TY - JOUR AU - Rashed, Aref AU - Frenyó, Magdolna AU - Gombocz, Károly AU - Szabados, Sándor AU - Alotti, Nasri TI - Incisional negative pressure wound therapy in reconstructive surgery of poststernotomy mediastinitis JF - INTERNATIONAL WOUND JOURNAL J2 - INT WOUND J VL - 14 PY - 2017 IS - 1 SP - 180 EP - 183 PG - 4 SN - 1742-4801 DO - 10.1111/iwj.12579 UR - https://m2.mtmt.hu/api/publication/3041414 ID - 3041414 LA - English DB - MTMT ER - TY - JOUR AU - Lerman, DA AU - Prasad, S AU - Alotti, Nasri TI - Denosumab could be a Potential Inhibitor of Valvular Interstitial Cells Calcification in vitro. JF - INTERNATIONAL JOURNAL OF CARDIOVASCULAR RESEARCH J2 - INTERNATIONAL JOURNAL OF CARDIOVASCULAR RESEARCH VL - 5 PY - 2016 PG - 19 SN - 2324-8602 DO - 10.4172/2324-8602.1000249 UR - https://m2.mtmt.hu/api/publication/3097561 ID - 3097561 AB - OBJECTIVE: Denosumab is a fully human monoclonal antibody and novel antiresorptive agent that works by binding receptor activator of nuclear factor kappa-beta ligand (RANKL) and inhibiting the signaling cascade that causes osteoclast maturation, activity, and survival. We aimed to elucidate the effect of Denosumab in the process of spontaneous and induced calcification in an in vitro porcine valvular interstitial cells (VICs) model. MATERIALS AND METHODS: VICs were extracted from fresh porcine hearts by serial collagenase digestion. Spontaneous calcification of VICs was increased in vitro by adding Na3PO4 (3 mM, pH 7.4) and different concentrations (0.1, 1 and 10 ng/ml) of transforming growth factor beta (TGFss). The degree of calcification before and after treatment with Denosumab was estimated by Alizarin Red staining for calcium deposition, and Sirius Red staining for collagen. Colorimetric techniques were used to determine calcium and collagen deposition quantitatively. For statistical analysis we used SPSS and Microsoft Office Excel 2013. RESULTS: Porcine aortic VICs in vitro were induced to calcify by the addition of either 3 mM Na3PO4, showing a 5.2 fold increase by 14 days (P<0.001), or 3 mM Na3PO4 + 10 ng/ml of TGFbeta, showing a 7 fold increase by Day 14 (P<0.001). Denosumab inhibited induced calcification by 3 mM Na3PO4 and 3 mM Na3PO4 with the addition of TGFss at either 0.1, 1 or 10 ng/ml to basal levels only at a concentration of 50 mug/ml (P<0.001). CONCLUSION: This study has proved that Denosumab could be a potential inhibitor of the calcification of VICs in vitro. A fuller understanding of the actions of Denosumab may identify a novel therapeutic strategy for clinical intervention against aortic valve calcification and aortic stenosis. LA - English DB - MTMT ER - TY - JOUR AU - Alejandro, Daniel Lerman AU - Alotti, Nasri TI - Cardiac Repair and Regeneration. The Value of Cell Therapies TS - The Value of Cell Therapies JF - EUROPEAN CARDIOLOGY REVIEW J2 - EUR CARDIOL REV VL - 11 PY - 2016 IS - 1 SP - 43 EP - 48 PG - 6 SN - 1758-3756 DO - 10.15420/ecr.2016:8:1 UR - https://m2.mtmt.hu/api/publication/3058136 ID - 3058136 N1 - Funding Agency and Grant Number: MRC [G1000816] Funding Source: UKRI; British Heart Foundation [RM/13/2/30158] Funding Source: Medline; Medical Research Council [G1000816] Funding Source: Medline LA - English DB - MTMT ER - TY - JOUR AU - Garzuly, Ferenc AU - Grubits, János AU - Nikl, János TI - A Nyugat-Pannon Neurológiai Fórum megalakulásának elôzményei és története. Antecedents to the commencement and history of the WestPannonic Neurological Forum TS - Antecedents to the commencement and history of the WestPannonic Neurological Forum JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 69 PY - 2016 IS - 3-4 SP - 139 EP - 143 PG - 5 SN - 0019-1442 DO - 10.18071/isz.69.0139 UR - https://m2.mtmt.hu/api/publication/3056804 ID - 3056804 AB - Introduction - Numerous professional groups and sections for the medical specialities have been organized since 1953 in the West-Transdanubian region of Hungary, but such association of neurologists had not occured. Establishing the West-Pannonic Neurological Forum - The lack of regional collaboration among neurologists was related to several factors, among which the most important factor was the lack of a regional medical university, which could coordinate the professional activities. This severe gap necessitated in 1998 the organization of a professional group, that has become a driver for case-consulting conferences and different postgraduate trainings for the physicians specialized in neurology, neurosurgery and neurorehabilitation in counties of Győr-Moson-Sopron, Vas, Veszprém and Zala. The functioning of the Forum - Meetings are organized twice a year for physicians and paramedical staff (nurses, hospital attendants, physiotherapists) on Thursdays afternoons in different towns of the region, in two sections. The lectures are followed by a buffet, after which everyone can get home before too late. Ocasionally guest-lecturers are invited to present scientific topics from Hungarian universities or abroad. However, the main form of the presentations is defined as case discussion. Conclusions - The numbers of platform and other presentations in the physicians’s section have exceeded half a thousand, while in the paramedical section reached the threehundreds. At the 38. meeting of the Forum in January of this year, the number of participants was more than twohundreds, reflecting that both physicians and their coworkers are greatly interested in this form of interactions. LA - Hungarian DB - MTMT ER - TY - GEN AU - Alotti, Nasri TI - Koronáriabetegségek invazív kezelése diabetesben. Mikor, melyiket, miért? (PCI vagy CABG) (előadás) TS - Mikor, melyiket, miért? (PCI vagy CABG) (előadás) PY - 2016 UR - https://m2.mtmt.hu/api/publication/3041635 ID - 3041635 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Alejandro, Daniel Lerman AU - Sai, Prasad AU - Alotti, Nasri TI - Using Na3PO4 to Enhance In vitro Animal Models of Aortic Valve Calcification JF - INTERNATIONAL JOURNAL OF CARDIOVASCULAR RESEARCH J2 - INTERNATIONAL JOURNAL OF CARDIOVASCULAR RESEARCH VL - 5 PY - 2016 IS - 1 PG - 7 SN - 2324-8602 DO - 10.4172/2324-8602.1000250 UR - https://m2.mtmt.hu/api/publication/3041391 ID - 3041391 LA - English DB - MTMT ER - TY - JOUR AU - Alotti, Nasri AU - Gombocz, Károly AU - Ume, L Kiddi AU - Sayour, Amer AU - Alejandro, Lerman Daniel AU - Rashed, Aref TI - Early Results of a Novel Mitral Valve Repair Prodcedure. The Interpapillary Polytetrafluoroethylene Bridge Formation TS - The Interpapillary Polytetrafluoroethylene Bridge Formation JF - INTERNATIONAL JOURNAL OF CARDIOVASCULAR RESEARCH J2 - INTERNATIONAL JOURNAL OF CARDIOVASCULAR RESEARCH VL - 5 PY - 2016 IS - 1 SN - 2324-8602 DO - 10.4172/2324-8602.1000254 UR - https://m2.mtmt.hu/api/publication/3041329 ID - 3041329 LA - English DB - MTMT ER - TY - JOUR AU - Gecse, Krisztina AU - Lovász, Barbara Dorottya AU - Farkas, Klaudia AU - Banai, J AU - Bene, L AU - Gasztonyi, Beáta AU - Golovics, Petra Anna AU - Kristóf, T AU - Lakatos, László AU - Csontos, Ágnes Anna AU - Juhász, Márk AU - Nagy, Ferenc AU - Palatka, Károly AU - Papp, Mária AU - Patai, Árpád AU - Lakner, L AU - Salamon, A AU - Szamosi, Tamás AU - Szepes, Zoltán AU - Tóth, GT AU - Vincze, Áron AU - Szalay, Balázs AU - Molnár, Tamás AU - Lakatos, Péter László TI - Efficacy and safety of the biosimilar infliximab CT-P13 treatment in inflammatory bowel diseases: a prospective, multicentre, nationwide cohort JF - JOURNAL OF CROHNS & COLITIS J2 - J CROHNS COLITIS VL - 10 PY - 2016 IS - 2 SP - 133 EP - 140 PG - 8 SN - 1873-9946 DO - 10.1093/ecco-jcc/jjv220 UR - https://m2.mtmt.hu/api/publication/2984734 ID - 2984734 LA - English DB - MTMT ER - TY - JOUR AU - Alejandro, Daniel Lerman AU - Sai, Prasad AU - Alotti, Nasri TI - Calcific Aortic Valve Disease. Molecular Mechanisms and Therapeutic Approaches TS - Molecular Mechanisms and Therapeutic Approaches JF - EUROPEAN CARDIOLOGY REVIEW J2 - EUR CARDIOL REV VL - 10 PY - 2015 IS - 2 SP - 108 EP - 112 PG - 5 SN - 1758-3756 DO - 10.15420/ecr.2015.10.2.108 UR - https://m2.mtmt.hu/api/publication/3043652 ID - 3043652 N1 - Funding Agency and Grant Number: British Heart Foundation [RM/13/2/30158] Funding Source: Medline LA - English DB - MTMT ER - TY - CHAP AU - Szepes, Attila AU - Gasztonyi, Beáta ED - Bene, L ED - Gyökeres, Tibor Zoltán ED - Pap, Á TI - Invazív endoszkópos ultrahang T2 - Emésztőszervi endoszkópia PB - ENDO-VILÁG Egészségügyi Kft. CY - Budapest SN - 9789631232684 PY - 2015 SP - 399 EP - 402 PG - 4 UR - https://m2.mtmt.hu/api/publication/3035098 ID - 3035098 LA - Hungarian DB - MTMT ER -