@article{MTMT:34774854, title = {Colonic tubular adenoma with clear cell change – case report with whole exome sequencing and updated review of the literature}, url = {https://m2.mtmt.hu/api/publication/34774854}, author = {Ferenczi, Ádám and Kuthi, Levente and Sejben, István and Sejben, Anita}, doi = {10.1159/000538705}, journal-iso = {PATHOBIOLOGY}, journal = {PATHOBIOLOGY}, volume = {&}, unique-id = {34774854}, issn = {1015-2008}, abstract = {Introduction: Colorectal tubular adenomas displaying clear cell change are rare entities, with unknown clinical relevance, prognosis, immunohistochemical, and molecular features. Case presentation: Hereby we report a case of a 43-year-old female patient with a rectosigmoid polyp. Histologically, conventional dysplasia was visible with scattered areas displaying clear cell change. Whole exome sequencing (WES) was carried out and revealed high tumour mutation burden, and 7 pathogenic mutations, including TP53, APC, FGFR4, EHBP1, IL4R, TYR, and ACTN3.Conclusion: Clear cell change may only be present in less than 0,1% of adenomas. Aetiology is not well understood, additionally, few authors suggest autolysis or fixation problems. Our WES resulted in newly found pathogenic mutations, and high mutation burden, proving the lesion’s neoplastic origin. Hitherto, neither special stainings, nor immunohistochemical markers proved to be useful in the diagnostic process. From a differential diagnostic perspective, enteroblastic differentiation, primary and secondary clear cell adenocarcinoma has to be excluded.}, year = {2024}, eissn = {1423-0291}, pages = {&}, orcid-numbers = {Kuthi, Levente/0000-0001-9247-6679; Sejben, Anita/0000-0002-9434-2989} } @article{MTMT:34757445, title = {Licensing effects of inflammatory factors and TLR ligands on the regenerative capacity of adipose-derived mesenchymal stem cells}, url = {https://m2.mtmt.hu/api/publication/34757445}, author = {Szűcs, Diána and Monostori, Tamás and Vanda, Miklós and Páhi, Zoltán Gábor and Szilard, Poliska and Kemény, Lajos and Veréb, Zoltán}, doi = {10.3389/fcell.2024.1367242}, journal-iso = {FRONT CELL DEV BIOL}, journal = {FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY}, volume = {12}, unique-id = {34757445}, issn = {2296-634X}, year = {2024}, eissn = {2296-634X}, orcid-numbers = {Páhi, Zoltán Gábor/0000-0002-3428-553X; Kemény, Lajos/0000-0002-2119-9501; Veréb, Zoltán/0000-0002-9518-2155} } @article{MTMT:34752035, title = {Accuracy of the Pancolonic Modified Mayo Score in predicting the long-term outcomes of ulcerative colitis: a promising scoring system}, url = {https://m2.mtmt.hu/api/publication/34752035}, author = {Bacsur, Péter and Wetwittayakhlang, Panu and Resál, Tamás and Földi, Emese and Vasas, Béla and Farkas, Bernadett and Rutka, Mariann and Bessissow, Talat and Afif, Waqqas and Bálint, Anita and Fábián, Anna and Bor, Renáta and Szepes, Zoltán and Farkas, Klaudia and Lakatos, Péter László and Molnár, Tamás}, doi = {10.1177/17562848241239606}, journal-iso = {THER ADV GASTROENTER}, journal = {THERAPEUTIC ADVANCES IN GASTROENTEROLOGY}, volume = {17}, unique-id = {34752035}, issn = {1756-283X}, year = {2024}, eissn = {1756-2848}, orcid-numbers = {Bacsur, Péter/0000-0002-8534-0068; Wetwittayakhlang, Panu/0000-0002-5962-4112; Resál, Tamás/0000-0002-3842-9094; Rutka, Mariann/0000-0003-2360-7836; Bálint, Anita/0000-0002-3624-896X; Fábián, Anna/0000-0002-0824-7476; Bor, Renáta/0000-0001-9393-5240; Szepes, Zoltán/0000-0002-9466-8719; Farkas, Klaudia/0000-0003-0599-182X; Lakatos, Péter László/0000-0002-3948-6488; Molnár, Tamás/0000-0002-4913-7599} } @article{MTMT:34677129, title = {Role of CFTR in diabetes‐induced pancreatic ductal fluid and HCO 3 − secretion}, url = {https://m2.mtmt.hu/api/publication/34677129}, author = {Ébert, Attila and Gál, Eleonóra and Tóth, Emese and Szögi, Titanilla and Hegyi, Péter and Venglovecz, Viktória}, doi = {10.1113/JP285702}, journal-iso = {J PHYSIOL-LONDON}, journal = {JOURNAL OF PHYSIOLOGY-LONDON}, volume = {602}, unique-id = {34677129}, issn = {0022-3751}, year = {2024}, eissn = {1469-7793}, pages = {1065-1083}, orcid-numbers = {Szögi, Titanilla/0000-0002-9854-7340; Hegyi, Péter/0000-0003-0399-7259; Venglovecz, Viktória/0000-0002-2316-7247} } @article{MTMT:34635367, title = {Szűrő kolonoszkópos vizsgálatok hatékonyságának és biztonságosságának értékelése a Szegedi Tudományegyetemen és a Bács-Kiskun Vármegyei Oktatókórházban 2019 és 2022 között [Analysis of efficacy and safety of colonoscopic screening program at the University of Szeged and the Bács-Kiskun County Teaching Hospital between 2019 and 2022]}, url = {https://m2.mtmt.hu/api/publication/34635367}, author = {Magyar, Dániel and Fábián, Anna and Vasas, Béla and Nacsev, Krisztián and Dubravcsik, Zsolt and Bősze, Zsófia and Tóth, Tibor and Bacsur, Péter and Bálint, Anita and Farkas, Klaudia and Molnár, Tamás and Resál, Tamás and Bor, Renáta and Szepes, Zoltán}, doi = {10.1556/650.2024.32979}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {165}, unique-id = {34635367}, issn = {0030-6002}, keywords = {colorectal cancer; colorectal adenoma; colorectal carcinoma; Polypectomy; vastagbélrák; colorectal screening program; colorectalis adenoma; colorectalis carcinoma; polypectomia; vastagbélszűrő program}, year = {2024}, eissn = {1788-6120}, pages = {221-231}, orcid-numbers = {Fábián, Anna/0000-0002-0824-7476; Bacsur, Péter/0000-0002-8534-0068; Bálint, Anita/0000-0002-3624-896X; Farkas, Klaudia/0000-0003-0599-182X; Molnár, Tamás/0000-0002-4913-7599; Resál, Tamás/0000-0002-3842-9094; Bor, Renáta/0000-0001-9393-5240; Szepes, Zoltán/0000-0002-9466-8719} } @misc{MTMT:34588333, title = {Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction}, url = {https://m2.mtmt.hu/api/publication/34588333}, author = {Indira, Pla and Botond, L. Szabolcs and Petra, Nikolett Péter and Zsuzsanna, Ujfaludi and Yonghyo, Kim and Peter, Horvatovich and Aniel, Sanchez and Krzysztof, Pawlowski Elisabet Wieslander and Jéssica, Guedes and Dorottya, MP Pál and Anna, A. Ascsillán and Lazaro, Hiram Betancourt and István, Balázs Németh and Jeovanis, Gil and Natália, Pinto de Almeida and Beáta, Szeitz and Leticia, Szadai and Viktória, Doma and Nicole, Woldmar and Áron, Bartha and Zoltan, Pahi and Pankotai, Tibor and Balázs, Győrffy and A., Marcell Szasz and Gilberto, Domont and Fábio, Nogueira and Ho, Jeong Kwon and Roger, Appelqvist and Sarolta, Kárpáti and David, Fenyö and Johan, Malm and György, Marko-Varga and Lajos, V. Kemény}, unique-id = {34588333}, year = {2024}, orcid-numbers = {Pankotai, Tibor/0000-0001-9810-5465} } @article{MTMT:34557470, title = {Cardiac Sarcoidosis: A Comprehensive Clinical Review}, url = {https://m2.mtmt.hu/api/publication/34557470}, author = {Vereckei, András and Besenyi, Zsuzsanna and Nagy, Viktória and Radics, Bence and Vágó, Hajnalka and Jenei, Zsigmond and Katona, Gábor and Sepp, Róbert}, doi = {10.31083/j.rcm2502037}, journal-iso = {REV CARDIOVASC MED}, journal = {REVIEWS IN CARDIOVASCULAR MEDICINE}, volume = {25}, unique-id = {34557470}, issn = {1530-6550}, year = {2024}, eissn = {2153-8174}, orcid-numbers = {Vereckei, András/0000-0001-7881-6585; Besenyi, Zsuzsanna/0000-0001-9115-9620; Jenei, Zsigmond/0000-0003-2807-7205; Sepp, Róbert/0000-0003-4964-1661} } @article{MTMT:34547544, title = {Primary follicular dendritic cell sarcoma of the kidney – a case report of a rare tumor with emphasis on diagnostic pitfalls}, url = {https://m2.mtmt.hu/api/publication/34547544}, author = {Pancsa, Tamás and Dénes, Borbála and Somorácz, Áron and Kelemen, Dóra and Salamon, Ferenc and Sánta, Fanni Viktória and Kuthi, Levente}, doi = {10.1186/s13000-024-01444-x}, journal-iso = {DIAGN PATHOL}, journal = {DIAGNOSTIC PATHOLOGY}, volume = {19}, unique-id = {34547544}, issn = {1746-1596}, year = {2024}, eissn = {1746-1596}, orcid-numbers = {Somorácz, Áron/0000-0003-4015-2263; Kuthi, Levente/0000-0001-9247-6679} } @article{MTMT:34538600, title = {P072 LDN-071, a novel first-in-class amino acid-based PAI-1 inhibitor, significantly reduces the severity of experimental colitis in mice}, url = {https://m2.mtmt.hu/api/publication/34538600}, author = {Jójárt, Boldizsár and Csákány-Papp, Noémi and Laub, H and Vasas, Béla and Barta, B and Szabó, Viktória and Bagyánszki, Mária and Mándity, I and Heltovics, G and Pallagi, Petra and Maléth, József}, doi = {10.1093/ecco-jcc/jjad212.0202}, journal-iso = {J CROHNS COLITIS}, journal = {JOURNAL OF CROHNS & COLITIS}, volume = {18}, unique-id = {34538600}, issn = {1873-9946}, year = {2024}, eissn = {1876-4479}, pages = {i342-i342}, orcid-numbers = {Jójárt, Boldizsár/0000-0002-2764-3925; Csákány-Papp, Noémi/0000-0002-3614-2698; Szabó, Viktória/0000-0001-6547-9102; Bagyánszki, Mária/0000-0003-3533-9461; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090} } @article{MTMT:34533349, title = {Microenvironment‐induced restoration of cohesive growth associated with focal activation of P ‐cadherin expression in lobular breast carcinoma metastatic to the colon}, url = {https://m2.mtmt.hu/api/publication/34533349}, author = {Gronewold, Malte and Grote, Isabel and Bartels, Stephan and Christgen, Henriette and Kandt, Leonie D and Brito, Maria Jose and Cserni, Gábor and Daemmrich, Maximilian E and Fogt, Franz and Helmke, Burkhard M and ter Hoeve, Natalie and Lang‐Schwarz, Corinna and Vieth, Michael and Wellmann, Axel and Kuehnle, Elna and Kulik, Ulf and Riedel, Gesa and Reineke‐Plaass, Tanja and Lehmann, Ulrich and Koorman, Thijs and Derksen, Patrick WB and Kreipe, Hans and Christgen, Matthias}, doi = {10.1002/2056-4538.12361}, journal-iso = {J PATHOL CLIN RES}, journal = {JOURNAL OF PATHOLOGY: CLINICAL RESEARCH}, volume = {10}, unique-id = {34533349}, abstract = {Invasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E‐cadherin loss. Focal activation of P‐cadherin expression in tumor cells that are deficient for E‐cadherin occurs in a subset of ILCs. Switching from an E‐cadherin deficient to P‐cadherin proficient status (EPS) partially restores cell–cell adhesion leading to the formation of cohesive tubular elements. It is unknown what conditions control EPS. Here, we report on EPS in ILC metastases in the large bowel. We reviewed endoscopic colon biopsies and colectomy specimens from a 52‐year‐old female (index patient) and of 18 additional patients (reference series) diagnosed with metastatic ILC in the colon. EPS was assessed by immunohistochemistry for E‐cadherin and P‐cadherin. CDH1 /E‐cadherin mutations were determined by next‐generation sequencing. The index patient's colectomy showed transmural metastatic ILC harboring a CDH1 /E‐cadherin p.Q610* mutation. ILC cells displayed different growth patterns in different anatomic layers of the colon wall. In the tunica muscularis propria and the tela submucosa, ILC cells featured noncohesive growth and were E‐cadherin‐negative and P‐cadherin‐negative. However, ILC cells invading the mucosa formed cohesive tubular elements in the intercryptal stroma of the lamina propria mucosae. Inter‐cryptal ILC cells switched to a P‐cadherin‐positive phenotype in this microenvironmental niche. In the reference series, colon mucosa infiltration was evident in 13 of 18 patients, one of which showed intercryptal EPS and conversion to cohesive growth as described in the index patient. The large bowel is a common metastatic site in ILC. In endoscopic colon biopsies, the typical noncohesive growth of ILC may be concealed by microenvironment‐induced EPS and conversion to cohesive growth.}, year = {2024}, eissn = {2056-4538}, orcid-numbers = {Bartels, Stephan/0000-0002-8903-2345; Cserni, Gábor/0000-0003-1344-7744; Koorman, Thijs/0000-0002-6064-3353; Christgen, Matthias/0000-0002-0891-7839} }