@article{MTMT:32874378,
	title = {Intelligent design of iron-doped LDH nanosheets for cooperative chemo-chemodynamic therapy of tumors},
	url = {https://m2.mtmt.hu/api/publication/32874378},
	author = {Zhang, Luyao and Li, Gaoming and Ouyang, Zhijun and Yang, Rui and Gao, Yue and Cao, Xueyan and Bányai, István and Shi, Xiangyang and Guo, Rui},
	doi = {10.1039/d2bm00102k},
	journal-iso = {BIOMATER SCI-UK},
	journal = {BIOMATERIALS SCIENCE},
	volume = {10},
	unique-id = {32874378},
	issn = {2047-4830},
	abstract = {Chemodynamic therapy (CDT) has received increasing attention due to its unique tumor microenvironment (TME) responsiveness and minimal adverse side effects, but the therapeutic effect of CDT alone is always limited due to the low Fenton or Fenton-like reaction efficiency at tumor sites. Herein, Fe-doped layered double hydroxide (LDH) nanosheets were synthesized to load the anticancer drug epigallocatechin-3-O-gallate (EGCG) and then conjugated with boronic acid-modified hyaluronic acid for targeted and cooperative chemo-chemodynamic therapy of tumors. The formed LDH-EGCG-HA nanoplatforms could specifically target tumor cells overexpressing CD44 receptors, quickly release iron ions and EGCG in the TME, and efficiently generate toxic hydroxyl radicals with the acceleration of Fe3+/Fe2+ cycling in the Fenton reaction by EGCG. The cooperative cancer cell inhibition effect through chemotherapy and chemodynamic therapy was achieved by the significant upregulation of caspase-3 and p53 expression to induce cell apoptosis, and the deactivation of xCT and GPX-4 to inhibit GSH synthesis and reduce lipid peroxides for reinforced ferroptosis. In vivo experiments further verified that the intelligently designed LDH-EGCG-HA nanoplatforms had a superior biocompatibility with normal organs with an excellent inhibition efficacy towards tumors overexpressing CD44 receptors by targeted chemo-chemodynamic therapy.},
	year = {2022},
	eissn = {2047-4849},
	pages = {2029-2039},
	orcid-numbers = {Li, Gaoming/0000-0002-7278-0777; Cao, Xueyan/0000-0003-4366-8943; Bányai, István/0000-0002-6260-9175}
}

@article{MTMT:3263511,
	title = {Increasing the histidine ‘density’ in tripodal peptides by gradual N-functionalization of tris(2-aminoethyl)amine (tren) with l-histidyl units: The effect on zinc(II) complexes},
	url = {https://m2.mtmt.hu/api/publication/3263511},
	author = {Dancs, Ágnes and Selmeczi, K and Bányai, István and Darula, Zsuzsanna and Gajda, Tamás},
	doi = {10.1016/j.ica.2017.06.049},
	journal-iso = {INORG CHIM ACTA},
	journal = {INORGANICA CHIMICA ACTA},
	volume = {472},
	unique-id = {3263511},
	issn = {0020-1693},
	abstract = {Tripodal peptidomimetics have received increasing interest among others as efficient metal ion chelators. Most of these studies have focused on symmetrical, tri-substituted ligands. Our aim was to establish how the increasing donor group 'density', i.e. the gradual N-histidyl substitution, alters the coordination chemical properties of the tripodal platform. To this end we synthesized mono-, bis- and tris(l-histidyl)-functionalized tren derivatives (L1, L2 and L3, respectively), and studied their zinc(II) complexes by pH potentiometry, 1H NMR and MS spectroscopy. The three ligands provide a variety of donor sites, and consequently different stability and structure for their zinc(II) complexes depending on the pH and metal-to-ligand ratios. In the neutral pH range histamine-like coordination is operating in all cases. Due to the formation of macrochelate between the two/three (Nim,NH2) binding sites, L2 and L3 have considerably higher zinc(II) binding ability than histamine, or any other simple peptide with N-terminal His unit. The situation is fundamentally different at higher pH. The tren-like subunit in L1 acts as an anchoring site for amide deprotonation, and the (3NH2,N-,Ntert) type coordination, a rare example where zinc(II)-amide N- coordination takes place, results in outstanding stability. Although L1 provides tight binding above pH 7, it forms only mononuclear species. However, the increasing level of functionalization in L2 and L3 allows the formation of oligonuclear complexes, and at threefold zinc(II) excess the three ligands share nearly the same amount of zinc(II). Moreover, the high histidine 'density' in L2 and L3 also provides the formation of imidazolato-bridged structures, which has never been observed before in zinc(II) complexes of simple linear peptides. © 2017.},
	year = {2018},
	eissn = {1873-3255},
	pages = {174-183},
	orcid-numbers = {Bányai, István/0000-0002-6260-9175; Gajda, Tamás/0000-0001-5777-315X}
}

@CONFERENCE{MTMT:30643598,
	title = {Growth-phase sterigmatocystin formation on lactose is mediated via low specific growth rates in Aspergillus nidulans.},
	url = {https://m2.mtmt.hu/api/publication/30643598},
	author = {Karaffa, Levente and Németh, Zoltán and Molnár, Ákos Péter and Fejes, Balázs and Novák, Levente and Nancy, P. Keller and Fekete, Erzsébet},
	booktitle = {29th Fungal Genetics Conference},
	unique-id = {30643598},
	abstract = {Seed contamination with polyketide mycotoxins such as aflatoxin (AF) and sterigmatocystin (ST) produced by Aspergillus spp., is an agricultural, economic, and medical issue worldwide. ST is the penultimate intermediate in the biosynthesis of AF, and in several fungi including the model fungus A. nidulans, it is the end product of the AF pathway. This biosynthetic pathway is well-characterized in A. nidulans, but many of the regulatory aspects related to the carbon source available for the fungus are still enigmatic. This is particularly true for the heterodisaccharide lactose (milk sugar; 1,4-O-beta-D-galactopyranosyl-D-glucose), inasmuch as some ST production mutant strains still synthesize ST on lactose but not on other carbon substrates including the customary D-glucose. Here, kinetic data from well-controlled single-carbon substrate submerged fermentations revealed that on D-glucose, ST forms only after the sugar is depleted from the medium, while on lactose, ST appears when the majority of the carbon source is still available. Maximal biomass-specified ST production in lactose medium was significantly higher than on D-glucose. These data suggested that ST formation may either be mediated by a carbon catabolite regulatory mechanism prominent on D-glucose, or induced by low specific growth rates attainable on lactose. These hypotheses were tested by constant-mass chemostat-type continuous fermentations on D-glucose as a sole carbon source at two different dilution rates (D = 0.090 h-1 and D = 0.020 h-1), representing a state of carbon catabolite repression and derepression, respectively. ST production under such conditions negatively correlated with the dilution rate, i.e., no ST formed at high growth rate, while low growth rate led to the formation of 0.4 mg L-1 ST. Essentially identical results were obtained with a CreA mutant strain, indicating that CreA does not regulate the formation of ST during growth on D-glucose. We concluded that low specific growth rates may be the primary cause of sustained, mid-growth ST formation on the slowly assimilating lactose in A. nidulans, and that carbon utilization rates likely play a general regulatory role during biosynthesis.},
	year = {2017},
	pages = {94-94}
}

@article{MTMT:3181940,
	title = {Clustering of carboxylated magnetite nanoparticles through polyethylenimine: Covalent versus electrostatic approach},
	url = {https://m2.mtmt.hu/api/publication/3181940},
	author = {Tóth, Ildikó and Nesztor, Dániel and Novák, Levente and Nyergesné Illés, Erzsébet and Szekeres, Márta and Szabó, Tamás and Csákiné Tombácz, Etelka},
	doi = {10.1016/j.jmmm.2016.11.011},
	journal-iso = {J MAGN MAGN MATER},
	journal = {JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS},
	volume = {427},
	unique-id = {3181940},
	issn = {0304-8853},
	abstract = {Carboxylated magnetite nanoparticles (MNPs) are frequently used to develop materials with enhanced properties for MRI and hyperthermia. The controlled clustering of MNPs via covalent or electrostatic approaches provides opportunity to prepare high quality materials. MNPs were prepared by co-precipitation and coated by poly(acrylic acid-co-maleic acid) (PAM@MNP). The clusters were synthesized from purified PAM@MNPs and polyethylenimine (PEI) solution via electrostatic interaction and covalent bond formation (ES-cluster and CB-cluster, respectively). The electrostatic adhesion (–NH3 + and –COO–) and the formed amide bond were confirmed by ATR-FTIR. The averaged area of CB-clusters was about twice as large as that of ES-cluster, based on TEM. The SAXS results showed that the surface of MNPs was smooth and the nanoparticles were close packed in both clusters. The pH-dependent aggregation state and zeta potential of clusters were characterized by DLS and electrophoresis measurements, the clusters were colloidally stable at pH>5. In hyperthermia experiments, the values of SAR were about two times larger for the chemically bonded cluster. The MRI studies showed exceptionally high transversion relaxivities, the r2 values are 457 mM−1 s−1 and 691 mM−1 s−1 for ES-cluster and CB-cluster, respectively. Based on these results, the chemically clustered product shows greater potential for feasible biomedical applications. © 2016 Elsevier B.V.},
	keywords = {ELECTROPHORESIS; NANOPARTICLES; MRI CONTRAST AGENTS; MRI CONTRAST AGENT; Electrostatics; Polyethylenes; MAGNETITE; Self assembly; Medical applications; Magnetite Nanoparticles; Nanomagnetics; Chemically bonded; Magnetic hyperthermia; Electrostatic self assembly; Electrostatic self-assembly; Chemically bonded cluster; Carboxylated MNPs},
	year = {2017},
	eissn = {1873-4766},
	pages = {280-288},
	orcid-numbers = {Tóth, Ildikó/0000-0002-4937-0526; Nyergesné Illés, Erzsébet/0000-0002-2901-9616; Szabó, Tamás/0000-0001-8182-640X; Csákiné Tombácz, Etelka/0000-0002-2068-0459}
}

@{MTMT:3201180,
	title = {Folyékony fázisú NMR alkalmazása kolloid rendszerek vizsgálatára},
	url = {https://m2.mtmt.hu/api/publication/3201180},
	author = {Kéri, Mónika},
	booktitle = {Az MTA Kolloidkémiai Munkabizottságának 50 éve, 1966-2016},
	unique-id = {3201180},
	year = {2016},
	pages = {146-147},
	orcid-numbers = {Kéri, Mónika/0000-0001-9095-8295}
}

@article{MTMT:3144010,
	title = {Structural characterization of PEGylated polyethylenimine-entrapped gold nanoparticles: an NMR study},
	url = {https://m2.mtmt.hu/api/publication/3144010},
	author = {Zhou, BQ and Shen, MW and Bányai, István and Shi, XY},
	doi = {10.1039/c6an00841k},
	journal-iso = {ANALYST},
	journal = {ANALYST},
	volume = {141},
	unique-id = {3144010},
	issn = {0003-2654},
	abstract = {NMR spectroscopy has been proven to be a useful method to characterize the spatial structure of polymer-protected nanoparticles (NPs). In the present study, polyethylenimine (PEI) partially modified with polyethylene glycol (PEG) was used as a template to form gold NPs (Au NPs) via either sodium borohydride reduction or PEI amine-mediated self-reduction of Au salt. The formed two types of PEGylated PEI-entrapped Au NPs (PEI-mPEG-Au NPs) were characterized by UV-vis spectroscopy and transmission electron microscopy, and their internal structures were characterized using NMR techniques. We show that the formed PEI-mPEG-Au NPs display a significant downfield shift in the proton signals of the innermost PEI methylene rather than the outer PEG methylene when compared to that of PEI-mPEG without Au NP entrapment. This result indicates that a strong interaction exists between the Au NPs and the innermost PEI, suggesting that the Au NPs are entrapped within individual PEI-mPEG instead of being stabilized by the surface PEG chains. In addition, the NMR diffusion coefficients of PEI (or PEG) in the PEI-mPEG-Au NPs are much higher than that of PEI-mPEG (without Au NPs), further demonstrating the effective Au NP entrapment. The present study provides a new physical insight into the internal spatial structure of polymer-protected Au NPs disclosed by NMR techniques, which may be used for structural characterization of other NP/polymer nanocomposites.},
	keywords = {PHARMACOKINETICS; CANCER; SPECTROSCOPY; Chemistry; CITRATE; GENE DELIVERY; BLOOD-POOL; SIRNA DELIVERY; DENDRIMER TEMPLATES; RAY COMPUTED-TOMOGRAPHY},
	year = {2016},
	eissn = {1364-5528},
	pages = {5390-5397},
	orcid-numbers = {Bányai, István/0000-0002-6260-9175}
}

@article{MTMT:3115515,
	title = {Depletion of human serum albumin in embryo culture media for in vitro fertilization using monolithic columns with immobilized antibodies},
	url = {https://m2.mtmt.hu/api/publication/3115515},
	author = {A, Tarasova and Anna, A Lobas and Urh, Cernigoj and Elizaveta, M Solovyeva and Barbara, Mahlberg and Mark, V Ivanov and Tanja, Panic-Jankovic and Nagy, Zoltán and Marina, L Pridatchenko and Pungor, András and Blaz, Nemec and Urska, Vidic and Jernej, Gaspersic and Nika, Lendero Krajnc and Jana, Vidic and Mikhail, V Gorshkov and Goran, Mitulovic},
	doi = {10.1002/elps.201500489},
	journal-iso = {ELECTROPHORESIS},
	journal = {ELECTROPHORESIS},
	volume = {37},
	unique-id = {3115515},
	issn = {0173-0835},
	year = {2016},
	eissn = {1522-2683},
	pages = {2322-2327}
}

@article{MTMT:3097530,
	title = {Mössbauer study of pH dependence of iron-intercalation in montmorillonite},
	url = {https://m2.mtmt.hu/api/publication/3097530},
	author = {Kuzmann, Ernő and Garg, VK and Singh, H and de Oliveira, AC and Pati, SS and Homonnay, Zoltán and Rudolf, M and Molnár, ÁM and Kovács, Eszter Mária and Baranyai, Edina and Kubuki, S and M. Nagy, Noémi and Kónya, József},
	doi = {10.1007/s10751-016-1314-5},
	journal-iso = {HYPERFINE INTERACT},
	journal = {HYPERFINE INTERACTIONS},
	volume = {237},
	unique-id = {3097530},
	issn = {0304-3843},
	abstract = {57Fe Mössbauer spectroscopy and XRD have successfully been applied to show the incorporation of Fe ion into the interlayer space of montmorillonite via treatment with FeCl 3 in acetone. The 78K 57Fe Mössbauer spectra of montmorillonite samples reflected magnetically split spectrum part indicating the intercalation of iron into the interlayer of montmorillonite via the treatment with FeCl 3+acetone and washed with water until the initial pH=2.3 increased to pH=4.14. It was found that the occurrence of intercalated iron in the form of oxide-oxihydroxide in montmorillonite increases with the pH. Intercalation was confirmed by the gradual increase in the basal spacing d001 with pH. © 2016, Springer International Publishing Switzerland.},
	keywords = {pH dependence; Ca-montmorillonite; 57Fe Mössbauer spectroscopy; Interlayer Fe},
	year = {2016},
	eissn = {1572-9540},
	orcid-numbers = {Kuzmann, Ernő/0000-0002-0183-6649; Homonnay, Zoltán/0000-0001-5299-5394; Kovács, Eszter Mária/0000-0002-3117-2521}
}

@article{MTMT:3030404,
	title = {Mössbauer study of the effect of rare earth substitution into montmorillonite},
	url = {https://m2.mtmt.hu/api/publication/3030404},
	author = {Kuzmann, Ernő and Singh, LH and Garg, VK and de Oliveira, AC and Kovács, Eszter Mária and Molnár, ÁM and Homonnay, Zoltán and Kónya, Péter and M. Nagy, Noémi and Kónya, József},
	doi = {10.1007/s10751-016-1225-5},
	journal-iso = {HYPERFINE INTERACT},
	journal = {HYPERFINE INTERACTIONS},
	volume = {237},
	unique-id = {3030404},
	issn = {0304-3843},
	abstract = {Novel montmorillonites were prepared by the exchange of the interlayer cations with a series of rare earth cations (La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, and Er) and characterized by XRD, XRF, SEM, chemical analysis and 57Fe Mössbauer spectroscopy. An unexpected magnetically split component, assigned to iron being in the interlayer space, was observed in the Mössbauer spectra at 78K in some rare earth cation exchanged montmorillonite. This paper is the initial report about this observation. The transition of iron from the octahedral site to the interlayer and possible incorporation of rare earths in sites different from those which are in the interlayer space was concluded. © 2016, Springer International Publishing Switzerland.},
	keywords = {Mössbauer-spectroscopy; Bentonite; Rare earth substitution; Interlayer Fe},
	year = {2016},
	eissn = {1572-9540},
	orcid-numbers = {Kuzmann, Ernő/0000-0002-0183-6649; Kovács, Eszter Mária/0000-0002-3117-2521; Homonnay, Zoltán/0000-0001-5299-5394}
}

@article{MTMT:3002146,
	title = {Ion exchange isotherms in solid: electrolyte solution systems},
	url = {https://m2.mtmt.hu/api/publication/3002146},
	author = {M. Nagy, Noémi and Kovács, Eszter Mária and Kónya, József},
	doi = {10.1007/s10967-015-4536-0},
	journal-iso = {J RADIOANAL NUCL CHEM},
	journal = {JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY},
	volume = {308},
	unique-id = {3002146},
	issn = {0236-5731},
	abstract = {It is shown show that the ion exchange isotherms and the law of mass action are equivalent, the c/a versus c functions can be derived from the law of mass action (c and a: the concentration of ions in ion exchanger and solution, respectively). The equations are applied for cation exchange processes of bentonite clay (cobalt, manganese, mercury ions with calcium-bentonite; strontium ions with sodium-bentonite; cesium ions with lanthanide bentonite; lutetium ion with calcium-bentonite). The linear or non-linear shape of the isotherms does not prove the heterogeneity of the ion exchanger or the interaction among the sorbed cations. © 2015 Akadémiai Kiadó, Budapest, Hungary},
	keywords = {Bentonite; Ion exchange isotherm; Law of mass action; Homovalent exchange; Heterovalent exchange},
	year = {2016},
	eissn = {1588-2780},
	pages = {1017-1026},
	orcid-numbers = {Kovács, Eszter Mária/0000-0002-3117-2521}
}