TY - JOUR AU - Rácz, Bálint AU - Kristof, Erzsebet AU - Kincses, Annamária AU - Dominguez-Alvarez, Enrique AU - Spengler, Gabriella TI - Antitumor Activity of Symmetrical Selenoesters in Doxorubicin Resistant Breast Cancer JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 43 PY - 2023 IS - 11 SP - 4865 EP - 4872 PG - 8 SN - 0250-7005 DO - 10.21873/anticanres.16683 UR - https://m2.mtmt.hu/api/publication/34231319 ID - 34231319 N1 - Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Instituto de Química Orgánica General (IQOG), CSIC, Madrid, Spain Export Date: 5 February 2024 CODEN: ANTRD Correspondence Address: Spengler, G.; Department of Medical Microbiology, Semmelweis utca 6, Hungary; email: spengler.gabriella@med.u-szeged.hu Correspondence Address: Dominguez-Alvarez, E.; Instituto de Química Orgánica General (IQOG), Juan de la Cierva 3, Spain; email: e.dominguez-alvarez@iqog.csic.es Chemicals/CAS: adenosine triphosphatase, 37289-25-1, 9000-83-3; doxorubicin, 23214-92-8, 25316-40-9; Adenosine Triphosphatases; Doxorubicin; Esters Funding details: PID2022-136438OB-I00 Funding details: European Commission, EC, BO/00158/22/5 Funding details: Magyar Tudományos Akadémia, MTA Funding details: Ministerio de Ciencia e Innovación, MICINN Funding details: European Regional Development Fund, ERDF Funding details: Agencia Estatal de Investigación, AEI Funding text 1: The study was supported by the following organizations and grants: Szeged Foundation for Cancer Research (Szegedi Rákkutatásért Alapítvány), Grant PID2022-136438OB-I00 funded by MCIN/AEI/ 10.13039/501100011033, European Regional Development Fund - "A way of making Europe" by the European Union. G.S. was supported by the János Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences. LA - English DB - MTMT ER - TY - JOUR AU - Rácz, Bálint AU - Kincses, Annamária AU - Laczi, Krisztián AU - Rákhely, Gábor AU - Domínguez-Álvarez, Enrique AU - Spengler, Gabriella TI - Reversal of Multidrug Resistance by Symmetrical Selenoesters in Colon Adenocarcinoma Cells JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 2 PG - 13 SN - 1999-4923 DO - 10.3390/pharmaceutics15020610 UR - https://m2.mtmt.hu/api/publication/33641641 ID - 33641641 N1 - További támogatások: SZTE ÁOK-KKA 2018/270-62-2 of the University of Szeged, Faculty of Medicine, János Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences, The study was supported by the Szeged Foundation for Cancer Research (Szegedi Rákkutatásért Alapítvány) AB - Recently, selenium containing derivatives have attracted more attention in medicinal chemistry. In the present work, the anticancer activity of symmetrical selenoesters was investigated by studying the reversal of efflux pump-related and apoptosis resistance in sensitive and resistant human colon adenocarcinoma cells expressing the ABCB1 protein. The combined effect of the compounds with doxorubicin was demonstrated with a checkerboard assay. The ABCB1 inhibitory and the apoptosis-inducing effects of the derivatives were measured with flow cytometry. Whole transcriptome sequencing was carried out on Illumina platform upon the treatment of resistant cells with the most potent derivatives. One ketone and three methyl ester selenoesters showed synergistic or weak synergistic interaction with doxorubicin, respectively. Ketone selenoesters were the most potent ABCB1 inhibitors and apoptosis inducers. Nitrile selenoesters could induce moderate early and late apoptotic processes that could be explained by their ABCB1 modulating properties. The transcriptome analysis revealed that symmetrical selenoesters may influence the redox state of the cells and interfere with metastasis formation. It can be assumed that these symmetrical selenocompounds possess toxic, DNA-damaging effects due to the presence of two selenium atoms in the molecule, which may be augmented by the presence of symmetrical groups. LA - English DB - MTMT ER - TY - JOUR AU - Zeslawska, Ewa AU - Tejchman, Waldemar AU - Kincses, Annamária AU - Spengler, Gabriella AU - Nitek, Wojciech AU - Zuchowski, Grzegorz AU - Szymanska, Ewa TI - 5-Arylidenerhodanines as P-gp Modulators: An Interesting Effect of the Carboxyl Group on ABCB1 Function in Multidrug-Resistant Cancer Cells JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 18 PG - 16 SN - 1661-6596 DO - 10.3390/ijms231810812 UR - https://m2.mtmt.hu/api/publication/33179818 ID - 33179818 N1 - Institute of Biology, Pedagogical University of Krakow, Podchorążych 2, Kraków, 30-084, Poland Department of Medical Microbiology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, H-6720, Hungary Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków, 30-387, Poland Chair of Organic Chemistry, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland Cited By :1 Export Date: 15 February 2023 Correspondence Address: Żesławska, E.; Institute of Biology, Podchorążych 2, Poland Correspondence Address: Szymańska, E.; Department of Technology and Biotechnology of Drugs, Medyczna 9, Poland; email: ewa.szymanska@uj.edu.pl Chemicals/CAS: verapamil, 152-11-4, 52-53-9; Antineoplastic Agents; Antiviral Agents; Verapamil Funding details: Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie, UP, BN.610-147/PBU/2020, BN.711-56/PBU/2021 Funding text 1: This research was funded by the Pedagogical University of Krakow, projects numbers BN.610-147/PBU/2020 and BN.711-56/PBU/2021. The APC was funded by the Pedagogical University of Krakow. AB - Multidrug resistance (MDR) is considered one of the major mechanisms responsible for the failure of numerous anticancer and antiviral chemotherapies. Various strategies to overcome the MDR phenomenon have been developed, and one of the most attractive research directions is focused on the inhibition of MDR transporters, membrane proteins that extrude cytotoxic drugs from living cells. Here, we report the results of our studies on a series newly synthesized of 5-arylidenerhodanines and their ability to inhibit the ABCB1 efflux pump in mouse T-lymphoma cancer cells. In the series, compounds possessing a triphenylamine moiety and the carboxyl group in their structure were of particular interest. These amphiphilic compounds showed over 17-fold stronger efflux pump inhibitory effects than verapamil. The cytotoxic and antiproliferative effects of target rhodanines on T-lymphoma cells were also investigated. A putative binding mode for 11, one of the most potent P-gp inhibitors tested here, was predicted by molecular docking studies and discussed with regard to the binding mode of verapamil. LA - English DB - MTMT ER - TY - JOUR AU - Ali, Wesam AU - Garbo, Sabrina AU - Kincses, Annamária AU - Nové, Márta AU - Spengler, Gabriella AU - Di Bello, Elisabetta AU - Honkisz-Orzechowska, Ewelina AU - Karcz, Tadeusz AU - Szymańska, Ewa AU - Żesławska, Ewa AU - Starek, Małgorzata AU - Dąbrowska, Monika AU - Nitek, Wojciech AU - Kucwaj-Brysz, Katarzyna AU - Pyka, Patryk AU - Fioravanti, Rossella AU - Jacob, Claus AU - Battistelli, Cecilia AU - Zwergel, Clemens AU - Handzlik, Jadwiga TI - Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 243 PY - 2022 PG - 19 SN - 0223-5234 DO - 10.1016/j.ejmech.2022.114761 UR - https://m2.mtmt.hu/api/publication/33150816 ID - 33150816 N1 - Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, Kraków, 30-688, Poland Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Campus B 2.1, Saarbruecken, D-66123, Germany Istituto Pasteur Italia, Fondazione Cenci-Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, 00161, Italy Institute of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, 00185, Italy Institute of Biology, Pedagogical University of Krakow, Podchorążych 2, Kraków, 30-084, Poland Department of Inorganic Chemistry, Jagiellonian University, Medical College, Medyczna 9, Kraków, 30-688, Poland Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków, 30-387, Poland Cited By :1 Export Date: 8 February 2023 CODEN: EJMCA Correspondence Address: Zwergel, C.; Department of Drug Chemistry and Technologies, Piazzale Aldo Moro 5, Italy; email: clemens.zwergel@uniroma1.it Correspondence Address: Battistelli, C.; Istituto Pasteur Italia, Viale Regina Elena 324, Italy; email: cecilia.battistelli@uniroma1.it Correspondence Address: Handzlik, J.; Department of Technology and Biotechnology of Drugs, Medyczna 9, Kraków, Poland; email: j.handzlik@uj.edu.pl Chemicals/CAS: sulfide, 18496-25-8; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Neoplasm Proteins; Pharmaceutical Preparations; Sulfides; Triazines Funding details: N42/DBS/000196 Funding details: Narodowe Centrum Nauki, NCN, UMO-2018/31/B/NZ7/02160 Funding details: Universität des Saarlandes, WT/2 – LFFP 16/01 Funding details: Regione Lazio, A0375-2020-36597 Funding text 1: All syntheses were financially supported by National Science Centre, Poland Grant No. UMO-2018/31/B/NZ7/02160 , biological studies of T.K. and E.H.O supported by Jagiellonian University project : N42/DBS/000196 . W. A. was financed by Saarland University , “Landesforschungsförderungsprogramm” (Grant No. WT/2 – LFFP 16/01). C. B. was funded by SEED PNR 2021. C.Z. acknowledge Regione Lazio PROGETTI DI GRUPPI DI RICERCA 2020, project ID A0375-2020-36597 and is thankful for the generous funding from FSE REACT-EU within the program PON “Research and Innovation” 2014–2020, Action IV.6 “Contratti di ricerca su tematiche Green” as well as from KOHR Aerospace GmbH. LA - English DB - MTMT ER - TY - JOUR AU - Mándi, Yvette AU - Stone, Trevor W AU - Guillemin, Gilles J AU - Vécsei, László AU - Williams, Richard O TI - Editorial. Multiple Implications of the Kynurenine Pathway in Inflammatory Diseases: Diagnostic and Therapeutic Applications. TS - Multiple Implications of the Kynurenine Pathway in Inflammatory Diseases: Diagnostic and Therapeutic Applications. JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 13 PY - 2022 PG - 3 SN - 1664-3224 DO - 10.3389/fimmu.2022.860867 UR - https://m2.mtmt.hu/api/publication/32727272 ID - 32727272 N1 - Department of Medical Microbiology and Immunobiology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary The Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom Neuroinflammation Group, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia Department of Neurology, Albert Szent-Györgyi Faculty of Medicine, University of Szeged, Szeged, Hungary Cited By :6 Export Date: 7 March 2024 Correspondence Address: Mándi, Y.; Department of Medical Microbiology and Immunobiology, Hungary; email: mandi.yvette@med.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Kreutzer, David AU - Gehrmann, Robin AU - Kincses, Annamária AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Molnár, József AU - Hilgeroth, Andreas TI - Discovery of a novel class of small-molecule antibacterial agents against Staphylococcus aureus JF - FUTURE MEDICINAL CHEMISTRY J2 - FUTURE MED CHEM VL - 14 PY - 2022 IS - 5 SP - 299 EP - 305 PG - 7 SN - 1756-8919 DO - 10.4155/fmc-2021-0272 UR - https://m2.mtmt.hu/api/publication/32554878 ID - 32554878 N1 - Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle, 06120, Germany Department of Medical Microbiology, University of Szeged6720, Hungary Export Date: 25 January 2023 Chemicals/CAS: tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1; acridine derivative, 34708-10-6; Acridines; Anti-Bacterial Agents; Small Molecule Libraries LA - English DB - MTMT ER - TY - JOUR AU - Magyari, Józef AU - Barta Holló, Berta AU - Rodić, Marko V. AU - Jovanović, Ljiljana S. AU - Mészáros Szécsényi, Katalin AU - Ferenc, Wiesława AU - Osypiuk, Dariusz AU - Mosolygó, Tímea AU - Kincses, Annamária AU - Spengler, Gabriella TI - Synthesis, characterization, thermal properties and biological activity of diazine-ring containing hydrazones and their metal complexes JF - JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY J2 - J THERM ANAL CALORIM VL - 147 PY - 2022 IS - 1 SP - 229 EP - 242 PG - 14 SN - 1388-6150 DO - 10.1007/s10973-020-10194-z UR - https://m2.mtmt.hu/api/publication/31605492 ID - 31605492 N1 - Funding Agency and Grant Number: Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-68/2020-14/200125]; University of Szeged [GINOP-2.3.2-15-2016-00038] Funding text: This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Grant No. 451-03-68/2020-14/200125). The study was supported by the project GINOP-2.3.2-15-2016-00038 of the University of Szeged. LA - English DB - MTMT ER - TY - CONF AU - Party, Petra AU - Kókai, Dávid AU - Burián, Katalin AU - Ambrus, Rita TI - Meloxikám tartalmú szub-mikronos száraz porinhalációs rendszerek aerodinamikai és sejtvonalas vizsgálata T2 - MKE Kristályosítási és Gyógyszerformulálási Szakosztály 13. Kerekasztal Konferenciája PY - 2021 SP - 22 EP - 23 PG - 2 UR - https://m2.mtmt.hu/api/publication/33215578 ID - 33215578 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Stefkó, Dóra AU - Kúsz, Norbert AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Hohmann, Judit AU - Vasas, Andrea TI - Biologically active phenanthrenes from four Juncus species native to Hungary JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 87 PY - 2021 IS - 15 SP - 1251 EP - 1251 PG - 1 SN - 0032-0943 DO - 10.1055/s-0041-1736786 UR - https://m2.mtmt.hu/api/publication/33041581 ID - 33041581 LA - English DB - MTMT ER - TY - JOUR AU - Yazdani, Morteza AU - Hohmann, Judit AU - Kincses, Annamária AU - Spengler, Gabriella AU - Béni, Zoltán AU - Dékány, Miklós AU - Ványolós, Attila TI - Pholiols A-D and other triterpenes from Pholiota populnea and their activity against colon carcinoma JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 87 PY - 2021 IS - 15 SP - 1302 EP - 1302 PG - 1 SN - 0032-0943 DO - 10.1055/s-0041-1736949 UR - https://m2.mtmt.hu/api/publication/33041580 ID - 33041580 LA - English DB - MTMT ER -