TY - JOUR AU - Boros, Attila Péter AU - Lehotay-Kéry, Péter AU - Kiss, Attila TI - PERFORMANCE IMPACT OF NETWORK SECURITY FEATURES ON LOG PROCESSING WITH SPARK JF - ANNALES UNIVERSITATIS SCIENTIARUM BUDAPESTINENSIS DE ROLANDO EOTVOS NOMINATAE SECTIO COMPUTATORICA J2 - ANN UNIV SCI BP R EÖTVÖS NOM SECT COMPUT VL - 55 PY - 2023 IS - October SP - 19 EP - 37 PG - 19 SN - 0138-9491 UR - https://m2.mtmt.hu/api/publication/34152516 ID - 34152516 LA - English DB - MTMT ER - TY - JOUR AU - Yousefi, Maryam AU - Andrejka, Laura AU - Szamecz, Márton AU - Winslow, Monte M. AU - Petrov, Dmitri A. AU - Boross, Gábor TI - Fully accessible fitness landscape of oncogene-negative lung adenocarcinoma JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA J2 - P NATL ACAD SCI USA VL - 120 PY - 2023 IS - 38 SN - 0027-8424 DO - 10.1073/pnas.2303224120 UR - https://m2.mtmt.hu/api/publication/34146082 ID - 34146082 AB - Cancer genomes are almost invariably complex with genomic alterations cooperating during each step of carcinogenesis. In cancers that lack a single dominant oncogene mutation, cooperation between the inactivation of multiple tumor suppressor genes can drive tumor initiation and growth. Here, we shed light on how the sequential acquisition of genomic alterations generates oncogene-negative lung tumors. We couple tumor barcoding with combinatorial and multiplexed somatic genome editing to characterize the fitness landscapes of three tumor suppressor genes NF1, RASA1, and PTEN, the inactivation of which jointly drives oncogene-negative lung adenocarcinoma initiation and growth. The fitness landscape was surprisingly accessible, with each additional mutation leading to growth advantage. Furthermore, the fitness landscapes remained fully accessible across backgrounds with the inactivation of additional tumor suppressor genes. These results suggest that while predicting cancer evolution will be challenging, acquiring the multiple alterations that drive the growth of oncogene-negative tumors can be facilitated by the lack of constraints on mutational order. LA - English DB - MTMT ER - TY - CHAP AU - Takáts, Tünde AU - Mészáros, János AU - Albert, Gáspár AU - Pásztor, László ED - Abriha-Molnár, Vanda Éva TI - Gépi tanuláson alapuló eróziós modell átvihetőségének vizsgálata borvidéken belül T2 - Az elmélet és gyakorlat találkozása a térinformatikában XIV. : Theory meets practice in GIS PB - Debreceni Egyetemi Kiadó CY - Debrecen SN - 9789636150846 PY - 2023 SP - 281 EP - 289 PG - 9 UR - https://m2.mtmt.hu/api/publication/33990408 ID - 33990408 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Hajdú, Edina AU - Pál, Márton TI - A Magas-Gerecse geoturisztikai értékelése JF - HONISMERET J2 - HONISMERET VL - 2023 PY - 2023 IS - 2 SP - 93 EP - 99 PG - 7 SN - 0324-7627 UR - https://m2.mtmt.hu/api/publication/33808932 ID - 33808932 LA - Hungarian DB - MTMT ER - TY - CONF AU - Takáts, Tünde AU - Mészáros, János AU - Albert, Gáspár AU - Pásztor, László TI - Spatial modelling of vineyard erosion using machine learning methods T2 - EGU General Assembly 2023: Abstracts PB - European Geosciences Union (EGU) C1 - München PY - 2023 DO - 10.5194/egusphere-egu23-2312 UR - https://m2.mtmt.hu/api/publication/33787013 ID - 33787013 LA - English DB - MTMT ER - TY - CONF AU - Hajdú, Edina AU - Pál, Márton TI - Creating a web-based 3D virtual field trip geotourism platform T2 - EGU General Assembly 2023: Abstracts PB - European Geosciences Union (EGU) C1 - München PY - 2023 SP - 1 UR - https://m2.mtmt.hu/api/publication/33786491 ID - 33786491 LA - English DB - MTMT ER - TY - CONF AU - Hajdú, Edina AU - Pál, Márton TI - HOW DO GEOPARKS COMMUNICATE WITH GEOTOURISM MAPS? T2 - 16th European Geoparks Conference Abstracts Book PY - 2022 SP - 1 UR - https://m2.mtmt.hu/api/publication/33807262 ID - 33807262 LA - English DB - MTMT ER - TY - GEN AU - Sárközy, Zsófia TI - Útvonal és időköltség tervezésének problémája terepi körülmények között PY - 2022 PG - 39 UR - https://m2.mtmt.hu/api/publication/33799453 ID - 33799453 LA - Hungarian DB - MTMT ER - TY - CONF AU - Zentai, László AU - Hajdú, Edina ED - Angeliki, Tsorlini TI - Exploring intentional distortions in Cold War tourist maps T2 - 16th ICA Conference Digital Approaches to Cartographic Heritage PY - 2022 SP - 181 EP - 191 PG - 11 UR - https://m2.mtmt.hu/api/publication/33192349 ID - 33192349 LA - English DB - MTMT ER - TY - CONF AU - Hajdú, Edina AU - Pál, Márton ED - Bandrova, Temenoujka ED - Konečný, Milan ED - Marinova, Silvia TI - INSPECTING GEOTOURIST MAPS TO ENHANCE VISUAL GEOSCIENTIFIC COMMUNICATION T2 - 8th International Conference on Cartography and GIS, proceedings Vol.2 PY - 2022 SP - 57 EP - 66 PG - 10 UR - https://m2.mtmt.hu/api/publication/33060309 ID - 33060309 LA - English DB - MTMT ER -