@article{MTMT:36183982,
	title = {Mathematical Modeling of Taylor-Aris Dispersion-Assisted Mass Spectrometry for the Study of Operating Conditions},
	url = {https://m2.mtmt.hu/api/publication/36183982},
	author = {Szabó, Dávid Ruben and Felinger, Attila and Horváth, Krisztián and Gáspár, Attila},
	doi = {10.1016/j.talanta.2025.128435},
	journal-iso = {TALANTA},
	journal = {TALANTA},
	volume = {296},
	unique-id = {36183982},
	issn = {0039-9140},
	year = {2026},
	eissn = {1873-3573},
	orcid-numbers = {Szabó, Dávid Ruben/0000-0002-8575-5570; Felinger, Attila/0000-0001-7130-1968; Horváth, Krisztián/0000-0003-4927-7919; Gáspár, Attila/0000-0002-0172-2393}
}

@article{MTMT:34722559,
	title = {Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants},
	url = {https://m2.mtmt.hu/api/publication/34722559},
	author = {Tóth, Balázs István and Bazeli, Bahar and Janssens, Annelies and Lisztes, Erika and Racskó, Márk and Kelemen, Balázs and Herczeg, Mihály and Nagy, Tamás Milán and E Kövér, Katalin and Mitra, Argha and Borics, Attila and Bíró, Tamás and Voets, Thomas},
	doi = {10.7554/eLife.97341.2},
	journal-iso = {ELIFE},
	journal = {ELIFE},
	volume = {13},
	unique-id = {34722559},
	abstract = {Rapamycin (sirolimus), a macrolide compound isolated from the bacterium Streptomyces hygroscopicus, is widely used as oral medication for the prevention of transplant rejection and the treatment of lymphangioleiomyomatosis. It is also incorporated in coronary stent coatings to prevent restenosis and in topical preparations for the treatment of skin disorders. Rapamycin’s in vivo activities are generally ascribed to its binding to the protein FKBP12, leading to potent inhibition of the mechanistic target of rapamycin kinase (mTOR) by the FKBP12-rapamycin complex. The specific rapamycin-induced interaction between domains from mTOR and FKBP12 is also frequently employed in cell biological research, for rapid chemically-induced protein dimerization strategies. Here we show that rapamycin activates TRPM8, a cation channel expressed in sensory nerve endings that serves as the primary cold sensor in mammals. Using a combination of electrophysiology, Saturation Transfer Triple-Difference (STTD) NMR spectroscopy and molecular docking-based targeted mutagenesis, we demonstrate that rapamycin directly binds to TRPM8. We identify a rapamycin-binding site in the groove between voltage sensor-like domain and the pore domain, distinct from the interaction sites of cooling agents and known TRPM8 agonists menthol and icilin. Related macrolide immunosuppressants act as partial TRPM8 agonists, competing with rapamycin for the same binding site. These findings identify a novel molecular target for rapamycin and provide new insights into the mechanisms of TRPM8 activation, which may assist in the development of therapies targeting this ion channel. Moreover, our findings also indicate that caution is needed when using molecular approaches based on rapamycin-induced dimerization to study ion channel regulation.},
	keywords = {IDENTIFICATION; ACTIVATION; SENSITIVITY; RAPAMYCIN; LIGAND-BINDING; Cold; Sirolimus; Ion Channel Gating; menthol; REVEALS; TRPM8; TRP ion channels},
	year = {2025},
	eissn = {2050-084X},
	orcid-numbers = {Herczeg, Mihály/0000-0002-7938-9789}
}

@article{MTMT:35708306,
	title = {Taylor-Aris dispersion assisted ESI-MS applied in a simple flow injection system},
	url = {https://m2.mtmt.hu/api/publication/35708306},
	author = {Szabó, Dávid Ruben and Szabo, Peter and Gáspár, Attila},
	doi = {10.1016/j.microc.2025.112785},
	journal-iso = {MICROCHEM J},
	journal = {MICROCHEMICAL JOURNAL},
	volume = {209},
	unique-id = {35708306},
	issn = {0026-265X},
	abstract = {This work demonstrates that the recently introduced TADA-MS method (originally designed in a CE instrument)
		can be applied in a simple, low-pressure flow injection system, which is more widely accessible in an average MS
		analytical laboratory. An essential part of the system is an internal sample chamber micro-scale injector. A
		sample volume of 0.5 μL was mobilized by a syringe pump. The analytical applicability of the proposed system
		was tested by analyzing concanavalin A protein under denaturing and native conditions. The obtained results
		demonstrated that in the proposed low-pressure flow injection TADA-MS system the capillaries of both 50 μm
		and 100 μm i.d., and both the conventional ESI interface and the coaxial sheath-liquid CE-ESI interface can be
		efficiently applied – the obtained MS spectra were similar.},
	year = {2025},
	eissn = {1095-9149}
}

@article{MTMT:35712556,
	title = {Thermal Reverse-Engineered Synthesis and Catalytic Activity of Nanogold-Containing Silica Aerogels},
	url = {https://m2.mtmt.hu/api/publication/35712556},
	author = {Csupász-Szabó, Hanna Judit and Döncző, Boglárka and Szarka, Máté and Daróczi, Lajos and Lázár, István},
	doi = {10.3390/gels11020087},
	journal-iso = {GELS-BASEL},
	journal = {GELS (BASEL)},
	volume = {11},
	unique-id = {35712556},
	abstract = {Silica aerogels are extensively used as catalyst supports due to their mesoporous structure and chemical inertness. In this study, SiO2–AuNP aerogels containing gold nanoparticles (AuNPs) were synthesized using the sol-gel method followed by supercritical CO2 drying. The inclusion of polyvinyl pyrrolidone (PVP) as a stabilizing agent preserved the gold particle sizes during the gelation process. In contrast, aerogels synthesized without PVP contained enlarged AuNP aggregates, resulting in a shift in the plasmon resonance color from red to bluish or blue–grey. Thermal treatment of these bluish-colored aerogels at high temperatures restored their red coloration, visually indicating the breakdown of large gold clusters into individual nanoparticles. Both types of aerogels were characterized using SEM, TEM, 3D optical microscopy, UV–vis and ATR-IR spectroscopy, and N2 porosimetry, with their properties analyzed as a function of annealing temperature. Their catalytic activity was evaluated through the reduction of 4-nitrophenol with sodium borohydride, and both aerogel types demonstrated catalytic activity. This thermal conversion of large clusters into individual nanoparticles within an aerogel matrix introduces a new and promising approach for creating catalytically active nanogold-containing aerogel catalysts.},
	year = {2025},
	eissn = {2310-2861},
	orcid-numbers = {Lázár, István/0000-0001-6006-7782}
}

@misc{MTMT:35718417,
	title = {57. Irinyi János Középiskolai Kémiaverseny, I. forduló - Feladatok és Megoldások, Pontozási Útmutató (2025)},
	url = {https://m2.mtmt.hu/api/publication/35718417},
	author = {Bárány, Zsolt Béla and Dóbéné, Cserjés Edit and Lente, Gábor and Márkus, Teréz and Musza, Katalin and Petri, Judit and Tóth, Imre and Várnagy, Katalin},
	editor = {Ősz, Katalin},
	unique-id = {35718417},
	year = {2025},
	orcid-numbers = {Lente, Gábor/0000-0003-2022-2156; Várnagy, Katalin/0000-0003-0846-4689}
}

@article{MTMT:35729613,
	title = {A comprehensive analysis of the effect of quorum-sensing molecule 3-oxo-C12-homoserine lactone on Candida auris and Candida albicans},
	url = {https://m2.mtmt.hu/api/publication/35729613},
	author = {Kovács, Fruzsina and Jakab, Ágnes and Balla , Noémi and Tóth, Zoltán and Balázsi, Dávid and Forgács, Lajos and Harmath, Andrea and Bozó, Aliz and Ragyák, Ágota and Majoros, László and Kovács, Renátó},
	doi = {10.1016/j.bioflm.2025.100259},
	journal-iso = {Biofilm},
	journal = {BIOFILM},
	volume = {9},
	unique-id = {35729613},
	issn = {2590-2075},
	year = {2025},
	eissn = {2590-2075},
	orcid-numbers = {Kovács, Renátó/0000-0003-3946-2424}
}

@article{MTMT:35767451,
	title = {A New Cu2+-Binding 1,3-Benzodioxole-Contaning N-Acylhydrazone Protects Saccharomyces cerevisiae Cells from Oxidative Stress},
	url = {https://m2.mtmt.hu/api/publication/35767451},
	author = {Barbosa, Barbara Marinho and Pires, Daniele C. and Galvácsi, Antal Tamás and Gaudard, Anna Julia and Flores, Leona S. and Sanchez-Lopez, Carolina and Correa, Charlane C. and Cukierman, Daphne S. and Hureau, Christelle and Kállay, Csilla and Pereira, Marcos D. and Quintanar, Liliana and Rey, Nicolas A.},
	doi = {10.1002/slct.202405195},
	journal-iso = {CHEMISTRYSELECT},
	journal = {CHEMISTRYSELECT},
	volume = {10},
	unique-id = {35767451},
	issn = {2365-6549},
	abstract = {Copper dyshomeostasis is related to an increase in oxidative stress that, in turn, has been associated with a myriad of diseases and physiological aging. Based on this, the study of compounds with moderate affinity for this biometal is of interest. In this scenario, a new, highly stable, and non-toxic (assessed in S. cerevisiae) 1-methylimidazole-containing N-acylhydrazone, HX1Diox, is synthesized and characterized, including by XRD. The compound forms complexes of 1:1 and 1:2 copper(II)-to-ligand stoichiometries in solution, while only the non-charged 1:2 compound, [Cu(X1Diox)2], is isolated in the solid state. In this case, each hydrazone unit is fully deprotonated and coordinates, in the iminolate X1Diox- form, as an N2O- meridional tridentate ligand. The soluble cationic species [Cu(X1Diox)(OH2)x]+ and [Cu(HX1Diox)(X1Diox)]+ are detected solely in solution, and stability constants of 12.49(4) and 28.42(6) are determined, respectively, for each of them. Interestingly, HX1Diox shows promising activity as a scavenger of superoxide radical anions, assessed in vitro, and eukaryotic cells by using wild-type and SOD1-deficient strains of S. cerevisiae yeast. Altogether, these results point to a promising copper interaction profile of HX1Diox, which, coupled with its favorable antioxidant profile, encourages further studies in the context of ROS-related diseases.},
	keywords = {DERIVATIVES; ALZHEIMERS-DISEASE; CYTOTOXICITY; AMYLOID-BETA; COPPER; COPPER; SUPEROXIDE; ZN; CU; Hydrazone; PHARMACOLOGICAL EVALUATION; N-acylhydrazone; Oxidative stress},
	year = {2025},
	eissn = {2365-6549}
}

@article{MTMT:35799281,
	title = {Assessment of anthropogenic activities impact based on metals in soil and tree leaves along roadside in Bangladesh},
	url = {https://m2.mtmt.hu/api/publication/35799281},
	author = {Anwar, Armin and Mezbah Uddin, A. H.M. and Hasan, Md. Siddiq and Parvez, Md Sohel and Sipos, Bianka and Bibi, Dina and Sajtos, Zsófi and Tóthmérész, Béla and Magura, Tibor and Simon, Edina},
	doi = {10.1038/s41598-025-91683-9},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {15},
	unique-id = {35799281},
	abstract = {The assessment of heavy metal pollution in leaves and soils is essential in environmental health monitoring. We assessed the effect of anthropogenic activities along an industrial–urban–rural gradient in the roadside soil and tree leaves of Bangladesh based on their metal concentration. The concentrations of Pb, Cr, Ni, and Cd were analysed in leaves of Ficus benghalensis , Swietenia macrophylla , and Polyalthia longifolia and topsoil samples using ICP-OES. We used pollution indices to quantify the impact of contaminants on ecosystems. Our findings indicated that there were higher metal concentrations, especially Cd and Pb, in soil and leaves in close proximity to locations with substantial traffic and industrial activities. Igeo index indicated moderately to strongly polluted areas by Cd. The contamination factor (CF) for Cd indicated a severe contamination, while moderately contamination show by Cr, Pb, and Ni. The value of the ecological risk factor was below 40 for Cr, Ni, and Pb; thus, negligible ecological risks were considered for these elements. But, the ecological risk assessment indices showed that Cd poses high ecological risks in soil and leaves across all study areas. Bioaccumulation analysis indicated substantial heavy metal absorption in tree foliage, with F. benghalensis and P. longifolia exhibiting elevated Pb accumulation in urban environments. The PCA indicated that Cd, Cr, Ni, and Pb mostly derived from anthropogenic sources in leaves and soil samples, too. Our results demonstrated that F. benghalensis , S. macrophylla , and P. longifolia are good indicator to assess the effect of anthropogenic activities on the terrestrial ecosystem. Our results also indicated the critical need for environmental monitoring and mitigation techniques in urban and industrial zones to reduce heavy metal pollution in roadside ecosystems.},
	year = {2025},
	eissn = {2045-2322},
	orcid-numbers = {Parvez, Md Sohel/0000-0002-9109-7340}
}

@article{MTMT:35805561,
	title = {Evaluation of structurally related acyclic ligands OBETA, EHDTA, and EGTA for stable Mn2+ complex formation},
	url = {https://m2.mtmt.hu/api/publication/35805561},
	author = {Grattoni, Elena and Travagin, Fabio and Kálmán, Ferenc Krisztián and Baranyai, Zsolt and Negri, Roberto and Carniato, Fabio and Giovenzana, Giovanni B. and Platas-Iglesias, Carlos and Botta, Mauro},
	doi = {10.1039/d4dt02761b},
	journal-iso = {DALTON TRANSACT},
	journal = {DALTON TRANSACTIONS},
	volume = {54},
	unique-id = {35805561},
	issn = {1477-9226},
	abstract = {In recent years, significant research efforts have been dedicated to finding efficient and safe alternatives to the currently used gadolinium (Gd)-based MRI contrast agents. Among the most explored alternatives are paramagnetic chelates of the Earth-abundant Mn2+, which form a prominent class of metal complexes. The design of Mn2+ complexes with enhanced relaxation properties and improved safety profiles hinges on a delicate balance between thermodynamic and kinetic stability, as well as the presence of coordinated water molecules. In this study, we present a comprehensive investigation into the coordination chemistry of three structurally related polyetheraminocarboxylic chelating agents. Our aim is to elucidate the structural features, paramagnetic properties, and thermodynamic and kinetic inertness of the corresponding Mn2+ complexes. The most significant finding is the considerable difference in the dissociation rates of the complexes, with the octadentate EGTA complex being the most labile. The observed dissociation rates correlate well with the nitrogen inversion dynamics, as assessed through NMR spectral analysis of the analogous Zn2+ complexes.},
	keywords = {STABILITY; MAGNETIC-RESONANCE; TRANSLATIONAL DIFFUSION; CONTRAST AGENTS; gadolinium; O-17 NMR; SPIN RELAXATION; PAIR CORRELATION-FUNCTIONS; PROTON RELAXATION-TIMES},
	year = {2025},
	eissn = {1477-9234},
	pages = {376-388},
	orcid-numbers = {Travagin, Fabio/0000-0003-3003-989X; Baranyai, Zsolt/0000-0001-6844-7974; Negri, Roberto/0000-0002-6792-8992; Platas-Iglesias, Carlos/0000-0002-6989-9654}
}

@article{MTMT:35860389,
	title = {Elemental analysis in the scales of commercially important coastal fishes and their connections with fish feeding habits and habitats},
	url = {https://m2.mtmt.hu/api/publication/35860389},
	author = {Parvez, Md Sohel and Imdadul Hoque, Md. and Nurul Momen Siddique, Md. and Rahman, Mohammad and Baranyai, Edina and Sajtos, Zsófi and Döncző, Boglárka and Aib, Haithem and Abdul Kader, Md. and Simon, Edina and Czédli, Herta},
	doi = {10.3389/fmars.2025.1546313},
	journal-iso = {FRONT MAR SCI},
	journal = {FRONTIERS IN MARINE SCIENCE},
	volume = {12},
	unique-id = {35860389},
	year = {2025},
	eissn = {2296-7745},
	orcid-numbers = {Aib, Haithem/0009-0003-1202-9687; Czédli, Herta/0000-0002-4152-7461}
}