TY - JOUR AU - Bene, László AU - Gogolák, Péter AU - Rubovszky, Bálint AU - Tóth, Dezső AU - Damjanovich, László TI - FRET calibration by symmetrization on the cell surface JF - OPTICS AND LASER TECHNOLOGY J2 - OPT LASER TECHNOL VL - 181 PY - 2025 SN - 0030-3992 DO - 10.1016/j.optlastec.2024.111524 UR - https://m2.mtmt.hu/api/publication/35201744 ID - 35201744 N1 - Department of Surgery, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Institute for Nuclear Research, Debrecen, Hungary Export Date: 4 September 2024 CODEN: OLTCA Correspondence Address: Bene, L.; Department of Biophysics and Cell Biology, H-4032 Egyetem tér 1, P.O. Box 400, Hungary; email: bene@med.unideb.hu LA - English DB - MTMT ER - TY - CHAP AU - Oláh, Attila AU - Szöllősi, Attila AU - Tóth, Balázs István ED - Szállási, Árpád TI - TRP channels in dermatology T2 - TRP Channels as Therapeutic Targets : Advances in Basic Science and Clinical Use PB - Elsevier Academic Press CY - Waltham (MA) SN - 9780443186530 PY - 2024 SP - 365 EP - 385 PG - 21 SN - 9780443186530 DO - 10.1016/B978-0-443-18653-0.00004-6 UR - https://m2.mtmt.hu/api/publication/35309780 ID - 35309780 LA - English DB - MTMT ER - TY - JOUR AU - Hoffka, Gyula AU - Mhana, Samara AU - Vas, Marcell AU - Toldi, Vanda AU - Mótyán, János András AU - Tőzsér, József AU - Szabó, András TI - Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog JF - JOURNAL OF BIOLOGICAL CHEMISTRY J2 - J BIOL CHEM PY - 2024 SN - 0021-9258 DO - 10.1016/j.jbc.2024.107763 UR - https://m2.mtmt.hu/api/publication/35309467 ID - 35309467 LA - English DB - MTMT ER - TY - JOUR AU - Espinosa-Ortega, Fabricio AU - Lodin, Karin AU - Dastmalchi, Maryam AU - Vencovsky, Jiri AU - Diederichsen, Louise P. AU - Shinjo, Samuel Katsuyuki AU - Danieli, Maria Giovanna AU - Selva-O'Callaghan, Albert AU - de Visser, Marianne AU - Griger, Zoltán AU - Ceribelli, Angela AU - Gómez-Martin, Diana AU - Andersson, Helena AU - Mercado, Mónica Vázquez-Del AU - Chinoy, Hector AU - Lilleker, James B. AU - New, Paul AU - Krogh, Niels S. AU - Lundberg, Ingrid E. AU - Alexanderson, Helene AU - MYONET, Registry Study Group TI - Autoantibodies and damage in patients with idiopathic inflammatory myopathies : a longitudinal multicenter study from the MYONET international network JF - SEMINARS IN ARTHRITIS AND RHEUMATISM J2 - SEMIN ARTHRITIS RHEU VL - 68 PY - 2024 SP - 1 EP - 10 PG - 10 SN - 0049-0172 DO - 10.1016/j.semarthrit.2024.152529 UR - https://m2.mtmt.hu/api/publication/35309407 ID - 35309407 LA - English DB - MTMT ER - TY - JOUR AU - Kóder, Gergely AU - Dinya, Tamás Ákos AU - Tóth, Dezső AU - Damjanovich, László AU - Lóránt, Ágoston AU - Tanyi, Miklós Tamás TI - Rare case of succesfully operated idiopathic colonic varicosity JF - INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS J2 - IINT J SURG CASE REP VL - 123 PY - 2024 SN - 2210-2612 DO - 10.1016/j.ijscr.2024.110196 UR - https://m2.mtmt.hu/api/publication/35309288 ID - 35309288 LA - English DB - MTMT ER - TY - JOUR AU - Pepin, JT AU - Chon, HS AU - Sundborg, MJ AU - Gold, MA AU - Kim, B-G AU - Blank, SV AU - Liu, J-H AU - McCollum, M AU - Mori, M AU - Moore, KN AU - Diaz, JR AU - Joseph, de Padua CA AU - Martinez-Garcia, J AU - Papadimitriou, C AU - Gri, K AU - Póka, Róbert AU - Kowgier, M AU - Oscroft, E AU - Nieuwenhuysen, EV AU - Westin, SN TI - Safety and tolerability of durvalumab + carboplatin/paclitaxel followed by durvalumab +/- olaparib in patients with newly diagnosed advanced or recurrent endometrial cancer (EC) in the DUO-E/GOG-3041/ENGOT-EN10 trial JF - JOURNAL OF CLINICAL ONCOLOGY J2 - J CLIN ONCOL VL - 42 PY - 2024 IS - 16 SP - 599_suppl SN - 0732-183X DO - 10.1200/JCO.2024.42.16_suppl.5599 UR - https://m2.mtmt.hu/api/publication/35309258 ID - 35309258 LA - English DB - MTMT ER - TY - JOUR AU - Pál, L. AU - Lovas, Szabolcs AU - McKee, M. AU - Diószegi, Judit AU - Kovács, N. AU - Szűcs, Sándor TI - Indoor air pollution from volatile organic compounds in residential buildings in the European Union between 2010 and 2023 JF - TOXICOLOGY LETTERS J2 - TOXICOL LETT VL - 399 PY - 2024 SP - S321 SN - 0378-4274 UR - https://m2.mtmt.hu/api/publication/35309212 ID - 35309212 LA - English DB - MTMT ER - TY - JOUR AU - Csilla, Markóth AU - Szász, Róbert AU - Bidiga, László AU - Zoltán, Prohászka AU - Balla, József AU - Mátyus, János TI - Two cases of chronic lymphocytic leukemia associated immunotactoid glomerulopathy : variable clinical presentation, close hematological collaboration JF - NEPHROLOGY DIALYSIS TRANSPLANTATION J2 - NEPHROL DIAL TRANSPL VL - 39 PY - 2024 IS - Suppl_1 SP - i2094 SN - 0931-0509 DO - 10.1093/ndt/gfae069.1296 UR - https://m2.mtmt.hu/api/publication/35308783 ID - 35308783 LA - English DB - MTMT ER - TY - JOUR AU - Harangi, Mariann AU - Homoródi, Nóra TI - A lizoszomális savas lipázdeficientia jelentősége, felismerése és hatékony kezelése JF - LEGE ARTIS MEDICINAE J2 - LEGE ART MED VL - 34 PY - 2024 IS - 7-8 SP - 337 EP - 345 PG - 9 SN - 0866-4811 DO - 10.33616/lam.34.0337 UR - https://m2.mtmt.hu/api/publication/35308622 ID - 35308622 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gáll, Tamás AU - Pethő, Dávid AU - Erdélyi, Katalin AU - Egri, Virág AU - Balla, György Jázon AU - Nagy, Annamária AU - Nagy, Annamária AU - Póliska, Szilárd AU - Gram, Magnus AU - Gábriel, Róbert AU - Nagy, Péter AU - Balla, József AU - Balla, György TI - Heme : a link between hemorrhage and retinopathy of prematurity progression. A link between hemorrhage and retinopathy of prematurity progression. TS - A link between hemorrhage and retinopathy of prematurity progression. JF - REDOX BIOLOGY J2 - REDOX BIOL VL - 76 PY - 2024 SP - 103316 SN - 2213-2317 DO - 10.1016/j.redox.2024.103316 UR - https://m2.mtmt.hu/api/publication/35307257 ID - 35307257 AB - Neovascularization is implicated in the pathology of retinopathy of prematurity (ROP), diabetic retinopathy (DR), and age-related macular degeneration (AMD), which are the leading causes of blindness worldwide. In our work, we analyzed how heme released during hemorrhage affects hypoxic response and neovascularization. Our retrospective clinical analysis demonstrated, that hemorrhage was associated with more severe retinal neovascularization in ROP patients. Our heme-stimulated human retinal pigment epithelial (ARPE-19) cell studies demonstrated increased expression of positive regulators of angiogenesis, including vascular endothelial growth factor-A (VEGFA), a key player of ROP, DR and AMD, and highlighted the activation of the PI3K/AKT/mTOR/VEGFA pathway involved in angiogenesis in response to heme. Furthermore, heme decreased oxidative phosphorylation in the mitochondria, augmented glycolysis, facilitated HIF-1α nuclear translocation, and increased VEGFA/GLUT1/PDK1 expression suggesting HIF-1α-driven hypoxic response in ARPE-19 cells without effecting the metabolism of reactive oxygen species. Inhibitors of HIF-1α, PI3K and suppression of mTOR pathway by clinically promising drug, rapamycin, mitigated heme-provoked cellular response. Our data proved that oxidatively modified forms of hemoglobin can be sources of heme to induce VEGFA during retinal hemorrhage. We propose that hemorrhage is involved in the pathology of ROP, DR, and AMD. LA - English DB - MTMT ER -