@CONFERENCE{MTMT:34821205, title = {Crystalline, poorly-crystalline and organic matter-complexed Fe and Al phases in acid and calcareous temperate forest topsoils and subsoils}, url = {https://m2.mtmt.hu/api/publication/34821205}, author = {Zacháry, Dóra and Zatykó, Ch and Mihucz, Viktor Gábor and Filep, Tibor and Jakab, Gergely Imre and Ringer, Marianna and Szalai, Zoltán}, booktitle = {EGU General Assembly 2024 : abstracts}, doi = {10.5194/egusphere-egu24-11914}, unique-id = {34821205}, year = {2024}, orcid-numbers = {Mihucz, Viktor Gábor/0000-0002-5320-669X; Jakab, Gergely Imre/0000-0001-5424-1983; Szalai, Zoltán/0000-0001-5267-411X} } @article{MTMT:34819821, title = {In situ captured antibacterial action of membrane-incising peptide lamellae}, url = {https://m2.mtmt.hu/api/publication/34819821}, author = {el Battioui, Kamal and Chakraborty, Sohini and Wacha, András and Molnár, Dániel and Quemé-Peña, Mayra and Szigyártó, Imola Cs. and Szabó, Csenge Lilla and Bodor, Andrea and Horváti, Kata and Gyulai, Gergő and Bősze, Szilvia and Mihály, Judith and Jezsó, Bálint and Románszki, Loránd and Tóth, Judit and Varga, Zoltán and Mándity, István and Juhász, Tünde and Beke-Somfai, Tamás}, doi = {10.1038/s41467-024-47708-4}, journal-iso = {NAT COMMUN}, journal = {NATURE COMMUNICATIONS}, volume = {15}, unique-id = {34819821}, issn = {2041-1723}, abstract = {Developing unique mechanisms of action are essential to combat the growing issue of antimicrobial resistance. Supramolecular assemblies combining the improved biostability of non-natural compounds with the complex membrane-attacking mechanisms of natural peptides are promising alternatives to conventional antibiotics. However, for such compounds the direct visual insight on antibacterial action is still lacking. Here we employ a design strategy focusing on an inducible assembly mechanism and utilized electron microscopy (EM) to follow the formation of supramolecular structures of lysine-rich heterochiral β 3 -peptides, termed lamellin-2K and lamellin-3K, triggered by bacterial cell surface lipopolysaccharides. Combined molecular dynamics simulations, EM and bacterial assays confirmed that the phosphate-induced conformational change on these lamellins led to the formation of striped lamellae capable of incising the cell envelope of Gram-negative bacteria thereby exerting antibacterial activity. Our findings also provide a mechanistic link for membrane-targeting agents depicting the antibiotic mechanism derived from the in-situ formation of active supramolecules.}, year = {2024}, eissn = {2041-1723}, orcid-numbers = {Wacha, András/0000-0002-9609-0893; Szabó, Csenge Lilla/0000-0002-6508-3439; Bodor, Andrea/0000-0002-7422-298X; Gyulai, Gergő/0000-0002-1352-2014; Jezsó, Bálint/0000-0002-1306-4797; Románszki, Loránd/0000-0002-6347-5228; Tóth, Judit/0000-0002-0965-046X; Varga, Zoltán/0000-0002-5741-2669; Mándity, István/0000-0003-2865-6143; Beke-Somfai, Tamás/0000-0002-4788-3758} } @article{MTMT:34804378, title = {Solving the puzzle of 2-hydroxypropyl β-cyclodextrin: Detailed assignment of the substituent distribution by NMR spectroscopy}, url = {https://m2.mtmt.hu/api/publication/34804378}, author = {Kalydi, Eszter and Malanga, Milo and Nielsen, Thorbjørn Terndrup and Wimmer, Reinhard and Béni, Szabolcs}, doi = {10.1016/j.carbpol.2024.122167}, journal-iso = {CARBOHYD POLYM}, journal = {CARBOHYDRATE POLYMERS}, unique-id = {34804378}, issn = {0144-8617}, year = {2024}, eissn = {1879-1344}, orcid-numbers = {Béni, Szabolcs/0000-0001-7056-6825} } @article{MTMT:34779108, title = {Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells}, url = {https://m2.mtmt.hu/api/publication/34779108}, author = {Gáborová, Mária and Vágvölgyi, Máté and Tayeb, Bizhar Ahmed and Minorics, Renáta and Zupkó, István and Jurček, Ondřej and Béni, Szabolcs and Kubínová, Renata and Balogh, György Tibor and Hunyadi, Attila}, doi = {10.1021/acsomega.4c00800}, journal-iso = {ACS OMEGA}, journal = {ACS OMEGA}, volume = {9}, unique-id = {34779108}, issn = {2470-1343}, year = {2024}, eissn = {2470-1343}, pages = {18495-18504}, orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Tayeb, Bizhar Ahmed/0000-0001-5197-564X; Minorics, Renáta/0000-0001-9685-813X; Zupkó, István/0000-0003-3243-5300; Béni, Szabolcs/0000-0001-7056-6825; Balogh, György Tibor/0000-0003-3347-1880; Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:34724516, title = {A GFP inspired 8-methoxyquinoline-derived fluorescent molecular sensor for the detection of Zn2+ by two-photon microscopy}, url = {https://m2.mtmt.hu/api/publication/34724516}, author = {Csomos, Attila and Madarász, Miklós and Turczel, Gábor and Cseri, Levente and Bodor, Andrea and Anett, Matuscsák and Katona, Gergely and Kovács, Ervin and Rózsa J., Balázs and Mucsi, Zoltán}, doi = {10.1002/chem.202400009}, journal-iso = {CHEM-EUR J}, journal = {CHEMISTRY-A EUROPEAN JOURNAL}, unique-id = {34724516}, issn = {0947-6539}, abstract = {An effective, GFP-inspired fluorescent Zn2+ sensor is developed for two-photon microscopy and related biological application that featured an 8-methoxyquinoline moiety. Excellent photophysical characteristics including a 37-fold fluorescence enhancement with excitation and emission maxima at 440 nm and 505 nm, respectively, as well as a high two-photon cross-section of 73 GM at 880 nm are reported. Based on the experimental data, the relationship between the structure and properties was elucidated and explained backed up by DFT calculations, particularly to the observed PeT phenomenon for the turn-on process. Biological validation and detailed experimental and theoretical characterization of the free and the zinc-bound compounds are presented.}, year = {2024}, eissn = {1521-3765}, orcid-numbers = {Madarász, Miklós/0000-0001-7057-303X; Bodor, Andrea/0000-0002-7422-298X; Katona, Gergely/0000-0002-4173-0355; Kovács, Ervin/0000-0002-3939-6925; Mucsi, Zoltán/0000-0003-3224-8847} } @article{MTMT:34601420, title = {Cyclodextrin-Enabled Enantioselective Complexation Study of Cathinone Analogs}, url = {https://m2.mtmt.hu/api/publication/34601420}, author = {Dohárszky, András and Kalydi, Eszter and Völgyi, Gergely and Béni, Szabolcs and Fejős, Ida}, doi = {10.3390/molecules29040876}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {29}, unique-id = {34601420}, issn = {1420-3049}, abstract = {The characteristic alkaloid component of the leaves of the catnip shrub (Catha edulis) is cathinone, and its synthetic analogs form a major group of recreational drugs. Cathinone derivatives are chiral compounds. In the literature, several chiral methods using cyclodextrins (CDs) have been achieved so far for diverse sets of analogs; however, a comprehensive investigation of the stability of their CD complexes has not been performed yet. To characterize the enantioselective complex formation, a systematic experimental design was developed in which a total number of 40 neutral, positively, and negatively charged CD derivatives were screened by affinity capillary electrophoresis and compared according to their cavity size, substituent type, and location. The functional groups responsible for the favorable interactions were identified in the case of para-substituted cathinone analog mephedrone, flephedrone, and 4-methylethcathinone (4-MEC) and in the case of 3,4-methylendioxy derivative butylone and methylenedioxypyrovalerone (MDPV). The succinylated-β-CD and subetadex exhibited the highest complex stabilities among the studied drugs. The complex stoichiometry was determined using the Job’s plot method, and the complex structures were further studied using ROESY NMR measurements. The results of our enantioselective complex formation study can facilitate chiral method development and may lead to evaluate potential CD-based antidotes for cathinone analogs.}, year = {2024}, eissn = {1420-3049}, orcid-numbers = {Völgyi, Gergely/0000-0001-8990-3916; Béni, Szabolcs/0000-0001-7056-6825; Fejős, Ida/0000-0002-3458-0854} } @article{MTMT:34538304, title = {Revealing the nuclearity of iron citrate complexes at biologically relevant conditions}, url = {https://m2.mtmt.hu/api/publication/34538304}, author = {Gracheva, Maria and Klencsár, Zoltán and Homonnay, Zoltán and Solti, Ádám and Péter, László and Machala, L. and Novak, P. and Kovács, Krisztina}, doi = {10.1007/s10534-023-00562-1}, journal-iso = {BIOMETALS}, journal = {BIOMETALS}, volume = {37}, unique-id = {34538304}, issn = {0966-0844}, year = {2024}, eissn = {1572-8773}, pages = {461-475}, orcid-numbers = {Gracheva, Maria/0000-0001-5245-8425; Klencsár, Zoltán/0000-0003-0175-7024; Homonnay, Zoltán/0000-0001-5299-5394; Solti, Ádám/0000-0003-1479-5492; Péter, László/0000-0001-5604-0982; Kovács, Krisztina/0000-0003-0018-1860} } @article{MTMT:34492242, title = {On-DNA Synthesis of Multisubstituted Indoles}, url = {https://m2.mtmt.hu/api/publication/34492242}, author = {Németh, András György and Kollár, Levente and Németh, K. and Schlosser, Gitta (Vácziné) and Minus, Annamária and Keserű, György Miklós}, doi = {10.1021/acs.orglett.3c03602}, journal-iso = {ORG LETT}, journal = {ORGANIC LETTERS}, volume = {26}, unique-id = {34492242}, issn = {1523-7060}, abstract = {The increasing role of the DNA-encoded library technology in early phase drug discovery represents a significant demand for DNA-compatible synthetic methods for therapeutically relevant heterocycles. Herein, we report the first on-DNA synthesis of multisubstituted indoles via a cascade reaction of Sonogashira coupling and intramolecular ring closure. Further functionalization by Suzuki coupling at the third position exploits a diverse chemical space. The high fidelity of the method also enabled the construction of an indole-based mock library. © 2023 The Authors. Published by American Chemical Society.}, year = {2024}, eissn = {1523-7052}, pages = {2517-2522}, orcid-numbers = {Schlosser, Gitta (Vácziné)/0000-0002-7637-7133; Minus, Annamária/0009-0003-4199-3942} } @article{MTMT:34457258, title = {Anticholinesterase and Antityrosinase Secondary Metabolites from the Fungus Xylobolus subpileatus}, url = {https://m2.mtmt.hu/api/publication/34457258}, author = {Felegyi, Kristóf and Garádi, Zsófia and Elżbieta, Studzińska-Sroka and Papp, Viktor and Boldizsár, Imre and Dancsó, András and Béni, Szabolcs and Przemysław, Zalewski and Ványolós, Attila}, doi = {10.3390/molecules29010213}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {29}, unique-id = {34457258}, issn = {1420-3049}, year = {2024}, eissn = {1420-3049}, orcid-numbers = {Garádi, Zsófia/0000-0002-0152-2746; Boldizsár, Imre/0000-0001-7852-8364; Dancsó, András/0000-0001-8460-217X; Béni, Szabolcs/0000-0001-7056-6825; Ványolós, Attila/0000-0002-4710-0004} } @book{MTMT:34407280, title = {Bevezetés a proteomikába : a fehérjék korszerű vizsgálata}, url = {https://m2.mtmt.hu/api/publication/34407280}, isbn = {9789633316009}, author = {Csősz, Éva and Darula, Zsuzsanna and Drahos, László and Emri, Miklós and Hunyadi-Gulyás, Éva and Janáky, Tamás and Juhász, Gábor and Kalló, Gergő and Kékesi, Adrienna Katalin and Klement, Éva and Márk, László and Medzihradszky, F. Katalin and Pettkó-Szandtner, Aladár and Rokobné Révész, Ágnes and Schlosser, Gitta (Vácziné) and Szabó, Zoltán and Tóth, Gábor and Turiák, Lilla}, publisher = {Semmelweis Egyetem}, unique-id = {34407280}, year = {2023}, orcid-numbers = {Rokobné Révész, Ágnes/0000-0002-6221-1239; Schlosser, Gitta (Vácziné)/0000-0002-7637-7133; Szabó, Zoltán/0000-0001-8278-8038} }