticed among the ORP, spermatozoa concentration, motility, progressive motility, and viability. Nevertheless, only the ORP value after normalization with the sperm count correlated with these parameters. Due to normalization, very low and very high sperm concentrations can give misleading results. The means of the non-normalized ORP values were almost the same. All of the applied treatments resulted in decreases in the viability, motility, and progressive motility, and interestingly, altered ORP levels were detected. In addition, it was determined that seminal plasma had a significant protective effect on spermatozoa. The elimination of seminal plasma caused higher sensitivity of spermatozoa against used OS inducers, and higher ORP levels and decreased viabilities and motilities were measured. The ORP level could be a good indicator of male OS; however, in cases of low and high sperm counts, its result can be misleading. Overall, the conclusion can be drawn that ORP determination is a suitable method for detecting intracellular ROS accumulation, but it has limitations that still need to be clarified.}, keywords = {Lipid Peroxidation; hydrogen peroxide; Reactive oxygen species; infertility; TERT-BUTYL HYDROPEROXIDE; menadione; andrology; Oxidative stress; oxido-reduction potential}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Márk, László/0000-0002-9301-8159} }