@article{MTMT:34095179,
	title = {Deconvolution Analysis of the Non-Ionic Iomeprol, Iobitridol and Iodixanol Contrast Media-Treated Human Whole Blood Thermograms: A Comparative Study},
	url = {https://m2.mtmt.hu/api/publication/34095179},
	author = {Telek, Elek and Ujfalusi, Zoltán and Nyitrai, Miklós and Bogner, Péter and Lukács, András Szilárd and Németh, Timea and Hild, Gabriella and Hild, Gábor},
	doi = {10.3390/diagnostics13152523},
	journal-iso = {DIAGNOSTICS},
	journal = {DIAGNOSTICS},
	volume = {13},
	unique-id = {34095179},
	issn = {2075-4418},
	abstract = {To study the effect of non-ionic contrast media on anticoagulated and non-anticoagulated human whole blood samples, calorimetric measurements were performed. The anticoagulated plasma showed the greatest fall in the total ΔH after Iodixanol treatment. The plasma-free erythrocytes revealed a pronounced shift in the Tmax and a decrease in the ΔH of hemoglobin and transferrin. The total ΔH of Iodixanol treatment showed the highest decline, while Iomeprol and Iobitridol had fewer adverse effects. Similarly, the non-anticoagulated samples revealed a decrease both in the Tmax and the ΔH of albumin and immunoglobulin-specific transitions. The total ΔH showed that Iodixanol had more influence on the serum. The serum-free erythrocyte samples resulted in a significant drop in the Tmax of erythrocyte and transferrin (~5–6 °C). The ΔH of deconvolved hemoglobin and transferrin decreased considerably; however, the ΔH of albumin increased. Surprisingly, compared to Iomeprol and Iobitridol treatments, the total ΔH of Iodixanol was less pronounced in the non-anticoagulated erythrocyte samples. In sum, each non-ionic contrast medium affected the thermal stability of anticoagulated and non-anticoagulated erythrocyte proteins. Interestingly, Iodixanol treatment caused more significant effects. These findings suggest that conformational changes in blood components can occur, which can potentially lead to the increased prevalence of cardiovascular dysfunctions and blood clotting.},
	year = {2023},
	eissn = {2075-4418},
	orcid-numbers = {Telek, Elek/0000-0003-0396-4799; Ujfalusi, Zoltán/0000-0001-5936-7286; Nyitrai, Miklós/0000-0002-6229-4337}
}

@article{MTMT:33366469,
	title = {Solubility and Thermal Stability of Thermotoga maritima MreB},
	url = {https://m2.mtmt.hu/api/publication/33366469},
	author = {Longauer, Beáta and Bódis, Emőke and Lukács, András Szilárd and Barkó, Szilvia and Nyitrai, Miklós},
	doi = {10.3390/ijms232416044},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33366469},
	issn = {1661-6596},
	abstract = {The basis of MreB research is the study of the MreB protein from the Thermotoga maritima species, since it was the first one whose crystal structure was described. Since MreB proteins from different bacterial species show different polymerisation properties in terms of nucleotide and salt dependence, we conducted our research in this direction. For this, we performed measurements based on tryptophan emission, which were supplemented with temperature-dependent and chemical denaturation experiments. The role of nucleotide binding was studied through the fluorescent analogue TNP-ATP. These experiments show that Thermotoga maritima MreB is stabilised in the presence of low salt buffer and ATP. In the course of our work, we developed a new expression and purification procedure that allows us to obtain a large amount of pure, functional protein.},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Lukács, András Szilárd/0000-0001-8841-9823; Nyitrai, Miklós/0000-0002-6229-4337}
}

@article{MTMT:33154711,
	title = {Remodeling of Liver and Plasma Lipidomes in Mice Lacking Cyclophilin D},
	url = {https://m2.mtmt.hu/api/publication/33154711},
	author = {Kőszegi, Balázs and Balogh, Gábor and Berente, Zoltán and Vranesics, Anett and Pollák, Edit and Molnár, László and Takátsy, Anikó and Poór, Viktória and Wahr, Mátyás and Antus, Csenge Petra and Erős, Krisztián and Vigh, László and Gallyas, Ferenc and Péter, Mária and Veres, Balázs},
	doi = {10.3390/ijms231911274},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33154711},
	issn = {1661-6596},
	abstract = {In recent years, several studies aimed to investigate the metabolic effects of non-functioning or absent cyclophilin D (CypD), a crucial regulatory component of mitochondrial permeability transition pores. It has been reported that the lack of CypD affects glucose and lipid metabolism. However, the findings are controversial regarding the metabolic pathways involved, and most reports describe the effect of a high-fat diet on metabolism. We performed a lipidomic analysis of plasma and liver samples of CypD-/- and wild-type (WT) mice to reveal the lipid-specific alterations resulting from the absence of CypD. In the CypD-/- mice compared to the WT animals, we found a significant change in 52% and 47% of the measured 225 and 201 lipid species in liver and plasma samples, respectively. The higher total lipid content detected in these tissues was not accompanied by abdominal fat accumulation assessed by nuclear magnetic resonance imaging. We also documented characteristic changes in the lipid composition of the liver and plasma as a result of CypD ablation with the relative increase in polyunsaturated membrane lipid species. In addition, we did not observe remarkable differences in the lipid distribution of hepatocytes using histochemistry, but we found characteristic changes in the hepatocyte ultrastructure in CypD-/- animals using electron microscopy. Our results highlight the possible long-term effects of CypD inhibition as a novel therapeutic consideration for various diseases.},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Molnár, László/0000-0002-0049-9679; Gallyas, Ferenc/0000-0002-1906-4333}
}

@article{MTMT:32760182,
	title = {Conformational dynamics and functional characterization of the C-terminal tail of Myosin 16},
	url = {https://m2.mtmt.hu/api/publication/32760182},
	author = {Telek, Elek and Karadi, Kristof and Kardos, József and Kengyel, Andras and Fekete, Zsuzsanna and Halasz, Henriett and Nyitrai, Miklos and Bugyi, Beata and Lukács, András Szilárd},
	journal-iso = {BIOPHYS J},
	journal = {BIOPHYSICAL JOURNAL},
	volume = {121},
	unique-id = {32760182},
	issn = {0006-3495},
	year = {2022},
	eissn = {1542-0086},
	pages = {181A-181A},
	orcid-numbers = {Telek, Elek/0000-0003-0396-4799; Kardos, József/0000-0002-2135-2932}
}

@article{MTMT:32653646,
	title = {The effect of Iodixanol on the thermodynamic properties of blood components},
	url = {https://m2.mtmt.hu/api/publication/32653646},
	author = {Ujfalusi, Zoltán and Telek, Elek and Nyitrai, Miklós and Bogner, Péter and Rostás, Tamás and Hild, Gabriella and Trif, László and Hild, Gábor},
	doi = {10.1016/j.tca.2022.179165},
	journal-iso = {THERMOCHIM ACTA},
	journal = {THERMOCHIMICA ACTA},
	volume = {710},
	unique-id = {32653646},
	issn = {0040-6031},
	year = {2022},
	eissn = {1872-762X},
	orcid-numbers = {Ujfalusi, Zoltán/0000-0001-5936-7286; Telek, Elek/0000-0003-0396-4799; Nyitrai, Miklós/0000-0002-6229-4337; Trif, László/0000-0002-3960-1829}
}

@article{MTMT:32466727,
	title = {Syntheses and study of a pyrroline nitroxide condensed phospholene oxide and a pyrroline nitroxide with diphenylphosphino moiety},
	url = {https://m2.mtmt.hu/api/publication/32466727},
	author = {Isbera, Mostafa and Bognár, Balázs and Gallyas, Ferenc and Bényei, Attila Csaba and Jekő, József and Kálai, Tamás},
	doi = {10.1080/10426507.2021.1989690},
	journal-iso = {PHOSPHOR SULFUR SIL REL ELEM},
	journal = {PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS},
	volume = {197},
	unique-id = {32466727},
	issn = {1042-6507},
	abstract = {The reaction of a diene nitroxide precursor with dichlorophenylphosphine in a McCormac procedure afforded pyrroline nitroxide condensed phospholen oxide. Lithiation of the protected 3-bromo-pyrroline nitroxide followed by treatment with chlorodiphenylphosphine after deprotection afforded (1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)diphenylphosphine oxide, and after reduction, (1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)diphenylphosphine was realized, which was also supported by X-ray single crystal diffraction measurements. This pyrroline diphenylphosphine derivative was converted to hexadecylphosphonium salt, which was more effective antineoplastic agent than its analogue MITO-CP.},
	year = {2022},
	eissn = {1563-5325},
	pages = {515-517},
	orcid-numbers = {Gallyas, Ferenc/0000-0002-1906-4333}
}

@{MTMT:33095981,
	title = {Desethylamiodarone may have cytostatic potential on triple negative breast cancer},
	url = {https://m2.mtmt.hu/api/publication/33095981},
	author = {Bognár, Zita and Ramadan, Fadi and Bognár, Rita and Hocsák, Enikő and Andreidesz, Kitti and Gallyas, Ferenc},
	booktitle = {Hungarian Molecular Life Sciences 2021},
	unique-id = {33095981},
	year = {2021},
	pages = {181-181},
	orcid-numbers = {Gallyas, Ferenc/0000-0002-1906-4333}
}

@{MTMT:33095958,
	title = {Involvement of mitochondrial mechanisms in the cytostatic effect of desethylamiodarone in B16F10 melanoma cells},
	url = {https://m2.mtmt.hu/api/publication/33095958},
	author = {Ramadan, Fadi and Bognár, Rita and Szabó, Aliz and Gallyas, Ferenc and Bognár, Zita},
	booktitle = {Hungarian Molecular Life Sciences 2021},
	unique-id = {33095958},
	year = {2021},
	pages = {47-47},
	orcid-numbers = {Gallyas, Ferenc/0000-0002-1906-4333}
}

@article{MTMT:32766022,
	title = {Nitroxide with diphenylphosphino moiety: synthesis, supramolecular structure, biology and catalysis},
	url = {https://m2.mtmt.hu/api/publication/32766022},
	author = {Benyei, A. and Isbera, Mostafa and Bognár, Balázs and Gallyas, Ferenc and Jekő, József and Kalai, T.},
	journal-iso = {ACTA CRYSTALLOGR A FOUND ADV},
	journal = {ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES},
	volume = {77},
	unique-id = {32766022},
	issn = {2053-2733},
	keywords = {Chemistry, Multidisciplinary; Nitroxide; Supramolecular structure; tertiary phosphane},
	year = {2021},
	eissn = {2053-2733},
	pages = {C886-C886},
	orcid-numbers = {Gallyas, Ferenc/0000-0002-1906-4333}
}

@article{MTMT:32266554,
	title = {Olaparib : A Clinically Applied PARP Inhibitor Protects from Experimental Crohn's Disease and Maintains Barrier Integrity by Improving Bioenergetics through Rescuing Glycolysis in Colonic Epithelial Cells},
	url = {https://m2.mtmt.hu/api/publication/32266554},
	author = {Kovács, Dominika and Bagóné Vántus, Viola and Vámos, Eszter and Kálmán, Nikoletta and Schicho, Rudolf and Gallyas, Ferenc and Radnai, Balázs},
	doi = {10.1155/2021/7308897},
	journal-iso = {OXID MED CELL LONGEV},
	journal = {OXIDATIVE MEDICINE AND CELLULAR LONGEVITY},
	volume = {2021},
	unique-id = {32266554},
	issn = {1942-0900},
	abstract = {Crohn's disease (CD) is an inflammatory disorder of the intestines characterized by epithelial barrier dysfunction and mucosal damage. The activity of poly(ADP-ribose) polymerase-1 (PARP-1) is deeply involved in the pathomechanism of inflammation since it leads to energy depletion and mitochondrial failure in cells. Focusing on the epithelial barrier integrity and bioenergetics of epithelial cells, we investigated whether the clinically applied PARP inhibitor olaparib might improve experimental CD. We used the oral PARP inhibitor olaparib in the 2,4,6-trinitrobenzene sulfonic acid- (TNBS-) induced mouse colitis model. Inflammatory scoring, cytokine levels, colon histology, hematological analysis, and intestinal permeability were studied. Caco-2 monolayer culture was utilized as an epithelial barrier model, on which we used qPCR and light microscopy imaging, and measured impedance-based barrier integrity, FITC-dextran permeability, apoptosis, mitochondrial oxygen consumption rate, and extracellular acidification rate. Olaparib reduced the inflammation score, the concentration of IL-1β and IL-6, enhanced the level of IL-10, and decreased the intestinal permeability in TNBS-colitis. Blood cell ratios, such as lymphocyte to monocyte ratio, platelet to lymphocyte ratio, and neutrophil to lymphocyte ratio were improved. In H2O2-treated Caco-2 monolayer, olaparib decreased morphological changes, barrier permeability, and preserved barrier integrity. In oxidative stress, olaparib enhanced glycolysis (extracellular acidification rate), and it improved mitochondrial function (mitochondrial coupling efficiency, maximal respiration, and spare respiratory capacity) in epithelial cells. Olaparib, a PARP inhibitor used in human cancer therapy, improved experimental CD and protected intestinal barrier integrity by preventing its energetic collapse; therefore, it could be repurposed for the therapy of Crohn's disease.},
	year = {2021},
	eissn = {1942-0994},
	orcid-numbers = {Vámos, Eszter/0000-0003-0622-442X; Gallyas, Ferenc/0000-0002-1906-4333}
}