@article{MTMT:3136945, title = {Penetration of lycopsamine from a comfrey ointment through human epidermis}, url = {https://m2.mtmt.hu/api/publication/3136945}, author = {Jedlinszki, Nikoletta and Balázs, Boglárka and Csányi, Erzsébet and Csupor, Dezső}, doi = {10.1016/j.yrtph.2016.11.015}, journal-iso = {REGUL TOXICOL PHARM}, journal = {REGULATORY TOXICOLOGY AND PHARMACOLOGY}, volume = {83}, unique-id = {3136945}, issn = {0273-2300}, abstract = {Abstract Mutagenic and teratogenic pyrrolizidine alkaloids (PAs) have been identified in several plant species. The industrially most important PA-containing plant is Symphytum officinale (common comfrey). The application of its root is restricted in several countries due to its PA content. In medicines, the daily alkaloid quantity and duration of treatment may be limited even in case of topical application. Due to the confirmed good absorption of PAs from the gastrointestinal tract, the prohibition of oral use is justified, however the limitation of external application is not supported by relevant data. Penetration experiments on human skin are not available to be a rational basis for limitation. The aim of our work was to carry out pharmacokinetic studies on the diffusion and penetration of lycopsamine (a main PA of comfrey) from a Symphytum product through a synthetic membrane and human skin. Investigations were carried out on vertical Franz diffusion cell and lycopsamine was quantified by a validated LC-MS method. The amount of lycopsamine diffused through a synthetic membrane varied between 0.11% and 0.72% (within 24 h). On human epidermis, the rate of penetration was lower (0.04–0.22%). Our results may contribute to the more realistic toxicological assessment of externally applied PA-containing products.}, keywords = {absorption; SKIN; Epidermis; pyrrolizidine alkaloid; Franz diffusion cell; Comfrey; Lycopsamine}, year = {2017}, eissn = {1096-0295}, pages = {1-4}, orcid-numbers = {Jedlinszki, Nikoletta/0000-0001-5070-9809; Csányi, Erzsébet/0000-0002-3010-1959; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:3307735, title = {Pikkelysömörben hatékony gyógyszerek azonosítása sejten belüli hálózatok modellezésével}, url = {https://m2.mtmt.hu/api/publication/3307735}, author = {Manczinger, Máté and Bodnár, VÁ and Papp, Benjamin Tamás and Bolla, Beáta Szilvia and Szabó, Kornélia Ágnes and Balázs, Boglárka and Csányi, Erzsébet and Szél, Edit and Erős, Gábor and Kemény, Lajos}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {93}, unique-id = {3307735}, issn = {0006-7768}, year = {2017}, eissn = {2064-261X}, pages = {267-267}, orcid-numbers = {Manczinger, Máté/0000-0003-0831-9617; Papp, Benjamin Tamás/0000-0002-5017-6739; Szabó, Kornélia Ágnes/0000-0002-6231-3251; Csányi, Erzsébet/0000-0002-3010-1959; Szél, Edit/0000-0001-9102-5542; Kemény, Lajos/0000-0002-2119-9501} } @misc{MTMT:3319927, title = {Primer oszteoblaszt sejtek vizsgálata periimplantitiszben használt fertőtlenítő szerekkel kezelt titán felszínen}, url = {https://m2.mtmt.hu/api/publication/3319927}, author = {Masa, Roland and Pelsőczi-Kovács, István and Aigner, Zoltán and Oszkó, Albert Zoltán and Turzó, Kinga Mónika and Ungvári, Krisztina}, unique-id = {3319927}, year = {2017}, orcid-numbers = {Pelsőczi-Kovács, István/0000-0003-3844-9519; Oszkó, Albert Zoltán/0000-0002-6215-2451} } @misc{MTMT:31373445, title = {Pulmonális gyógyszerbevitel, készítmény- és vizsgálati módszerfejlesztés}, url = {https://m2.mtmt.hu/api/publication/31373445}, author = {Révész, Piroska and Benke, Edit}, unique-id = {31373445}, year = {2017}, orcid-numbers = {Révész, Piroska/0000-0002-5336-6052} } @article{MTMT:2810589, title = {Study of the compressibility of chewing gum and its applicability as an oral drug delivery system.}, url = {https://m2.mtmt.hu/api/publication/2810589}, author = {Jójárt, I and Kása, Péter and Kelemen, András and Hódi, Klára}, doi = {10.3109/10837450.2014.1003654}, journal-iso = {PHARM DEV TECHNOL}, journal = {PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY}, volume = {21}, unique-id = {2810589}, issn = {1083-7450}, year = {2016}, eissn = {1097-9867}, pages = {321-327}, orcid-numbers = {Kása, Péter/0000-0002-6134-0928; Hódi, Klára/0000-0002-0794-1423} } @article{MTMT:2963824, title = {Optimization and development of stable w/o/w cosmetic multiple emulsions by means of the Quality by Design approach}, url = {https://m2.mtmt.hu/api/publication/2963824}, author = {Kovács, Anita and Erős, István and Pannonhalminé Csóka, Ildikó}, doi = {10.1111/ics.12248}, journal-iso = {INT J COSMET SCI}, journal = {INTERNATIONAL JOURNAL OF COSMETIC SCIENCE}, volume = {38}, unique-id = {2963824}, issn = {0142-5463}, year = {2016}, eissn = {1468-2494}, pages = {128-138}, orcid-numbers = {Kovács, Anita/0000-0001-5593-1329; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @article{MTMT:2974941, title = {In vitro testing of thiolated poly(aspartic acid) from ophthalmic formulation aspects}, url = {https://m2.mtmt.hu/api/publication/2974941}, author = {Budai-Szűcs, Mária and Horvát, Gabriella and Gyarmati, Benjámin Sándor and Szilágyi, Barnabás Áron and Szilágyi, András Ferenc and Tímea, Csihi and Berkó, Szilvia and Révész, Piroska and Michela, Mori and Giuseppina, Sandri and Maria, Cristina Bonferoni and Carla, Caramella and Csányi, Erzsébet}, doi = {10.3109/03639045.2015.1118497}, journal-iso = {DRUG DEV IND PHARM}, journal = {DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY}, volume = {42}, unique-id = {2974941}, issn = {0363-9045}, year = {2016}, eissn = {1520-5762}, pages = {1241-1246}, orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702; Szilágyi, András Ferenc/0000-0001-6898-1755; Berkó, Szilvia/0000-0002-3842-8876; Révész, Piroska/0000-0002-5336-6052; Csányi, Erzsébet/0000-0002-3010-1959} } @article{MTMT:2979216, title = {Development of Pellets for Oral Lysozyme Delivery by Using a Quality by Design Approach}, url = {https://m2.mtmt.hu/api/publication/2979216}, author = {Sovány, Tamás and Kitti, Csordás and Kelemen, András and Regdon, Géza (ifj.) and Hódi, Klára}, doi = {10.1016/j.cherd.2015.11.022}, journal-iso = {CHEM ENG RES DES}, journal = {CHEMICAL ENGINEERING RESEARCH AND DESIGN}, volume = {106}, unique-id = {2979216}, issn = {0263-8762}, year = {2016}, eissn = {1744-3563}, pages = {92-100}, orcid-numbers = {Sovány, Tamás/0000-0003-3392-7788; Regdon, Géza (ifj.)/0000-0002-6921-3069; Hódi, Klára/0000-0002-0794-1423} } @article{MTMT:2981310, title = {ATR-FTIR and Raman spectroscopic investigation of the electroporation-mediated transdermal delivery of a nanocarrier system containing an antitumour drug}, url = {https://m2.mtmt.hu/api/publication/2981310}, author = {Balázs, Boglárka and Sipos, Péter and Corina, Danciu and Stefana, Avram and Codruta, Soica and Cristina, Dehelean and Gábor, Varju and Erős, Gábor and Budai-Szűcs, Mária and Berkó, Szilvia and Csányi, Erzsébet}, doi = {10.1364/BOE.7.000067}, journal-iso = {BIOMED OPT EXPRESS}, journal = {BIOMEDICAL OPTICS EXPRESS}, volume = {7}, unique-id = {2981310}, issn = {2156-7085}, year = {2016}, eissn = {2156-7085}, pages = {67-78}, orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702; Berkó, Szilvia/0000-0002-3842-8876; Csányi, Erzsébet/0000-0002-3010-1959} } @article{MTMT:2993074, title = {Recycling of filter tea industry by-products: Production of A. millefolium powder using spray drying technique}, url = {https://m2.mtmt.hu/api/publication/2993074}, author = {Vladić, J and Ambrus, Rita and Révész, Piroska and Vasić, A and Cvejin, A and Pavlić, B and Vidović, S}, doi = {10.1016/j.indcrop.2015.11.085}, journal-iso = {IND CROP PROD}, journal = {INDUSTRIAL CROPS AND PRODUCTS}, volume = {80}, unique-id = {2993074}, issn = {0926-6690}, year = {2016}, eissn = {1872-633X}, pages = {197-206}, orcid-numbers = {Révész, Piroska/0000-0002-5336-6052} }