TY - JOUR AU - Jedlinszki, Nikoletta AU - Balázs, Boglárka AU - Csányi, Erzsébet AU - Csupor, Dezső TI - Penetration of lycopsamine from a comfrey ointment through human epidermis JF - REGULATORY TOXICOLOGY AND PHARMACOLOGY J2 - REGUL TOXICOL PHARM VL - 83 PY - 2017 SP - 1 EP - 4 PG - 4 SN - 0273-2300 DO - 10.1016/j.yrtph.2016.11.015 UR - https://m2.mtmt.hu/api/publication/3136945 ID - 3136945 AB - Abstract Mutagenic and teratogenic pyrrolizidine alkaloids (PAs) have been identified in several plant species. The industrially most important PA-containing plant is Symphytum officinale (common comfrey). The application of its root is restricted in several countries due to its PA content. In medicines, the daily alkaloid quantity and duration of treatment may be limited even in case of topical application. Due to the confirmed good absorption of PAs from the gastrointestinal tract, the prohibition of oral use is justified, however the limitation of external application is not supported by relevant data. Penetration experiments on human skin are not available to be a rational basis for limitation. The aim of our work was to carry out pharmacokinetic studies on the diffusion and penetration of lycopsamine (a main PA of comfrey) from a Symphytum product through a synthetic membrane and human skin. Investigations were carried out on vertical Franz diffusion cell and lycopsamine was quantified by a validated LC-MS method. The amount of lycopsamine diffused through a synthetic membrane varied between 0.11% and 0.72% (within 24 h). On human epidermis, the rate of penetration was lower (0.04–0.22%). Our results may contribute to the more realistic toxicological assessment of externally applied PA-containing products. LA - English DB - MTMT ER - TY - JOUR AU - Manczinger, Máté AU - Bodnár, VÁ AU - Papp, Benjamin Tamás AU - Bolla, Beáta Szilvia AU - Szabó, Kornélia Ágnes AU - Balázs, Boglárka AU - Csányi, Erzsébet AU - Szél, Edit AU - Erős, Gábor AU - Kemény, Lajos TI - Pikkelysömörben hatékony gyógyszerek azonosítása sejten belüli hálózatok modellezésével JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 93 PY - 2017 IS - 6 SP - 267 EP - 267 PG - 1 SN - 0006-7768 UR - https://m2.mtmt.hu/api/publication/3307735 ID - 3307735 LA - Hungarian DB - MTMT ER - TY - GEN AU - Masa, Roland AU - Pelsőczi-Kovács, István AU - Aigner, Zoltán AU - Oszkó, Albert Zoltán AU - Turzó, Kinga Mónika AU - Ungvári, Krisztina TI - Primer oszteoblaszt sejtek vizsgálata periimplantitiszben használt fertőtlenítő szerekkel kezelt titán felszínen PY - 2017 UR - https://m2.mtmt.hu/api/publication/3319927 ID - 3319927 N1 - [Poszter] LA - Hungarian DB - MTMT ER - TY - GEN AU - Révész, Piroska AU - Benke, Edit TI - Pulmonális gyógyszerbevitel, készítmény- és vizsgálati módszerfejlesztés PY - 2017 UR - https://m2.mtmt.hu/api/publication/31373445 ID - 31373445 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Jójárt, I AU - Kása, Péter AU - Kelemen, András AU - Hódi, Klára TI - Study of the compressibility of chewing gum and its applicability as an oral drug delivery system. JF - PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY J2 - PHARM DEV TECHNOL VL - 21 PY - 2016 IS - 3 SP - 321 EP - 327 PG - 7 SN - 1083-7450 DO - 10.3109/10837450.2014.1003654 UR - https://m2.mtmt.hu/api/publication/2810589 ID - 2810589 LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Anita AU - Erős, István AU - Pannonhalminé Csóka, Ildikó TI - Optimization and development of stable w/o/w cosmetic multiple emulsions by means of the Quality by Design approach JF - INTERNATIONAL JOURNAL OF COSMETIC SCIENCE J2 - INT J COSMET SCI VL - 38 PY - 2016 IS - 2 SP - 128 EP - 138 PG - 11 SN - 0142-5463 DO - 10.1111/ics.12248 UR - https://m2.mtmt.hu/api/publication/2963824 ID - 2963824 N1 - Institute of Drug Regulatory Affairs, University of Szeged, Eötvös str. 6., Szeged, 6720, Hungary Institute of Pharmaceutical Technology, University of Szeged, Eötvös str. 6, Szeged, 6720, Hungary Cited By :12 Export Date: 15 November 2019 CODEN: IJCMD Correspondence Address: Kovács, A.; Institute of Drug Regulatory Affairs, University of Szeged, Eötvös str. 6., Hungary; email: anita.kovacs@pharm.u-szeged.hu Chemicals/CAS: water, 7732-18-5; Cosmetics; Emulsions LA - English DB - MTMT ER - TY - JOUR AU - Budai-Szűcs, Mária AU - Horvát, Gabriella AU - Gyarmati, Benjámin Sándor AU - Szilágyi, Barnabás Áron AU - Szilágyi, András Ferenc AU - Tímea, Csihi AU - Berkó, Szilvia AU - Révész, Piroska AU - Michela, Mori AU - Giuseppina, Sandri AU - Maria, Cristina Bonferoni AU - Carla, Caramella AU - Csányi, Erzsébet TI - In vitro testing of thiolated poly(aspartic acid) from ophthalmic formulation aspects JF - DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY J2 - DRUG DEV IND PHARM VL - 42 PY - 2016 IS - 8 SP - 1241 EP - 1246 PG - 6 SN - 0363-9045 DO - 10.3109/03639045.2015.1118497 UR - https://m2.mtmt.hu/api/publication/2974941 ID - 2974941 N1 - Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Soft Matters Group, Department of Physical Chemistry and Materials Science, Budapest, University of Technology and Economics, Budapest, Hungary Department of Drug Sciences, Faculty of Pharmacy, University of Pavia, Pavia, Italy Cited By :5 Export Date: 11 January 2020 CODEN: DDIPD Correspondence Address: Csányi, E.; Department of Pharmaceutical Technology, Faculty of Pharmacy, University of SzegedHungary; email: csanyi@pharm.u-szeged.hu Chemicals/CAS: polyaspartic acid, 25608-40-6, 26063-13-8; aspartic acid, 56-84-8, 6899-03-2; thiol derivative, 13940-21-1; Aspartic Acid; Drug Carriers; Gels; Ophthalmic Solutions; Polymers; Sulfhydryl Compounds Funding Agency and Grant Number: European UnionEuropean Union (EU); European Social FundEuropean Social Fund (ESF) [TAMOP-4.2.2.A-11/1/KONV-2012-0035]; New Szechenyi Plan [TAMOP-4.2.1/B-09/1-2010-0002] Funding text: This project was supported by the European Union and co-financed by the European Social Fund TAMOP-4.2.2.A-11/1/KONV-2012-0035, and also by the New Szechenyi Plan (TAMOP-4.2.1/B-09/1-2010-0002). The authors report no declarations of interest. Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Soft Matters Group, Department of Physical Chemistry and Materials Science, Budapest, University of Technology and Economics, Budapest, Hungary Department of Drug Sciences, Faculty of Pharmacy, University of Pavia, Pavia, Italy Cited By :5 Export Date: 4 February 2021 CODEN: DDIPD Correspondence Address: Csányi, E.; Department of Pharmaceutical Technology, Hungary; email: csanyi@pharm.u-szeged.hu Chemicals/CAS: polyaspartic acid, 25608-40-6, 26063-13-8; aspartic acid, 56-84-8, 6899-03-2; thiol derivative, 13940-21-1; Aspartic Acid; Drug Carriers; Gels; Ophthalmic Solutions; Polymers; Sulfhydryl Compounds LA - English DB - MTMT ER - TY - JOUR AU - Sovány, Tamás AU - Kitti, Csordás AU - Kelemen, András AU - Regdon, Géza (ifj.) AU - Hódi, Klára TI - Development of Pellets for Oral Lysozyme Delivery by Using a Quality by Design Approach JF - CHEMICAL ENGINEERING RESEARCH AND DESIGN J2 - CHEM ENG RES DES VL - 106 PY - 2016 SP - 92 EP - 100 PG - 9 SN - 0263-8762 DO - 10.1016/j.cherd.2015.11.022 UR - https://m2.mtmt.hu/api/publication/2979216 ID - 2979216 LA - English DB - MTMT ER - TY - JOUR AU - Balázs, Boglárka AU - Sipos, Péter AU - Corina, Danciu AU - Stefana, Avram AU - Codruta, Soica AU - Cristina, Dehelean AU - Gábor, Varju AU - Erős, Gábor AU - Budai-Szűcs, Mária AU - Berkó, Szilvia AU - Csányi, Erzsébet TI - ATR-FTIR and Raman spectroscopic investigation of the electroporation-mediated transdermal delivery of a nanocarrier system containing an antitumour drug JF - BIOMEDICAL OPTICS EXPRESS J2 - BIOMED OPT EXPRESS VL - 7 PY - 2016 IS - 1 SP - 67 EP - 78 PG - 12 SN - 2156-7085 DO - 10.1364/BOE.7.000067 UR - https://m2.mtmt.hu/api/publication/2981310 ID - 2981310 N1 - Department of Pharmaceutical Technology, University of Szeged, Szeged, H-6720, Hungary Gedeon Richter Plc, Budapest, H-1103, Hungary Department of Pharmacognosy, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, 300041, Romania Discipline of Pharmacology, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, 300041, Romania Discipline of Pharmaceutical Chemistry, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, 300041, Romania Department of Toxicology, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, 300041, Romania Dr. Derm Clinic of Anti-Aging Dermatology, Aesthetic Laser and Plastic Surgery, Budapest, H-1026, Hungary Department of Dermatology and Allergology, University of Szeged, Szeged, H-6720, Hungary Department of Oral Biology and Experimental Dental Research, University of Szeged, Szeged, H-6720, Hungary Cited By :15 Export Date: 11 January 2020 Chemicals/CAS: cremophor, 39279-69-1, 51142-51-9; genistein, 446-72-0; myristic acid isopropyl ester, 110-27-0 Department of Pharmaceutical Technology, University of Szeged, Szeged, H-6720, Hungary Gedeon Richter Plc, Budapest, H-1103, Hungary Department of Pharmacognosy, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, 300041, Romania Discipline of Pharmacology, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, 300041, Romania Discipline of Pharmaceutical Chemistry, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, 300041, Romania Department of Toxicology, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, 300041, Romania Dr. Derm Clinic of Anti-Aging Dermatology, Aesthetic Laser and Plastic Surgery, Budapest, H-1026, Hungary Department of Dermatology and Allergology, University of Szeged, Szeged, H-6720, Hungary Department of Oral Biology and Experimental Dental Research, University of Szeged, Szeged, H-6720, Hungary Cited By :15 Export Date: 13 January 2020 Chemicals/CAS: cremophor, 39279-69-1, 51142-51-9; genistein, 446-72-0; myristic acid isopropyl ester, 110-27-0 LA - English DB - MTMT ER - TY - JOUR AU - Vladić, J AU - Ambrus, Rita AU - Révész, Piroska AU - Vasić, A AU - Cvejin, A AU - Pavlić, B AU - Vidović, S TI - Recycling of filter tea industry by-products: Production of A. millefolium powder using spray drying technique JF - INDUSTRIAL CROPS AND PRODUCTS J2 - IND CROP PROD VL - 80 PY - 2016 SP - 197 EP - 206 PG - 10 SN - 0926-6690 DO - 10.1016/j.indcrop.2015.11.085 UR - https://m2.mtmt.hu/api/publication/2993074 ID - 2993074 LA - English DB - MTMT ER -