TY - JOUR AU - Dobos, Dóra AU - Kökönyei, Gyöngyi AU - Gyebnár, Gyula AU - Szabó, Edina AU - Kocsel, Natália AU - Galambos, Attila AU - Gecse, Kinga AU - Baksa, Dániel AU - Kozák, Lajos Rudolf AU - Juhász, Gabriella TI - Microstructural differences in migraine: A diffusion-tensor imaging study JF - CEPHALALGIA J2 - CEPHALALGIA VL - 43 PY - 2023 IS - 12 PG - 9 SN - 0333-1024 DO - 10.1177/03331024231216456 UR - https://m2.mtmt.hu/api/publication/34474549 ID - 34474549 LA - English DB - MTMT ER - TY - JOUR AU - Dobner, Sarolta AU - Szabó, Léna AU - Hudák, Mária AU - Benke, Péter AU - Constantin, Tamás AU - Varga, Edit AU - Liptai, Zoltán TI - Központi idegrendszeri vasculitises eseteink retrospektív vizsgálata JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 4 SP - 193 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/33895542 ID - 33895542 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Rados, Matea AU - Mouthaan, Brian AU - Barsi, Péter AU - Carmichael, David AU - Heckemann, Rolf A AU - Kelemen, Anna AU - Kobulashvili, Teia AU - Kuchukhidze, Giorgi AU - Marusic, Petr AU - Minkin, Krasimir AU - Tisdall, Martin AU - Trinka, Eugen AU - Veersema, Tim AU - Vos, Sjoerd B AU - Wagner, Jan AU - Braun, Kees AU - van Eijsden, Pieter TI - Diagnostic value of MRI in the presurgical evaluation of patients with epilepsy. influence of field strength and sequence selection: a systematic review and meta-analysis from the E-PILEPSY Consortium. TS - influence of field strength and sequence selection: a systematic review and meta-analysis from the E-PILEPSY Consortium. JF - EPILEPTIC DISORDERS J2 - EPILEPTIC DISORD VL - 24 PY - 2022 IS - 2 SP - 323 EP - 342 PG - 20 SN - 1294-9361 DO - 10.1684/epd.2021.1399 UR - https://m2.mtmt.hu/api/publication/32754998 ID - 32754998 N1 - UMC Utrecht Brain Center, University Medical Center Utrecht, Department of (Child) Neurology and Neurosurgery, Utrecht University the Netherlands, Netherlands MR Research Center, Semmelweis University, Budapest, Hungary Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, Kings College London, London UK & UCL Great Ormond Street Institute of Child Health, London, United Kingdom Department of Medical Radiation Sciences, University of Gothenburg, Gothenburg, Sweden MedTech West at Sahlgrenska University Hospital Campus, Gothenburg, Sweden Department of Psychiatry and Neurology, Budapest, Hungary Department of Neurology, Christian-Doppler University Hospital, Paracelsus Medical University, affiliated EpiCARE Member, and Centre for Cognitive Neuroscience, Salzburg, Austria Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria Department of Neurology, Charles University, Second Faculty of Medicine, Motol University Hospital, Prague, Czech Republic Department of Neurosurgery, University Hospital “Saint Ivan Rilski,” Sofia, Bulgaria Great Ormond Street Hospital for Children NHS Trust, Department of Neurosurgery, & UCL Great Ormond Street Institute of Child Health, London, United Kingdom Neuroscience Institute, Christan Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, Austria Department of Public Health, Health Services Research and Health Technology Assessment, UMIT – University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria Centre for Medical Image Computing, University College London, London, United Kingdom, MRI Unit, Epilepsy Society, Chalfont St Peter, United Kingdom Department of Neurology, University of Ulm and Universitäts- and Rehabilitationskliniken Ulm, Ulm, Germany Cited By :7 Export Date: 31 October 2023 CODEN: EPDIF Correspondence Address: Braun, K.; UMC Utrecht Brain Center, Netherlands; email: k.braun@umcutrecht.nl AB - MRI is a cornerstone in presurgical evaluation of epilepsy. Despite guidelines, clinical practice varies. In light of the E-PILEPSY pilot reference network, we conducted a systematic review and meta-analysis on the diagnostic value of MRI in the presurgical evaluation of epilepsy patients. We included original research articles on diagnostic value of higher MRI field strength and guideline-recommended and additional MRI sequences in detecting an epileptogenic lesion in adult or paediatric epilepsy surgery candidates. Lesion detection rate was used as a metric in meta-analysis. Eighteen studies were included for MRI field strength and 25 for MRI sequences, none were free from bias. In patients with normal MRI at lower-field strength, 3T improved lesion detection rate by 18% and 7T by 23%. Field strengths higher than 1.5T did not have higher lesion detection rates in patients with hippocampal sclerosis (HS). The lesion detection rate of epilepsy-specific MRI protocols was 83% for temporal lobe epilepsy (TLE) patients. Dedicated MRI protocols and evaluation by an experienced epilepsy neuroradiologist increased lesion detection. For HS, 3DT1, T2, and FLAIR each had a lesion detection rate at around 90%. Apparent diffusion coefficient indices had a lateralizing value of 33% for TLE. DTI fractional anisotropy and mean diffusivity had a localizing value of 8% and 34%. A dedicated MRI protocol and expert evaluation benefits lesion detection rate in epilepsy surgery candidates. If patients remain MRI negative, imaging at higher-field strength may reveal lesions. In HS, apparent diffusion coefficient indices may aid lateralization and localization more than increasing field strength. DTI can add further diagnostic information. For other additional sequences, the quality and number of studies is insufficient to draw solid conclusions. Our findings may be used as evidence base for developing new high-quality MRI studies and clinical guidelines. LA - English DB - MTMT ER - TY - JOUR AU - Kelemen, Andrea Judit AU - Halász, László AU - Erőss, Loránd AU - Rudas, Gábor AU - Muthuraman, Muthuraman AU - Zádori, Dénes AU - Laczó, Bence AU - Kis, Dávid AU - Klivényi, Péter AU - Fekete, Gábor AU - Bognár, László AU - Bereczki, Dániel AU - Tamás, Gertrúd TI - Factors affecting postural instability after more than one-year bilateral subthalamic stimulation in Parkinson's disease: A cross-sectional study JF - PLOS ONE J2 - PLOS ONE VL - 17 PY - 2022 IS - 2 PG - 17 SN - 1932-6203 DO - 10.1371/journal.pone.0264114 UR - https://m2.mtmt.hu/api/publication/32704613 ID - 32704613 AB - Balance impairment in Parkinson's disease is multifactorial and its changes due to subthalamic stimulation vary in different studies.We aimed to analyze the combination of predictive clinical factors of balance impairment in patients with Parkinson's disease treated with bilateral subthalamic stimulation for at least one year.We recruited 24 patients with Parkinson's disease treated with bilateral subthalamic stimulation and 24 healthy controls. They wore an Opal monitor (APDM Inc.) consisting of three-dimensional gyroscopes and accelerometers in the lumbar region. We investigated four stimulation conditions (bilateral stimulation OFF, bilateral stimulation ON, and unilateral right- and left-sided stimulation ON) with four tests: stance on a plain ground with eyes open and closed, stance on a foam platform with eyes open and closed. Age, disease duration, the time elapsed after implantation, levodopa, and stimulation responsiveness were analyzed. The distance of stimulation location from the subthalamic motor center was calculated individually in each plane of the three dimensions. We analyzed the sway values in the four stimulation conditions in the patient group and compared them with the control values. We explored factor combinations (with age as confounder) in the patient group predictive for imbalance with cluster analysis and a machine-learning-based multiple regression method.Sway combined from the four tasks did not differ in the patients and controls on a group level. The combination of the disease duration, the preoperative levodopa responsiveness, and the stimulation responsiveness predicted individual stimulation-induced static imbalance. The more affected patients had more severe motor symptoms; primarily, the proprioceptive followed by visual sensory feedback loss provoked imbalance in them when switching on the stimulation.The duration of the disease, the severity of motor symptoms, the levodopa responsiveness, and additional sensory deficits should be carefully considered during preoperative evaluation to predict subthalamic stimulation-induced imbalance in Parkinson's disease. LA - English DB - MTMT ER - TY - JOUR AU - Dérfalvi, Beáta AU - Boros, Kriszta Katinka AU - Szabó, Dolóresz AU - Bozsaki, Gabor AU - Cseh, Áron AU - Rudas, Gábor AU - Müller, Katalin Eszter AU - Veres, Gábor TI - Joint involvement, disease activity and quality of life in pediatric Crohn's disease - a cross-sectional study JF - PEDIATRIC RHEUMATOLOGY J2 - PEDIATR RHEUMATOL VL - 20 PY - 2022 IS - 1 PG - 9 SN - 1546-0096 DO - 10.1186/s12969-022-00664-z UR - https://m2.mtmt.hu/api/publication/32635795 ID - 32635795 AB - Few published data describe how joint involvement, the most prevalent extraintestinal manifestation, affects quality of life (QoL) of children with Crohn's disease (CD). Arthritis and arthralgia rates in pediatric CD patients are reportedly 3-24% and 17-22%, respectively, but studies on pre-emptive and systematic screening of joint involvement with detailed musculoskeletal rheumatological exam are lacking. More detailed data collection on joint involvement improves our understanding of how arthropathy relates to disease activity and QoL measured by the Pediatric CD Activity Index (PCDAI) and IMPACT-III questionnaire. Our study aims were to assess joint involvement in pediatric CD and correlate it with the PCDAI and IMPACT-III.In this cross-sectional, observational study, a pediatric gastroenterologist assessed consecutively-seen pediatric CD patients at a tertiary care center. Patients were screened for prevalence of current and previous arthropathy, including arthritis, enthesitis and arthralgia. A single experienced pediatric rheumatologist evaluated detailed musculoskeletal history, joint status, and modified Juvenile Arthritis Multidimensional Assessment Reports (JAMAR). PCDAI, IMPACT-III, sacroiliac MRI, and HLA-B27 genetic testing were also completed.A total of 82 (male:female, 1.2:1; age, 13.7 ± 3.2 years) patients were involved in this study. Mean disease duration at time of study was 21.6 ± 21 months; eight of the patients were newly-diagnosed. Of the 82 patients, 29 (35%) had evidence of arthritis; for 24 of those, this was revealed by physical exam during cross-sectional screening, and by prior documentation for the remaining five patients. Joint examination confirmed active arthritis in 8/24 (33%), active enthesitis in 1/24 (4%), and evidence of previous arthritis in 15/24 (62.5%) patients. Hip (41%) and knee (38%) joints were most commonly affected. Cumulative incidence of arthralgia was 48% (39/82), and 46% (18/39) of those patients had only arthralgia without arthritis, usually affecting the knee. Axial involvement was present in 10/82 (12%) patients. Joint involvement correlated with more severe CD disease activity, specifically higher PCDAI and lower IMPACT-III scores, and increased requirement for infliximab treatment. Sacroiliitis and HLA-B27 positivity were insignificant factors in this cohort.When a rheumatologist performed the assessment, joint involvement in pediatric CD was more prevalent than previously reported, in this cross-sectional study. Arthritis was associated with more severe CD disease activity and lower QoL. LA - English DB - MTMT ER - TY - JOUR AU - Dobos, Dóra AU - Szabó, Edina AU - Baksa, Dániel AU - Gecse, Kinga AU - Kocsel, Natália AU - Pap, Dorottya AU - Zsombók, Terézia Ibolya AU - Kozák, Lajos Rudolf AU - Kökönyei, Gyöngyi AU - Juhász, Gabriella TI - Regular Practice of Autogenic Training Reduces Migraine Frequency and Is Associated With Brain Activity Changes in Response to Fearful Visual Stimuli JF - FRONTIERS IN BEHAVIORAL NEUROSCIENCE J2 - FRONT BEHAV NEUROSCI VL - 15 PY - 2022 PG - 13 SN - 1662-5153 DO - 10.3389/fnbeh.2021.780081 UR - https://m2.mtmt.hu/api/publication/32606943 ID - 32606943 N1 - SE-NAP 2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary Center for Pain and the Brain (PAIN Research Group), Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary Magnetic Resonance Research Center, Semmelweis University, Budapest, Hungary NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary Cited By :1 Export Date: 12 January 2023 Correspondence Address: Juhász, G.; SE-NAP 2 Genetic Brain Imaging Migraine Research Group, Hungary; email: juhasz.gabriella@pharma.semmelweis-univ.hu LA - English DB - MTMT ER - TY - JOUR AU - Dobos, Dóra AU - Szabó, Edina AU - Baksa, Dániel AU - Gecse, Kinga AU - Kocsel, Natália AU - Pap, Dorottya AU - Zsombók, Terézia Ibolya AU - Kozák, Lajos Rudolf AU - Kökönyei, Gyöngyi AU - Juhász, Gabriella TI - Regular practice of autogenic training reduces migraine frequency and associated with brain activity changes in response to fearful visual stimuli. JF - JOURNAL OF HEADACHE AND PAIN J2 - J HEADACHE PAIN VL - 22 PY - 2021 IS - S1 SP - 48 EP - 49 PG - 2 SN - 1129-2369 UR - https://m2.mtmt.hu/api/publication/32594100 ID - 32594100 LA - English DB - MTMT ER - TY - GEN AU - Kökönyei, Gyöngyi AU - Galambos, Attila AU - Gecse, Kinga AU - Dobos, Dóra AU - Aranyi, Sándor Csaba AU - Emri, Miklós AU - Kozák, Lajos Rudolf AU - Bagdy, György AU - Juhász, Gabriella TI - Increased mPFC-ACC functional connectivity is associated with increased pain perception in migraine. PY - 2021 UR - https://m2.mtmt.hu/api/publication/32592204 ID - 32592204 LA - English DB - MTMT ER - TY - JOUR AU - Kökönyei, Gyöngyi AU - Galambos, Attila AU - Kocsel, Natália AU - Szabó, Edina AU - Édes, Andrea Edit AU - Gecse, Kinga AU - Baksa, Dániel AU - Pap, Dorottya AU - Kozák, Lajos Rudolf AU - Bagdy, György AU - Juhász, Gabriella TI - Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio JF - PLOS ONE J2 - PLOS ONE VL - 16 PY - 2021 IS - 12 PG - 21 SN - 1932-6203 DO - 10.1371/journal.pone.0261570 UR - https://m2.mtmt.hu/api/publication/32554831 ID - 32554831 N1 - SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary Doctoral School of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary Center for Pain and the Brain (PAIN Research Group), Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States MR Research Center, Semmelweis University, Budapest, Hungary MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary Cited By :2 Export Date: 12 January 2023 CODEN: POLNC Correspondence Address: Kökönyei, G.; SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungary; email: kokonyei.gyongyi@pharma.semmelweis-univ.hu LA - English DB - MTMT ER - TY - JOUR AU - Tóth-Bencsik, Renáta AU - Balicza, Péter AU - Varga, Edina Tímea AU - Lengyel, Andras AU - Rudas, Gábor AU - Gál, Anikó AU - Molnár, Mária Judit TI - New Insights of Phospholipase A2 Associated Neurodegeneration Phenotype Based on the Long-Term Follow-Up of a Large Hungarian Family JF - FRONTIERS IN GENETICS J2 - FRONT GENET VL - 12 PY - 2021 PG - 11 SN - 1664-8021 DO - 10.3389/fgene.2021.628904 UR - https://m2.mtmt.hu/api/publication/32062144 ID - 32062144 LA - English DB - MTMT ER -