@article{MTMT:34841588, title = {Interplay between autophagy and CncC regulates dendrite pruning in Drosophila}, url = {https://m2.mtmt.hu/api/publication/34841588}, author = {Tan, Jue Yu Kelly and Chew, Liang Yuh and Juhász, Gábor and Yu, Fengwei}, doi = {10.1073/pnas.2310740121}, journal-iso = {P NATL ACAD SCI USA}, journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA}, volume = {121}, unique-id = {34841588}, issn = {0027-8424}, abstract = {Autophagy is essential for the turnover of damaged organelles and long-lived proteins. It is responsible for many biological processes such as maintaining brain functions and aging. Impaired autophagy is often linked to neurodevelopmental and neurodegenerative diseases in humans. However, the role of autophagy in neuronal pruning during development remains poorly understood. Here, we report that autophagy regulates dendrite-specific pruning of ddaC sensory neurons in parallel to local caspase activation. Impaired autophagy causes the formation of ubiquitinated protein aggregates in ddaC neurons, dependent on the autophagic receptor Ref(2)P. Furthermore, the metabolic regulator AMP-activated protein kinase and the insulin–target of rapamycin pathway act upstream to regulate autophagy during dendrite pruning. Importantly, autophagy is required to activate the transcription factor CncC (Cap “n” collar isoform C), thereby promoting dendrite pruning. Conversely, CncC also indirectly affects autophagic activity via proteasomal degradation, as impaired CncC results in the inhibition of autophagy through sequestration of Atg8a into ubiquitinated protein aggregates. Thus, this study demonstrates the important role of autophagy in activating CncC prior to dendrite pruning, and further reveals an interplay between autophagy and CncC in neuronal pruning.}, year = {2024}, eissn = {1091-6490}, orcid-numbers = {Chew, Liang Yuh/0000-0002-6821-0595; Juhász, Gábor/0000-0001-8548-8874; Yu, Fengwei/0000-0003-0268-199X} } @article{MTMT:34836717, title = {Microcystin-LR, a cyanotoxin, modulates division of higher plant chloroplasts through protein phosphatase inhibition and affects cyanobacterial division}, url = {https://m2.mtmt.hu/api/publication/34836717}, author = {Máthé, Csaba and Bóka, Károly and Kónya, Zoltán and Erdődi, Ferenc and Vasas, Gábor and Freytag, Csongor and Garda, Tamás}, doi = {10.1016/j.chemosphere.2024.142125}, journal-iso = {CHEMOSPHERE}, journal = {CHEMOSPHERE}, volume = {358}, unique-id = {34836717}, issn = {0045-6535}, keywords = {PROTEIN PHOSPHATASE; microcystin-LR; Arabidopsis.; chloroplast division/fission}, year = {2024}, eissn = {1879-1298}, orcid-numbers = {Bóka, Károly/0000-0002-1324-3592; Freytag, Csongor/0000-0002-3356-4182} } @article{MTMT:34834630, title = {Invisible invaders: range expansion of feral Neocaridina davidi offers new opportunities for generalist intracellular parasites}, url = {https://m2.mtmt.hu/api/publication/34834630}, author = {Prati, Sebastian and Grabner, Daniel S. and Hupało, Kamil and Weiperth, András and Maciaszek, Rafał and Lipták, Boris and Bojko, Jamie and Bérces, Fanni and Sures, Bernd}, doi = {10.1007/s10530-024-03324-3}, journal-iso = {BIOL INVASIONS}, journal = {BIOLOGICAL INVASIONS}, volume = {1}, unique-id = {34834630}, issn = {1387-3547}, abstract = {The release of ornamental pets and associated pathogens outside their native range might directly or indirectly impact the recipient community. In temperate regions, e.g., central Europe, feral freshwater species of tropical and sub-tropical origins are mainly constrained to thermally polluted waters and thermal springs. However, species with high environmental plasticity and reproduction rates, such as the shrimp Neocaridina davidi , may adapt to colder water regimes over time. A widening thermal niche may eventually overcome thermal barriers, further expanding the range and enhancing transmission opportunities for host generalist parasites. This study assesses the observed (field observations) and theoretical (species distribution models) range expansion of N. davidi and associated parasites in Europe. We report three newly established N. davidi populations from thermally polluted waters in central Europe (Germany, Hungary, and Slovakia) and provide further evidence of its range expansion into colder environments. Species distribution models predict thermally suitable habitats in the Mediterranean and a foreseeable expansion into Western Europe and the Balkans by 2050. We confirm the presence of the microsporidian parasite Ecytonucleospora hepatopenaei in feral N. davidi populations across Europe and expand the list of microsporidians found in this host from two to four. Furthermore, we provide the first evidence of parasite spillover from/to the invasive crayfish Procambarus clarkii, suggesting that parasite exchange with native biota might be possible. Such possibility, coupled with an ongoing range expansion of N. davidi bolstered by human-mediated introductions and climate change, will likely exacerbate the impact on native biota.}, year = {2024}, eissn = {1573-1464}, pages = {1-26}, orcid-numbers = {Prati, Sebastian/0000-0001-9878-3848; Grabner, Daniel S./0000-0002-1251-7096; Hupało, Kamil/0000-0002-9979-1185; Weiperth, András/0000-0001-7824-6885; Maciaszek, Rafał/0000-0002-3041-6336; Lipták, Boris/0000-0002-7924-992X; Bojko, Jamie/0000-0001-5972-0844; Sures, Bernd/0000-0001-6865-6186} } @article{MTMT:34831542, title = {Potential interactive effect of positive expectancy violation and sleep on memory consolidation in dogs}, url = {https://m2.mtmt.hu/api/publication/34831542}, author = {Reicher, Vivien and Kovács, Tímea and Csibra, Barbara and Gácsi, Márta}, doi = {10.1038/s41598-024-60166-8}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34831542}, issn = {2045-2322}, abstract = {In dogs, as in humans, both emotional and learning pretreatment affect subsequent behaviour and sleep. Although learning often occurs in an emotional-social context, the emotion-learning interplay in such context remain mainly unknown. Aims were to assess the effects of Controlling versus Permissive (emotional factors) training (learning factors) styles on dogs’ behaviour, learning performance, and sleep. Family dogs ( N = 24) participated in two command learning sessions employing the two training styles with each session followed by assessment of learning performance, a 2-h-long non-invasive sleep EEG measurement, and a retest of learning performance. Pre- to post-sleep improvement in learning performance was evident in dogs that received the Permissive training during the second learning session, indicating that dogs that experienced a more rewarding situation than expected (positive expectancy violation) during the second training session showed improved learning success after their afternoon sleep. These results possibly indicate an interactive effect of expectancy violation and sleep on enhancing learning.}, year = {2024}, eissn = {2045-2322}, orcid-numbers = {Gácsi, Márta/0000-0003-3080-7545} } @article{MTMT:34828140, title = {Lateral septum as a possible regulatory center of maternal behaviors}, url = {https://m2.mtmt.hu/api/publication/34828140}, author = {Puska, Gina and Szendi, Vivien and Dobolyi, Árpád}, doi = {10.1016/j.neubiorev.2024.105683}, journal-iso = {NEUROSCI BIOBEHAV R}, journal = {NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS}, volume = {161}, unique-id = {34828140}, issn = {0149-7634}, year = {2024}, eissn = {1873-7528}, orcid-numbers = {Dobolyi, Árpád/0000-0003-0397-2991} } @article{MTMT:34826724, title = {Corrigendum to “Exploring the relationship between metal(loid) contamination rate, physicochemical conditions, and microbial community dynamics in industrially contaminated urban soils” [Sci. Total Environ. 897 (2023) 166094]}, url = {https://m2.mtmt.hu/api/publication/34826724}, author = {Abbaszade, Gorkhmaz and Toumi, Marwene and Farkas, Rózsa and Vajna, Balázs and Krett, Gergely and Dobosy, Péter and Szabó, Csaba and M Tóth, Erika}, doi = {10.1016/j.scitotenv.2024.172532}, journal-iso = {SCI TOTAL ENVIRON}, journal = {SCIENCE OF THE TOTAL ENVIRONMENT}, volume = {928}, unique-id = {34826724}, issn = {0048-9697}, year = {2024}, eissn = {1879-1026}, orcid-numbers = {Vajna, Balázs/0000-0002-5604-7997; Krett, Gergely/0000-0003-1145-4852; M Tóth, Erika/0000-0001-9048-5758} } @article{MTMT:34825010, title = {The Dopaminergic Cells in the Median Raphe Region Regulate Social Behavior in Male Mice.}, url = {https://m2.mtmt.hu/api/publication/34825010}, author = {Chaves, Tiago and Török, Bibiána and Fazekas, Csilla Lea and Correia, Pedro and Bodóné Sipos, Eszter and Várkonyi, Dorottya and Tóth, Zsuzsanna and Dóra, Fanni and Dobolyi, Árpád and Zelena, Dóra}, doi = {10.3390/ijms25084315}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {34825010}, issn = {1661-6596}, abstract = {According to previous studies, the median raphe region (MRR) is known to contribute significantly to social behavior. Besides serotonin, there have also been reports of a small population of dopaminergic neurons in this region. Dopamine is linked to reward and locomotion, but very little is known about its role in the MRR. To address that, we first confirmed the presence of dopaminergic cells in the MRR of mice (immunohistochemistry, RT-PCR), and then also in humans (RT-PCR) using healthy donor samples to prove translational relevance. Next, we used chemogenetic technology in mice containing the Cre enzyme under the promoter of the dopamine transporter. With the help of an adeno-associated virus, designer receptors exclusively activated by designer drugs (DREADDs) were expressed in the dopaminergic cells of the MRR to manipulate their activity. Four weeks later, we performed an extensive behavioral characterization 30 min after the injection of the artificial ligand (Clozapine-N-Oxide). Stimulation of the dopaminergic cells in the MRR decreased social interest without influencing aggression and with an increase in social discrimination. Additionally, inhibition of the same cells increased the friendly social behavior during social interaction test. No behavioral changes were detected in anxiety, memory or locomotion. All in all, dopaminergic cells were present in both the mouse and human samples from the MRR, and the manipulation of the dopaminergic neurons in the MRR elicited a specific social response.}, keywords = {Dopamine; BEHAVIOR; DREADD; Median raphe region}, year = {2024}, eissn = {1422-0067}, orcid-numbers = {Chaves, Tiago/0000-0001-8761-2728; Correia, Pedro/0000-0002-4410-9855; Tóth, Zsuzsanna/0000-0002-0628-1320; Dóra, Fanni/0000-0001-8301-8203; Dobolyi, Árpád/0000-0003-0397-2991} } @article{MTMT:34822257, title = {Network of large pedigrees reveals social practices of Avar communities}, url = {https://m2.mtmt.hu/api/publication/34822257}, author = {Gnecchi-Ruscone, Guido Alberto and Rácz, Zsófia and Samu, Levente and Szeniczey, Tamás and Faragó, Norbert and Knipper, Corina and Friedrich, Ronny and Zlámalová, Denisa and Traverso, Luca and Liccardo, Salvatore and Wabnitz, Sandra and Popli, Divyaratan and Wang, Ke and Radzeviciute, Rita and Gulyás, Bence and Koncz, István and Balogh, Csilla and Lezsák, Gabriella M. and Mácsai, Viktor and Bunbury, Magdalena M. E. and Spekker, Olga and le Roux, Petrus and Szécsényi-Nagy, Anna and Mende, Balázs Gusztáv and Colleran, Heidi and Hajdu, Tamás and Geary, Patrick and Pohl, Walter and Vida, Tivadar and Krause, Johannes and Hofmanová, Zuzana}, doi = {10.1038/s41586-024-07312-4}, journal-iso = {NATURE}, journal = {NATURE}, unique-id = {34822257}, issn = {0028-0836}, abstract = {From ad 567–568, at the onset of the Avar period, populations from the Eurasian Steppe settled in the Carpathian Basin for approximately 250 years 1 . Extensive sampling for archaeogenomics (424 individuals) and isotopes, combined with archaeological, anthropological and historical contextualization of four Avar-period cemeteries, allowed for a detailed description of the genomic structure of these communities and their kinship and social practices. We present a set of large pedigrees, reconstructed using ancient DNA, spanning nine generations and comprising around 300 individuals. We uncover a strict patrilineal kinship system, in which patrilocality and female exogamy were the norm and multiple reproductive partnering and levirate unions were common. The absence of consanguinity indicates that this society maintained a detailed memory of ancestry over generations. These kinship practices correspond with previous evidence from historical sources and anthropological research on Eurasian Steppe societies 2 . Network analyses of identity-by-descent DNA connections suggest that social cohesion between communities was maintained via female exogamy. Finally, despite the absence of major ancestry shifts, the level of resolution of our analyses allowed us to detect genetic discontinuity caused by the replacement of a community at one of the sites. This was paralleled with changes in the archaeological record and was probably a result of local political realignment.}, year = {2024}, eissn = {1476-4687}, orcid-numbers = {Gnecchi-Ruscone, Guido Alberto/0000-0002-6490-8101; Rácz, Zsófia/0000-0001-5116-2235; Samu, Levente/0000-0002-9967-9468; Szeniczey, Tamás/0000-0003-1546-7140; Faragó, Norbert/0000-0002-0351-1223; Friedrich, Ronny/0000-0001-5199-1957; Gulyás, Bence/0000-0002-7682-2065; Koncz, István/0000-0002-8113-5753; Balogh, Csilla/0000-0002-9161-1653; Bunbury, Magdalena M. E./0000-0003-3114-3138; Spekker, Olga/0000-0002-0350-1906; le Roux, Petrus/0000-0002-5930-4995; Szécsényi-Nagy, Anna/0000-0003-2095-738X; Colleran, Heidi/0000-0002-2126-8116; Hajdu, Tamás/0000-0002-3604-1125; Geary, Patrick/0000-0002-3971-2588; Vida, Tivadar/0000-0002-0588-1906; Krause, Johannes/0000-0001-9144-3920; Hofmanová, Zuzana/0000-0003-1336-4455} } @article{MTMT:34820583, title = {The effect of environmental variation on the relationship between survival and risk-taking behaviour in a migratory songbird}, url = {https://m2.mtmt.hu/api/publication/34820583}, author = {Krenhardt, Katalin and Martínez-Padilla, Jesús and Canal, David and Jablonszky, Mónika and Hegyi, Gergely and Herényi, Márton and Laczi, Miklós and Markó, Gábor and Nagy, Gergely and Rosivall, Balázs and Szász, Eszter and Szöllősi, Eszter and Török, János and Vaskuti, Éva and Zsebők, Sándor and Garamszegi, László Zsolt}, doi = {10.1093/jeb/voae046}, journal-iso = {J EVOLUTION BIOL}, journal = {JOURNAL OF EVOLUTIONARY BIOLOGY}, unique-id = {34820583}, issn = {1010-061X}, abstract = {Temporal changes in environmental conditions may play a major role in the year-to-year variation in fitness consequences of behaviours. Identifying environmental drivers of such variation is crucial to understand the evolutionary trajectories of behaviours in natural contexts. However, our understanding of how environmental variation influences behaviours in the wild remains limited. Using data collected over 14 breeding seasons from a collared flycatcher (Ficedula albicollis) population, we examined the effect of environmental variation on the relationship between survival and risk-taking behaviour, a highly variable behavioural trait with great evolutionary and ecological significance. Specifically, using annual recapture probability as a proxy of survival, we evaluated the specific effect of predation pressure, food availability and mean temperature on the relationship between annual recapture probability and risk-taking behaviour (measured as flight initiation distance, FID). We found a negative trend, as the relationship between annual recapture probability and FID decreased over the study years, and changed from positive to negative. Specifically, in the early years of the study, risk-avoiding individuals exhibited a higher annual recapture probability, whereas in the later years, risk-avoiders had a lower annual recapture probability. However, we did not find evidence that any of the considered environmental factors mediated the variation in the relationship between survival and risk-taking behaviour.}, year = {2024}, eissn = {1420-9101}, orcid-numbers = {Krenhardt, Katalin/0000-0002-3753-1353; Hegyi, Gergely/0000-0002-4906-3550; Herényi, Márton/0000-0003-4457-9096; Laczi, Miklós/0000-0001-9235-2553; Nagy, Gergely/0000-0002-0943-2876; Rosivall, Balázs/0000-0002-0732-1160; Szász, Eszter/0000-0002-9810-2085; Szöllősi, Eszter/0000-0003-2913-2894; Török, János/0000-0002-4799-5522; Zsebők, Sándor/0000-0003-4463-4753; Garamszegi, László Zsolt/0000-0001-8920-2183} } @article{MTMT:34819821, title = {In situ captured antibacterial action of membrane-incising peptide lamellae}, url = {https://m2.mtmt.hu/api/publication/34819821}, author = {el Battioui, Kamal and Chakraborty, Sohini and Wacha, András and Molnár, Dániel and Quemé-Peña, Mayra and Szigyártó, Imola Cs. and Szabó, Csenge Lilla and Bodor, Andrea and Horváti, Kata and Gyulai, Gergő and Bősze, Szilvia and Mihály, Judith and Jezsó, Bálint and Románszki, Loránd and Tóth, Judit and Varga, Zoltán and Mándity, István and Juhász, Tünde and Beke-Somfai, Tamás}, doi = {10.1038/s41467-024-47708-4}, journal-iso = {NAT COMMUN}, journal = {NATURE COMMUNICATIONS}, volume = {15}, unique-id = {34819821}, issn = {2041-1723}, abstract = {Developing unique mechanisms of action are essential to combat the growing issue of antimicrobial resistance. Supramolecular assemblies combining the improved biostability of non-natural compounds with the complex membrane-attacking mechanisms of natural peptides are promising alternatives to conventional antibiotics. However, for such compounds the direct visual insight on antibacterial action is still lacking. Here we employ a design strategy focusing on an inducible assembly mechanism and utilized electron microscopy (EM) to follow the formation of supramolecular structures of lysine-rich heterochiral β 3 -peptides, termed lamellin-2K and lamellin-3K, triggered by bacterial cell surface lipopolysaccharides. Combined molecular dynamics simulations, EM and bacterial assays confirmed that the phosphate-induced conformational change on these lamellins led to the formation of striped lamellae capable of incising the cell envelope of Gram-negative bacteria thereby exerting antibacterial activity. Our findings also provide a mechanistic link for membrane-targeting agents depicting the antibiotic mechanism derived from the in-situ formation of active supramolecules.}, year = {2024}, eissn = {2041-1723}, orcid-numbers = {Wacha, András/0000-0002-9609-0893; Szabó, Csenge Lilla/0000-0002-6508-3439; Bodor, Andrea/0000-0002-7422-298X; Gyulai, Gergő/0000-0002-1352-2014; Jezsó, Bálint/0000-0002-1306-4797; Románszki, Loránd/0000-0002-6347-5228; Tóth, Judit/0000-0002-0965-046X; Varga, Zoltán/0000-0002-5741-2669; Mándity, István/0000-0003-2865-6143; Beke-Somfai, Tamás/0000-0002-4788-3758} }