TY  - JOUR
AU  - Wéber, Ildikó
AU  - Dakos, Adél
AU  - Mészár, Zoltán
AU  - Matesz, Klára
AU  - Birinyi, András
TI  - Developmental patterns of extracellular matrix molecules in the embryonic and postnatal mouse hindbrain
JF  - FRONTIERS IN NEUROANATOMY
J2  - FRONT NEUROANAT
VL  - 18
PY  - 2024
SP  - 1
EP  - 24
PG  - 24
SN  - 1662-5129
DO  - 10.3389/fnana.2024.1369103
UR  - https://m2.mtmt.hu/api/publication/34813316
ID  - 34813316
AB  - Normal brain development requires continuous communication between developing neurons and their environment filled by a complex network referred to as extracellular matrix (ECM). The ECM is divided into distinct families of molecules including hyaluronic acid, proteoglycans, glycoproteins such as tenascins, and link proteins. In this study, we characterize the temporal and spatial distribution of the extracellular matrix molecules in the embryonic and postnatal mouse hindbrain by using antibodies and lectin histochemistry. In the embryo, hyaluronan and neurocan were found in high amounts until the time of birth whereas versican and tenascin-R were detected in lower intensities during the whole embryonic period. After birth, both hyaluronic acid and neurocan still produced intense staining in almost all areas of the hindbrain, while tenascin-R labeling showed a continuous increase during postnatal development. The reaction with WFA and aggrecan was revealed first 4th postnatal day (P4) with low staining intensities, while HAPLN was detected two weeks after birth (P14). The perineuronal net appeared first around the facial and vestibular neurons at P4 with hyaluronic acid cytochemistry. One week after birth aggrecan, neurocan, tenascin-R, and WFA were also accumulated around the neurons located in several hindbrain nuclei, but HAPLN1 was detected on the second postnatal week. Our results provide further evidence that many extracellular macromolecules that will be incorporated into the perineuronal net are already expressed at embryonic and early postnatal stages of development to control differentiation, migration, and synaptogenesis of neurons. In late postnatal period, the experience-driven neuronal activity induces formation of perineuronal net to stabilize synaptic connections.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Árpád, Kunka
AU  - Lisztes, Erika
AU  - Judit, Bohács
AU  - Márk, Racskó
AU  - Balázs, Kelemen
AU  - Kovalecz, Gabriella
AU  - D. Tóth, Etelka
AU  - Hegedűs, Csaba
AU  - Bágyi, Kinga, Ágnes
AU  - Marincsák, Rita
AU  - Tóth, Balázs István
TI  - TRPA1 upregulation mediates oxidative stress in a pulpitis model in vitro
JF  - BRITISH JOURNAL OF PHARMACOLOGY
J2  - BR J PHARMACOL
PY  - 2024
SN  - 0007-1188
UR  - https://m2.mtmt.hu/api/publication/34715686
ID  - 34715686
N1  - accepted for publication
AB  - BACKGROUND AND PURPOSE
Pulpitis is associated with tooth hypersensitivity and results in pulpal damage. Thermosensitive transient receptor potential (TRP) ion channels expressed in the dental pulp may be key transducers of inflammation and nociception. We aimed at investigating the expression and role of thermo-TRPs in primary human dental pulp cells (hDPCs) in normal and inflammatory conditions.
EXPERIMENTAL APPROACH
Inflammatory conditions were induced in hDPC cultures by applying polyinosinic:polycytidylic acid (poly(I:C)). Gene expression and proinflammatory cytokine-release were measured by RT-qPCR and ELISA. Function of TRPA1 was investigated by monitoring changes in intracellular Ca2+ concentration. Mitochondrial superoxide production was measured using a fluorescent substrate and cellular viability was assessed by measuring the activity of mitochondrial dehydrogenases and cytoplasmic esterases. TRPA1 activity was manipulated by agonists, antagonists, and gene silencing.
KEY RESULTS
The transcripts of TRPV1, TRPV2, TRPV4, TRPC5, and TRPA1 were highly expressed in control hDPCs, whereas TRPV3, TRPM2, and TRPM3 expressions were much lower, and TRPM8 was not detected. Poly(I:C) markedly upregulated TRPA1 but not other thermo-TRPs. TRPA1 agonist-induced Ca2+ signals were highly potentiated in inflammatory conditions. Poly(I:C)-treated cells displayed increased Ca2+ responses to H2O2 which was abolished by TRPA1 antagonism. Inflammatory conditions induced oxidative stress, stimulated mitochondrial superoxide production, resulted in mitochondrial damage, and decreased cellular viability of hDPCs. This inflammatory cellular damage was partially prevented by the co-application of TRPA1 antagonist or TRPA1 silencing. 
CONCLUSION AND IMPLICATIONS
The pharmacological blockade of TRPA1 may be a promising therapeutic approach to alleviate pulpitis and inflammation-associated pulpal damage.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Skopkó, Boglárka Emese
AU  - Homoki, Judit Rita
AU  - Fazekas, Mónika Éva
AU  - Paholcsek, Melinda
AU  - Fauszt, Péter
AU  - Dávid, Péter
AU  - Stündl, László
AU  - Molnár, Piroska Bíróné
AU  - Forgács, Ildikó Noémi
AU  - Váradi, Judit
AU  - Bágyi, Kinga, Ágnes
AU  - Gálné Remenyik, Judit
TI  - Changes in the Composition of Unstimulated and Stimulated Saliva Due to Chewing Sour Cherry Gum and a Toothbrush Change
JF  - CELLS
J2  - CELLS-BASEL
VL  - 13
PY  - 2024
IS  - 3
SN  - 2073-4409
DO  - 10.3390/cells13030251
UR  - https://m2.mtmt.hu/api/publication/34546012
ID  - 34546012
AB  - Background: Our previous studies demonstrated that sour cherry anthocyanins (AC) reduce the salivary count of Streptococcus mutans and inhibit salivary amylase activity within 30 minutes after chewing AC gum. AC gum and changing toothbrushes after scaling reduced the Gram-negative species in the unstimulated salivary microbiota. The present study examined the effect of AC gums on salivary factors, including changes in microbiome. Methods: The study was conducted over three weeks with two groups; young adults (18–30) and adults (30–45). Ten participants changed their toothbrushes, while the other 10 participants did not change after the control period. After scaling, all participants received three doses of AC gum daily. The salivary mRNA and protein levels of cytokines, mucins, melatonin, and the microbiota of unstimulated and stimulated saliva were determined by polymerase chain reaction, enzyme-linked immunosorbent assay, and 16S rRNA gene sequencing. Results: Significantly higher levels of tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), mucin5B (MUC5B), mucin7 (MUC7), and melatonin were detected in stimulated saliva. Correlation analysis of these factors with the microbiota showed positive correlations with the genera Lachnospiraceae, Eikenella, Saccharibacteria_(TM7), Streptococcus, Prevotella, and Haemophilus. Conclusions: AC chewing gum has a beneficial effect on the composition of the oral microbiome, and toothbrush replacement leads to changes in the levels of salivary pro-inflammatory cytokines.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tar, Ildikó
AU  - Végh, Edit
AU  - Martos, Renáta
AU  - Boglárka, Soós
AU  - Márton, Ildikó
AU  - Szekanecz, Zoltán
TI  - Six-Month Follow-Up of Periodontal Condition in Rheumatoid Arthritis and Ankylosing Spondylitis Arthritis Patients Undergoing Anti-Tumour Necrosis Factor-α Therapy
JF  - JOURNAL OF CLINICAL MEDICINE
J2  - J CLIN MED
VL  - 13
PY  - 2024
PG  - 10
SN  - 2077-0383
DO  - 10.3390/jcm13020448
UR  - https://m2.mtmt.hu/api/publication/34502100
ID  - 34502100
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Juhász, István
TI  - A bazálsejtes carcinoma
JF  - ORVOSTOVÁBBKÉPZŐ SZEMLE
J2  - ORVOSTOVÁBBKÉPZŐ SZLE
VL  - 30
PY  - 2023
SP  - 22
EP  - 30
PG  - 9
SN  - 1218-2583
UR  - https://m2.mtmt.hu/api/publication/34728929
ID  - 34728929
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Dienes, Csaba Bálint
AU  - Kovács, Zsigmond Máté
AU  - Óvári, József
AU  - Szentandrássy, Norbert
TI  - TRPM4-ioncsatornák vizsgálatának farmakológiai lehetőségei [=Pharmacological possibilities of testing TRPM4 ion channels]
JF  - CARDIOLOGIA HUNGARICA
J2  - CARDIOL HUNG
VL  - 53
PY  - 2023
IS  - 5
SP  - 446
EP  - 450
PG  - 5
SN  - 0133-5596
DO  - 10.26430/CHUNGARICA.2023.53.5.446
UR  - https://m2.mtmt.hu/api/publication/34477780
ID  - 34477780
AB  - A tranziens receptorpotenciál melasztatin-4 a TRPM-fehérjecsalád egyedülálló tagja. A TRPM5-höz hasonlóan Ca2+-érzékeny és csak egyértékű kationokra permeábilis. Sok szervben, széles körben expresszálódik és a membránpotenciál és a Ca2+-homeosztázis szabályozásával számos funkcióval is bír mind az ingerlékeny, mind a nem ingerelhető sejtekben. Az áttekintés a TRPM4 farmakológiai modulációját tárgyalja az ioncsatorna egy régebbi, gyakrabban használt, valamint két újabb, potenciálisan szelektívebb inhibitorának összehasonlításával és leírásával. A TRPM4 egyre nagyobb figyelmet kap és valószínűleg a jövőben is a kutatások témája lesz.

Summary
The Transient Receptor Potential Melastatin 4 is a unique member of the TRPM protein family. Like TRPM5, it is Ca2+-sensitive and permeable only to monovalent cations. It is widely expressed in many organs and has multiple functions in both excitable and non-excitable cells by regulating membrane potential and Ca2+ homeostasis. This review discusses the pharmacological modulation of TRPM4 by comparing and describing one older, more commonly used inhibitor of the ion channel and two newer, potentially more selective inhibitors. TRPM4 is receiving increasing attention and is likely to be a topic of future research.
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Nemes, Judit
ED  - Rózsa, Noémi Katinka
ED  - Gábris, Katalin
ED  - Tarján, Ildikó
TI  - Tej- és fiatal maradófogak szuvasodásának ellátása
T2  - Gyermek- és ifjúsági fogászat
PB  - Semmelweis Kiadó
CY  - Budapest
SN  - 9789633315743
PY  - 2023
SP  - 95
EP  - 120
PG  - 26
UR  - https://m2.mtmt.hu/api/publication/34431378
ID  - 34431378
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tar, Ildikó
AU  - Szegedi, Márta
AU  - Krasuska-Sławińska, Ewa
AU  - Heropolitańska-Pliszka, Edyta
AU  - Bernatowska, Ewa A.
AU  - Öncü, Elif
AU  - Keles, Sevgi
AU  - Guner, Sukru N.
AU  - Reisli, Ismail
AU  - Gesheva, Nevena
AU  - Naumova, Elissaveta
AU  - Izakovicova-Holla, Lydie
AU  - Litzman, Jiri
AU  - Savchak, Igor
AU  - Kostyuchenko, Larysa
AU  - Erdős, Melinda
TI  - Intraoral and maxillofacial abnormalities in patients with autosomal dominant hyper-IgE syndrome
JF  - CENTRAL-EUROPEAN JOURNAL OF IMMUNOLOGY
J2  - CENT EUR J IMMUNOL
VL  - 48
PY  - 2023
IS  - 3
SP  - 228
EP  - 236
PG  - 9
SN  - 1426-3912
DO  - 10.5114/ceji.2023.130874
UR  - https://m2.mtmt.hu/api/publication/34428422
ID  - 34428422
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ráduly, Arnold Péter
AU  - Sárkány, Fruzsina
AU  - Kovács, Máté Balázs
AU  - Juhász, Béla
AU  - Horváth, Balázs
AU  - Szentandrássy, Norbert
AU  - Nánási, Péter Pál
AU  - Édes, István
AU  - Csanádi, Zoltán
AU  - Tóth, Attila
AU  - Papp, Zoltán
AU  - Priksz, Dániel
AU  - Borbély, Attila
TI  - A kardiális miozinaktivátorok klinikai alkalmazhatósága a preklinikai vizsgálatok tükrében [= Clinical applications of cardiac myosin activators in the light of preclinical studies]
JF  - CARDIOLOGIA HUNGARICA
J2  - CARDIOL HUNG
VL  - 53
PY  - 2023
IS  - 5
SP  - 476
EP  - 483
PG  - 8
SN  - 0133-5596
DO  - 10.26430/CHUNGARICA.2023.53.5.476
UR  - https://m2.mtmt.hu/api/publication/34400338
ID  - 34400338
AB  - A csökkent ejekciós frakciójú szívelégtelenség (HFrEF) gyógyszeres kezelésében az utóbbi évtizedben jelentős fejlődés következett be. A kórkép patomechanizmusának középpontjában álló kontraktilis diszfunkciót direkten javító, úgynevezett pozitív inotróp szerek azonban továbbra sem hoztak átütő sikert. Az ideális pozitív inotróp szer nem fokozza a myocardium energiaigényét és oxigénfelhasználását. Az eddig használt gyógyszerek sajnos maradéktalanul nem tudtak megfelelni ezeknek az elvárásoknak. Az aktin-miozin-interakció direkt modulálása miozinaktivátorokkal egy új terápiás célpont a kontrakciós erő fokozására, a korábbi szerekre jellemző káros mellékhatások nélkül. Klinikai vizsgálatokban az első ilyen gyógyszer, az omecamtiv-mecarbil (OM) – a III. fázis vizsgálatok kezdeti pozitív eredményei ellenére – megfelelő hatékonyság hiánya miatt mégsem került bevezetésre a klinikai gyakorlatba. Ezen vegyület alkalmazhatóságát korlátozó tényezőket számos preklinikai tanulmány vizsgálta. Az OM sikertelensége ugyanakkor egy új típusú miozinaktivátor, a danicamtiv kifejlesztését is potencírozta. A danicamtivval kapcsolatos preklinikai és klinikai vizsgálatok jelenleg még korlátozott számban érhetőek el. Az eddigi eredmények biztatóbbak a danicamtivval kapcsolatban, azonban ennek megerősítésére még számos vizsgálatra van szükség. Feltételezhetően mindkét gyógyszerjelölt jövőbeli alkalmazhatóságát diasztolés diszfunkciót okozó hatásuk korlátozhatja.

Summary:
There have been significant advances in the management of heart failure with reduced ejection fraction (HFrEF) over the last decade. However, the so-called positive inotropic agents, which directly correct the contractile dysfunction at the heart of the pathomechanism of the disease, have still not been a resounding success. The ideal positive inotropic agent does not increase myocardial energy demand and oxygen consumption. Unfortunately, the drugs used so far have not fully met these requirements. Direct modulation of the actin-myosin interaction by myosin activators is a new therapeutic target to enhance contractile force without the adverse side effects typical of previous agents. In clinical trials, the first such drug, omecamtiv mecarbil (OM), has not been introduced into clinical practice due to lack of adequate efficacy, despite initial positive results in phase III trials. Several preclinical studies have investigated the limiting factors for the applicability of this compound. However, the failure of OM has also stimulated the development of a new type of myosin activator, danicamtiv. Preclinical and clinical studies on danicamtiv are currently limited. The results to date are more encouraging for danicamtiv, but many more studies are needed to confirm this. Presumably, the future applicability of both candidates may be limited by their adverse effects on diastolic function.
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Gruper, Yael
AU  - Wolff, Anette S. B.
AU  - Glanz, Liad
AU  - Spoutil, Frantisek
AU  - Marthinussen, Mihaela Cuida
AU  - Osickova, Adriana
AU  - Herzig, Yonatan
AU  - Goldfarb, Yael
AU  - Aranaz-Novaliches, Goretti
AU  - Dobeš, Jan
AU  - Kadouri, Noam
AU  - Ben-Nun, Osher
AU  - Binyamin, Amit
AU  - Lavi, Bar
AU  - Givony, Tal
AU  - Khalaila, Razi
AU  - Gome, Tom
AU  - Wald, Tomáš
AU  - Mrazkova, Blanka
AU  - Sochen, Carmel
AU  - Besnard, Marine
AU  - Ben-Dor, Shifra
AU  - Feldmesser, Ester
AU  - Orlova, Elisaveta M.
AU  - Hegedűs, Csaba
AU  - Lampé, István
AU  - Papp, Tamás
AU  - Felszeghy, Szabolcs
AU  - Sedlacek, Radislav
AU  - Davidovich, Esti
AU  - Tal, Noa
AU  - Shouval, Dror S.
AU  - Shamir, Raanan
AU  - Guillonneau, Carole
AU  - Szondy, Zsuzsanna
AU  - Lundin, Knut E. A.
AU  - Osicka, Radim
AU  - Prochazka, Jan
AU  - Husebye, Eystein S.
AU  - Abramson, Jakub
TI  - Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease
JF  - NATURE
J2  - NATURE
VL  - 624
PY  - 2023
IS  - 7992
SP  - 653
EP  - 662
PG  - 10
SN  - 0028-0836
DO  - 10.1038/s41586-023-06776-0
UR  - https://m2.mtmt.hu/api/publication/34399937
ID  - 34399937
LA  - English
DB  - MTMT
ER  -