@article{MTMT:34802521, title = {Organic Solvent-Based Li–Air Batteries with Cotton and Charcoal Cathode}, url = {https://m2.mtmt.hu/api/publication/34802521}, author = {Nagy, Lajos and Üneri, Haymana Serra and Kordován, Marcell Árpád and Nagy, Tibor and Kuki, Ákos and Nyul, Dávid and Pál, Petra and Erdélyi, Zoltán and Zsuga, Miklós and Kéki, Sándor}, doi = {10.1149/1945-7111/ad3857}, journal-iso = {J ELECTROCHEM SOC}, journal = {JOURNAL OF THE ELECTROCHEMICAL SOCIETY}, volume = {171}, unique-id = {34802521}, issn = {0013-4651}, abstract = {We report on the construction and investigation of Li–air batteries consisting of a charcoal cathode and cotton texture soaked with different organic solvents containing a lithium triflate (LiOTf) electrolyte. Charcoal was found to be an appropriate cathode for Li–air batteries. Furthermore, cycling tests showed stable operation at over 800 cycles when dimethyl sulfoxide (DMSO) and diethylene glycol dimethyl ether (DEGME) were used as solvents, whereas low electrochemical stability was observed when propylene carbonate was used. The charging, discharging, and long-term discharging steps were mathematically modeled. Electrochemical impedance spectroscopy showed Gerischer impedance, suggesting intensive oxygen transport at the surface of the charcoal cathode. Diffusion, charge transfer, and solid electrolyte interphase processes were identified using distribution of relaxation time analysis. In the polypropylene (PP) membrane soaked with LiOTf in DEGME, three different states of Li ions were identified by 7 Li-triple-quantum time proportional phase increment nuclear magnetic resonance measurements. On the basis of the latter results, a mechanism was suggested for Li-ion transport inside the PP membrane. The activity of the charcoal cathode was confirmed by Raman and cyclic voltammetry measurements.}, year = {2024}, eissn = {1945-7111}, orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X} } @article{MTMT:34744438, title = {The triumvirate of effective and rapid synthesis, analysis, and artificial intelligence to explore the structure-property relationship of copolymers}, url = {https://m2.mtmt.hu/api/publication/34744438}, author = {Nagy, Tibor and Róth, Gergő and Kuki, Ákos and Pardi-Tóth, Veronika Csilla and Nyul, Dávid and Kyzy, Zuura Kaldybek and Palacios, Isaac Alexander Iglesias and Benedek, Máté and Nagy, Lajos and Zsuga, Miklós and Kéki, Sándor}, doi = {10.1016/j.giant.2024.100248}, journal-iso = {GIANT}, journal = {GIANT}, volume = {17}, unique-id = {34744438}, issn = {2666-5425}, abstract = {Understanding the structure-property relationship is of paramount importance for tailoring copolymers for specific applications. Poly(N-acryloylmorpholine)-block-poly(N-isopropylacrylamide) (PNAM-b-PNIPAM) diblock copolymers were synthesized by reversible addition?fragmentation chain transfer (RAFT) polymerization with varying Mn and composition, providing the basis for deducing structure-property relationships. The chemical structure of the copolymers was analyzed by mass spectrometry (MS). A novel and efficient mass spectrum processing methodology was developed for the detailed analysis of polymers/copolymers that greatly expands the upper mass limit of the time-of-flight (TOF) analyzers in the linear mode up to 20,000 Da. Our method "makes visible" the mass peaks of the individual copolymer species and their isotopologues providing effective and fast automatized analysis. The self-assembly property of the thermoresponsive PNAM-b-PNIPAM diblocks in aqueous solutions was investigated by dynamic light scattering (DLS) experiments, and quantified by determining the incipient temperature of the phase transition. For rapid evaluation, an artificial neural network (ANN) was created to explore the hidden relationships between the structural information obtained by our novel mass analysis method and the properties as well as to predict the self-assembly behavior of the copolymers.}, keywords = {COPOLYMERS; Artificial intelligence; MALDI-TOF MS; Structure-property relation}, year = {2024}, orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X} } @article{MTMT:34742565, title = {“Inverted” Cyclic(Alkyl)(Amino)Carbene (CAAC) Ruthenium Complex Catalyzed Isomerization Metathesis (ISOMET) of Long Chain Olefins to Propylene at Low Ethylene Pressure}, url = {https://m2.mtmt.hu/api/publication/34742565}, author = {Farkas, Vajk and Csókás, Dániel and Erdélyi, Ádám and Turczel, Gábor and Bényei, Attila Csaba and Nagy, Tibor and Kéki, Sándor and Pápai, Imre and Tuba, Róbert}, doi = {10.1002/advs.202400118}, journal-iso = {ADV SCI}, journal = {ADVANCED SCIENCE}, volume = {11}, unique-id = {34742565}, abstract = {Isomerization Metathesis (ISOMET) reaction is an emerging tool for “open loop” chemical recycling of polyethylene to propylene. Novel, latent N ‐Alkyl substituted Cyclic(Alkyl)(Amino)Carbene (CAAC)–ruthenium catalysts ( 5a‐Ru , 3b‐Ru – 6c‐Ru ) are developed rendering “inverted” chemical structure while showing enhanced ISOMET activity in combination with (RuHCl)(CO)(PPh 3 ) 3 ( RuH ) double bond isomerization co‐catalyst. Systematic investigations reveal that the steric hindrance of the substituents on nitrogen and carbon atom adjacent to carbene moiety in the CAAC ligand have significantly improved the catalytic activity and robustness. In contrast to the NHC‐Ru and CAAC‐Ru catalyst systems known so far, these systems show higher isomerization metathesis (ISOMET) activity (TON: 7400) on the model compound 1‐octadecene at as low as 3.0 bar optimized pressure, using technical grade (3.0) ethylene. The propylene content formed in the gas phase can reach up to 20% by volume.}, year = {2024}, eissn = {2198-3844}, orcid-numbers = {Farkas, Vajk/0000-0002-1189-0032; Csókás, Dániel/0000-0002-4150-477X; Erdélyi, Ádám/0009-0008-0715-8907; Turczel, Gábor/0000-0002-6753-6796; Nagy, Tibor/0000-0001-8568-914X; Pápai, Imre/0000-0002-4978-0365; Tuba, Róbert/0000-0001-8929-2713} } @article{MTMT:34720754, title = {Optimization of Extraction Conditions to Synthesize Green Carbon Nanodots from Maillard Reaction}, url = {https://m2.mtmt.hu/api/publication/34720754}, author = {Nguyen Huu Huong, Duyen and Muthu, Arjun and El-Ramady, Hassan and Daróczi, Lajos and Nagy, Lajos and Kéki, Sándor and Béni, Áron and Csarnovics, István and Prokisch, József}, doi = {10.1039/D4MA00037D}, journal-iso = {MATER ADV}, journal = {MATERIALS ADVANCES}, volume = {5}, unique-id = {34720754}, abstract = {Carbon nanodots (CNDs) are a class of nanoparticles with unique optical properties with broad applications in various fields. However, synthesizing CNDs with high fluorescence intensity and small size using green...}, year = {2024}, eissn = {2633-5409}, pages = {3499-3505}, orcid-numbers = {Nguyen Huu Huong, Duyen/0000-0002-8450-2272} } @article{MTMT:34502650, title = {Block Synthesis and Step-Growth Polymerization of C-6-Sulfonatomethyl-Containing Sulfated Malto-Oligosaccharides and Their Biological Profiling}, url = {https://m2.mtmt.hu/api/publication/34502650}, author = {Herczeg, Mihály and Demeter, Fruzsina and Nagy, Tibor and Rusznyák, Ágnes and Hodek, Jan and Sipos, Éva and Lekli, István and Fenyvesi, Ferenc and Weber, Jan and Kéki, Sándor and Borbás, Anikó}, doi = {10.3390/ijms25010677}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {34502650}, issn = {1661-6596}, abstract = {Highly sulfated malto-oligomers, similar to heparin and heparan-sulfate, have good antiviral, antimetastatic, anti-inflammatory and cell growth inhibitory effects. Due to their broad biological activities and simple structure, sulfated malto-oligomer derivatives have a great therapeutic potential, therefore, the development of efficient synthesis methods for their production is of utmost importance. In this work, preparation of α-(1→4)-linked oligoglucosides containing a sulfonatomethyl moiety at position C-6 of each glucose unit was studied by different approaches. Malto-oligomeric sulfonic acid derivatives up to dodecasaccharides were prepared by polymerization using different protecting groups, and the composition of the product mixtures was analyzed by MALDI-MS methods and size-exclusion chromatography. Synthesis of lower oligomers was also accomplished by stepwise and block synthetic methods, and then the oligosaccharide products were persulfated. The antiviral, anti-inflammatory and cell growth inhibitory activity of the fully sulfated malto-oligosaccharide sulfonic acids were determined by in vitro tests. Four tested di- and trisaccharide sulfonic acids effectively inhibited the activation of the TNF-α-mediated inflammatory pathway without showing cytotoxicity.}, year = {2024}, eissn = {1422-0067}, orcid-numbers = {Herczeg, Mihály/0000-0002-7938-9789; Nagy, Tibor/0000-0001-8568-914X; Sipos, Éva/0009-0001-9561-2450; Borbás, Anikó/0000-0001-8462-4547} } @CONFERENCE{MTMT:34453415, title = {Comprehensive functional analyses of the bzip transciption factors AtfA and AtfB in Aspergillus Nidulans}, url = {https://m2.mtmt.hu/api/publication/34453415}, author = {Kocsis, Beatrix and Mi-Kyung, Lee and Jae-Hyuk, Yu and Nagy, Tibor and Daróczi, Lajos and Batta, Gyula Gábor (Ifj.) and Pócsi, István and Leiter, Éva Juliánna}, booktitle = {16th European Conference on Fungal Genetics: Programme & Abstracts}, unique-id = {34453415}, year = {2023}, pages = {705-706}, orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X; Batta, Gyula Gábor (Ifj.)/0000-0001-8735-6920} } @article{MTMT:34448544, title = {Functional analysis of the deletion and overexpression mutants of the transcription factor (an7872) regulating the an7884 secondary metabolite gene cluster}, url = {https://m2.mtmt.hu/api/publication/34448544}, author = {Kocsis, Beatrix and Imre, Boldizsár and Gábor, M. Kovács and Nagy, Tibor and Gyémánt, Gyöngyi and Gáspár, Attila and Csillag, Kinga Karola and Pócsi, István and Leiter, Éva Juliánna}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {70}, unique-id = {34448544}, issn = {1217-8950}, year = {2023}, eissn = {1588-2640}, pages = {68}, orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X; Gyémánt, Gyöngyi/0000-0003-2374-3408} } @article{MTMT:34427826, title = {Amphiphilic Sialic Acid Derivatives as Potential Dual-Specific Inhibitors of Influenza Hemagglutinin and Neuraminidase}, url = {https://m2.mtmt.hu/api/publication/34427826}, author = {Lőrincz, Eszter Boglárka and Herczeg, Mihály and Houser, Josef and Rievajová, Martina and Kuki, Ákos and Malinovská, Lenka and Naesens, Lieve and Wimmerová, Michaela and Borbás, Anikó and Herczegh, Pál and Bakai-Bereczki, Ilona}, doi = {10.3390/ijms242417268}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34427826}, issn = {1661-6596}, abstract = {In the shadow of SARS-CoV-2, influenza seems to be an innocent virus, although new zoonotic influenza viruses evolved by mutations may lead to severe pandemics. According to WHO, there is an urgent need for better antiviral drugs. Blocking viral hemagglutinin with multivalent N-acetylneuraminic acid derivatives is a promising approach to prevent influenza infection. Moreover, dual inhibition of both hemagglutinin and neuraminidase may result in a more powerful effect. Since both viral glycoproteins can bind to neuraminic acid, we have prepared three series of amphiphilic self-assembling 2-thio-neuraminic acid derivatives constituting aggregates in aqueous medium to take advantage of their multivalent effect. One of the series was prepared by the azide-alkyne click reaction, and the other two by the thio-click reaction to yield neuraminic acid derivatives containing lipophilic tails of different sizes and an enzymatically stable thioglycosidic bond. Two of the three bis-octyl derivatives produced proved to be active against influenza viruses, while all three octyl derivatives bound to hemagglutinin and neuraminidase from H1N1 and H3N2 influenza types.}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Herczeg, Mihály/0000-0002-7938-9789; Houser, Josef/0000-0003-4504-3891; Naesens, Lieve/0000-0001-9742-9302; Wimmerová, Michaela/0000-0002-7108-4198; Borbás, Anikó/0000-0001-8462-4547; Bakai-Bereczki, Ilona/0000-0003-4601-7257} } @article{MTMT:34391882, title = {Synthesis of Galacto-oligosaccharides in Milk by Using Bifidobacterium bifidum β-galactosidases (Saphera 2600L and Nola Fit 5500) Immobilized on Chitosan Beads}, url = {https://m2.mtmt.hu/api/publication/34391882}, author = {Bodnár, Magdolna and Fazekas, Erika and Nagy, Tibor and Miltner, Noémi and Kalló, Gergő and Kerekes, Krisztina and Prépost, Eszter and Mótyán, János András}, doi = {10.1007/s11947-023-03222-x}, journal-iso = {FOOD BIOPROCESS TECH}, journal = {FOOD AND BIOPROCESS TECHNOLOGY}, unique-id = {34391882}, issn = {1935-5130}, abstract = {The lactose intolerance—as a limiting factor for dairy milk consumption—has a high prevalence worldwide. Dairy milk and milk-derived products are major sources of multiple inorganic compounds and nutrients and thus are considered to be functional foods. β-galactosidases are able to hydrolyze lactose and are therefore widely applied for the production of lactose-free products. In addition, they are capable of the synthesis of galacto-oligosaccharides (GOSs); thus, the dairy industry has a special interest in applying them for the enrichment of dairy products with prebiotic GOSs. In this work, we studied two commercially available β-galactosidase products: Saphera 2600L and Nola Fit 5500. Both enzyme solutions contain a recombinant β-galactosidase of Bifidobacterium bifidum and have already been authorized for food industrial application, but the information about their hydrolytic and/or synthetic activities is only limited. After immobilization on chitosan beads, the enzymes were used for lactose hydrolysis and simultaneous synthesis of GOSs, by performing the reactions in pasteurized milk (skim milk). Both immobilized β-galactosidase exhibited elevated lactose hydrolysis (v max increased from ~ 1 to ~ 4 mM/min) and GOS synthesis as compared to the free enzymes. The enzyme-coated beads were efficiently re-used at least 15 cycles; the residual lactose concentration was < 2 mg/ml after each cycle. After treatment, GOSs were present in ≤ 9% of the total sugar content, indicating that the prepared low-lactose milks were enriched in prebiotic GOSs. The application of immobilized Saphera 2600L and Nola Fit 5500 β-galactosidases may be implemented for the large-scale production of GOS-enriched low-lactose milk.}, year = {2023}, eissn = {1935-5149}, pages = {1-20}, orcid-numbers = {Nagy, Tibor/0000-0001-8568-914X} } @CONFERENCE{MTMT:34274180, title = {Alifás diizocianátok és butan-1-ol reakcióinak kinetikai vizsgálata =$bKinetic study of the reactions between aliphatic diisocyanates and butan-1-ol}, url = {https://m2.mtmt.hu/api/publication/34274180}, author = {Vadkerti, Bence and Lakatos, Csilla and Üneri, Haymana Serra and Rágyanszki, Anita and Farkas, Ödön and Juhász, Anett and Zsuga, Miklós and Kéki, Sándor and Nagy, Lajos}, booktitle = {XXIX. Nemzetközi Vegyészkonferencia / 29th International Conference on Chemistry}, unique-id = {34274180}, year = {2023}, pages = {61}, orcid-numbers = {Farkas, Ödön/0000-0002-4217-0150} }