TY - JOUR AU - Antal, Márk Ádám AU - Kiscsatári, Ramóna AU - Braunitzer, Gábor AU - Piffkó, József AU - Varga, Endre AU - Eliaz, Noam TI - Assessment of a novel electrochemically deposited smart bioactive trabecular coating (SBTC®): a randomized controlled clinical trial JF - HEAD AND FACE MEDICINE J2 - HEAD FACE MED VL - 20 PY - 2024 IS - 1 PG - 14 SN - 1746-160X DO - 10.1186/s13005-024-00426-0 UR - https://m2.mtmt.hu/api/publication/34794084 ID - 34794084 LA - English DB - MTMT ER - TY - JOUR AU - Vlocskó, Máté AU - Piffkó, József AU - Janovszky, Ágnes TI - Intraoperative Assessment of Resection Margin in Oral Cancer: The Potential Role of Spectroscopy JF - CANCERS J2 - CANCERS VL - 16 PY - 2024 IS - 1 PG - 15 SN - 2072-6694 DO - 10.3390/cancers16010121 UR - https://m2.mtmt.hu/api/publication/34450467 ID - 34450467 AB - In parallel with the increasing number of oncological cases, the need for faster and more efficient diagnostic tools has also appeared. Different diagnostic approaches are available, such as radiological imaging or histological staining methods, but these do not provide adequate information regarding the resection margin, intraoperatively, or are time consuming. The purpose of this review is to summarize the current knowledge on spectrometric diagnostic modalities suitable for intraoperative use, with an emphasis on their relevance in the management of oral cancer. The literature agrees on the sensitivity, specificity, and accuracy of spectrometric diagnostic modalities, but further long-term prospective, multicentric clinical studies are needed, which may standardize the intraoperative assessment of the resection margin and the use of real-time spectroscopic approaches. LA - English DB - MTMT ER - TY - JOUR AU - Kiscsatári, Ramóna AU - Nagy, Eszter AU - Szabó, Máté AU - Braunitzer, Gábor AU - Piffkó, József AU - Fráter, Márk Tibor AU - Antal, Márk Ádám TI - Comparison of the Three-Dimensional Accuracy of Guided Apicoectomy Performed with a Drill or a Trephine: An In Vitro Study JF - APPLIED SCIENCES-BASEL J2 - APPL SCI-BASEL VL - 13 PY - 2023 IS - 17 PG - 11 SN - 2076-3417 DO - 10.3390/app13179642 UR - https://m2.mtmt.hu/api/publication/34119738 ID - 34119738 N1 - Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Szeged, Szeged, 6725, Hungary Department of Operative and Esthetic Dentistry, Faculty of Dentistry, University of Szeged, Szeged, 6720, Hungary dicomLAB Dental, Ltd, Szeged, 6726, Hungary Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates Export Date: 7 October 2023 Correspondence Address: Antal, M.Á.; Department of Operative and Esthetic Dentistry, Hungary; email: antal.mark@szte.hu AB - Guided apicoectomy performed with 3D-printed polymer-based static surgical guides is an emerging trend in endodontic surgery. Static-guided apicoectomy is carried out with either a drill or a trephine. The aim of this in vitro study was to assess the accuracy of osteotomy and apicoectomy performed through a polymer guide, with both drill and trephine, and to compare the accuracy achievable with the two instruments. Six plaster models of a maxilla master model with extracted human maxillary teeth in polymethyl-methacrylate resin were used. The modeled osteotomies were performed in these. The master model was CBCT-scanned, and digital surgical plans were prepared, based on which the surgical guides were printed. The plans contained both drill and trephine apicoectomies. Digital three-dimensional position analysis was performed with dedicated algorithms. A total of 39 drill and 47 trephine osteotomies were analyzed. A statistically significant difference between the two instruments was found only in the global deviation of the distal endpoint, indicating lower deviation for the trephine procedure (1.53 mm vs. 1.31 mm, p = 0.038). Nevertheless, from a clinical perspective, this distinction is inconsequential. The results suggest that, for all practical purposes, the two approaches to apicoectomy allow the same level of accuracy. LA - English DB - MTMT ER - TY - JOUR AU - Pál, Margit AU - Vetró, Éva AU - Nagy, Nikoletta AU - Nagy, Dóra AU - Ferdinandyné Horváth, Emese AU - Bokor, Barbara Anna AU - Varga, Anita AU - Seres, László AU - Oláh, Judit Magdolna AU - Piffkó, József AU - Széll, Márta TI - Whole-Exome Sequencing Identified Two Novel Pathogenic Mutations in the PTCH1 Gene in BCNS JF - CURRENT ISSUES IN MOLECULAR BIOLOGY J2 - CURR ISSUES MOL BIOL VL - 45 PY - 2023 IS - 7 SP - 5293 EP - 5304 PG - 12 SN - 1467-3037 DO - 10.3390/cimb45070336 UR - https://m2.mtmt.hu/api/publication/34035935 ID - 34035935 AB - Basal cell nevus syndrome (BCNS, OMIM 109400) is a familial cancer syndrome characterized by the development of numerous basal cell cancers and various other developmental abnormalities, including epidermal cysts of the skin, calcified dural folds, keratocysts of the jaw, palmar and plantar pits, ovarian fibromas, medulloblastomas, lymphomesenteric cysts, and fetal rhabdomyomas. BCNS shows autosomal dominant inheritance and is caused by mutations in the patched 1 (PTCH1) gene and the suppressor of the fused homolog (SUFU) gene. In a few cases, variants of patched 2 (PTCH2) have been found in patients who met the criteria for BCNS. In an investigation of 11 Hungarian families who fulfilled the diagnostic criteria for BCNS, whole-exome sequencing (WES) and multiplex ligation-dependent probe amplification (MLPA) identified two novel pathogenic variants (c.2994C>A; p.Cys998Ter and c.814_818del; p.Asn272SerfsTer11), one recently identified variant (c.1737_1745del p.Val580_Val582del), and three recurrent disease-causing variants of the PTCH1 gene with a diagnosis rate of 63.6%. Disease-causing variants were not found for the SUFU and PTCH2 genes. These applied methods could not fully elucidate the genetic background of all the BCNS cases that we investigated. To uncover the missing heritability of BCNS, whole-genome sequencing or an epigenetic approach might be considered in the future. LA - English DB - MTMT ER - TY - JOUR AU - Sáfrány-Fárk, Árpád AU - Laczi, Balázs AU - Nagy, Antal AU - Lengyel, Laura AU - Piffkó, József AU - Segatto, Emil TI - A novel approach for determining instantaneous centers of rotation of the mandible with an intraoral scanner: A preliminary study JF - PLOS ONE J2 - PLOS ONE VL - 18 PY - 2023 IS - 5 PG - 15 SN - 1932-6203 DO - 10.1371/journal.pone.0285162 UR - https://m2.mtmt.hu/api/publication/33790411 ID - 33790411 N1 - Department of Oral and Maxillofacial Surgery, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Faculty of Science and Informatics, Department of Image Processing and Computer Graphics, Institute of Informatics, University of Szeged, Szeged, Hungary Export Date: 04 January 2024; Cited By: 0; Correspondence Address: A. Safrany-Fark; Department of Oral and Maxillofacial Surgery, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary; email: safrany-fark.arpad@med.u-szeged.hu; CODEN: POLNC LA - English DB - MTMT ER - TY - JOUR AU - Lázár, Péter AU - Tóth-Molnár, Edit AU - Bende, Balázs AU - Vass, Gábor AU - Baltás, Eszter AU - Paczona, Róbert AU - Varga, Erika AU - Piffkó, József AU - Kemény, Lajos AU - Oláh, Judit Magdolna AU - Kis, Erika TI - Challenges in the complex management of neglected cutaneous melanomas in the head and neck area: a single center experience JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 12 PY - 2023 IS - 5 PG - 11 SN - 2077-0383 DO - 10.3390/jcm12051910 UR - https://m2.mtmt.hu/api/publication/33680226 ID - 33680226 AB - Familiar controversies in the management of head and neck melanomas are more remarkable in locally advanced cases, and they represent a treatment challenge both surgically and oncologically. In our retrospective study, patients with surgically treated primary malignant melanoma of the head and neck region larger than 3 cm in diameter were included. Five patients met our inclusion criteria. In all cases, wide excision and immediate reconstruction were performed without sentinel lymph node biopsy. The defect on the scalp was covered by a split skin graft, with local flaps chosen for reconstruction on the face on an individual basis. After a 2–6 year follow-up, a good oncological, functional, and esthetic result was achieved. Our results show that in the case of large, locally advanced melanomas, surgical treatment still plays a crucial role that can provide long-term local control and support the effect of systemic treatment. LA - English DB - MTMT ER - TY - JOUR AU - Vetró, Éva AU - Vlocskó, Máté AU - Piffkó, József AU - Janovszky, Ágnes TI - Odontogén tályogok diagnosztikája és kezelése a nemzetközi ajánlások tükrében [Current approaches to the diagnosis and management of odontogenic abscesses] JF - ORVOSI HETILAP J2 - ORV HETIL VL - 163 PY - 2022 IS - 37 SP - 1455 EP - 1463 PG - 9 SN - 0030-6002 DO - 10.1556/650.2022.32587 UR - https://m2.mtmt.hu/api/publication/33194226 ID - 33194226 N1 - Journal Article; Review AB - A wide scale of medical professionals including general practitioners, dentists, maxillofacial surgeons, otolaryngologists or even emergency physicians frequently encounter patients suffering from abscesses of odontogenic origin. These dental infections spreading along the fascial planes into the adjacent anatomical spaces or by the lymphatic vessels and veins may result in life-threatening situations. It is essential to prevent and - in the case of an evolved disease pattern - to treat them properly, since improper or delayed treatment may entail avoidable burdens on the healthcare system. Our aim was to review the current literature regarding the development, diagnostics and treatment of odontogenic infections. A review of the English and Hungarian literature was performed. Considerations regarding the surgical management of dental abscesses have well-tried, traditional routes. Prompt intervention is considered mandatory with surgical decompression of the swelling by performing incision and drainage. A rapid improvement of radiology has provided the possibility to realize and avoid fatal consequences of this disorder. The administration route, necessity and duration of empiric antibiotic therapy are still "debated", protocols vary across studies. Based on inconsistency in findings among the studies and lack of high-quality prospective studies, future research should evaluate evidence-based and effective management of dental abscesses. Orv Hetil. 2022; 163(37): 1455-1463. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Paczona, Róbert AU - Csenki, Melinda AU - Hideghéty, Katalin AU - Piffkó, József TI - A szájüregi daganatok korszerű kezelése JF - KLINIKAI ONKOLÓGIA J2 - KLINIKAI ONKOLÓGIA VL - 9 PY - 2022 IS - 3 SP - 253 EP - 261 PG - 9 SN - 2064-5058 UR - https://m2.mtmt.hu/api/publication/33152214 ID - 33152214 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Mucsi, Marietta AU - Mányai, A. AU - Mészáros, Bence AU - Piffkó, József AU - Seres, László TI - Állcsontnövekedési zavarokra specifikus életminőség-kérdőív magyar nyelvű adaptálása [Translation and validation of the Hungarian version of the Orthognathic Quality of Life Questionnaire] JF - ORVOSI HETILAP J2 - ORV HETIL VL - 163 PY - 2022 IS - 32 SP - 1275 EP - 1280 PG - 6 SN - 0030-6002 DO - 10.1556/650.2022.32533 UR - https://m2.mtmt.hu/api/publication/33055740 ID - 33055740 LA - Hungarian DB - MTMT ER - TY - THES AU - Sass, Tamás TI - Clinical Efficiency of Different Regenerative Surgical Approaches to Restore Vertical Defects of the Mandible and Maxilla [A mandibula és a maxilla vertikális defektusainak helyreállítására irányuló egyes regeneratív sebészeti megoldások klinikai hatékonysága] PB - Szegedi Tudományegyetem (SZTE) PY - 2022 SP - 43 DO - 10.14232/phd.11170 UR - https://m2.mtmt.hu/api/publication/32858723 ID - 32858723 LA - English DB - MTMT ER -