TY - CONF AU - Zacháry, Dóra AU - Zatykó, Ch AU - Mihucz, Viktor Gábor AU - Filep, Tibor AU - Jakab, Gergely Imre AU - Ringer, Marianna AU - Szalai, Zoltán TI - Crystalline, poorly-crystalline and organic matter-complexed Fe and Al phases in acid and calcareous temperate forest topsoils and subsoils T2 - EGU General Assembly 2024 : abstracts PB - European Geosciences Union (EGU) C1 - Wien PY - 2024 PG - 2 DO - 10.5194/egusphere-egu24-11914 UR - https://m2.mtmt.hu/api/publication/34821205 ID - 34821205 N1 - poszter LA - English DB - MTMT ER - TY - JOUR AU - el Battioui, Kamal AU - Chakraborty, Sohini AU - Wacha, András AU - Molnár, Dániel AU - Quemé-Peña, Mayra AU - Szigyártó, Imola Cs. AU - Szabó, Csenge Lilla AU - Bodor, Andrea AU - Horváti, Kata AU - Gyulai, Gergő AU - Bősze, Szilvia AU - Mihály, Judith AU - Jezsó, Bálint AU - Románszki, Loránd AU - Tóth, Judit AU - Varga, Zoltán AU - Mándity, István AU - Juhász, Tünde AU - Beke-Somfai, Tamás TI - In situ captured antibacterial action of membrane-incising peptide lamellae JF - NATURE COMMUNICATIONS J2 - NAT COMMUN VL - 15 PY - 2024 IS - 1 PG - 14 SN - 2041-1723 DO - 10.1038/s41467-024-47708-4 UR - https://m2.mtmt.hu/api/publication/34819821 ID - 34819821 AB - Developing unique mechanisms of action are essential to combat the growing issue of antimicrobial resistance. Supramolecular assemblies combining the improved biostability of non-natural compounds with the complex membrane-attacking mechanisms of natural peptides are promising alternatives to conventional antibiotics. However, for such compounds the direct visual insight on antibacterial action is still lacking. Here we employ a design strategy focusing on an inducible assembly mechanism and utilized electron microscopy (EM) to follow the formation of supramolecular structures of lysine-rich heterochiral β 3 -peptides, termed lamellin-2K and lamellin-3K, triggered by bacterial cell surface lipopolysaccharides. Combined molecular dynamics simulations, EM and bacterial assays confirmed that the phosphate-induced conformational change on these lamellins led to the formation of striped lamellae capable of incising the cell envelope of Gram-negative bacteria thereby exerting antibacterial activity. Our findings also provide a mechanistic link for membrane-targeting agents depicting the antibiotic mechanism derived from the in-situ formation of active supramolecules. LA - English DB - MTMT ER - TY - JOUR AU - Kalydi, Eszter AU - Malanga, Milo AU - Nielsen, Thorbjørn Terndrup AU - Wimmer, Reinhard AU - Béni, Szabolcs TI - Solving the puzzle of 2-hydroxypropyl β-cyclodextrin: Detailed assignment of the substituent distribution by NMR spectroscopy JF - CARBOHYDRATE POLYMERS J2 - CARBOHYD POLYM PY - 2024 SN - 0144-8617 DO - 10.1016/j.carbpol.2024.122167 UR - https://m2.mtmt.hu/api/publication/34804378 ID - 34804378 LA - English DB - MTMT ER - TY - JOUR AU - Gáborová, Mária AU - Vágvölgyi, Máté AU - Tayeb, Bizhar Ahmed AU - Minorics, Renáta AU - Zupkó, István AU - Jurček, Ondřej AU - Béni, Szabolcs AU - Kubínová, Renata AU - Balogh, György Tibor AU - Hunyadi, Attila TI - Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells JF - ACS OMEGA J2 - ACS OMEGA VL - 9 PY - 2024 IS - 16 SP - 18495 EP - 18504 PG - 10 SN - 2470-1343 DO - 10.1021/acsomega.4c00800 UR - https://m2.mtmt.hu/api/publication/34779108 ID - 34779108 LA - English DB - MTMT ER - TY - JOUR AU - Csomos, Attila AU - Madarász, Miklós AU - Turczel, Gábor AU - Cseri, Levente AU - Bodor, Andrea AU - Anett, Matuscsák AU - Katona, Gergely AU - Kovács, Ervin AU - Rózsa J., Balázs AU - Mucsi, Zoltán TI - A GFP inspired 8-methoxyquinoline-derived fluorescent molecular sensor for the detection of Zn2+ by two-photon microscopy JF - CHEMISTRY-A EUROPEAN JOURNAL J2 - CHEM-EUR J PY - 2024 SN - 0947-6539 DO - 10.1002/chem.202400009 UR - https://m2.mtmt.hu/api/publication/34724516 ID - 34724516 AB - An effective, GFP-inspired fluorescent Zn2+ sensor is developed for two-photon microscopy and related biological application that featured an 8-methoxyquinoline moiety. Excellent photophysical characteristics including a 37-fold fluorescence enhancement with excitation and emission maxima at 440 nm and 505 nm, respectively, as well as a high two-photon cross-section of 73 GM at 880 nm are reported. Based on the experimental data, the relationship between the structure and properties was elucidated and explained backed up by DFT calculations, particularly to the observed PeT phenomenon for the turn-on process. Biological validation and detailed experimental and theoretical characterization of the free and the zinc-bound compounds are presented. LA - English DB - MTMT ER - TY - JOUR AU - Dohárszky, András AU - Kalydi, Eszter AU - Völgyi, Gergely AU - Béni, Szabolcs AU - Fejős, Ida TI - Cyclodextrin-Enabled Enantioselective Complexation Study of Cathinone Analogs JF - MOLECULES J2 - MOLECULES VL - 29 PY - 2024 IS - 4 PG - 20 SN - 1420-3049 DO - 10.3390/molecules29040876 UR - https://m2.mtmt.hu/api/publication/34601420 ID - 34601420 N1 - Department of Pharmacognosy, Semmelweis University, Üllői út 26, Budapest, H-1085, Hungary Department of Organic Chemistry, Semmelweis University, Hőgyes Endre utca 7, Budapest, H-1092, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre utca 7, Budapest, H-1092, Hungary Department of Analytical Chemistry, Institute of Chemistry, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/A, Budapest, H-1117, Hungary Export Date: 12 April 2024 CODEN: MOLEF Correspondence Address: Béni, S.; Department of Pharmacognosy, Üllői út 26, Hungary; email: szabolcs.beni@ttk.elte.hu Correspondence Address: Fejős, I.; Department of Pharmacognosy, Üllői út 26, Hungary; email: fejos.ida@semmelweis.hu AB - The characteristic alkaloid component of the leaves of the catnip shrub (Catha edulis) is cathinone, and its synthetic analogs form a major group of recreational drugs. Cathinone derivatives are chiral compounds. In the literature, several chiral methods using cyclodextrins (CDs) have been achieved so far for diverse sets of analogs; however, a comprehensive investigation of the stability of their CD complexes has not been performed yet. To characterize the enantioselective complex formation, a systematic experimental design was developed in which a total number of 40 neutral, positively, and negatively charged CD derivatives were screened by affinity capillary electrophoresis and compared according to their cavity size, substituent type, and location. The functional groups responsible for the favorable interactions were identified in the case of para-substituted cathinone analog mephedrone, flephedrone, and 4-methylethcathinone (4-MEC) and in the case of 3,4-methylendioxy derivative butylone and methylenedioxypyrovalerone (MDPV). The succinylated-β-CD and subetadex exhibited the highest complex stabilities among the studied drugs. The complex stoichiometry was determined using the Job’s plot method, and the complex structures were further studied using ROESY NMR measurements. The results of our enantioselective complex formation study can facilitate chiral method development and may lead to evaluate potential CD-based antidotes for cathinone analogs. LA - English DB - MTMT ER - TY - JOUR AU - Gracheva, Maria AU - Klencsár, Zoltán AU - Homonnay, Zoltán AU - Solti, Ádám AU - Péter, László AU - Machala, L. AU - Novak, P. AU - Kovács, Krisztina TI - Revealing the nuclearity of iron citrate complexes at biologically relevant conditions JF - BIOMETALS J2 - BIOMETALS VL - 37 PY - 2024 IS - 2 SP - 461 EP - 475 PG - 15 SN - 0966-0844 DO - 10.1007/s10534-023-00562-1 UR - https://m2.mtmt.hu/api/publication/34538304 ID - 34538304 LA - English DB - MTMT ER - TY - JOUR AU - Németh, András György AU - Kollár, Levente AU - Németh, K. AU - Schlosser, Gitta (Vácziné) AU - Minus, Annamária AU - Keserű, György Miklós TI - On-DNA Synthesis of Multisubstituted Indoles JF - ORGANIC LETTERS J2 - ORG LETT VL - 26 PY - 2024 IS - 13 SP - 2517 EP - 2522 PG - 6 SN - 1523-7060 DO - 10.1021/acs.orglett.3c03602 UR - https://m2.mtmt.hu/api/publication/34492242 ID - 34492242 N1 - Export Date: 10 January 2024; Cited By: 0; Correspondence Address: G.M. Keserű; Medicinal Chemistry Research Group, HUN-REN Research Centre for Natural Sciences, Budapest, H-1117, Hungary; email: keseru.gyorgy@ttk.hu; CODEN: ORLEF AB - The increasing role of the DNA-encoded library technology in early phase drug discovery represents a significant demand for DNA-compatible synthetic methods for therapeutically relevant heterocycles. Herein, we report the first on-DNA synthesis of multisubstituted indoles via a cascade reaction of Sonogashira coupling and intramolecular ring closure. Further functionalization by Suzuki coupling at the third position exploits a diverse chemical space. The high fidelity of the method also enabled the construction of an indole-based mock library. © 2023 The Authors. Published by American Chemical Society. LA - English DB - MTMT ER - TY - JOUR AU - Felegyi, Kristóf AU - Garádi, Zsófia AU - Elżbieta, Studzińska-Sroka AU - Papp, Viktor AU - Boldizsár, Imre AU - Dancsó, András AU - Béni, Szabolcs AU - Przemysław, Zalewski AU - Ványolós, Attila TI - Anticholinesterase and Antityrosinase Secondary Metabolites from the Fungus Xylobolus subpileatus JF - MOLECULES J2 - MOLECULES VL - 29 PY - 2024 IS - 1 PG - 11 SN - 1420-3049 DO - 10.3390/molecules29010213 UR - https://m2.mtmt.hu/api/publication/34457258 ID - 34457258 LA - English DB - MTMT ER - TY - BOOK AU - Csősz, Éva AU - Darula, Zsuzsanna AU - Drahos, László AU - Emri, Miklós AU - Hunyadi-Gulyás, Éva AU - Janáky, Tamás AU - Juhász, Gábor AU - Kalló, Gergő AU - Kékesi, Adrienna Katalin AU - Klement, Éva AU - Márk, László AU - Medzihradszky, F. Katalin AU - Pettkó-Szandtner, Aladár AU - Rokobné Révész, Ágnes AU - Schlosser, Gitta (Vácziné) AU - Szabó, Zoltán AU - Tóth, Gábor AU - Turiák, Lilla TI - Bevezetés a proteomikába : a fehérjék korszerű vizsgálata PB - Semmelweis Egyetem CY - Budapest PY - 2023 SN - 9789633316009 UR - https://m2.mtmt.hu/api/publication/34407280 ID - 34407280 LA - Hungarian DB - MTMT ER -