@article{MTMT:35320283,
	title = {De novo evolution of transmissible tumours in hydra},
	url = {https://m2.mtmt.hu/api/publication/35320283},
	author = {Tissot, Sophie and Meliani, Jordan and Boutry, Justine and Brazier, Lionel and Tökölyi, Jácint and Roche, Benjamin and Ujvari, Beata and Nedelcu, Aurora M. and Thomas, Frédéric and Dujon, Antoine M.},
	doi = {10.1098/rspb.2024.1636},
	journal-iso = {P ROY SOC B-BIOL SCI},
	journal = {PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES},
	volume = {291},
	unique-id = {35320283},
	issn = {0962-8452},
	abstract = {While most cancers are not transmissible, there are rare cases where cancer cells can spread between individuals and even across species, leading to epidemics. Despite their significance, the origins of such cancers remain elusive due to late detection in host populations. Using Hydra oligactis , which exhibits spontaneous tumour development that in some strains became vertically transmitted, this study presents the first experimental observation of the evolution of a transmissible tumour. Specifically, we assessed the initial vertical transmission rate of spontaneous tumours and explored the potential for optimizing this rate through artificial selection. One of the hydra strains, which evolved transmissible tumours over five generations, was characterized by analysis of cell type and bacteriome, and assessment of life-history traits. Our findings indicate that tumour transmission can be immediate for some strains and can be enhanced by selection. The resulting tumours are characterized by overproliferation of large interstitial stem cells and are not associated with a specific bacteriome. Furthermore, despite only five generations of transmission, these tumours induced notable alterations in host life-history traits, hinting at a compensatory response. This work, therefore, makes the first contribution to understanding the conditions of transmissible cancer emergence and their short-term consequences for the host.},
	year = {2024},
	eissn = {1471-2954},
	orcid-numbers = {Tissot, Sophie/0009-0008-0717-4990; Ujvari, Beata/0000-0003-2391-2988; Nedelcu, Aurora M./0000-0002-7517-2419; Thomas, Frédéric/0000-0003-2238-1978; Dujon, Antoine M./0000-0002-1579-9156}
}

@article{MTMT:35286549,
	title = {Forest encroachment in Eastern European forest-steppes at a decadal time scale},
	url = {https://m2.mtmt.hu/api/publication/35286549},
	author = {Erdős, László and Ónodi, Gábor and Tölgyesi, Csaba and Kröel-Dulay, György and Bátori, Zoltán and Aradi, Eszter and Török, Péter and Vu, Ho Khanh and Puspitasari, Indri and Körmöczi, László},
	doi = {10.1093/jpe/rtae086},
	journal-iso = {J PLANT ECOL-UK},
	journal = {JOURNAL OF PLANT ECOLOGY},
	unique-id = {35286549},
	issn = {1752-9921},
	year = {2024},
	eissn = {1752-993X},
	pages = {rtae086},
	orcid-numbers = {Erdős, László/0000-0002-6750-0961; Ónodi, Gábor/0000-0003-4308-7997; Tölgyesi, Csaba/0000-0002-0770-2107; Bátori, Zoltán/0000-0001-9915-5309}
}

@article{MTMT:35261807,
	title = {Cancer and One Health: tumor-bearing individuals can act as super spreaders of symbionts in communities},
	url = {https://m2.mtmt.hu/api/publication/35261807},
	author = {Tissot, Sophie and Meliani, Jordan and Chee, Matthew and Nedelcu, Aurora M. and Boutry, Justine and Tökölyi, Jácint and Hamede, Rodrigo and Roche, Benjamin and Ujvari, Beata and Thomas, Frédéric and Dujon, Antoine M.},
	doi = {10.1038/s41598-024-72171-y},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {35261807},
	issn = {2045-2322},
	year = {2024},
	eissn = {2045-2322}
}

@article{MTMT:35259048,
	title = {Novel Saccharomyces uvarum x Saccharomyces kudriavzevii synthetic hybrid with enhanced 2-phenylethanol production},
	url = {https://m2.mtmt.hu/api/publication/35259048},
	author = {Drężek, Karolina and Antunovics, Zsuzsa and Grabiec, Agnieszka Karolina},
	doi = {10.1186/s12934-024-02473-3},
	journal-iso = {MICROB CELL FACT},
	journal = {MICROBIAL CELL FACTORIES},
	volume = {23},
	unique-id = {35259048},
	issn = {1475-2859},
	keywords = {Saccharomyces; 2-phenylethanol; Ehrlich pathway},
	year = {2024},
	eissn = {1475-2859},
	pages = {203-213}
}

@article{MTMT:35258094,
	title = {High species richness of sheep‐grazed sand pastures is driven by disturbance‐tolerant and weedy short‐lived species},
	url = {https://m2.mtmt.hu/api/publication/35258094},
	author = {Kovacsics-Vári, Gergely and Sonkoly, Judit and Tóth, Katalin and McIntoshné Buday, Andrea and Díaz Cando, Patricia Elizabeth and Törő-Szijgyártó, Viktória and Balogh, Nóra and Guallichico Suntaxi, Luis Roberto and Espinoza Ami, Francis David and Matus, Gábor and Tóthmérész, Béla and Török, Péter},
	doi = {10.1002/ece3.70282},
	journal-iso = {ECOL EVOL},
	journal = {ECOLOGY AND EVOLUTION},
	volume = {14},
	unique-id = {35258094},
	issn = {2045-7758},
	abstract = {We selected 15 sheep‐grazed sand pastures along a gradient of increasing grazing intensity to study the fine‐scale patterns of main biomass fractions (green biomass, litter) and that of plant species and functional groups (life forms and social behaviour types). We classified them into five grazing intensity levels based on stocking density, proximity to drinking and resting places and the number of faeces. We aimed to answer the following questions: (i) How does increasing intensity of sheep grazing affect the amount of green biomass, the species richness and their relationship in sand pastures? (ii) How does increasing intensity of sheep grazing affect the biomass of perennial and short‐lived graminoids and forbs? (iii) How does the disturbance value—expressed in the biomass ratio of disturbance‐tolerant and ruderal species—change along the gradient of grazing intensity? A unimodal relationship between green biomass and species richness was detected; however, the ordination (canonical correspondence analysis, CCA) showed no clustering of pastures subjected to the same levels of grazing intensity. Along the grazing intensity gradient we found an increasing trend in species richness and significant differences in green biomass (decreasing trend), litter (decreasing trend), graminoids (decreasing trend) and short‐lived forbs (increasing trend). We found an increasing amount of disturbance‐tolerant and ruderal species with increasing grazing intensity. We suggest that we might need to use multiple scales for sampling and a fine‐scale assessment of grazing intensity. Our findings might be instructive for pastures in densely populated regions, which are prone to the encroachment of disturbance‐tolerant and ruderal species.},
	keywords = {functional groups; DISTURBANCE; Plant biomass; sheep grazing; European steppes; humped-back curve},
	year = {2024},
	eissn = {2045-7758},
	orcid-numbers = {Kovacsics-Vári, Gergely/0000-0002-9995-5733}
}

@article{MTMT:35220164,
	title = {Embryonic Leucine Promotes Early Postnatal Growth via mTOR Signalling in Japanese Quails},
	url = {https://m2.mtmt.hu/api/publication/35220164},
	author = {Ndunguru, Sawadi Fransisco and Gebrehaweria Kidane, Reda and Csernus, Brigitta and Knop, Renáta and Lugata, James Kachungwa and Szabó, Csaba and Lendvai, Ádám Zoltán and Czeglédi, Levente},
	doi = {10.3390/ani14172596},
	journal-iso = {ANIMALS-BASEL},
	journal = {ANIMALS},
	volume = {14},
	unique-id = {35220164},
	abstract = {Nutritional cues during embryonic development can alter developmental trajectories and affect postnatal growth. However, the specific mechanisms by which nutrients influence avian growth remain largely unknown. Amino acids can directly interact with the nutrient-sensing pathways, such as the insulin-like growth factor 1 (IGF-1)/mechanistic target of rapamycin (mTOR) pathways, which are known to regulate growth. We examined the effects of embryonic leucine on gene expression and phenotypic growth in Japanese quails by injecting 2.5 mg leucine or saline (control) into Japanese quail eggs on the tenth day of incubation and incubating them under standard conditions. The treatment groups had similar hatching success and size at hatching. However, between 3 and 7 days post-hatching, quails treated with embryonic leucine showed increased growth in body mass and wing, tarsus, head, and intestinal lengths, lasting up to 21 days. The hepatic expression of IGF1, IGF1R, mTOR, and RPS6K1 was upregulated in leucine-treated quails, while the expression of FOXO1 remained unaffected. In conclusion, a subtle increase in embryonic leucine may induce developmental programming effects in Japanese quail by interacting with the IGF-1/mTOR nutrient-sensing pathway to promote growth. This study highlights the role of embryonic amino acids as crucial nutrients for enhancing growth. It provides valuable insight into nutrient intervention strategies during embryonic development to potentially improve poultry growth performance.},
	year = {2024},
	eissn = {2076-2615},
	orcid-numbers = {Lendvai, Ádám Zoltán/0000-0002-8953-920X}
}

@article{MTMT:35212141,
	title = {Transcriptomics identify the triggering of citrate export as the key event caused by manganese deficiency in Aspergillus niger},
	url = {https://m2.mtmt.hu/api/publication/35212141},
	author = {Fekete, Erzsébet and Bíró, Vivien and Márton, Alexandra and Bakondi-Kovács, István and Karaffa, Erzsébet Mónika and KOVÁCS, B and GEOFFRION, N and TSANG, A and KUBICEK, CP and Karaffa, Levente},
	journal-iso = {MICROBIOL SPEC},
	journal = {MICROBIOLOGY SPECTRUM},
	volume = {&},
	unique-id = {35212141},
	issn = {2165-0497},
	year = {2024},
	eissn = {2165-0497}
}

@article{MTMT:35203216,
	title = {Testing treecbh in Central European forests: an R package for crown base height detection using high-resolution aerial laser-scanned data},
	url = {https://m2.mtmt.hu/api/publication/35203216},
	author = {Diószegi, Gergő and Abriha-Molnár, Vanda Éva and Nagy, Loránd Attila and Enyedi, Péter and Török, Péter and Szabó, Szilárd},
	doi = {10.1093/forestry/cpae044},
	journal-iso = {FORESTRY},
	journal = {FORESTRY},
	unique-id = {35203216},
	issn = {0015-752X},
	abstract = {Accurate information regarding tree canopy characteristics is crucial for forest management, but it is often difficult to assess. This study presents an innovative framework designed for crown base height (CBH) detection using high-resolution laser-scanned data, with a specific focus on individual trees within forests. The framework comprises three key steps: (i) segmenting the input tree point cloud to identify the tree trunk and its branches using the treesio software; (ii) applying vertical cross-sectional K-means clustering to cluster the identified tree and to define the elevation threshold for removing low-lying understory vegetation; (iii) employing a novel 2D kernel method for detecting CBH after eliminating low-lying understory vegetation. The 2D kernel method, developed for broadleaf forests using leaf-off airborne laser scanning (ALS) data, underpins the treecbh tool. This tool features a visual CBH adjustment component that shows a 2D profile plot of the tree point cloud, and suggests a CBH value for user approval or adjustment. To evaluate accuracy, in situ measured CBH data from five forest plots in Germany and Hungary with varied species compositions were used. ALS data were collected during leaf-off conditions for the two Hungarian plots and during leaf-on conditions for the three German plots. Leaf-off terrestrial laser-scanned data from individual trees were also used in the accuracy assessment. A sensitivity analysis using random point decimation was conducted on the terrestrial laser-scanned data to assess treecbh’s sensitivity to point density. The initial results exhibited matching rates of 45% and 60% for leaf-off ALS plots, which significantly improved to 71% and 77%, respectively, when using the visual CBH adjustment feature of the tool. The leaf-on ALS results demonstrated matching rates between 24% and 33%, whereas the CBHs of individual terrestrial laser-scanned trees could be detected with 93% accuracy in visual mode. It was observed that treecbh operates effectively when the input ALS data have a minimum point density of 20 pts/, with its optimal performance achieved at 110 pts/. These findings indicated treecbh’s sensitivity to ALS data quality, scanning season (leaf-on and leaf-off), and point density. This sensitivity can be effectively mitigated in the case of leaf-off ALS data by utilizing the visual CBH adjustment feature of the tool.},
	keywords = {crown base height detection; tree isolation},
	year = {2024},
	eissn = {1464-3626},
	orcid-numbers = {Szabó, Szilárd/0000-0002-2670-7384}
}

@article{MTMT:35202224,
	title = {Between‐year weather differences and long‐term environmental trends both contribute to observed vegetation changes in a plot resurvey study},
	url = {https://m2.mtmt.hu/api/publication/35202224},
	author = {Erdős, László and Ónodi, Gábor and Ho, Vu Khanh and Tanács, Eszter and Akinyi, Rabuogi Quinter and Török, Péter and Tölgyesi, Csaba and Bátori, Zoltán and Kröel-Dulay, György},
	doi = {10.1002/ece3.70244},
	journal-iso = {ECOL EVOL},
	journal = {ECOLOGY AND EVOLUTION},
	volume = {14},
	unique-id = {35202224},
	issn = {2045-7758},
	abstract = {Repeated surveys of vegetation plots offer a viable tool to detect fine‐scale responses of vegetation to environmental changes. In this study, our aim was to explore how the species composition and species richness of dry grasslands changed over a period of 17 years, how these changes relate to environmental changes and how the presence of spring ephemerals, which may react to short‐term weather fluctuations rather than long‐term climatic trends, may influence the results. A total of 95 plots was surveyed in 2005 and resurveyed in 2022 in dry grasslands of the Kiskunság Sand Ridge (Hungary, Eastern Central Europe), where there has been a significant increase in mean annual temperature during the last decades, while no trends in precipitation can be identified. Db‐RDA was performed to reveal compositional changes. The changes in environmental conditions and naturalness state were assessed using ecological and naturalness indicator values. We also compared per‐plot richness of all species, native species and non‐native species of the old and the new relevés. All analyses were repeated after removing all spring ephemerals. We found clear temporal changes in species composition. Mean temperature indicator values increased, while mean soil moisture indicator values decreased during the 17 years. Also, decreasing per‐plot richness was detected both for all species and for native species, while mean naturalness increased. After the removal of spring ephemerals, the compositional changes were less obvious although still significant. The increase in the temperature indicator values remained significant even without the spring ephemerals. However, the decrease in the moisture indicator values, the decrease in the number of all species and native species, as well as the increase in naturalness indicator values disappeared when spring ephemerals were excluded from the analyses. Our study demonstrates that between‐year weather differences and long‐term environmental trends both contribute to observed vegetation changes.},
	year = {2024},
	eissn = {2045-7758},
	orcid-numbers = {Erdős, László/0000-0002-6750-0961; Ónodi, Gábor/0000-0003-4308-7997; Ho, Vu Khanh/0000-0002-9117-7789; Tanács, Eszter/0000-0003-1953-9340; Tölgyesi, Csaba/0000-0002-0770-2107; Bátori, Zoltán/0000-0001-9915-5309}
}

@article{MTMT:35198148,
	title = {The widespread vulnerability of Hydra oligactis to tumourigenesis confirms its value as a model for studying the effects of tumoural processes on the ecology and evolution of species},
	url = {https://m2.mtmt.hu/api/publication/35198148},
	author = {Dujon, Antoine M. and Boutry, Justine and Tissot, Sophie and Meliani, Jordan and Miltiadous, Anna and Tökölyi, Jácint and Ujvari, Beata and Thomas, Frédéric},
	doi = {10.1016/j.scitotenv.2024.175785},
	journal-iso = {SCI TOTAL ENVIRON},
	journal = {SCIENCE OF THE TOTAL ENVIRONMENT},
	volume = {951},
	unique-id = {35198148},
	issn = {0048-9697},
	year = {2024},
	eissn = {1879-1026}
}