@article{MTMT:34231319,
	title = {Antitumor Activity of Symmetrical Selenoesters in Doxorubicin Resistant Breast Cancer},
	url = {https://m2.mtmt.hu/api/publication/34231319},
	author = {Rácz, Bálint and Kristof, Erzsebet and Kincses, Annamária and Dominguez-Alvarez, Enrique and Spengler, Gabriella},
	doi = {10.21873/anticanres.16683},
	journal-iso = {ANTICANCER RES},
	journal = {ANTICANCER RESEARCH},
	volume = {43},
	unique-id = {34231319},
	issn = {0250-7005},
	year = {2023},
	eissn = {1791-7530},
	pages = {4865-4872},
	orcid-numbers = {Rácz, Bálint/0000-0003-0088-3408; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950}
}

@article{MTMT:33641641,
	title = {Reversal of Multidrug Resistance by Symmetrical Selenoesters in Colon Adenocarcinoma Cells},
	url = {https://m2.mtmt.hu/api/publication/33641641},
	author = {Rácz, Bálint and Kincses, Annamária and Laczi, Krisztián and Rákhely, Gábor and Domínguez-Álvarez, Enrique and Spengler, Gabriella},
	doi = {10.3390/pharmaceutics15020610},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {33641641},
	issn = {1999-4923},
	abstract = {Recently, selenium containing derivatives have attracted more attention in medicinal chemistry. In the present work, the anticancer activity of symmetrical selenoesters was investigated by studying the reversal of efflux pump-related and apoptosis resistance in sensitive and resistant human colon adenocarcinoma cells expressing the ABCB1 protein. The combined effect of the compounds with doxorubicin was demonstrated with a checkerboard assay. The ABCB1 inhibitory and the apoptosis-inducing effects of the derivatives were measured with flow cytometry. Whole transcriptome sequencing was carried out on Illumina platform upon the treatment of resistant cells with the most potent derivatives. One ketone and three methyl ester selenoesters showed synergistic or weak synergistic interaction with doxorubicin, respectively. Ketone selenoesters were the most potent ABCB1 inhibitors and apoptosis inducers. Nitrile selenoesters could induce moderate early and late apoptotic processes that could be explained by their ABCB1 modulating properties. The transcriptome analysis revealed that symmetrical selenoesters may influence the redox state of the cells and interfere with metastasis formation. It can be assumed that these symmetrical selenocompounds possess toxic, DNA-damaging effects due to the presence of two selenium atoms in the molecule, which may be augmented by the presence of symmetrical groups.},
	year = {2023},
	eissn = {1999-4923},
	orcid-numbers = {Rácz, Bálint/0000-0003-0088-3408; Kincses, Annamária/0000-0002-1591-1419; Laczi, Krisztián/0000-0002-9399-7406; Rákhely, Gábor/0000-0003-2557-3641; Domínguez-Álvarez, Enrique/0000-0003-2655-1575; Spengler, Gabriella/0000-0001-8085-0950}
}

@article{MTMT:33179818,
	title = {5-Arylidenerhodanines as P-gp Modulators: An Interesting Effect of the Carboxyl Group on ABCB1 Function in Multidrug-Resistant Cancer Cells},
	url = {https://m2.mtmt.hu/api/publication/33179818},
	author = {Zeslawska, Ewa and Tejchman, Waldemar and Kincses, Annamária and Spengler, Gabriella and Nitek, Wojciech and Zuchowski, Grzegorz and Szymanska, Ewa},
	doi = {10.3390/ijms231810812},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {33179818},
	issn = {1661-6596},
	abstract = {Multidrug resistance (MDR) is considered one of the major mechanisms responsible for the failure of numerous anticancer and antiviral chemotherapies. Various strategies to overcome the MDR phenomenon have been developed, and one of the most attractive research directions is focused on the inhibition of MDR transporters, membrane proteins that extrude cytotoxic drugs from living cells. Here, we report the results of our studies on a series newly synthesized of 5-arylidenerhodanines and their ability to inhibit the ABCB1 efflux pump in mouse T-lymphoma cancer cells. In the series, compounds possessing a triphenylamine moiety and the carboxyl group in their structure were of particular interest. These amphiphilic compounds showed over 17-fold stronger efflux pump inhibitory effects than verapamil. The cytotoxic and antiproliferative effects of target rhodanines on T-lymphoma cells were also investigated. A putative binding mode for 11, one of the most potent P-gp inhibitors tested here, was predicted by molecular docking studies and discussed with regard to the binding mode of verapamil.},
	keywords = {P-GLYCOPROTEIN; crystal structure; Molecular docking; Efflux pump inhibition; Cancer multidrug resistance; rhodanine; T-lymphoma cancer cells},
	year = {2022},
	eissn = {1422-0067},
	orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950}
}

@article{MTMT:33150816,
	title = {Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma},
	url = {https://m2.mtmt.hu/api/publication/33150816},
	author = {Ali, Wesam and Garbo, Sabrina and Kincses, Annamária and Nové, Márta and Spengler, Gabriella and Di Bello, Elisabetta and Honkisz-Orzechowska, Ewelina and Karcz, Tadeusz and Szymańska, Ewa and Żesławska, Ewa and Starek, Małgorzata and Dąbrowska, Monika and Nitek, Wojciech and Kucwaj-Brysz, Katarzyna and Pyka, Patryk and Fioravanti, Rossella and Jacob, Claus and Battistelli, Cecilia and Zwergel, Clemens and Handzlik, Jadwiga},
	doi = {10.1016/j.ejmech.2022.114761},
	journal-iso = {EUR J MED CHEM},
	journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY},
	volume = {243},
	unique-id = {33150816},
	issn = {0223-5234},
	year = {2022},
	eissn = {1768-3254},
	orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Zwergel, Clemens/0000-0002-3097-0003}
}

@article{MTMT:32727272,
	title = {Editorial. Multiple Implications of the Kynurenine Pathway in Inflammatory Diseases: Diagnostic and Therapeutic Applications.},
	url = {https://m2.mtmt.hu/api/publication/32727272},
	author = {Mándi, Yvette and Stone, Trevor W and Guillemin, Gilles J and Vécsei, László and Williams, Richard O},
	doi = {10.3389/fimmu.2022.860867},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {13},
	unique-id = {32727272},
	issn = {1664-3224},
	keywords = {Inflammation; KYNURENINE; IDO; INFLAMMATORY DISEASES; NEUROLOGICAL DISEASE; AhR},
	year = {2022},
	eissn = {1664-3224},
	orcid-numbers = {Mándi, Yvette/0000-0003-4729-2445; Vécsei, László/0000-0001-8037-3672}
}

@article{MTMT:32554878,
	title = {Discovery of a novel class of small-molecule antibacterial agents against Staphylococcus aureus},
	url = {https://m2.mtmt.hu/api/publication/32554878},
	author = {Kreutzer, David and Gehrmann, Robin and Kincses, Annamária and Szemerédi, Nikoletta and Spengler, Gabriella and Molnár, József and Hilgeroth, Andreas},
	doi = {10.4155/fmc-2021-0272},
	journal-iso = {FUTURE MED CHEM},
	journal = {FUTURE MEDICINAL CHEMISTRY},
	volume = {14},
	unique-id = {32554878},
	issn = {1756-8919},
	year = {2022},
	eissn = {1756-8927},
	pages = {299-305},
	orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950}
}

@article{MTMT:31605492,
	title = {Synthesis, characterization, thermal properties and biological activity of diazine-ring containing hydrazones and their metal complexes},
	url = {https://m2.mtmt.hu/api/publication/31605492},
	author = {Magyari, Józef and Barta Holló, Berta and Rodić, Marko V. and Jovanović, Ljiljana S. and Mészáros Szécsényi, Katalin and Ferenc, Wiesława and Osypiuk, Dariusz and Mosolygó, Tímea and Kincses, Annamária and Spengler, Gabriella},
	doi = {10.1007/s10973-020-10194-z},
	journal-iso = {J THERM ANAL CALORIM},
	journal = {JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY},
	volume = {147},
	unique-id = {31605492},
	issn = {1388-6150},
	year = {2022},
	eissn = {1572-8943},
	pages = {229-242},
	orcid-numbers = {Mosolygó, Tímea/0000-0002-4499-388X; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950}
}

@CONFERENCE{MTMT:33215578,
	title = {Meloxikám tartalmú szub-mikronos száraz porinhalációs rendszerek aerodinamikai és sejtvonalas vizsgálata},
	url = {https://m2.mtmt.hu/api/publication/33215578},
	author = {Party, Petra and Kókai, Dávid and Burián, Katalin and Ambrus, Rita},
	booktitle = {MKE Kristályosítási és Gyógyszerformulálási Szakosztály 13. Kerekasztal Konferenciája},
	unique-id = {33215578},
	year = {2021},
	pages = {22-23},
	orcid-numbers = {Burián, Katalin/0000-0003-1300-2374}
}

@article{MTMT:33041581,
	title = {Biologically active phenanthrenes from four Juncus species native to Hungary},
	url = {https://m2.mtmt.hu/api/publication/33041581},
	author = {Stefkó, Dóra and Kúsz, Norbert and Szemerédi, Nikoletta and Spengler, Gabriella and Hohmann, Judit and Vasas, Andrea},
	doi = {10.1055/s-0041-1736786},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	volume = {87},
	unique-id = {33041581},
	issn = {0032-0943},
	year = {2021},
	eissn = {1439-0221},
	pages = {1251-1251},
	orcid-numbers = {Stefkó, Dóra/0000-0002-5435-546X; Kúsz, Norbert/0000-0002-9973-6442; Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702}
}

@article{MTMT:33041580,
	title = {Pholiols A-D and other triterpenes from Pholiota populnea and their activity against colon carcinoma},
	url = {https://m2.mtmt.hu/api/publication/33041580},
	author = {Yazdani, Morteza and Hohmann, Judit and Kincses, Annamária and Spengler, Gabriella and Béni, Zoltán and Dékány, Miklós and Ványolós, Attila},
	doi = {10.1055/s-0041-1736949},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	volume = {87},
	unique-id = {33041580},
	issn = {0032-0943},
	year = {2021},
	eissn = {1439-0221},
	pages = {1302-1302},
	orcid-numbers = {Hohmann, Judit/0000-0002-2887-6392; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Ványolós, Attila/0000-0002-4710-0004}
}