@article{MTMT:34813316,
	title = {Developmental patterns of extracellular matrix molecules in the embryonic and postnatal mouse hindbrain},
	url = {https://m2.mtmt.hu/api/publication/34813316},
	author = {Wéber, Ildikó and Dakos, Adél and Mészár, Zoltán and Matesz, Klára and Birinyi, András},
	doi = {10.3389/fnana.2024.1369103},
	journal-iso = {FRONT NEUROANAT},
	journal = {FRONTIERS IN NEUROANATOMY},
	volume = {18},
	unique-id = {34813316},
	issn = {1662-5129},
	abstract = {Normal brain development requires continuous communication between developing neurons and their environment filled by a complex network referred to as extracellular matrix (ECM). The ECM is divided into distinct families of molecules including hyaluronic acid, proteoglycans, glycoproteins such as tenascins, and link proteins. In this study, we characterize the temporal and spatial distribution of the extracellular matrix molecules in the embryonic and postnatal mouse hindbrain by using antibodies and lectin histochemistry. In the embryo, hyaluronan and neurocan were found in high amounts until the time of birth whereas versican and tenascin-R were detected in lower intensities during the whole embryonic period. After birth, both hyaluronic acid and neurocan still produced intense staining in almost all areas of the hindbrain, while tenascin-R labeling showed a continuous increase during postnatal development. The reaction with WFA and aggrecan was revealed first 4th postnatal day (P4) with low staining intensities, while HAPLN was detected two weeks after birth (P14). The perineuronal net appeared first around the facial and vestibular neurons at P4 with hyaluronic acid cytochemistry. One week after birth aggrecan, neurocan, tenascin-R, and WFA were also accumulated around the neurons located in several hindbrain nuclei, but HAPLN1 was detected on the second postnatal week. Our results provide further evidence that many extracellular macromolecules that will be incorporated into the perineuronal net are already expressed at embryonic and early postnatal stages of development to control differentiation, migration, and synaptogenesis of neurons. In late postnatal period, the experience-driven neuronal activity induces formation of perineuronal net to stabilize synaptic connections.},
	year = {2024},
	eissn = {1662-5129},
	pages = {1-24}
}

@article{MTMT:34715686,
	title = {TRPA1 upregulation mediates oxidative stress in a pulpitis model in vitro},
	url = {https://m2.mtmt.hu/api/publication/34715686},
	author = {Árpád, Kunka and Lisztes, Erika and Judit, Bohács and Márk, Racskó and Balázs, Kelemen and Kovalecz, Gabriella and D. Tóth, Etelka and Hegedűs, Csaba and Bágyi, Kinga, Ágnes and Marincsák, Rita and Tóth, Balázs István},
	journal-iso = {BR J PHARMACOL},
	journal = {BRITISH JOURNAL OF PHARMACOLOGY},
	unique-id = {34715686},
	issn = {0007-1188},
	abstract = {BACKGROUND AND PURPOSE
		Pulpitis is associated with tooth hypersensitivity and results in pulpal damage. Thermosensitive transient receptor potential (TRP) ion channels expressed in the dental pulp may be key transducers of inflammation and nociception. We aimed at investigating the expression and role of thermo-TRPs in primary human dental pulp cells (hDPCs) in normal and inflammatory conditions.
		EXPERIMENTAL APPROACH
		Inflammatory conditions were induced in hDPC cultures by applying polyinosinic:polycytidylic acid (poly(I:C)). Gene expression and proinflammatory cytokine-release were measured by RT-qPCR and ELISA. Function of TRPA1 was investigated by monitoring changes in intracellular Ca2+ concentration. Mitochondrial superoxide production was measured using a fluorescent substrate and cellular viability was assessed by measuring the activity of mitochondrial dehydrogenases and cytoplasmic esterases. TRPA1 activity was manipulated by agonists, antagonists, and gene silencing.
		KEY RESULTS
		The transcripts of TRPV1, TRPV2, TRPV4, TRPC5, and TRPA1 were highly expressed in control hDPCs, whereas TRPV3, TRPM2, and TRPM3 expressions were much lower, and TRPM8 was not detected. Poly(I:C) markedly upregulated TRPA1 but not other thermo-TRPs. TRPA1 agonist-induced Ca2+ signals were highly potentiated in inflammatory conditions. Poly(I:C)-treated cells displayed increased Ca2+ responses to H2O2 which was abolished by TRPA1 antagonism. Inflammatory conditions induced oxidative stress, stimulated mitochondrial superoxide production, resulted in mitochondrial damage, and decreased cellular viability of hDPCs. This inflammatory cellular damage was partially prevented by the co-application of TRPA1 antagonist or TRPA1 silencing. 
		CONCLUSION AND IMPLICATIONS
		The pharmacological blockade of TRPA1 may be a promising therapeutic approach to alleviate pulpitis and inflammation-associated pulpal damage.},
	keywords = {immunopharmacology; TRPA1; Dental Pulp},
	year = {2024},
	eissn = {1476-5381},
	orcid-numbers = {Marincsák, Rita/0000-0003-2944-5612}
}

@article{MTMT:34546012,
	title = {Changes in the Composition of Unstimulated and Stimulated Saliva Due to Chewing Sour Cherry Gum and a Toothbrush Change},
	url = {https://m2.mtmt.hu/api/publication/34546012},
	author = {Skopkó, Boglárka Emese and Homoki, Judit Rita and Fazekas, Mónika Éva and Paholcsek, Melinda and Fauszt, Péter and Dávid, Péter and Stündl, László and Molnár, Piroska Bíróné and Forgács, Ildikó Noémi and Váradi, Judit and Bágyi, Kinga, Ágnes and Gálné Remenyik, Judit},
	doi = {10.3390/cells13030251},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {13},
	unique-id = {34546012},
	abstract = {Background: Our previous studies demonstrated that sour cherry anthocyanins (AC) reduce the salivary count of Streptococcus mutans and inhibit salivary amylase activity within 30 minutes after chewing AC gum. AC gum and changing toothbrushes after scaling reduced the Gram-negative species in the unstimulated salivary microbiota. The present study examined the effect of AC gums on salivary factors, including changes in microbiome. Methods: The study was conducted over three weeks with two groups; young adults (18–30) and adults (30–45). Ten participants changed their toothbrushes, while the other 10 participants did not change after the control period. After scaling, all participants received three doses of AC gum daily. The salivary mRNA and protein levels of cytokines, mucins, melatonin, and the microbiota of unstimulated and stimulated saliva were determined by polymerase chain reaction, enzyme-linked immunosorbent assay, and 16S rRNA gene sequencing. Results: Significantly higher levels of tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), mucin5B (MUC5B), mucin7 (MUC7), and melatonin were detected in stimulated saliva. Correlation analysis of these factors with the microbiota showed positive correlations with the genera Lachnospiraceae, Eikenella, Saccharibacteria_(TM7), Streptococcus, Prevotella, and Haemophilus. Conclusions: AC chewing gum has a beneficial effect on the composition of the oral microbiome, and toothbrush replacement leads to changes in the levels of salivary pro-inflammatory cytokines.},
	year = {2024},
	eissn = {2073-4409},
	orcid-numbers = {Dávid, Péter/0000-0002-6451-1200}
}

@article{MTMT:34502100,
	title = {Six-Month Follow-Up of Periodontal Condition in Rheumatoid Arthritis and Ankylosing Spondylitis Arthritis Patients Undergoing Anti-Tumour Necrosis Factor-α Therapy},
	url = {https://m2.mtmt.hu/api/publication/34502100},
	author = {Tar, Ildikó and Végh, Edit and Martos, Renáta and Boglárka, Soós and Márton, Ildikó and Szekanecz, Zoltán},
	doi = {10.3390/jcm13020448},
	journal-iso = {J CLIN MED},
	journal = {JOURNAL OF CLINICAL MEDICINE},
	volume = {13},
	unique-id = {34502100},
	year = {2024},
	eissn = {2077-0383}
}

@article{MTMT:34728929,
	title = {A bazálsejtes carcinoma},
	url = {https://m2.mtmt.hu/api/publication/34728929},
	author = {Juhász, István},
	journal-iso = {ORVOSTOVÁBBKÉPZŐ SZLE},
	journal = {ORVOSTOVÁBBKÉPZŐ SZEMLE},
	volume = {30},
	unique-id = {34728929},
	issn = {1218-2583},
	year = {2023},
	pages = {22-30}
}

@article{MTMT:34477780,
	title = {TRPM4-ioncsatornák vizsgálatának farmakológiai lehetőségei [=Pharmacological possibilities of testing TRPM4 ion channels]},
	url = {https://m2.mtmt.hu/api/publication/34477780},
	author = {Dienes, Csaba Bálint and Kovács, Zsigmond Máté and Óvári, József and Szentandrássy, Norbert},
	doi = {10.26430/CHUNGARICA.2023.53.5.446},
	journal-iso = {CARDIOL HUNG},
	journal = {CARDIOLOGIA HUNGARICA},
	volume = {53},
	unique-id = {34477780},
	issn = {0133-5596},
	abstract = {A tranziens receptorpotenciál melasztatin-4 a TRPM-fehérjecsalád egyedülálló tagja. A TRPM5-höz hasonlóan Ca2+-érzékeny és csak egyértékű kationokra permeábilis. Sok szervben, széles körben expresszálódik és a membránpotenciál és a Ca2+-homeosztázis szabályozásával számos funkcióval is bír mind az ingerlékeny, mind a nem ingerelhető sejtekben. Az áttekintés a TRPM4 farmakológiai modulációját tárgyalja az ioncsatorna egy régebbi, gyakrabban használt, valamint két újabb, potenciálisan szelektívebb inhibitorának összehasonlításával és leírásával. A TRPM4 egyre nagyobb figyelmet kap és valószínűleg a jövőben is a kutatások témája lesz.
		
		Summary
		The Transient Receptor Potential Melastatin 4 is a unique member of the TRPM protein family. Like TRPM5, it is Ca2+-sensitive and permeable only to monovalent cations. It is widely expressed in many organs and has multiple functions in both excitable and non-excitable cells by regulating membrane potential and Ca2+ homeostasis. This review discusses the pharmacological modulation of TRPM4 by comparing and describing one older, more commonly used inhibitor of the ion channel and two newer, potentially more selective inhibitors. TRPM4 is receiving increasing attention and is likely to be a topic of future research.},
	keywords = {9-phenanthrol; CBA; transient receptor potential melastatin 4 (TRPM4); meklofenamát; Meclofenamate},
	year = {2023},
	eissn = {1588-0230},
	pages = {446-450},
	orcid-numbers = {Szentandrássy, Norbert/0000-0003-0197-9567}
}

@{MTMT:34431378,
	title = {Tej- és fiatal maradófogak szuvasodásának ellátása},
	url = {https://m2.mtmt.hu/api/publication/34431378},
	author = {Nemes, Judit},
	booktitle = {Gyermek- és ifjúsági fogászat},
	unique-id = {34431378},
	year = {2023},
	pages = {95-120}
}

@article{MTMT:34428422,
	title = {Intraoral and maxillofacial abnormalities in patients with autosomal dominant hyper-IgE syndrome},
	url = {https://m2.mtmt.hu/api/publication/34428422},
	author = {Tar, Ildikó and Szegedi, Márta and Krasuska-Sławińska, Ewa and Heropolitańska-Pliszka, Edyta and Bernatowska, Ewa A. and Öncü, Elif and Keles, Sevgi and Guner, Sukru N. and Reisli, Ismail and Gesheva, Nevena and Naumova, Elissaveta and Izakovicova-Holla, Lydie and Litzman, Jiri and Savchak, Igor and Kostyuchenko, Larysa and Erdős, Melinda},
	doi = {10.5114/ceji.2023.130874},
	journal-iso = {CENT EUR J IMMUNOL},
	journal = {CENTRAL-EUROPEAN JOURNAL OF IMMUNOLOGY},
	volume = {48},
	unique-id = {34428422},
	issn = {1426-3912},
	year = {2023},
	eissn = {1644-4124},
	pages = {228-236},
	orcid-numbers = {Szegedi, Márta/0000-0002-9462-3211}
}

@article{MTMT:34400338,
	title = {A kardiális miozinaktivátorok klinikai alkalmazhatósága a preklinikai vizsgálatok tükrében [= Clinical applications of cardiac myosin activators in the light of preclinical studies]},
	url = {https://m2.mtmt.hu/api/publication/34400338},
	author = {Ráduly, Arnold Péter and Sárkány, Fruzsina and Kovács, Máté Balázs and Juhász, Béla and Horváth, Balázs and Szentandrássy, Norbert and Nánási, Péter Pál and Édes, István and Csanádi, Zoltán and Tóth, Attila and Papp, Zoltán and Priksz, Dániel and Borbély, Attila},
	doi = {10.26430/CHUNGARICA.2023.53.5.476},
	journal-iso = {CARDIOL HUNG},
	journal = {CARDIOLOGIA HUNGARICA},
	volume = {53},
	unique-id = {34400338},
	issn = {0133-5596},
	abstract = {A csökkent ejekciós frakciójú szívelégtelenség (HFrEF) gyógyszeres kezelésében az utóbbi évtizedben jelentős fejlődés következett be. A kórkép patomechanizmusának középpontjában álló kontraktilis diszfunkciót direkten javító, úgynevezett pozitív inotróp szerek azonban továbbra sem hoztak átütő sikert. Az ideális pozitív inotróp szer nem fokozza a myocardium energiaigényét és oxigénfelhasználását. Az eddig használt gyógyszerek sajnos maradéktalanul nem tudtak megfelelni ezeknek az elvárásoknak. Az aktin-miozin-interakció direkt modulálása miozinaktivátorokkal egy új terápiás célpont a kontrakciós erő fokozására, a korábbi szerekre jellemző káros mellékhatások nélkül. Klinikai vizsgálatokban az első ilyen gyógyszer, az omecamtiv-mecarbil (OM) – a III. fázis vizsgálatok kezdeti pozitív eredményei ellenére – megfelelő hatékonyság hiánya miatt mégsem került bevezetésre a klinikai gyakorlatba. Ezen vegyület alkalmazhatóságát korlátozó tényezőket számos preklinikai tanulmány vizsgálta. Az OM sikertelensége ugyanakkor egy új típusú miozinaktivátor, a danicamtiv kifejlesztését is potencírozta. A danicamtivval kapcsolatos preklinikai és klinikai vizsgálatok jelenleg még korlátozott számban érhetőek el. Az eddigi eredmények biztatóbbak a danicamtivval kapcsolatban, azonban ennek megerősítésére még számos vizsgálatra van szükség. Feltételezhetően mindkét gyógyszerjelölt jövőbeli alkalmazhatóságát diasztolés diszfunkciót okozó hatásuk korlátozhatja.
		
		Summary:
		There have been significant advances in the management of heart failure with reduced ejection fraction (HFrEF) over the last decade. However, the so-called positive inotropic agents, which directly correct the contractile dysfunction at the heart of the pathomechanism of the disease, have still not been a resounding success. The ideal positive inotropic agent does not increase myocardial energy demand and oxygen consumption. Unfortunately, the drugs used so far have not fully met these requirements. Direct modulation of the actin-myosin interaction by myosin activators is a new therapeutic target to enhance contractile force without the adverse side effects typical of previous agents. In clinical trials, the first such drug, omecamtiv mecarbil (OM), has not been introduced into clinical practice due to lack of adequate efficacy, despite initial positive results in phase III trials. Several preclinical studies have investigated the limiting factors for the applicability of this compound. However, the failure of OM has also stimulated the development of a new type of myosin activator, danicamtiv. Preclinical and clinical studies on danicamtiv are currently limited. The results to date are more encouraging for danicamtiv, but many more studies are needed to confirm this. Presumably, the future applicability of both candidates may be limited by their adverse effects on diastolic function.},
	keywords = {Myosin activators; Danicamtiv; omecamtiv-mecarbil; pozitív inotrópia; diasztolés diszfunkció; positive inotropy; miozinaktivátor; diastolic dyfunction},
	year = {2023},
	eissn = {1588-0230},
	pages = {476-483},
	orcid-numbers = {Horváth, Balázs/0000-0003-2562-8446; Szentandrássy, Norbert/0000-0003-0197-9567}
}

@article{MTMT:34399937,
	title = {Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease},
	url = {https://m2.mtmt.hu/api/publication/34399937},
	author = {Gruper, Yael and Wolff, Anette S. B. and Glanz, Liad and Spoutil, Frantisek and Marthinussen, Mihaela Cuida and Osickova, Adriana and Herzig, Yonatan and Goldfarb, Yael and Aranaz-Novaliches, Goretti and Dobeš, Jan and Kadouri, Noam and Ben-Nun, Osher and Binyamin, Amit and Lavi, Bar and Givony, Tal and Khalaila, Razi and Gome, Tom and Wald, Tomáš and Mrazkova, Blanka and Sochen, Carmel and Besnard, Marine and Ben-Dor, Shifra and Feldmesser, Ester and Orlova, Elisaveta M. and Hegedűs, Csaba and Lampé, István and Papp, Tamás and Felszeghy, Szabolcs and Sedlacek, Radislav and Davidovich, Esti and Tal, Noa and Shouval, Dror S. and Shamir, Raanan and Guillonneau, Carole and Szondy, Zsuzsanna and Lundin, Knut E. A. and Osicka, Radim and Prochazka, Jan and Husebye, Eystein S. and Abramson, Jakub},
	doi = {10.1038/s41586-023-06776-0},
	journal-iso = {NATURE},
	journal = {NATURE},
	volume = {624},
	unique-id = {34399937},
	issn = {0028-0836},
	year = {2023},
	eissn = {1476-4687},
	pages = {653-662},
	orcid-numbers = {Gruper, Yael/0000-0001-7912-2243; Wolff, Anette S. B./0000-0002-8485-2248; Aranaz-Novaliches, Goretti/0000-0001-6859-1095; Dobeš, Jan/0000-0003-1853-1603; Kadouri, Noam/0000-0002-2978-4318; Binyamin, Amit/0000-0002-0046-0029; Gome, Tom/0000-0002-2514-6845; Mrazkova, Blanka/0000-0003-1985-2361; Besnard, Marine/0000-0002-3009-5528; Ben-Dor, Shifra/0000-0001-9604-1939; Feldmesser, Ester/0000-0002-7017-4861; Sedlacek, Radislav/0000-0002-3352-392X; Prochazka, Jan/0000-0003-4675-8995; Abramson, Jakub/0000-0002-1745-8996}
}