@misc{MTMT:35256034, title = {Distressz hômérôvel kapcsolatos tapasztalatok az SZTE Szent-Györgyi Albert Klinikai Központ Onkoterápiás Klinikán}, url = {https://m2.mtmt.hu/api/publication/35256034}, author = {Kormányos, Ákos and Hamvai, Csaba and Hajnal-Gregus, Henrietta and Török-Szabó, Renáta and Galsi, Gabriella}, unique-id = {35256034}, year = {2024} } @misc{MTMT:35255979, title = {Bemutatkozik az SZTE Szent-Györgyi Albert Klinikai Központ Onkoterápiás Klinika Pszichoonkológia munkacsoportja}, url = {https://m2.mtmt.hu/api/publication/35255979}, author = {Kormányos, Ákos}, unique-id = {35255979}, year = {2024} } @article{MTMT:35061763, title = {TRPS1 expression in breast angiosarcoma}, url = {https://m2.mtmt.hu/api/publication/35061763}, author = {Pancsa, Tamás and Pósfai, Boglárka and Schubert, Anna and Almási, Szintia and Papp, Eszter and ChangChien, Yi-Che and Kálmán, Endre and Kovács, Attila and Kulka, Janina and Varga, Linda and Cserni, Gábor and Kuthi, Levente}, doi = {10.1007/s00428-024-03852-2}, journal-iso = {VIRCHOWS ARCH}, journal = {VIRCHOWS ARCHIV}, volume = {In press}, unique-id = {35061763}, issn = {0945-6317}, abstract = {Angiosarcoma (AS) of the breast, a rare mesenchymal neoplasm, exhibits distinct forms based on etiological and genetic features. While cases with typical clinical presentation and morphology allow for a straightforward diagnosis, challenges arise when clinical data are scarce, diagnostic material is limited, or morphological characteristics overlap with other tumors, including undifferentiated carcinomas. The trichorhinophalangeal syndrome protein 1 (TRPS1), once regarded as highly specific for breast carcinomas, now faces doubts regarding its reliability. This study explores TRPS1 expression in breast AS. Our investigation revealed that 60% of AS cases displayed TRPS1 labeling, contrasting with the 40% lacking expression. Scoring by four independent readers established a consensus, designating 12/35 ASs as unequivocally TRPS1-positive. However, uncertainty surrounded nine further cases due to a lack of reader agreement (being substantial as reflected by a kappa value of 0.76). These findings challenge the perceived specificity of TRPS1, shedding light on its presence in a noteworthy proportion of breast ASs. Consequently, the study underscores the importance of a comprehensive approach in evaluating breast ASs and expands the range of entities within the differential diagnosis associated with TRPS1 labeling.}, year = {2024}, eissn = {1432-2307}, pages = {In press}, orcid-numbers = {Kulka, Janina/0000-0001-6498-5943; Varga, Linda/0000-0003-4116-9497; Cserni, Gábor/0000-0003-1344-7744; Kuthi, Levente/0000-0001-9247-6679} } @article{MTMT:35023137, title = {Correction to: Nationwide Study of Real-World Treatment Patterns and Clinical Outcomes in Patients with Metastatic Urothelial Carcinoma in Hungary}, url = {https://m2.mtmt.hu/api/publication/35023137}, author = {Maráz, Anikó and Nagy, Bence and Macher, Tamara and Jesko, Jozsef and Tischler, Erika and Csongvai, Csaba and Kearney, Mairead}, doi = {10.1007/s12325-023-02740-6}, journal-iso = {ADV THER}, journal = {ADVANCES IN THERAPY}, volume = {41}, unique-id = {35023137}, issn = {0741-238X}, year = {2024}, eissn = {1865-8652}, pages = {881-882}, orcid-numbers = {Maráz, Anikó/0000-0002-2018-8413} } @article{MTMT:34918137, title = {The Proteoglycans Biglycan and Decorin Protect Cardiac Cells against Irradiation-Induced Cell Death by Inhibiting Apoptosis}, url = {https://m2.mtmt.hu/api/publication/34918137}, author = {Molnár-Gáspár, Renáta and Diószegi, Petra and Nógrádi-Halmi, Dóra and Erdélyi-Furka, Barbara Fanni and Varga, Zoltán and Kahán, Zsuzsanna and Csont, Tamás Bálint}, doi = {10.3390/cells13100883}, journal-iso = {CELLS-BASEL}, journal = {CELLS}, volume = {13}, unique-id = {34918137}, keywords = {APOPTOSIS; Biglycan; proteoglycan; cardioprotection; Decorin; radiation-induced heart disease}, year = {2024}, eissn = {2073-4409}, orcid-numbers = {Molnár-Gáspár, Renáta/0000-0001-9673-4532; Diószegi, Petra/0000-0001-8109-2266; Nógrádi-Halmi, Dóra/0000-0001-9496-9354; Erdélyi-Furka, Barbara Fanni/0009-0005-7805-1910; Varga, Zoltán/0000-0001-8537-6282; Kahán, Zsuzsanna/0000-0002-5021-8775; Csont, Tamás Bálint/0000-0001-5792-2768} } @CONFERENCE{MTMT:34861649, title = {ANTITHROMBOTIKUS KEZELÉS KLINIKAI NEHÉZSÉGEI: A GI tumorok}, url = {https://m2.mtmt.hu/api/publication/34861649}, author = {Torday, László}, booktitle = {VII. ONKO-KARDIOLÓGIAI NAPOK TOVÁBBKÉPZŐ TANFOLYAM Programfüzet}, unique-id = {34861649}, year = {2024}, pages = {16}, orcid-numbers = {Torday, László/0000-0002-2911-5499} } @article{MTMT:34684406, title = {Individual benefit in heart sparing during DIBH-supported left breast radiotherapy}, url = {https://m2.mtmt.hu/api/publication/34684406}, author = {Gaál, Szilvia and Kahán, Zsuzsanna and Rárosi, Ferenc and Fodor, Gergely and Tolnai, József and Deák , Bence and Hideghéty, Katalin and Varga, Zoltán}, doi = {10.1016/j.ctro.2024.100746}, journal-iso = {CLIN TRANSL RADIAT ONCOL (CTRO)}, journal = {CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY}, volume = {46}, unique-id = {34684406}, year = {2024}, eissn = {2405-6308}, orcid-numbers = {Kahán, Zsuzsanna/0000-0002-5021-8775; Rárosi, Ferenc/0000-0002-1014-9242; Fodor, Gergely/0000-0002-4736-4966; Tolnai, József/0000-0002-7648-764X; Hideghéty, Katalin/0000-0001-7080-2365; Varga, Zoltán/0000-0001-8537-6282} } @article{MTMT:34534149, title = {Diagnostic value of [ 99m Tc]Tc-PSMA-I&S-SPECT/CT for the primary staging and restaging of prostate cancer}, url = {https://m2.mtmt.hu/api/publication/34534149}, author = {Farkas, István and Sipka, Gábor and Bakos, Annamária and Maráz, Anikó and Bajory, Zoltán and Mikó, Zsófia Sára and Czékus, Tamás and Urbán, Szabolcs and Varga, Linda and Pávics, László and Besenyi, Zsuzsanna}, doi = {10.1177/17588359231221342}, journal-iso = {THER ADV MED ONCOL}, journal = {THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY}, volume = {16}, unique-id = {34534149}, issn = {1758-8340}, year = {2024}, eissn = {1758-8359}, orcid-numbers = {Farkas, István/0000-0002-0270-7101; Sipka, Gábor/0000-0002-1259-0576; Bakos, Annamária/0000-0003-2235-9754; Maráz, Anikó/0000-0002-2018-8413; Bajory, Zoltán/0000-0003-3835-2549; Mikó, Zsófia Sára/0000-0001-6293-6451; Czékus, Tamás/0000-0001-7612-4905; Urbán, Szabolcs/0000-0001-5463-6811; Varga, Linda/0000-0003-4116-9497; Pávics, László/0000-0002-7319-1667; Besenyi, Zsuzsanna/0000-0001-9115-9620} } @article{MTMT:34509121, title = {Survival Benefit of Stereotactic Radiotherapy in the Complex Management of Metastatic Melanoma}, url = {https://m2.mtmt.hu/api/publication/34509121}, author = {Kelemen, Gyöngyi and Együd, Zsófia and Dobi, Ágnes and Varga, Linda and Kószó, Renáta Lilla and Borzási, Emőke and Paczona, Viktor Róbert and Végváry, Zoltán and Borzák, Ferenc and Fodor, Emese and Ócsai, Henriette and Baltás, Eszter and Oláh, Judit Magdolna and Hideghéty, Katalin}, doi = {10.21873/anticanres.16803}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {44}, unique-id = {34509121}, issn = {0250-7005}, year = {2024}, eissn = {1791-7530}, pages = {205-212}, orcid-numbers = {Varga, Linda/0000-0003-4116-9497; Kószó, Renáta Lilla/0000-0002-1958-7839; Fodor, Emese/0009-0008-6961-6731; Baltás, Eszter/0000-0003-0357-7393; Hideghéty, Katalin/0000-0001-7080-2365} } @article{MTMT:34486290, title = {POLE-Mutant Colon Adenocarcinoma-Case Presentation and Histopathological Evaluation. [case report]}, url = {https://m2.mtmt.hu/api/publication/34486290}, author = {Pancsa, Tamás and Vasas, Béla and Melegh, Zsombor and Tóth, Erika and Torday, László and Sejben, Anita}, doi = {10.1007/s12029-023-01004-4}, journal-iso = {J GASTROINTEST CANCER}, journal = {JOURNAL OF GASTROINTESTINAL CANCER}, volume = {55}, unique-id = {34486290}, issn = {1941-6628}, abstract = {POLE mutant phenotype in colon adenocarcinomas represents a rare molecular subtype. These tumours are generally responsive to immune-checkpoint inhibition therapy and, therefore, are currently considered as a subtype with good prognosis. We hereby present the first detailed case presentation of a POLE mutant colon adenocarcinoma with useful microscopic features.A 53-year-old male patient's colon adenocarcinoma histologically showed wide variety of growth patterns and massive intra- and peritumoural lymphocytic infiltrate. The majority of the tumour consisted of a high-grade component resembling medullary carcinoma of the colon, while approximately one-third of the tumour was composed of conventional areas exhibiting a tubular pattern. A minority of the tumour was constituted by poorly cohesive rhabdoid cells. Immunohistochemistry was performed, and colorectal origin was proven with CDX-2 and SATB2. Furthermore, proficiency in mismatch repair proteins and SMARCB1 deficiency was observed. The unusually high-grade colon adenocarcinoma, with areas mimicking medullary carcinoma, and generally aggressive morphology raised suspicion of microsatellite instability. The diverse morphology and the SMARCB1 deficiency also raised suspicion of ultramutation caused by POLE alteration. Next-generation sequencing panel confirmed a pathogenetic mutation in POLE exon 9: p.Pro286Arg, c.857C > G.The diverse, high-grade morphology and increased intratumoural lymphoid infiltration should raise suspicion for POLE-mutated adenocarcinoma during everyday histopathological practice. Mismatch repair proficiency results on immunohistochemistry should not determine the final diagnosis, as only a minor percentage of these tumours are MSI. In every case suspicious for POLE-mutated adenocarcinoma, a 500-cancer gene panel should be carried out.}, keywords = {Next-generation sequencing; POLE mutation; Immune-checkpoint inhibition therapy; POLE-mutant colon adenocarcinoma}, year = {2024}, eissn = {1941-6636}, pages = {961-964}, orcid-numbers = {Melegh, Zsombor/0000-0001-7605-5719; Tóth, Erika/0000-0003-2054-8447; Torday, László/0000-0002-2911-5499; Sejben, Anita/0000-0002-9434-2989} }