TY - CONF AU - Péter, Bátor Kemenesi-Gedei AU - Karcsúné Kis, Gyöngyi TI - Oxytocin Receptor Expression In Primary Sensory Neurons: Unveiling How Oxytocin And Its Receptor Contribute To The Sensory Processing And The Modulation Of Pain T2 - International Neuroscience Conference, Pécs 2024 PY - 2024 SP - S6.05 UR - https://m2.mtmt.hu/api/publication/34694071 ID - 34694071 N1 - (Poszter) LA - English DB - MTMT ER - TY - JOUR AU - El Heni, Heni AU - Kemenesi-Gedei, Péter Bátor AU - Pálvölgyi, Laura AU - Szeredi, Ivett Dorina AU - Karcsúné Kis, Gyöngyi TI - Peripheral Branch Injury Induces Oxytocin Receptor Expression at the Central Axon Terminals of Primary Sensory Neurons JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 1 PG - 15 SN - 1661-6596 DO - 10.3390/ijms25010007 UR - https://m2.mtmt.hu/api/publication/34443978 ID - 34443978 AB - Considerable evidence suggests that oxytocin, as a regulatory nonapeptide, participates in modulatory mechanisms of nociception. Nonetheless, the role of this hypothalamic hormone and its receptor in the sensory pathway has yet to be fully explored. The present study performed immunohistochemistry, enzyme-linked immunosorbent assay, and RT-qPCR analysis to assess changes in the expression of the neuronal oxytocin receptor in female rats following tight ligation of the sciatic nerve after 1, 3, and 7 days of survival. Oxytocin receptor immunoreactivity was present in both dorsal root ganglia and lumbar spinal cord segments, but not accumulated at the site of the ligation of the peripheral nerve branch. We found a time-dependent change in the expression of oxytocin receptor mRNA in L5 dorsal root ganglion neurons, as well as an increase in the level of the receptor protein in the lumbar segment of the spinal cord. A peak in the expression was observed on day 3, which downturned slightly by day 7 after the nerve ligation. These results show that OTR expression is up-regulated in response to peripheral nerve lesions. We assume that the importance of OTR is to modify spinal presynaptic inputs of the sensory neurons upon injury-induced activation, thus to be targets of the descending oxytocinergic neurons from supraspinal levels. The findings of this study support the concept that oxytocin plays a role in somatosensory transmission. LA - English DB - MTMT ER - TY - JOUR AU - Börzsei, Denise AU - Priksz, Dániel AU - Szabó, Renáta AU - Bombicz, Mariann AU - Karácsonyi, Zoltán AU - Puskás, László AU - Fehér, Liliána Z. AU - Radák, Zsolt AU - Kupai, Krisztina AU - Magyariné, Berkó Anikó AU - Varga, Csaba AU - Juhász, Béla AU - Pósa, Anikó TI - Exercise-mitigated sex-based differences in aging: From genetic alterations to heart performance JF - AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY J2 - AM J PHYSIOL HEART C VL - 320 PY - 2021 IS - 2 SP - H854 EP - H866 PG - 13 SN - 0363-6135 DO - 10.1152/ajpheart.00643.2020 UR - https://m2.mtmt.hu/api/publication/31853713 ID - 31853713 LA - English DB - MTMT ER - TY - JOUR AU - Knapp, Levente AU - Szita, B AU - Kocsis, Kitti AU - Vécsei, László AU - Toldi, József TI - Nitroglycerin enhances the propagation of cortical spreading depression: Comparative studies with sumatriptan and novel kynurenic acid analogues JF - DRUG DESIGN DEVELOPMENT AND THERAPY J2 - DRUG DES DEV THER VL - 11 PY - 2017 SP - 27 EP - 34 PG - 8 SN - 1177-8881 DO - 10.2147/DDDT.S117166 UR - https://m2.mtmt.hu/api/publication/3163480 ID - 3163480 N1 - Department of Physiology, Anatomy, and Neuroscience, University of Szeged, Szeged, Hungary MTA-SZTE Neuroscience Research Group, University of Szeged, Szeged, Hungary Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary Cited By :14 Export Date: 7 March 2024 Correspondence Address: Toldi, J.; Department of Physiology, 52 Közép Fasor, Hungary; email: toldi@bio.u-szeged.hu Funding details: GINOP-2.3.2-15-2016-00034, KTIA_13_NAPA- III/9 Funding details: Seventh Framework Programme, FP7, 602633 Funding details: European Commission, EC Funding details: European Social Fund, ESF, A/2-11-1-2012-0001 Funding text 1: This work was supported by projects OTKA KI05077 and TÁMOP-4.2.2.A-11/1/KONV-2012-0052, the European Union and the state of Hungary, cofinanced by the European Social Fund in the framework of TÁMOP 4.2.4.A/2-11-1-2012-0001 National Excellence Program, by the MTA-SZTE Neuroscience Research Group, by the Hungarian Brain Research Program (grant KTIA_13_NAPA- III/9), by GINOP-2.3.2-15-2016-00034 and by the EUROHEADPAIN (FP7-Health 2013 Innovation, grant 602633). The authors gratefully thank Dr Levente Szalárdy for linguistic correction of the manuscript. AB - Background: The complex pathophysiology of migraine is not yet clearly understood; therefore, experimental models are essential for the investigation of the processes related to migraine headache, which include cortical spreading depression (CSD) and NO donor-induced neurovascular changes. Data on the assessment of drug efficacy in these models are often limited, which prompted us to investigate a novel combined migraine model in which an effective pharmacon could be more easily identified. Materials and methods: In vivo electrophysiological experiments were performed to investigate the effect of nitroglycerin (NTG) on CSD induced by KCl application. In addition, sumatriptan and newly synthesized neuroactive substances (analogues of the neuromodulator kynurenic acid [KYNA]) were also tested. Results: The basic parameters of CSDs were unchanged following NTG administration; however, propagation failure was decreased compared to the controls. Sumatriptan decreased the number of CSDs, whereas propagation failure was as minimal as in the NTG group. On the other hand, both of the KYNA analogues restored the ratio of propagation to the control level. Discussion: The ratio of propagation appeared to be the indicator of the effect of NTG. This is the first study providing direct evidence that NTG influences CSD; furthermore, we observed different effects of sumatriptan and KYNA analogues. Sumatriptan changed the generation of CSDs, whereas the analogues acted on the propagation of the waves. Our experimental design overlaps with a large spectrum of processes present in migraine pathophysiology, and it can be a useful experimental model for drug screening. © 2017 Knapp et al. LA - English DB - MTMT ER - TY - JOUR AU - Kocsis, Kitti AU - Frank, Rita AU - Szabó, J AU - Knapp, Levente AU - Kis, Zsolt AU - Farkas, Tamás AU - Vécsei, László AU - Toldi, József TI - Acetyl-L-carnitine restores synaptic transmission and enhances the inducibility of stable LTP after oxygen–glucose deprivation JF - NEUROSCIENCE J2 - NEUROSCIENCE VL - 332 PY - 2016 SP - 203 EP - 211 PG - 9 SN - 0306-4522 DO - 10.1016/j.neuroscience.2016.06.046 UR - https://m2.mtmt.hu/api/publication/3097684 ID - 3097684 AB - Hypoxic circumstances result in functional and structural impairments of the brain. Oxygen–glucose deprivation (OGD) on hippocampal slices is a technique widely used to investigate the consequences of ischemic stroke and the potential neuroprotective effects of different drugs. Acetyl-L-carnitine (ALC) is a naturally occurring substance in the body, and it can therefore be administered safely even in relatively high doses. In previous experiments, ALC pretreatment proved to be effective against global hypoperfusion. In the present study, we investigated whether ALC can be protective in an OGD model. We are not aware of any earlier study in which the long-term potentiation (LTP) function on hippocampal slices was measured after OGD. Therefore, we set out to determine whether an effective ALC concentration has an effect on synaptic plasticity after OGD in the hippocampal CA1 subfield of rats. A further aim was to investigate the mechanism underlying the protective effect of this compound. The experiments revealed that ALC is neuroprotective against OGD in a dose-dependent manner, which is manifested not only in the regeneration of the impaired synaptic transmission after the OGD, but also in the inducibility and stability of the LTP. In the case of the most effective concentration of ALC (500 μM), use of a phosphoinositide 3-kinase (PI3K) inhibitor (LY294002) revealed that the PI3K/Akt signaling pathway has a key role in the restoration of the synaptic transmission and plasticity reached by ALC treatment. © 2016 IBRO LA - English DB - MTMT ER - TY - JOUR AU - Furdan, Szabina AU - Lőrincz, László Magor TI - Routing of olfactory inputs to the brainstem raphé nucleus JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 127 PY - 2016 IS - 3 PG - 1 SN - 1388-2457 DO - 10.1016/j.clinph.2015.11.417 UR - https://m2.mtmt.hu/api/publication/3085614 ID - 3085614 LA - English DB - MTMT ER - TY - GEN AU - Szabó, Renáta TI - Gyulladásos és keringési paraméterek vizsgálata ösztrogénhiányos patkány modellekben CY - Témavezető: Dr. Varga Csaba, Dr. Pósa Anikó PY - 2016 UR - https://m2.mtmt.hu/api/publication/3080759 ID - 3080759 N1 - [előadás] LA - Hungarian DB - MTMT ER - TY - GEN AU - Szabó, Renáta AU - Csonka, Anett AU - Veszelka, Médea AU - Kupai, Krisztina AU - Magyariné, Berkó Anikó AU - Deim, Zoltán AU - Baráth, Zoltán Lajos AU - Ménesi, Rudolf AU - Pávó, Imre AU - Gyöngyösi, Mariann AU - László, Ferenc AU - Varga, Csaba AU - Pósa, Anikó TI - The effects of aging and experimental menopause on the cardiac and inflammatory parameters PY - 2016 UR - https://m2.mtmt.hu/api/publication/3080751 ID - 3080751 N1 - [előadás] LA - English DB - MTMT ER - TY - GEN AU - Szabó, Renáta AU - Veszelka, Médea AU - Csonka, Anett AU - Kupai, Krisztina AU - Börzsei, Denise AU - Szűcs, Gergő AU - Török, Szilvia AU - Amin, Al-Awar AU - Magyariné, Berkó Anikó AU - Varga, Csaba AU - Pósa, Anikó TI - Metabolikus, gyulladásos és kardiovaszkuláris eltérések vizsgálata ösztrogénhiányos állapotokban PY - 2016 UR - https://m2.mtmt.hu/api/publication/3080732 ID - 3080732 N1 - [poszter] LA - Hungarian DB - MTMT ER - TY - THES AU - Pósa, Anikó TI - A szelektív ösztrogén receptor modulátorok által közvetített protektív mechanizmusok PB - Szegedi Tudományegyetem (SZTE) PY - 2015 UR - https://m2.mtmt.hu/api/publication/33401913 ID - 33401913 LA - Hungarian DB - MTMT ER -