TY - JOUR AU - Battaglia, Simone AU - Avenanti, Alessio AU - Vécsei, László AU - Tanaka, Masaru TI - Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry. JF - BIOMEDICINES J2 - BIOMEDICINES VL - 12 PY - 2024 IS - 3 PG - 9 SN - 2227-9059 DO - 10.3390/biomedicines12030574 UR - https://m2.mtmt.hu/api/publication/34768126 ID - 34768126 AB - Neurodegeneration poses a significant challenge for the fields of neuroscience and medicine, as it is the underlying cause of the development and advancement of numerous neurodegenerative and psychiatric disorders [...]. LA - English DB - MTMT ER - TY - JOUR AU - Tanaka, Masaru AU - Vécsei, László TI - From Lab to Life. Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders. TS - Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders. JF - BIOMEDICINES J2 - BIOMEDICINES VL - 12 PY - 2024 IS - 3 PG - 9 SN - 2227-9059 DO - 10.3390/biomedicines12030613 UR - https://m2.mtmt.hu/api/publication/34768110 ID - 34768110 AB - Neuroscience, neurology, and psychiatry are rapidly evolving fields that aim to understand the complex mechanisms underlying brain function and dysfunction, as well as to develop effective interventions for various neurological and psychiatric disorders [...]. LA - English DB - MTMT ER - TY - JOUR AU - Spekker, Eleonóra AU - Fejes-Szabó, Annamária AU - Nagy-Grócz, Gábor TI - Models of Trigeminal Activation: Is There an Animal Model of Migraine? JF - BRAIN SCIENCES J2 - BRAIN SCI VL - 14 PY - 2024 IS - 4 PG - 19 SN - 2076-3425 DO - 10.3390/brainsci14040317 UR - https://m2.mtmt.hu/api/publication/34760616 ID - 34760616 AB - Migraine, recognized as a severe headache disorder, is widely prevalent, significantly impacting the quality of life for those affected. This article aims to provide a comprehensive review of the application of animal model technologies in unraveling the pathomechanism of migraine and developing more effective therapies. It introduces a variety of animal experimental models used in migraine research, emphasizing their versatility and importance in simulating various aspects of the condition. It details the benefits arising from the utilization of these models, emphasizing their role in elucidating pain mechanisms, clarifying trigeminal activation, as well as replicating migraine symptoms and histological changes. In addition, the article consciously acknowledges the inherent limitations and challenges associated with the application of animal experimental models. Recognizing these constraints is a fundamental step toward fine-tuning and optimizing the models for a more accurate reflection of and translatability to the human environment. Overall, a detailed and comprehensive understanding of migraine animal models is crucial for navigating the complexity of the disease. These findings not only provide a deeper insight into the multifaceted nature of migraine but also serve as a foundation for developing effective therapeutic strategies that specifically address the unique challenges arising from migraine pathology. LA - English DB - MTMT ER - TY - JOUR AU - Martos, Diána AU - Lőrinczi, Bálint AU - Szatmári, István AU - Vécsei, László AU - Tanaka, Masaru TI - The Impact of C-3 Side Chain Modifications on Kynurenic Acid: A Behavioral Analysis of Its Analogs in the Motor Domain JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 6 PG - 25 SN - 1661-6596 DO - 10.3390/ijms25063394 UR - https://m2.mtmt.hu/api/publication/34743321 ID - 34743321 N1 - HUN-REN-SZTE Neuroscience Research Group, Hungarian Research Network, University of Szeged, Danube Neuroscience Research Laboratory, Tisza Lajos krt. 113, Szeged, H-6725, Hungary Institute of Pharmaceutical Chemistry and HUN-REN–SZTE Stereochemistry Research Group, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Department of Neurology, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Export Date: 9 April 2024 Correspondence Address: Vécsei, L.; HUN-REN-SZTE Neuroscience Research Group, Tisza Lajos krt. 113, Hungary; email: vecsei.laszlo@med.u-szeged.hu Correspondence Address: Tanaka, M.; HUN-REN-SZTE Neuroscience Research Group, Tisza Lajos krt. 113, Hungary; email: tanaka.masaru.1@med.u-szeged.hu Chemicals/CAS: kynurenic acid, 492-27-3; Kynurenic Acid; Neuroprotective Agents AB - The central nervous system (CNS) is the final frontier in drug delivery because of the blood–brain barrier (BBB), which poses significant barriers to the access of most drugs to their targets. Kynurenic acid (KYNA), a tryptophan (Trp) metabolite, plays an important role in behavioral functions, and abnormal KYNA levels have been observed in neuropsychiatric conditions. The current challenge lies in delivering KYNA to the CNS owing to its polar side chain. Recently, C-3 side chain-modified KYNA analogs have been shown to cross the BBB; however, it is unclear whether they retain the biological functions of the parent molecule. This study examined the impact of KYNA analogs, specifically, SZR-72, SZR-104, and the newly developed SZRG-21, on behavior. The analogs were administered intracerebroventricularly (i.c.v.), and their effects on the motor domain were compared with those of KYNA. Specifically, open-field (OF) and rotarod (RR) tests were employed to assess motor activity and skills. SZR-104 increased horizontal exploratory activity in the OF test at a dose of 0.04 μmol/4 μL, while SZR-72 decreased vertical activity at doses of 0.04 and 0.1 μmol/4 μL. In the RR test, however, neither KYNA nor its analogs showed any significant differences in motor skills at either dose. Side chain modification affects affective motor performance and exploratory behavior, as the results show for the first time. In this study, we showed that KYNA analogs alter emotional components such as motor-associated curiosity and emotions. Consequently, drug design necessitates the development of precise strategies to traverse the BBB while paying close attention to modifications in their effects on behavior. LA - English DB - MTMT ER - TY - JOUR AU - Battaglia, Simone AU - Avenanti, Alessio AU - Vécsei, László AU - Tanaka, Masaru TI - Neural Correlates and Molecular Mechanisms of Memory and Learning JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 5 PG - 11 SN - 1661-6596 DO - 10.3390/ijms25052724 UR - https://m2.mtmt.hu/api/publication/34736186 ID - 34736186 AB - Memory and learning are essential cognitive processes that enable us to obtain, retain, and recall information [...]. LA - English DB - MTMT ER - TY - CONF AU - Horváth, Orsolya AU - Török, Rita AU - Klivényi, Péter TI - The role of SIRT3 in cerebral ischemia and its effect on sirtuin expression T2 - International Neuroscience Conference, Pécs 2024 PY - 2024 SP - 59 UR - https://m2.mtmt.hu/api/publication/34734191 ID - 34734191 LA - English DB - MTMT ER - TY - JOUR AU - Jászberényi, Miklós AU - Thurzó, Balázs AU - Bagosi, Zsolt AU - Vécsei, László AU - Tanaka, Masaru TI - The Orexin/Hypocretin System, the Peptidergic Regulator of Vigilance, Orchestrates Adaptation to Stress. JF - BIOMEDICINES J2 - BIOMEDICINES VL - 12 PY - 2024 IS - 2 SN - 2227-9059 DO - 10.3390/biomedicines12020448 UR - https://m2.mtmt.hu/api/publication/34684386 ID - 34684386 N1 - Journal Article; Review AB - The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific research following the discovery that this family plays a crucial role in a variety of physiological and behavioral processes. These neuropeptides serve as powerful neuromodulators, intricately shaping autonomic, endocrine, and behavioral responses across species. Notably, they serve as master regulators of vigilance and stress responses; however, their roles in food intake, metabolism, and thermoregulation appear complementary and warrant further investigation. This narrative review provides a journey through the evolution of our understanding of the orexin system, from its initial discovery to the promising progress made in developing orexin derivatives. It goes beyond conventional boundaries, striving to synthesize the multifaceted activities of orexins. Special emphasis is placed on domains such as stress response, fear, anxiety, and learning, in which the authors have contributed to the literature with original publications. This paper also overviews the advancement of orexin pharmacology, which has already yielded some promising successes, particularly in the treatment of sleep disorders. LA - English DB - MTMT ER - TY - JOUR AU - Nagy-Grócz, Gábor AU - Spekker, Eleonóra AU - Vécsei, László TI - Kynurenines, Neuronal Excitotoxicity, and Mitochondrial Oxidative Stress: Role of the Intestinal Flora JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 3 PG - 20 SN - 1661-6596 DO - 10.3390/ijms25031698 UR - https://m2.mtmt.hu/api/publication/34545668 ID - 34545668 AB - The intestinal flora has been the focus of numerous investigations recently, with inquiries not just into the gastrointestinal aspects but also the pathomechanism of other diseases such as nervous system disorders and mitochondrial diseases. Mitochondrial disorders are the most common type of inheritable metabolic illness caused by mutations of mitochondrial and nuclear DNA. Despite the intensive research, its diagnosis is usually difficult, and unfortunately, treating it challenges physicians. Metabolites of the kynurenine pathway are linked to many disorders, such as depression, schizophrenia, migraine, and also diseases associated with impaired mitochondrial function. The kynurenine pathway includes many substances, for instance kynurenic acid and quinolinic acid. In this review, we would like to show a possible link between the metabolites of the kynurenine pathway and mitochondrial stress in the context of intestinal flora. Furthermore, we summarize the possible markers of and future therapeutic options for the kynurenine pathway in excitotoxicity and mitochondrial oxidative stress. LA - English DB - MTMT ER - TY - JOUR AU - Ivánkovits, László AU - Kazinczi, Csaba AU - Kocsis, Krisztián AU - Stankovic, Mona AU - Koday, Zsuzsanna AU - Pető, Zoltán AU - Töreki, Annamária TI - A simplified measure of burnout symptoms among paramedics - an exploratory analysis of a Hungarian sample JF - BMC PSYCHOLOGY J2 - BMC PSYCHOLOGY VL - 12 PY - 2024 IS - 1 PG - 8 SN - 2050-7283 DO - 10.1186/s40359-024-01518-x UR - https://m2.mtmt.hu/api/publication/34543385 ID - 34543385 LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Zsófia Flóra AU - Pál, Margit AU - Engelhardt, József István AU - Molnár, Mária Judit AU - Klivényi, Péter AU - Széll, Márta TI - Beyond C9orf72: repeat expansions and copy number variations as risk factors of amyotrophic lateral sclerosis across various populations JF - BMC MEDICAL GENOMICS J2 - BMC MED GENOMICS VL - 17 PY - 2024 IS - 1 PG - 8 SN - 1755-8794 DO - 10.1186/s12920-024-01807-9 UR - https://m2.mtmt.hu/api/publication/34543229 ID - 34543229 LA - English DB - MTMT ER -